-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
2
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Jr, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004;42:983-991
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
3
-
-
42449086900
-
Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome
-
Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 2008;149:2138-2148
-
(2008)
Endocrinology
, vol.149
, pp. 2138-2148
-
-
Bingham, N.C.1
Anderson, K.K.2
Reuter, A.L.3
Stallings, N.R.4
Parker, K.L.5
-
4
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203
-
(2006)
Neuron
, vol.49
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
Coppari, R.11
Balthasar, N.12
Cowley, M.A.13
Chua Jr., S.14
Elmquist, J.K.15
Lowell, B.B.16
-
5
-
-
33748541108
-
Leptin regulation of the mesoaccumbens dopamine pathway
-
Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006;51:811-822
-
(2006)
Neuron
, vol.51
, pp. 811-822
-
-
Fulton, S.1
Pissios, P.2
Manchon, R.P.3
Stiles, L.4
Frank, L.5
Pothos, E.N.6
Maratos-Flier, E.7
Flier, J.S.8
-
6
-
-
0036142589
-
Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake
-
Grill HJ, Schwartz MW, Kaplan JM, Foxhall JS, Breininger J, Baskin DG. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 2002;143:239-246
-
(2002)
Endocrinology
, vol.143
, pp. 239-246
-
-
Grill, H.J.1
Schwartz, M.W.2
Kaplan, J.M.3
Foxhall, J.S.4
Breininger, J.5
Baskin, D.G.6
-
7
-
-
33748540764
-
Leptin receptor signaling in midbrain dopamine neurons regulates feeding
-
Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 2006;51:801-810
-
(2006)
Neuron
, vol.51
, pp. 801-810
-
-
Hommel, J.D.1
Trinko, R.2
Sears, R.M.3
Georgescu, D.4
Liu, Z.W.5
Gao, X.B.6
Thurmon, J.J.7
Marinelli, M.8
DiLeone, R.J.9
-
8
-
-
34249785695
-
Leptin and the control of food intake: Neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin
-
Huo L, Maeng L, Bjorbaek C, Grill HJ. Leptin and the control of food intake: neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology 2007;148:2189-2197
-
(2007)
Endocrinology
, vol.148
, pp. 2189-2197
-
-
Huo, L.1
Maeng, L.2
Bjorbaek, C.3
Grill, H.J.4
-
9
-
-
67849092898
-
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
-
Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Munzberg H, Myers MG Jr. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 2009;10:89-98
-
(2009)
Cell Metab
, vol.10
, pp. 89-98
-
-
Leinninger, G.M.1
Jo, Y.H.2
Leshan, R.L.3
Louis, G.W.4
Yang, H.5
Barrera, J.G.6
Wilson, H.7
Opland, D.M.8
Faouzi, M.A.9
Gong, Y.10
Jones, J.C.11
Rhodes, C.J.12
Chua Jr., S.13
Diano, S.14
Horvath, T.L.15
Seeley, R.J.16
Becker, J.B.17
Munzberg, H.18
Myers Jr., M.G.19
-
10
-
-
69449083603
-
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
-
Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 2009;138:976-989
-
(2009)
Cell
, vol.138
, pp. 976-989
-
-
Yadav, V.K.1
Oury, F.2
Suda, N.3
Liu, Z.W.4
Gao, X.B.5
Confavreux, C.6
Klemenhagen, K.C.7
Tanaka, K.F.8
Gingrich, J.A.9
Guo, X.E.10
Tecott, L.H.11
Mann, J.J.12
Hen, R.13
Horvath, T.L.14
Karsenty, G.15
-
11
-
-
0032747280
-
Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, doseescalation trial
-
Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, doseescalation trial. JAMA 1999;282:1568-1575
-
(1999)
JAMA
, vol.282
, pp. 1568-1575
-
-
Heymsfield, S.B.1
Greenberg, A.S.2
Fujioka, K.3
Dixon, R.M.4
Kushner, R.5
Hunt, T.6
Lubina, J.A.7
Patane, J.8
Self, B.9
Hunt, P.10
McCamish, M.11
-
12
-
-
0034522997
-
Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men
-
Hukshorn CJ, Saris WH, Westerterp-Plantenga MS, Farid AR, Smith FJ, Campfield LA. Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men. J Clin Endocrinol Metab 2000;85:4003-4009
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 4003-4009
-
-
