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Volumn 67, Issue 4, 2015, Pages 1074-1095

Rho kinases in health and disease: From basic science to translational research

Author keywords

[No Author keywords available]

Indexed keywords

FASUDIL; GSK 269962A; H 1152; MYOSIN LIGHT CHAIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHO KINASE 1; RHO KINASE 2; RHO KINASE INHIBITOR; SB 772077B; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLUCOSE; ROCK1 PROTEIN, HUMAN; ROCK2 PROTEIN, HUMAN;

EID: 84942900076     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.115.010595     Document Type: Review
Times cited : (156)

References (211)
  • 4
    • 0033780417 scopus 로고    scopus 로고
    • Purification and in vitro activity of Rho-associated kinase
    • Amano M, Fukata Y, Shimokawa H, and Kaibuchi K (2000) Purification and in vitro activity of Rho-associated kinase. Methods Enzymol 325:149-155.
    • (2000) Methods Enzymol , vol.325 , pp. 149-155
    • Amano, M.1    Fukata, Y.2    Shimokawa, H.3    Kaibuchi, K.4
  • 6
    • 84921539331 scopus 로고    scopus 로고
    • Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure
    • AR-13324-CS202 Study Group
    • Bacharach J, Dubiner HB, Levy B, Kopczynski CC, and Novack GD; AR-13324-CS202 Study Group (2015) Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure. Ophthalmology 122:302-307.
    • (2015) Ophthalmology , vol.122 , pp. 302-307
    • Bacharach, J.1    Dubiner, H.B.2    Levy, B.3    Kopczynski, C.C.4    Novack, G.D.5
  • 9
    • 77956361520 scopus 로고    scopus 로고
    • Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 pro¬duction and the development of autoimmunity in mice
    • Biswas PS, Gupta S, Chang E, Song L, Stirzaker RA, Liao JK, Bhagat G, and Pernis AB (2010) Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 pro¬duction and the development of autoimmunity in mice. J Clin Invest 120: 3280-3295.
    • (2010) J Clin Invest , vol.120 , pp. 3280-3295
    • Biswas, P.S.1    Gupta, S.2    Chang, E.3    Song, L.4    Stirzaker, R.A.5    Liao, J.K.6    Bhagat, G.7    Pernis, A.B.8
  • 13
    • 33645747309 scopus 로고    scopus 로고
    • The Rac and Rho hall of fame: A decade of hypertrophic signaling hits
    • Brown JH, Del Re DP, and Sussman MA (2006) The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res 98:730-742.
    • (2006) Circ Res , vol.98 , pp. 730-742
    • Brown, J.H.1    Del Re, D.P.2    Sussman, M.A.3
  • 14
    • 33749233824 scopus 로고    scopus 로고
    • Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
    • Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, and Schwartz RJ (2006) Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci USA 103:14495-14500.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14495-14500
    • Chang, J.1    Xie, M.2    Shah, V.R.3    Schneider, M.D.4    Entman, M.L.5    Wei, L.6    Schwartz, R.J.7
  • 15
    • 84921895781 scopus 로고    scopus 로고
    • In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction
    • Chen CP, Chen X, Qiao YN, Wang P, He WQ, Zhang CH, Zhao W, Gao YQ, Chen C, and Tao T, et al. (2015) In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol 593:681-700.
    • (2015) J Physiol , vol.593 , pp. 681-700
    • Chen, C.P.1    Chen, X.2    Qiao, Y.N.3    Wang, P.4    He, W.Q.5    Zhang, C.H.6    Zhao, W.7    Gao, Y.Q.8    Chen, C.9    Tao, T.10
  • 16
    • 0037066777 scopus 로고    scopus 로고
    • Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies
    • Chen XQ, Tan I, Ng CH, Hall C, Lim L, and Leung T (2002) Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies. J Biol Chem 277: 12680-12688.
    • (2002) J Biol Chem , vol.277 , pp. 12680-12688
    • Chen, X.Q.1    Tan, I.2    Ng, C.H.3    Hall, C.4    Lim, L.5    Leung, T.6
  • 20
    • 84875301533 scopus 로고    scopus 로고
    • Role of ROCK upregulation in endo¬thelial and smooth muscle vascular functions in diabetic rat aorta
    • Cicek FA, Kandilci HB, and Turan B (2013) Role of ROCK upregulation in endo¬thelial and smooth muscle vascular functions in diabetic rat aorta. Cardiovasc Diabetol 12:51.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 51
    • Cicek, F.A.1    Kandilci, H.B.2    Turan, B.3
  • 21
    • 77954546832 scopus 로고    scopus 로고
    • Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil ad¬ministration
    • Couch BA, DeMarco GJ, Gourley SL, and Koleske AJ (2010) Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil ad¬ministration. J Alzheimers Dis 20:1003-1008.
    • (2010) J Alzheimers Dis , vol.20 , pp. 1003-1008
    • Couch, B.A.1    Demarco, G.J.2    Gourley, S.L.3    Koleske, A.J.4
  • 22
    • 0141615827 scopus 로고    scopus 로고
    • Diabetes and vas¬cular disease: Pathophysiology, clinical consequences, and medical therapy: Part I
    • Creager MA, Lüscher TF, Cosentino F, and Beckman JA (2003) Diabetes and vas¬cular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108:1527-1532.
    • (2003) Circulation , vol.108 , pp. 1527-1532
    • Creager, M.A.1    Lüscher, T.F.2    Cosentino, F.3    Beckman, J.A.4
  • 23
    • 79953800449 scopus 로고    scopus 로고
    • Molecular basis for en¬dothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting
    • Davis GE, Stratman AN, Sacharidou A, and Koh W (2011) Molecular basis for en¬dothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol 288:101-165.
    • (2011) Int Rev Cell Mol Biol , vol.288 , pp. 101-165
    • Davis, G.E.1    Stratman, A.N.2    Sacharidou, A.3    Koh, W.4
  • 29
    • 84879122131 scopus 로고    scopus 로고
    • Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease
    • Dong M, Jiang X, Liao JK, and Yan BP (2013) Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease. Clin Cardiol 36:347-351.
