Allosteric inhibition of protein tyrosine phosphatase 1B

Nature Structural and Molecular Biology

Volumn 11, Issue 8, 2004, Pages 730-737

  Wiesmann, Christian ^a,b   Barr, Kenneth J ^a   Kung, Jenny ^a   Zhu, Jiang ^a   Erlanson, Daniel A ^a   Shen, Wang ^a   Fahr, Bruce J ^a   Zhong, Min ^a   Taylor, Lisa ^a   Randall, Mike ^a   McDowell, Robert S ^a   Hansen, Stig K ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; INSULIN; PROTEIN TYROSINE PHOSPHATASE 1B;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ALLOSTERIC SITE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; CATALYTIC DOMAIN; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; OBESITY; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; TIME FACTORS; TRANSFECTION; TYROSINE;

EID: 3543017313     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb803     Document Type: Article

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