Hukshorn, C.J.1
Saris, W.H.2
Westerterp-Plantenga, M.S.3
Farid, A.R.4
Smith, F.J.5
Campfield, L.A.6
-
13
-
-
0028793697
-
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
-
Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995;1:1311-1314
-
(1995)
Nat Med
, vol.1
, pp. 1311-1314
-
-
Frederich, R.C.1
Hamann, A.2
Anderson, S.3
Lollmann, B.4
Lowell, B.B.5
Flier, J.S.6
-
14
-
-
2342449315
-
Triglycerides induce leptin resistance at the blood-brain barrier
-
Banks WA, Coon AB, Robinson SM, Moinuddin A, Shultz JM, Nakaoke R, Morley JE. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 2004;53:1253-1260
-
(2004)
Diabetes
, vol.53
, pp. 1253-1260
-
-
Banks, W.A.1
Coon, A.B.2
Robinson, S.M.3
Moinuddin, A.4
Shultz, J.M.5
Nakaoke, R.6
Morley, J.E.7
-
15
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/ serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348:159-161
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.L.8
Sinha, M.K.9
Considine, R.V.10
-
16
-
-
0033931981
-
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
-
El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000;105:1827-1832
-
(2000)
J Clin Invest
, vol.105
, pp. 1827-1832
-
-
El-Haschimi, K.1
Pierroz, D.D.2
Hileman, S.M.3
Bjorbaek, C.4
Flier, J.S.5
-
17
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996;2:589-593
-
(1996)
Nat Med
, vol.2
, pp. 589-593
-
-
Schwartz, M.W.1
Peskind, E.2
Raskind, M.3
Boyko, E.J.4
Porte Jr., D.5
-
18
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009;9:35-51
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
Myers Jr., M.G.7
Ozcan, U.8
-
19
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008;454:455-462
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
-
20
-
-
33750153292
-
Attenuation of leptin and insulin signaling by SOCS proteins
-
Epub 2006 Sep 2028
-
Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006;17:365-371;Epub 2006 Sep 2028
-
(2006)
Trends Endocrinol Metab
, vol.17
, pp. 365-371
-
-
Howard, J.K.1
Flier, J.S.2
-
21
-
-
17844401180
-
Molecular and anatomical determinants of central leptin resistance
-
Munzberg H, Myers MG Jr. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005;8:566-570
-
(2005)
Nat Neurosci
, vol.8
, pp. 566-570
-
-
Munzberg, H.1
Myers Jr., M.G.2
-
22
-
-
0031943479
-
Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
-
Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 1998;182:91-99
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 91-99
-
-
Goldstein, B.J.1
Ahmad, F.2
Ding, W.3
Li, P.M.4
Zhang, W.R.5
-
23
-
-
18344379861
-
PTP1B regulates leptin signal transduction in vivo
-
Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. PTP1B regulates leptin signal transduction in vivo. Dev Cell 2002;2:489-495
-
(2002)
Dev Cell
, vol.2
, pp. 489-495
-
-
Zabolotny, J.M.1
Bence-Hanulec, K.K.2
Stricker-Krongrad, A.3
Haj, F.4
Wang, Y.5
Minokoshi, Y.6
Kim, Y.B.7
Elmquist, J.K.8
Tartaglia, L.A.9
Kahn, B.B.10
Neel, B.G.11
-
24
-
-
33745362866
-
Critical role of STAT3 in leptin's metabolic actions
-
Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG Jr, Rossetti L. Critical role of STAT3 in leptin's metabolic actions. Cell Metab 2006;4:49-60
-
(2006)
Cell Metab
, vol.4
, pp. 49-60
-
-
Buettner, C.1
Pocai, A.2
Muse, E.D.3
Etgen, A.M.4
Myers Jr., M.G.5
Rossetti, L.6
-
25
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998;1:619-625
-
(1998)
Mol Cell
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
27
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999;23:775-786
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
28
-
-
9244219587
-
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
-
Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;145:4880-4889
-
(2004)
Endocrinology
, vol.145
, pp. 4880-4889
-
-