    • (2013) Clin Cardiol , vol.36 , pp. 347-351
    • Dong, M.1    Jiang, X.2    Liao, J.K.3    Yan, B.P.4
  • 31
    • 10644234702 scopus 로고    scopus 로고
    • New insights into the structure-function relationships of Rho-associated kinase: A thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implica¬tions
    • Doran JD, Liu X, Taslimi P, Saadat A, and Fox T (2004) New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implica¬tions. Biochem J 384:255-262.
    • (2004) Biochem J , vol.384 , pp. 255-262
    • Doran, J.D.1    Liu, X.2    Taslimi, P.3    Saadat, A.4    Fox, T.5
  • 33
    • 0032548848 scopus 로고    scopus 로고
    • A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin sig¬naling
    • Farah S, Agazie Y, Ohan N, Ngsee JK, and Liu XJ (1998) A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin sig¬naling. J Biol Chem 273:4740-4746.
    • (1998) J Biol Chem , vol.273 , pp. 4740-4746
    • Farah, S.1    Agazie, Y.2    Ohan, N.3    Ngsee, J.K.4    Liu, X.J.5
  • 37
    • 84896726589 scopus 로고    scopus 로고
    • Rho kinase inhibitors: A patent review (2012-2013)
    • Feng Y and LoGrasso PV (2014) Rho kinase inhibitors: a patent review (2012-2013). Expert Opin Ther Pat 24:295-307.
    • (2014) Expert Opin Ther Pat , vol.24 , pp. 295-307
    • Feng, Y.1    Lograsso, P.V.2
  • 39
    • 0037443069 scopus 로고    scopus 로고
    • Rho kinase inhibition enhances axonal regeneration in the injured CNS
    • Fournier AE, Takizawa BT, and Strittmatter SM (2003) Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci 23:1416-1423.
    • (2003) J Neurosci , vol.23 , pp. 1416-1423
    • Fournier, A.E.1    Takizawa, B.T.2    Strittmatter, S.M.3
  • 40
    • 33750693942 scopus 로고    scopus 로고
    • Signaling mechanism ofrenal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice
    • Fu P, Liu F, Su S, Wang W, Huang XR, Entman ML, Schwartz RJ, Wei L, and Lan HY (2006) Signaling mechanism ofrenal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol 17:3105-3114.
    • (2006) J am Soc Nephrol , vol.17 , pp. 3105-3114
    • Fu, P.1    Liu, F.2    Su, S.3    Wang, W.4    Huang, X.R.5    Entman, M.L.6    Schwartz, R.J.7    Wei, L.8    Lan, H.Y.9
  • 41
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
    • Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, and Shimokawa H (2010) Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 25:144-149.
    • (2010) Heart Vessels , vol.25 , pp. 144-149
    • Fujita, H.1    Fukumoto, Y.2    Saji, K.3    Sugimura, K.4    Demachi, J.5    Nawata, J.6    Shimokawa, H.7
  • 42
    • 84910092956 scopus 로고    scopus 로고
    • Axon growth inhibition by RhoA/ROCK in the central nervous system
    • Fujita Y and Yamashita T (2014) Axon growth inhibition by RhoA/ROCK in the central nervous system. Front Neurosci 8:338.
    • (2014) Front Neurosci , vol.8 , pp. 338
    • Fujita, Y.1    Yamashita, T.2
  • 47
    • 84887084044 scopus 로고    scopus 로고
    • Advances in the studies ofroles ofRho/Rho-kinase in diseases and the development ofits inhibitors
    • Guan R, Xu X, Chen M, Hu H, Ge H, Wen S, Zhou S, and Pi R (2013) Advances in the studies ofroles ofRho/Rho-kinase in diseases and the development ofits inhibitors. Eur J Med Chem 70:613-622.
    • (2013) Eur J Med Chem , vol.70 , pp. 613-622
    • Guan, R.1    Xu, X.2    Chen, M.3    Hu, H.4    Ge, H.5    Wen, S.6    Zhou, S.7    Pi, R.8
  • 49
    • 24944513184 scopus 로고    scopus 로고
    • Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and sponta¬neous migration of Walker 256 carcinosarcoma cells
    • Gutjahr MC, Rossy J, and Niggli V (2005) Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and sponta¬neous migration of Walker 256 carcinosarcoma cells. Exp Cell Res 308: 422-438.
    • (2005) Exp Cell Res , vol.308 , pp. 422-438
    • Gutjahr, M.C.1    Rossy, J.2    Niggli, V.3
  • 50
    • 0033946174 scopus 로고    scopus 로고
    • Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats
    • Hara M, Takayasu M, Watanabe K, Noda A, Takagi T, Suzuki Y, and Yoshida J (2000) Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats. J Neurosurg 93(1, Suppl)94-101.
    • (2000) J Neurosurg , vol.93 , Issue.1 , pp. 94-101
    • Hara, M.1    Takayasu, M.2    Watanabe, K.3    Noda, A.4    Takagi, T.5    Suzuki, Y.6    Yoshida, J.7
  • 51
    • 78650832970 scopus 로고    scopus 로고
    • Measurement of Rho-associated kinase (ROCK) activity in humans: Validity of leukocyte p-MBS/t-MBS in comparison with vas¬cular response to fasudil
    • Hata T, Goto C, Soga J, Hidaka T, Fujii Y, idei N, Fujimura N, Maruhashi T, Mikami S, and Kihara Y, et al. (2011a) Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vas¬cular response to fasudil. Atherosclerosis 214:117-121.
    • (2011) Atherosclerosis , vol.214 , pp. 117-121
    • Hata, T.1    Goto, C.2    Soga, J.3    Hidaka, T.4    Fujii, Y.5    Idei, N.6    Fujimura, N.7    Maruhashi, T.8    Mikami, S.9    Kihara, Y.10
  • 53
    • 2442509844 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses left ven¬tricular remodeling after myocardial infarction in mice
    • Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, and Takeshita A (2004) Long-term inhibition of Rho-kinase suppresses left ven¬tricular remodeling after myocardial infarction in mice. Circulation 109: 2234-2239.
