Cellular Effects of Small Molecule PTP1B Inhibitors on Insulin Signaling

Biochemistry

Volumn 42, Issue 44, 2003, Pages 12792-12804

  Xie, Laiping ^a   Lee, Seung Yub ^a   Andersen, Jannik N ^b,e   Waters, Steve ^c   Shen, Kui ^a,f   Guo, Xiao Ling ^a   Moller, Niels Peter H ^b   Olefsky, Jerrold M ^d   Lawrence, David S ^a   Zhang, Zhong Yin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NOVO NORDISK A S   (Denmark)

^c Metabolex Inc   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e Simons Center for Quantitative Biology   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; DRUG PRODUCTS; ENZYMES; GLUCOSE; METABOLISM;

TRANSCRIPTIONAL ACTIVATION;

INSULIN;

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN MIMETIC AGENT; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN SENSITIZING AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SMALL MOLECULE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GLUCOSE TRANSPORT; INSULIN SIGNALING; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIVISION; CELL LINE; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; ENZYME ACTIVATORS; ENZYME INHIBITORS; ETS-DOMAIN PROTEIN ELK-1; GLUCOSE; HUMANS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOBLASTS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TYROSINE;

ANIMALIA;

EID: 10744223631     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035238p     Document Type: Article

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