Munzberg, H.1
Flier, J.S.2
Bjorbaek, C.3
-
29
-
-
2542499538
-
Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression
-
Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression. Mol Endocrinol 2004;18:1333-1345
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1333-1345
-
-
Lam, N.T.1
Lewis, J.T.2
Cheung, A.T.3
Luk, C.T.4
Tse, J.5
Wang, J.6
Bryer-Ash, M.7
Kolls, J.K.8
Kieffer, T.J.9
-
30
-
-
33845882537
-
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
-
Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW. Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology 2007;148:433-440
-
(2007)
Endocrinology
, vol.148
, pp. 433-440
-
-
Morrison, C.D.1
White, C.L.2
Wang, Z.3
Lee, S.Y.4
Lawrence, D.S.5
Cefalu, W.T.6
Zhang, Z.Y.7
Gettys, T.W.8
-
31
-
-
60849120123
-
HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms
-
White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab 2009;296:E291-E299
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
White, C.L.1
Whittington, A.2
Barnes, M.J.3
Wang, Z.4
Bray, G.A.5
Morrison, C.D.6
-
32
-
-
47249148827
-
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
-
Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 2008;283:14230-14241
-
(2008)
J Biol Chem
, vol.283
, pp. 14230-14241
-
-
Zabolotny, J.M.1
Kim, Y.B.2
Welsh, L.A.3
Kershaw, E.E.4
Neel, B.G.5
Kahn, B.B.6
-
33
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-738
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjorbaek, C.5
Flier, J.S.6
-
34
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 2004;10:739-743
-
(2004)
Nat Med
, vol.10
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
Aki, D.4
Mashima, R.5
Nishinakamura, H.6
Torisu, T.7
Chien, K.R.8
Yasukawa, H.9
Yoshimura, A.10
-
35
-
-
33746810001
-
Neuronal PTP1B regulates body weight, adiposity and leptin action
-
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 2006;12:917-924
-
(2006)
Nat Med
, vol.12
, pp. 917-924
-
-
Bence, K.K.1
Delibegovic, M.2
Xue, B.3
Gorgun, C.Z.4
Hotamisligil, G.S.5
Neel, B.G.6
Kahn, B.B.7
-
36
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999;283:1544-1548
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
Ramachandran, C.11
Gresser, M.J.12
Tremblay, M.L.13
Kennedy, B.P.14
-
37
-
-
0033942614
-
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
-
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 2000;20:5479-5489
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5479-5489
-
-
Klaman, L.D.1
Boss, O.2
Peroni, O.D.3
Kim, J.K.4
Martino, J.L.5
Zabolotny, J.M.6
Moghal, N.7
Lubkin, M.8
Kim, Y.B.9
Sharpe, A.H.10
Stricker-Krongrad, A.11
Shulman, G.I.12
Neel, B.G.13
Kahn, B.B.14
-
38
-
-
0037600741
-
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
-
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 2003;4:551-556
-
(2003)
Nat Immunol
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
Ohishi, M.2
Mori, H.3
Murakami, M.4
Chinen, T.5
Aki, D.6
Hanada, T.7
Takeda, K.8
Akira, S.9
Hoshijima, M.10
Hirano, T.11
Chien, K.R.12
Yoshimura, A.13
-
39
-
-
54349113070
-
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
-
Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 2008;149:5654-5661
-
(2008)
Endocrinology
, vol.149
, pp. 5654-5661
-
-
Zhang, R.1
Dhillon, H.2
Yin, H.3
Yoshimura, A.4
Lowell, B.B.5
Maratos-Flier, E.6
Flier, J.S.7
-
40
-
-
36549059075
-
Inhibition of the protein tyrosine phosphatase PTP1B: Potential therapy for obesity, insulin resistance and type-2 diabetes mellitus
-
Koren S, Fantus IG. Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus. Best Pract Res Clin Endocrinol Metab 2007;21:621-640
-
(2007)
Best Pract Res Clin Endocrinol Metab
, vol.21
, pp. 621-640
-
-
Koren, S.1
Fantus, I.G.2
-
41
-
-
34347260715
-
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B