    • (2004) Circulation , vol.109 , pp. 2234-2239
    • Hattori, T.1    Shimokawa, H.2    Higashi, M.3    Hiroki, J.4    Mukai, Y.5    Tsutsui, H.6    Kaibuchi, K.7    Takeshita, A.8
  • 54
    • 31544439891 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic strategies ofchronic renal injury: Role ofrho-kinase in the development of renal injury
    • Hayashi K, Wakino S, Kanda T, Homma K, Sugano N, and Saruta T (2006) Molecular mechanisms and therapeutic strategies ofchronic renal injury: role ofrho-kinase in the development of renal injury. J Pharmacol Sci 100:29-33.
    • (2006) J Pharmacol Sci , vol.100 , pp. 29-33
    • Hayashi, K.1    Wakino, S.2    Kanda, T.3    Homma, K.4    Sugano, N.5    Saruta, T.6
  • 55
    • 55849145500 scopus 로고    scopus 로고
    • Antiin¬flammatory effect ofRho kinase blockade via inhibition ofNF-kappaB activation in rheumatoid arthritis
    • He Y, Xu H, Liang L, Zhan Z, Yang X, Yu X, Ye Y, and Sun L (2008) Antiin¬flammatory effect ofRho kinase blockade via inhibition ofNF-kappaB activation in rheumatoid arthritis. Arthritis Rheum 58:3366-3376.
    • (2008) Arthritis Rheum , vol.58 , pp. 3366-3376
    • He, Y.1    Xu, H.2    Liang, L.3    Zhan, Z.4    Yang, X.5    Yu, X.6    Ye, Y.7    Sun, L.8
  • 56
    • 84901457450 scopus 로고    scopus 로고
    • Rho-GTPase signaling in leu¬kocyte extravasation: An endothelial point of view
    • Heemskerk N, van Rijssel J, and van Buul JD (2014) Rho-GTPase signaling in leu¬kocyte extravasation: an endothelial point of view. Cell Adhes Migr 8:67-75.
    • (2014) Cell Adhes Migr , vol.8 , pp. 67-75
    • Heemskerk, N.1    Van Rijssel, J.2    Van Buul, J.D.3
  • 58
    • 0142120102 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase sup¬presses angiotensin ii-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system
    • Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, ichiki T, Takahashi S, and Takeshita A (2003) Long-term inhibition of Rho-kinase sup¬presses angiotensin ii-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 93:767-775.
    • (2003) Circ Res , vol.93 , pp. 767-775
    • Higashi, M.1    Shimokawa, H.2    Hattori, T.3    Hiroki, J.4    Mukai, Y.5    Morikawa, K.6    Ichiki, T.7    Takahashi, S.8    Takeshita, A.9
  • 60
    • 0032571395 scopus 로고    scopus 로고
    • The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase
    • Hoshijima M, Sah VP, Wang Y, Chien KR, and Brown JH (1998) The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. involvement of Rho kinase. J Biol Chem 273:7725-7730.
    • (1998) J Biol Chem , vol.273 , pp. 7725-7730
    • Hoshijima, M.1    Sah, V.P.2    Wang, Y.3    Chien, K.R.4    Brown, J.H.5
  • 61
    • 84855189897 scopus 로고    scopus 로고
    • Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride
    • Hou Y, Zhou L, Yang QD, Du XP, Li M, Yuan M, and Zhou ZW (2012) Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride. Neuroscience 200: 120-129.
    • (2012) Neuroscience , vol.200 , pp. 120-129
    • Hou, Y.1    Zhou, L.2    Yang, Q.D.3    Du, X.P.4    Li, M.5    Yuan, M.6    Zhou, Z.W.7
  • 62
    • 84862831046 scopus 로고    scopus 로고
    • Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina
    • Hung MJ, Cherng WJ, Hung MY, Kuo LT, Cheng CW, Wang CH, Yang Ni, and Liao JK (2012) increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina. Ath¬erosclerosis 221:521-526.
    • (2012) Ath¬erosclerosis , vol.221 , pp. 521-526
    • Hung, M.J.1    Cherng, W.J.2    Hung, M.Y.3    Kuo, L.T.4    Cheng, C.W.5    Wang, C.H.6    Ni, Y.7    Liao, J.K.8
  • 63
    • 84887410136 scopus 로고    scopus 로고
    • Rho-associated kinase inhibitors: A novel glaucoma therapy
    • Inoue T and Tanihara H (2013) Rho-associated kinase inhibitors: a novel glaucoma therapy. Prog Retin Eye Res 37:1-12.
    • (2013) Prog Retin Eye Res , vol.37 , pp. 1-12
    • Inoue, T.1    Tanihara, H.2
  • 65
    • 33744996300 scopus 로고    scopus 로고
    • Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats
    • Ishikawa Y, Nishikimi T, Akimoto K, ishimura K, Ono H, and Matsuoka H (2006) Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats. Hypertension 47:1075-1083.
    • (2006) Hypertension , vol.47 , pp. 1075-1083
    • Ishikawa, Y.1    Nishikimi, T.2    Akimoto, K.3    Ishimura, K.4    Ono, H.5    Matsuoka, H.6
  • 66
    • 31644431508 scopus 로고    scopus 로고
    • Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
    • Ishikura K, Yamada N, ito M, Ota S, Nakamura M, isaka N, and Nakano T (2006) Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 70:174-178.
    • (2006) Circ J , vol.70 , pp. 174-178
    • Ishikura, K.1    Yamada, N.2    Ito, M.3    Ota, S.4    Nakamura, M.5    Isaka, N.6    Nakano, T.7
  • 67
    • 84904348321 scopus 로고    scopus 로고
    • Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits
    • Isobe T, Mizuno K, Kaneko Y, Ohta M, Koide T, and Tanabe S (2014) Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res 39:813-822.
