Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor

Molecular Metabolism

Volumn 3, Issue 3, 2014, Pages 301-312

  Tsou, Ryan C ^a   Rak, Kimberly S ^a   Zimmer, Derek J ^a   Bence, Kendra K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypothalamus; Leptin; Obesity; Phosphatase

Indexed keywords

LEPTIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE 1B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; ENZYME METABOLISM; FEMALE; GLUCOSE TOLERANCE; HYPERPHAGIA; HYPOTHALAMIC PROTEIN TYROSINE PHOSPHATASE 1B DEFICIENCY; HYPOTHALAMUS DISEASE; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

MUS;

EID: 84897110775     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.01.008     Document Type: Article

References (49)

1. Flegal K.M., Carroll M.D., Kit B.K., Ogden C.L. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. Journal of the American Medical Association 2012, 307:491-497.
2. Popkin B.M., Adair L.S., Ng S.W. Global nutrition transition and the pandemic of obesity in developing countries. Nutrition Reviews 2012, 70:3-21.
3. Popkin B.M., Slining M.M. New dynamics in global obesity facing low- and middle-income countries. Obesity Reviews 2013, 14(Suppl. 2):S11-S20.
4. Catenacci V.A., Hill J.O., Wyatt H.R. The obesity epidemic. Clinics in Chest Medicine 2009, 30:415-444. (vii).
5. Flegal K.M., Kit B.K., Orpana H., Graubard B.I. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. Journal of the American Medical Association 2013, 309:71-82.
6. Patterson C.M., Leshan R.L., Jones J.C., Myers M.G. Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Research 2011, 1378:18-28.
7. Scott M.M., Lachey J.L., Sternson S.M., Lee C.E., Elias C.F., Friedman J.M., et al. Leptin targets in the mouse brain. Journal of Comparative Neurology 2009, 514:518-532.
8. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
9. Chua S.C., Chung W.K., Wu-Peng X.S., Zhang Y., Liu S.M., Tartaglia L., et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996, 271:994-996.
10. Lee G.H., Proenca R., Montez J.M., Carroll K.M., Darvishzadeh J.G., Lee J.I., et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996, 379:632-635.
11. Ring L.E., Zeltser L.M. Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. Journal of Clinical Investigation 2010, 120:2931-2941.
12. Scott M.M., Williams K.W., Rossi J., Lee C.E., Elmquist J.K. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. Journal of Clinical Investigation 2011, 121:2413-2421.
13. Robertson S.A., Leinninger G.M., Myers M.G. Molecular and neural mediators of leptin action. Physiology and Behavior 2008, 94:637-642.
14. Bjørbaek C., Kahn B.B. Leptin signaling in the central nervous system and the periphery. Recent Progress in Hormone Research 2004, 59:305-331.
15. Zabolotny J.M., Bence-Hanulec K.K., Stricker-Krongrad A., Haj F., Wang Y., Minokoshi Y., et al. PTP1B regulates leptin signal transduction in vivo. Developmental Cell 2002, 2:489-495.
16. Myers M.P., Andersen J.N., Cheng A., Tremblay M.L., Horvath C.M., Parisien J.P., et al. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. Journal of Biological Chemistry 2001, 276:47771-47774.
17. Cheng A., Uetani N., Simoncic P.D., Chaubey V.P., Lee-Loy A., McGlade C.J., et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Developmental Cell 2002, 2:497-503.
18. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
19. Klaman L.D., Sharpe A.H., Boss O., Stricker-Krongrad A., Peroni O.D., Kim J.K., et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Molecular Cell Biololgy 2000, 20:5479-5489.
20. Bence K.K., Delibegovic M., Xue B., Gorgun C.Z., Hotamisligil G.S., Neel B.G., et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine 2006, 12:917-924.
21. Tsou R.C., Zimmer D.J., De Jonghe B.C., Bence K.K. Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology 2012, 153:1-11.
22. Banno R., Zimmer D., De Jonghe B.C., Atienza M., Rak K., Yang W., et al. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Journal of Clinical Investigation 2010, 120:720-734.
23. Delibegovic M., Bence K.K., Mody N., Hong E.G., Ko H.J., Kim J.K., et al. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Molecular Cell Biology 2007, 27:7727.