-
Lee S, Wang Q. Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B. Med Res Rev 2007;27:553-573
-
(2007)
Med Res Rev
, vol.27
, pp. 553-573
-
-
Lee, S.1
Wang, Q.2
-
42
-
-
21044453354
-
Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms
-
Kokkotou E, Jeon JY, Wang X, Marino FE, Carlson M, Trombly DJ, Maratos-Flier E. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol. 2005;289:R117-R124
-
(2005)
Am J Physiol Regul Integr Comp Physiol
, vol.289
-
-
Kokkotou, E.1
Jeon, J.Y.2
Wang, X.3
Marino, F.E.4
Carlson, M.5
Trombly, D.J.6
Maratos-Flier, E.7
-
43
-
-
33748705967
-
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly
-
Forni PE, Scuoppo C, Imayoshi I, Taulli R, Dastru W, Sala V, Betz UA, Muzzi P, Martinuzzi D, Vercelli AE, Kageyama R, Ponzetto C. High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci 2006;26:9593-9602
-
(2006)
J Neurosci
, vol.26
, pp. 9593-9602
-
-
Forni, P.E.1
Scuoppo, C.2
Imayoshi, I.3
Taulli, R.4
Dastru, W.5
Sala, V.6
Betz, U.A.7
Muzzi, P.8
Martinuzzi, D.9
Vercelli, A.E.10
Kageyama, R.11
Ponzetto, C.12
-
44
-
-
0038584904
-
Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling
-
Gu F, Dube N, Kim JW, Cheng A, Ibarra-Sanchez Mde J, Tremblay ML, Boisclair YR. Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol 2003;23:3753-3762
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3753-3762
-
-
Gu, F.1
Dube, N.2
Kim, J.W.3
Cheng, A.4
Ibarra-Sanchez, Mde.J.5
Tremblay, M.L.6
Boisclair, Y.R.7
-
45
-
-
0036121371
-
Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts
-
Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R. Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol 2002;22:1998-2010
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1998-2010
-
-
Buckley, D.A.1
Cheng, A.2
Kiely, P.A.3
Tremblay, M.L.4
O'Connor, R.5
-
46
-
-
2542445326
-
Suppressors of cytokine signalling and regulation of growth hormone action
-
Greenhalgh CJ, Alexander WS. Suppressors of cytokine signalling and regulation of growth hormone action. Growth Horm IGF Res 2004;14:200-206
-
(2004)
Growth Horm IGF Res
, vol.14
, pp. 200-206
-
-
Greenhalgh, C.J.1
Alexander, W.S.2
-
47
-
-
24744468600
-
JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
-
Yadav A, Kalita A, Dhillon S, Banerjee K. JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. J Biol Chem 2005;280:31830-31840
-
(2005)
J Biol Chem
, vol.280
, pp. 31830-31840
-
-
Yadav, A.1
Kalita, A.2
Dhillon, S.3
Banerjee, K.4
-
48
-
-
59449093033
-
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity
-
Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Jr, Chua SC, Jr, Kim JK, Kaestner KH, Karsenty G. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 2008;183:1235-1242
-
(2008)
J Cell Biol
, vol.183
, pp. 1235-1242
-
-
Hinoi, E.1
Gao, N.2
Jung, D.Y.3
Yadav, V.4
Yoshizawa, T.5
Myers Jr., M.G.6
Chua Jr., S.C.7
Kim, J.K.8
Kaestner, K.H.9
Karsenty, G.10
-
49
-
-
42649144463
-
Beneficial effects of subcutaneous fat transplantation on metabolism
-
Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008;7:410-420
-
(2008)
Cell Metab
, vol.7
, pp. 410-420
-
-
Tran, T.T.1
Yamamoto, Y.2
Gesta, S.3
Kahn, C.R.4
-
50
-
-
58149334897
-
Leptin reverses long-term potentiation at hippocampal CA1 synapses
-
Moult PR, Milojkovic B, Harvey J. Leptin reverses long-term potentiation at hippocampal CA1 synapses. J Neurochem 2009;108:685-696
-
(2009)
J Neurochem
, vol.108
, pp. 685-696
-
-
Moult, P.R.1
Milojkovic, B.2
Harvey, J.3
-
51
-
-
27344441682
-
Neurogenesis in the hypothalamus of adult mice: Potential role in energy balance
-
Kokoeva MV, Yin H, Flier JS. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005;310:679-683
-
(2005)
Science
, vol.310
, pp. 679-683
-
-
Kokoeva, M.V.1
Yin, H.2
Flier, J.S.3
|