    • (2014) Curr Eye Res , vol.39 , pp. 813-822
    • Isobe, T.1    Mizuno, K.2    Kaneko, Y.3    Ohta, M.4    Koide, T.5    Tanabe, S.6
  • 71
    • 0037817325 scopus 로고    scopus 로고
    • Signif¬icant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T, Tsujii T, Arai K, Takagi K, Asami H, ito Y, and Oshima H (2003) Signif¬icant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 9:2632-2641.
    • (2003) Clin Cancer Res , vol.9 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3    Takagi, K.4    Asami, H.5    Ito, Y.6    Oshima, H.7
  • 73
    • 0344514708 scopus 로고    scopus 로고
    • Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontane¬ously hypertensive rats
    • Kanda T, Wakino S, Hayashi K, Homma K, Ozawa Y, and Saruta T (2003) Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontane¬ously hypertensive rats. Kidney Int 64:2009-2019.
    • (2003) Kidney Int , vol.64 , pp. 2009-2019
    • Kanda, T.1    Wakino, S.2    Hayashi, K.3    Homma, K.4    Ozawa, Y.5    Saruta, T.6
  • 75
    • 84923085361 scopus 로고    scopus 로고
    • Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency
    • Kasahara Di, Ninin FM, Wurmbrand AP, Liao JK, and Shore SA (2015) Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency. Clin Exp Allergy 45:457-470.
    • (2015) Clin Exp Allergy , vol.45 , pp. 457-470
    • Di, K.1    Ninin, F.M.2    Wurmbrand, A.P.3    Liao, J.K.4    Shore, S.A.5
  • 77
    • 80052848443 scopus 로고    scopus 로고
    • Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: A possible bio¬marker for diagnosis and disease activity assessment
    • Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, ito Y, Takeda M, Nakayama M, ito K, Takahashi J, and Shimokawa H (2011) Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible bio¬marker for diagnosis and disease activity assessment. J Am Coll Cardiol 58: 1231-1237.
    • (2011) J am Coll Cardiol , vol.58 , pp. 1231-1237
    • Kikuchi, Y.1    Yasuda, S.2    Aizawa, K.3    Tsuburaya, R.4    Ito, Y.5    Takeda, M.6    Nakayama, M.7    Ito, K.8    Takahashi, J.9    Shimokawa, H.10
  • 78
    • 84916241169 scopus 로고    scopus 로고
    • The Rho kinases: Critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis
    • Knipe RS, Tager AM, and Liao JK (2015) The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis. Pharmacol Rev 67:103-117.
    • (2015) Pharmacol Rev , vol.67 , pp. 103-117
    • Knipe, R.S.1    Tager, A.M.2    Liao, J.K.3
  • 80
    • 40949137434 scopus 로고    scopus 로고
    • Targeting of RhoA/ ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control
    • Kolavennu V, Zeng L, Peng H, Wang Y, and Danesh FR (2008) Targeting of RhoA/ ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. Diabetes 57:714-723.
    • (2008) Diabetes , vol.57 , pp. 714-723
    • Kolavennu, V.1    Zeng, L.2    Peng, H.3    Wang, Y.4    Danesh, F.R.5
  • 81
    • 77956629432 scopus 로고    scopus 로고
    • Myocardin-related transcription factor A is a common mediator of mechanical stress-and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression
    • Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, Minami T, Yamada Y, Fujiwara M, and Nakao K (2010) Myocardin-related transcription factor A is a common mediator of mechanical stress-and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression. Mol Cell Biol 30:4134-4148.
    • (2010) Mol Cell Biol , vol.30 , pp. 4134-4148
    • Kuwahara, K.1    Kinoshita, H.2    Kuwabara, Y.3    Nakagawa, Y.4    Usami, S.5    Minami, T.6    Yamada, Y.7    Fujiwara, M.8    Nakao, K.9
  • 82
    • 54849186600 scopus 로고    scopus 로고
    • The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer
    • Lane J, Martin TA, Watkins G, Mansel RE, and Jiang WG (2008) The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int JOncol 33:585-593.
    • (2008) Int Joncol , vol.33 , pp. 585-593
    • Lane, J.1    Martin, T.A.2    Watkins, G.3    Mansel, R.E.4    Jiang, W.G.5
  • 83
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation ofendothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U and Liao JK (1998) Post-transcriptional regulation ofendothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 273:24266-24271.
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 85
    • 77956915812 scopus 로고    scopus 로고
    • Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics
    • Lee HH, Tien SC, Jou TS, Chang YC, Jhong JG, and Chang ZF (2010) Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics. J Cell Sci 123:3368-3377.
    • (2010) J Cell Sci , vol.123 , pp. 3368-3377
    • Lee, H.H.1    Tien, S.C.2    Jou, T.S.3    Chang, Y.C.4    Jhong, J.G.5    Chang, Z.F.6
  • 88
    • 0029789678 scopus 로고    scopus 로고
    • The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    • Leung T, Chen XQ, Manser E, and Lim L (1996) The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol CellBiol 16:5313-5327.
    • (1996) Mol Cellbiol , vol.16 , pp. 5313-5327
    • Leung, T.1    Chen, X.Q.2    Manser, E.3    Lim, L.4
  • 89
    • 0028863142 scopus 로고
    • A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral mem¬branes
    • Leung T, Manser E, Tan L, and Lim L (1995) A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral mem¬branes. JBiol Chem 270:29051-29054.
    • (1995) Jbiol Chem , vol.270 , pp. 29051-29054
    • Leung, T.1    Manser, E.2    Tan, L.3    Lim, L.4
  • 90
    • 70350348368 scopus 로고    scopus 로고
    • Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice
    • Li M, Huang Y, Ma AA, Lin E, and Diamond MI (2009) Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis 36: 413-420.
    • (2009) Neurobiol Dis , vol.36 , pp. 413-420
    • Li, M.1    Huang, Y.2    Ma, A.A.3    Lin, E.4    Diamond, M.I.5
  • 91
    • 84859384858 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: Role of TGF-ß1-TAK1
    • Li Q, Xu Y, Li X, Guo Y, and Liu G (2012a) Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-ß1-TAK1. ToxicolLett 211:91-97.
