Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice

Journal of Clinical Investigation

Volumn 124, Issue 9, 2014, Pages 3781-3792

  Chiappini, Franck ^a   Catalano, Karyn J ^a   Lee, Jennifer ^a   Peroni, Odile D ^a   Lynch, Jacqueline ^a   Dhaneshwar, Abha S ^a   Wellenstein, Kerry ^a   Sontheimer, Alexandra ^a   Neel, Benjamin G ^b   Kahn, Barbara B ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN; PROOPIOMELANOCORTIN; PROTEIN TYROSINE PHOSPHATASE 1B; STEROIDOGENIC FACTOR 1; ESTROGEN; PTPN1 PROTEIN, MOUSE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; BRAIN NERVE CELL; CONTROLLED STUDY; DISEASE EXACERBATION; ENERGY EXPENDITURE; FEMALE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HORMONE SENSITIVITY; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LIPID DIET; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PROTEIN FUNCTION; SYMPATHETIC FUNCTION; WEIGHT GAIN; WEIGHT REDUCTION; ZONA INCERTA; ANIMAL; DRUG EFFECTS; ENERGY METABOLISM; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INSULIN RESISTANCE; PHYSIOLOGY;

ANIMALS; DIET, HIGH-FAT; ENERGY METABOLISM; ESTROGENS; FEMALE; INSULIN RESISTANCE; MICE; OBESITY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STEROIDOGENIC FACTOR 1; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84907014635     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI68585     Document Type: Article

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