24. Delibegovic M., Zimmer D., Kauffman C., Rak K., Hong E., Cho Y., et al. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 2009, 58:590-599.
25. Owen C., Czopek A., Agouni A., Grant L., Judson R., Lees E.K., et al. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One 2012, 7:e32700.
26. L. Grant, K. Shearer, A. Czopek, E. Lees, C. Owen, A. Agouni, et al., Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide induced inflammation, hyperinsulinemia and endotoxemia through an IL10 STAT3 dependent mechanism., Diabetes. (2013) db13-0885r-.
27. De Jonghe B.C., Hayes M.R., Zimmer D.J., Kanoski S.E., Grill H.J., Bence K.K. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American Journal of Physiology - Endocrinology and Metabolism 2012, 303:E644-E651.
28. Ali M.I., Ketsawatsomkron P., Chantemele E.J.Belin De, Mintz J.D., Muta K., Salet C., et al. Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circulation Research 2009, 105:1013-1022.
29. Zinker B.A., Rondinone C.M., Trevillyan J.M., Gum R.J., Clampit J.E., Waring J.F., et al. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:11357-11362.
30. Seale P., Kajimura S., Yang W., Chin S., Rohas L.M., Uldry M., et al. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism 2007, 6:38-54.
31. Xu Q., Tam M., Anderson S.A. Fate mapping Nkx2. 1-lineage cells in the mouse telencephalon. Comparative and General Pharmacology 2008, 29:16-29.
32. Cohen P., Zhao C., Cai X., Montez J.M., Rohani S.C., Feinstein P., et al. Selective deletion of leptin receptor in neurons leads to obesity. Journal of Clinical Investigation 2001, 108:1113-1121.
33. Korner J., Chua S.C., Williams J.A., Leibel R.L., Wardlaw S.L. Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 1999, 70:377-383.
34. De Jonghe B.C., Hayes M.R., Banno R., Skibicka K.P., Zimmer D.J., Bowen K.a., et al. Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American Journal of Physiology - Endocrinology and Metabolism 2011, 300:E1002-E1011.
35. Picardi P.K., Calegari V.C., Prada P.D.O., Moraes J.C., Araújo E., Marcondes M.C.C.G., et al. Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 2008, 149:3870-3880.
36. Klöckener T., Hess S., Belgardt B.F., Paeger L., Verhagen L.a.W., Husch A., et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience 2011, 14:911-918.
37. Byon J.C., Kusari A.B., Kusari J. Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Molecular and Cellular Biochemistry 1998, 182:101-108.
38. Seely B.L., Staubs P.A., Reichart D.R., Berhanu P., Milarski K.L., Saltiel A.R., et al. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes 1996, 45:1379-1385.
39. Bandyopadhyay D., Kusari A., Kenner K.A., Liu F., Chernoff J., Gustafson T.A., et al. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. Journal of Biological Chemistry 1997, 272:1639-1645.
40. Woods S.C., Lotter E.C., McKay L.D., Porte D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979, 282:503-505.
41. Sipols A.J., Baskin D.G., Schwartz M.W. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 1995, 44:147-151.
42. Schwartz M.W., Sipols A.J., Marks J.L., Sanacora G., White J.D., Scheurink A., et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 1992, 130:3608-3616.
43. McGowan M.K., Andrews K.M., Fenner D., Grossman S.P. Chronic intrahypothalamic insulin infusion in the rat: behavioral specificity. Physiology and Behavior 1993, 54:1031-1034.
44. Lambert P.D., Anderson K.D., Sleeman M.W., Wong V., Tan J., Hijarunguru a., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:4652-4657.
45. Wallenius K., Wallenius V., Sunter D., Dickson S.L., Jansson J.-O. Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochemical and Biophysical Research Communications 2002, 293:560-565.
46. Brüning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
47. Wallenius V., Wallenius K., Ahrén B., Rudling M., Carlsten H., Dickson S.L., et al. Interleukin-6-deficient mice develop mature-onset obesity. Nature Medicine 2002, 8:75-79.
48. Bouret S.G., Simerly R.B. Minireview: leptin and development of hypothalamic feeding circuits. Endocrinology 2004, 145:2621-2626.
49. Bouret S.G., Draper S.J., Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304:108-110.