    • (2012) Toxicollett , vol.211 , pp. 91-97
    • Li, Q.1    Xu, Y.2    Li, X.3    Guo, Y.4    Liu, G.5
  • 93
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, ad¬hesion, and migration in patients with systemic lupus erythematosus
    • Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, Tung K, and Tsokos GC (2007) Phosphorylated ERM is responsible for increased T cell polarization, ad¬hesion, and migration in patients with systemic lupus erythematosus. J Immunol 178:1938-1947.
    • (2007) J Immunol , vol.178 , pp. 1938-1947
    • Li, Y.1    Harada, T.2    Juang, Y.T.3    Kyttaris, V.C.4    Wang, Y.5    Zidanic, M.6    Tung, K.7    Tsokos, G.C.8
  • 94
    • 84919798074 scopus 로고    scopus 로고
    • Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its ac¬tivity and expression
    • Liao YC, Liu PY, Lin HF, Lin WY, Liao JK, and Juo SH (2015) Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its ac¬tivity and expression. J Mol Cell Cardiol 79:180-186.
    • (2015) J Mol Cell Cardiol , vol.79 , pp. 180-186
    • Liao, Y.C.1    Liu, P.Y.2    Lin, H.F.3    Lin, W.Y.4    Liao, J.K.5    Juo, S.H.6
  • 95
    • 84857054821 scopus 로고    scopus 로고
    • Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage
    • Liu GJ, Wang Zj, Wang YF, Xu LL, Wang XL, Liu Y, Luo GJ, He GH, and Zeng YJ (2012) Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. Eur J Clin Pharmacol 68:131-139.
    • (2012) Eur J Clin Pharmacol , vol.68 , pp. 131-139
    • Liu, G.J.1    Zj, W.2    Wang, Y.F.3    Xu, L.L.4    Wang, X.L.5    Liu, Y.6    Luo, G.J.7    He, G.H.8    Zeng, Y.J.9
  • 96
    • 84872236260 scopus 로고    scopus 로고
    • Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population
    • Liu L, Cao Y, Cui G, Li Z, Sun J, Zhang L, Chen C, Wang Y, Wang P, and Ding H, et al. (2013) Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population. PLoS One 8:e53905.
    • (2013) Plos One , vol.8
    • Liu, L.1    Cao, Y.2    Cui, G.3    Li, Z.4    Sun, J.5    Zhang, L.6    Chen, C.7    Wang, Y.8    Wang, P.9    Ding, H.10
  • 97
    • 34047260912 scopus 로고    scopus 로고
    • Increased Rho kinase activity in a Taiwanese population with metabolic syndrome
    • Liu PY, Chen JH, Lin LJ, and Liao JK (2007) Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol 49:1619-1624.
    • (2007) J am Coll Cardiol , vol.49 , pp. 1619-1624
    • Liu, P.Y.1    Chen, J.H.2    Lin, L.J.3    Liao, J.K.4
  • 98
    • 59049103155 scopus 로고    scopus 로고
    • Evidence for statin pleiotropy in humans: Differential effects ofstatins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation
    • Liu PY, Liu YW, Lin LJ, Chen JH, and Liao JK (2009a) Evidence for statin pleiotropy in humans: differential effects ofstatins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation. Circu¬lation 119:131-138.
    • (2009) Circu¬lation , vol.119 , pp. 131-138
    • Liu, P.Y.1    Liu, Y.W.2    Lin, L.J.3    Chen, J.H.4    Liao, J.K.5
  • 99
    • 72249097073 scopus 로고    scopus 로고
    • Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone
    • Liu S, Goldstein RH, Scepansky EM, and Rosenblatt M (2009b) Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. CancerRes 69:8742-8751.
    • (2009) Cancerres , vol.69 , pp. 8742-8751
    • Liu, S.1    Goldstein, R.H.2    Scepansky, E.M.3    Rosenblatt, M.4
  • 101
    • 77951880868 scopus 로고    scopus 로고
    • Activating ROCK1 so¬matic mutations in human cancer
    • Lochhead PA, Wickman G, Mezna M, and Olson MF (2010) Activating ROCK1 so¬matic mutations in human cancer. Oncogene 29:2591-2598.
    • (2010) Oncogene , vol.29 , pp. 2591-2598
    • Lochhead, P.A.1    Wickman, G.2    Mezna, M.3    Olson, M.F.4
  • 103
    • 33646763902 scopus 로고    scopus 로고
    • Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guérin P, and Pacaud P (2006) Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98:322-334.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guérin, P.2    Pacaud, P.3
  • 104
    • 78049274198 scopus 로고    scopus 로고
    • The role of Rho protein signaling in hypertension
    • Loirand G and Pacaud P (2010) The role of Rho protein signaling in hypertension. Nat Rev Cardiol 7:637-647.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 637-647
    • Loirand, G.1    Pacaud, P.2
  • 105
    • 84885900541 scopus 로고    scopus 로고
    • Small G proteins in the cardiovascular system: Physiological and pathological aspects
    • Loirand G, Sauzeau V, and Pacaud P (2013) Small G proteins in the cardiovascular system: physiological and pathological aspects. Physiol Rev 93:1659-1720.
    • (2013) Physiol Rev , vol.93 , pp. 1659-1720
    • Loirand, G.1    Sauzeau, V.2    Pacaud, P.3
  • 108
    • 0028078824 scopus 로고
    • A brain serine/ threonine protein kinase activated by Cdc42 and Rac1
    • Manser E, Leung T, Salihuddin H, Zhao ZS, and Lim L (1994) A brain serine/ threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-6.
    • (1994) Nature , vol.367 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.S.4    Lim, L.5
  • 110
    • 0037007054 scopus 로고    scopus 로고
    • Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina
    • Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, and Takeshita A (2002) Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105:1545-1547.
    • (2002) Circulation , vol.105 , pp. 1545-1547
    • Masumoto, A.1    Mohri, M.2    Shimokawa, H.3    Urakami, L.4    Usui, M.5    Takeshita, A.6
  • 111
    • 9144227431 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: Involvement of multiple mechanisms
    • Matsumoto Y, Uwatoku T, Oi K, Abe K, Hattori T, Morishige K, Eto Y, Fukumoto Y, Nakamura K, and Shibata Y, et al. (2004) Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms. Arterioscler Thromb Vasc Biol 24: 181-186.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 181-186
    • Matsumoto, Y.1    Uwatoku, T.2    Oi, K.3    Abe, K.4    Hattori, T.5    Morishige, K.6    Eto, Y.7    Fukumoto, Y.8    Nakamura, K.9    Shibata, Y.10
  • 112
    • 20844459470 scopus 로고    scopus 로고
    • Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: Implications for atherosclerotic endothelial dysfunction
    • Ming XF, Barandier C, Viswambharan H, Kwak BR, Mach F, Mazzolai L, Hayoz D, Ruffieux J, Rusconi S, and Montani JP, et al. (2004) Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. Circulation 110: 3708-3714.
    • (2004) Circulation , vol.110 , pp. 3708-3714
    • Ming, X.F.1    Barandier, C.2    Viswambharan, H.3    Kwak, B.R.4    Mach, F.5    Mazzolai, L.6    Hayoz, D.7    Ruffieux, J.8    Rusconi, S.9    Montani, J.P.10
  • 113
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, and Yang Z (2002) Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 22:8467-8477.
    • (2002) Mol Cell Biol , vol.22 , pp. 8467-8477
    • Ming, X.F.1    Viswambharan, H.2    Barandier, C.3    Ruffieux, J.4    Kaibuchi, K.5    Rusconi, S.6    Yang, Z.7
  • 114
    • 12344323503 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats
    • Mita S, Kobayashi N, Yoshida K, Nakano S, and Matsuoka H (2005) Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats. J Hypertens 23:87-96.
    • (2005) J Hypertens , vol.23 , pp. 87-96
    • Mita, S.1    Kobayashi, N.2    Yoshida, K.3    Nakano, S.4    Matsuoka, H.5
  • 116
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller BK, Mack H, and Teusch N (2005) Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 4:387-398.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 121
    • 44449176536 scopus 로고    scopus 로고
    • Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling
    • Nishimura T and Takeichi M (2008) Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling. Development 135:1493-1502.
    • (2008) Development , vol.135 , pp. 1493-1502
    • Nishimura, T.1    Takeichi, M.2
  • 123
    • 77953925092 scopus 로고    scopus 로고
    • The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes
    • Nuno DW and Lamping KG (2010) The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes. Exp Diabetes Res 2010:176361.
    • (2010) Exp Diabetes Res , vol.2010 , pp. 176361
    • Nuno, D.W.1    Lamping, K.G.2
  • 126
    • 84875728071 scopus 로고    scopus 로고
    • FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
    • Okamoto R, Li Y, Noma K, Hiroi Y, Liu PY, Taniguchi M, Ito M, and Liao JK (2013) FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2. FASEB J 27:1439-1449.
    • (2013) FASEB J , vol.27 , pp. 1439-1449
    • Okamoto, R.1    Li, Y.2    Noma, K.3    Hiroi, Y.4    Liu, P.Y.5    Taniguchi, M.6    Ito, M.7    Liao, J.K.8
  • 127
    • 84865227307 scopus 로고    scopus 로고
    • Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1, 25-dihydroxyvitamin D3 in experimental autoimmune en¬cephalomyelitis
    • Paintlia AS, Paintlia MK, Hollis BW, Singh AK, and Singh I (2012) Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1, 25-dihydroxyvitamin D3 in experimental autoimmune en¬cephalomyelitis. Am J Pathol 181:993-1006.
    • (2012) Am J Pathol , vol.181 , pp. 993-1006
    • Paintlia, A.S.1    Paintlia, M.K.2    Hollis, B.W.3    Singh, A.K.4    Singh, I.5
  • 129
    • 84889088178 scopus 로고    scopus 로고
    • Advances in the development of Rho-associated protein kinase (ROCK) inhibitors
    • Pan P, Shen M, Yu H, Li Y, Li D, and Hou T (2013) Advances in the development of Rho-associated protein kinase (ROCK) inhibitors. Drug Discov Today 18: 1323-1333.
    • (2013) Drug Discov Today , vol.18 , pp. 1323-1333
    • Pan, P.1    Shen, M.2    Yu, H.3    Li, Y.4    Li, D.5    Hou, T.6
  • 130
    • 84895070483 scopus 로고    scopus 로고
    • Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
    • Patel RA, Liu Y, Wang B, Li R, and Sebti SM (2014) Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities. Oncogene 33:550-555.
    • (2014) Oncogene , vol.33 , pp. 550-555
    • Patel, R.A.1    Liu, Y.2    Wang, B.3    Li, R.4    Sebti, S.M.5
  • 131
    • 38849185196 scopus 로고    scopus 로고
    • PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
    • Pinner S and Sahai E (2008) PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol 10:127-137.
    • (2008) Nat Cell Biol , vol.10 , pp. 127-137
    • Pinner, S.1    Sahai, E.2
  • 132
    • 55449105596 scopus 로고    scopus 로고
    • A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: The HYPGENE study
    • Rankinen T, Church T, Rice T, Markward N, Blair SN, and Bouchard C (2008) A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study. Hyper-tens Res 31:1651-1657.
    • (2008) Hyper-Tens Res , vol.31 , pp. 1651-1657
    • Rankinen, T.1    Church, T.2    Rice, T.3    Markward, N.4    Blair, S.N.5    Bouchard, C.6
  • 133
    • 84867024393 scopus 로고    scopus 로고
    • Rho-associated kinases in tumorigenesis: Re-considering ROCK inhibition for cancer therapy
    • Rath N and Olson MF (2012) Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep 13:900-908.
    • (2012) EMBO Rep , vol.13 , pp. 900-908
    • Rath, N.1    Olson, M.F.2
  • 135
    • 84870979274 scopus 로고    scopus 로고
    • Signal transduction pathways in chronic in¬flammatory autoimmune disease: Small GTPases
    • Reedquist KA and Tak PP (2012) Signal transduction pathways in chronic in¬flammatory autoimmune disease: small GTPases. Open Rheumatol J 6:259-272.
    • (2012) Open Rheumatol J , vol.6 , pp. 259-272
    • Reedquist, K.A.1    Tak, P.P.2
  • 136
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: Multifunctional kinases in cell behaviour
    • Riento K and Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4:446-456.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 137
    • 33644694919 scopus 로고    scopus 로고
    • Rho GTPases, statins, and nitric oxide
    • Rikitake Y and Liao JK (2005) Rho GTPases, statins, and nitric oxide. Circ Res 97: 1232-1235.
    • (2005) Circ Res , vol.97 , pp. 1232-1235
    • Rikitake, Y.1    Liao, J.K.2
  • 138
    • 27744466333 scopus 로고    scopus 로고
    • Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/-hap-loinsufficient mice
    • Rikitake Y, Oyama N, Wang CY, Noma K, Satoh M, Kim HH, and Liao JK (2005) Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/-hap-loinsufficient mice. Circulation 112:2959-2965.
    • (2005) Circulation , vol.112 , pp. 2959-2965
    • Rikitake, Y.1    Oyama, N.2    Wang, C.Y.3    Noma, K.4    Satoh, M.5    Kim, H.H.6    Liao, J.K.7
  • 140
    • 33748705954 scopus 로고    scopus 로고
    • Thrombin-induced endothelial microparticle generation: Identification of a novel pathway involving ROCK-II activation by caspase-2
    • Sapet C, Simoncini S, Loriod B, Puthier D, Sampol J, Nguyen C, Dignat-George F, and Anfosso F (2006) Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood 108:1868-1876.
    • (2006) Blood , vol.108 , pp. 1868-1876
    • Sapet, C.1    Simoncini, S.2    Loriod, B.3    Puthier, D.4    Sampol, J.5    Nguyen, C.6    Dignat-George, F.7    Anfosso, F.8
  • 141
    • 84869186635 scopus 로고    scopus 로고
    • Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development
    • Sari I, Berberoglu B, Ozkara E, Oztuzcu S, Camci C, and Demiryurek AT (2013) Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development. Pathobiology 80:138-145.
    • (2013) Pathobiology , vol.80 , pp. 138-145
    • Sari, I.1    Berberoglu, B.2    Ozkara, E.3    Oztuzcu, S.4    Camci, C.5    Demiryurek, A.T.6
  • 142
    • 0035990918 scopus 로고    scopus 로고
    • The novel and specific Rho-kinase in¬hibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway
    • Sasaki Y, Suzuki M, and Hidaka H (2002) The novel and specific Rho-kinase in¬hibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther 93: 225-232.
    • (2002) Pharmacol Ther , vol.93 , pp. 225-232
    • Sasaki, Y.1    Suzuki, M.2    Hidaka, H.3
  • 143
    • 0037214686 scopus 로고    scopus 로고
    • Chronic inhibition of Rho kinase blunts the process of left ventricular hy¬pertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure
    • Satoh S, Ueda Y, Koyanagi M, Kadokami T, Sugano M, Yoshikawa Y, and Makino N (2003) Chronic inhibition of Rho kinase blunts the process of left ventricular hy¬pertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. J Mol Cell Cardiol 35:59-70.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 59-70
    • Satoh, S.1    Ueda, Y.2    Koyanagi, M.3    Kadokami, T.4    Sugano, M.5    Yoshikawa, Y.6    Makino, N.7
  • 144
    • 0035838950 scopus 로고    scopus 로고
    • Pharmacological profile ofhydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
    • Satoh S, Utsunomiya T, Tsurui K, Kobayashi T, Ikegaki I, Sasaki Y, and Asano T (2001) Pharmacological profile ofhydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. Life Sci 69:1441-1453.
    • (2001) Life Sci , vol.69 , pp. 1441-1453
    • Satoh, S.1    Utsunomiya, T.2    Tsurui, K.3    Kobayashi, T.4    Ikegaki, I.5    Sasaki, Y.6    Asano, T.7
  • 147
    • 33749433631 scopus 로고    scopus 로고
    • Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperrespon¬siveness after the early and late asthmatic reaction
    • Schaafsma D, Bos IS, Zuidhof AB, Zaagsma J, and Meurs H (2006) Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperrespon¬siveness after the early and late asthmatic reaction. Respir Res 7:121.
    • (2006) Respir Res , vol.7 , pp. 121
    • Schaafsma, D.1    Bos, I.S.2    Zuidhof, A.B.3    Zaagsma, J.4    Meurs, H.5
  • 148
    • 49049090820 scopus 로고    scopus 로고
    • The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchocon-striction, airway hyperresponsiveness, and inflammation
    • Schaafsma D, Bos IS, Zuidhof AB, Zaagsma J, and Meurs H (2008) The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchocon-striction, airway hyperresponsiveness, and inflammation. Am J Physiol Lung Cell Mol Physiol 295:L214-L219.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. L214-L219
    • Schaafsma, D.1    Bos, I.S.2    Zuidhof, A.B.3    Zaagsma, J.4    Meurs, H.5
  • 149
    • 84880904769 scopus 로고    scopus 로고
    • Rho-associated coiled-coil kinase (ROCK) sig¬naling and disease
    • Schofield AV and Bernard O (2013) Rho-associated coiled-coil kinase (ROCK) sig¬naling and disease. Crit Rev Biochem Mol Biol 48:301-316.
    • (2013) Crit Rev Biochem Mol Biol , vol.48 , pp. 301-316
    • Schofield, A.V.1    Bernard, O.2
  • 151
    • 13644252220 scopus 로고    scopus 로고
    • Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
    • Sebbagh M, Hamelin J, Bertoglio J, Solary E, and Bréard J (2005) Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med 201:465-471.
    • (2005) J Exp Med , vol.201 , pp. 465-471
    • Sebbagh, M.1    Hamelin, J.2    Bertoglio, J.3    Solary, E.4    Bréard, J.5
  • 152
    • 0035075597 scopus 로고    scopus 로고
    • Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apo-ptotic membrane blebbing
    • Sebbagh M, Renvoizé C, Hamelin J, Riché N, Bertoglio J, and Bréard J (2001) Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apo-ptotic membrane blebbing. Nat Cell Biol 3:346-352.
    • (2001) Nat Cell Biol , vol.3 , pp. 346-352
    • Sebbagh, M.1    Renvoizé, C.2    Hamelin, J.3    Riché, N.4    Bertoglio, J.5    Bréard, J.6
  • 153
    • 33749352941 scopus 로고    scopus 로고
    • Effect of fasudil on macrovascular disorder-induced endothelial dysfunction
    • Shah DI and Singh M (2006a) Effect of fasudil on macrovascular disorder-induced endothelial dysfunction. Can J Physiol Pharmacol 84:835-845.
    • (2006) Can J Physiol Pharmacol , vol.84 , pp. 835-845
    • Shah, D.I.1    Singh, M.2
  • 154
    • 33645774175 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in experimental vascular endothelial dysfunction
    • Shah DI and Singh M (2006b) Involvement of Rho-kinase in experimental vascular endothelial dysfunction. Mol Cell Biochem 283:191-199.
    • (2006) Mol Cell Biochem , vol.283 , pp. 191-199
    • Shah, D.I.1    Singh, M.2
  • 155
    • 40849134146 scopus 로고    scopus 로고
    • Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy
    • Shi J, Zhang YW, Summers LJ, Dorn GW 2nd, and Wei L (2008) Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy. J Mol Cell Cardiol 44:551-560.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 551-560
    • Shi, J.1    Zhang, Y.W.2    Summers, L.J.3    Dorn, G.W.4    Wei, L.5
  • 156
    • 77957236340 scopus 로고    scopus 로고
    • ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice
    • Shi J, Zhang YW, Yang Y, Zhang L, and Wei L (2010) ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice. J Mol Cell Cardiol 49: 819-828.
    • (2010) J Mol Cell Cardiol , vol.49 , pp. 819-828
    • Shi, J.1    Zhang, Y.W.2    Yang, Y.3    Zhang, L.4    Wei, L.5
  • 157
    • 27644505297 scopus 로고    scopus 로고
    • Effects of fasudil in acute ischemic stroke: Results of a prospective placebo-controlled double-blind trial
    • Fasudil Ischemic Stroke Study Group
    • Shibuya M, Hirai S, Seto M, Satoh S, and Ohtomo E; Fasudil Ischemic Stroke Study Group (2005) Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci 238:31-39.
    • (2005) J Neurol Sci , vol.238 , pp. 31-39
    • Shibuya, M.1    Hirai, S.2    Seto, M.3    Satoh, S.4    Ohtomo, E.5
  • 158
    • 0026534605 scopus 로고
    • Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo¬controlled double-blind trial
    • Shibuya M, Suzuki Y, Sugita K, Saito I, Sasaki T, Takakura K, Nagata I, Kikuchi H, Takemae T, and Hidaka H, et al. (1992) Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo¬controlled double-blind trial. J Neurosurg 76:571-577.
    • (1992) J Neurosurg , vol.76 , pp. 571-577
    • Shibuya, M.1    Suzuki, Y.2    Sugita, K.3    Saito, I.4    Sasaki, T.5    Takakura, K.6    Nagata, I.7    Kikuchi, H.8    Takemae, T.9    Hidaka, H.10
  • 159
    • 84888202856 scopus 로고    scopus 로고
    • Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pul¬monary hypertension in mice
    • Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Ikeda S, and Shimokawa H (2013) Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pul¬monary hypertension in mice. Arterioscler Thromb Vasc Biol 33:2780-2791.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 2780-2791
    • Shimizu, T.1    Fukumoto, Y.2    Tanaka, S.3    Satoh, K.4    Ikeda, S.5    Shimokawa, H.6
  • 163
    • 0031770943 scopus 로고    scopus 로고
    • RhoA-binding kinase alpha trans¬location is facilitated by the collapse of the vimentin intermediate filament net¬work
    • Sin WC, Chen XQ, Leung T, and Lim L (1998) RhoA-binding kinase alpha trans¬location is facilitated by the collapse of the vimentin intermediate filament net¬work. Mol Cell Biol 18:6325-6339.
    • (1998) Mol Cell Biol , vol.18 , pp. 6325-6339
    • Sin, W.C.1    Chen, X.Q.2    Leung, T.3    Lim, L.4
  • 164
    • 84876340735 scopus 로고    scopus 로고
    • Rho-Kinase activity and cuta¬neous vasoconstriction is upregulated in essential hypertensive humans
    • Smith CJ, Santhanam L, and Alexander LM (2013) Rho-Kinase activity and cuta¬neous vasoconstriction is upregulated in essential hypertensive humans. Microvasc Res 87:58-64.
    • (2013) Microvasc Res , vol.87 , pp. 58-64
    • Smith, C.J.1    Santhanam, L.2    Alexander, L.M.3
  • 166
    • 84880701367 scopus 로고    scopus 로고
    • Rho kinase inhibitor fasudil protects against ß-amyloid-induced hippocampal neurodegeneration in rats
    • Song Y, Chen X, Wang LY, Gao W, and Zhu MJ (2013) Rho kinase inhibitor fasudil protects against ß-amyloid-induced hippocampal neurodegeneration in rats. CNS Neurosci Ther 19:603-610.
    • (2013) CNS Neurosci Ther , vol.19 , pp. 603-610
    • Song, Y.1    Chen, X.2    Wang, L.Y.3    Gao, W.4    Zhu, M.J.5
  • 167
    • 84927575395 scopus 로고    scopus 로고
    • Understanding and targeting the Rho kinase pathway in erectile dysfunction
    • Sopko NA, Hannan JL, and Bivalacqua TJ (2014) Understanding and targeting the Rho kinase pathway in erectile dysfunction. Nat Rev Urol 11:622-628.
    • (2014) Nat Rev Urol , vol.11 , pp. 622-628
    • Sopko, N.A.1    Hannan, J.L.2    Bivalacqua, T.J.3
  • 168
    • 84859921644 scopus 로고    scopus 로고
    • Ad¬ministration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/ W F1 female mice
    • Stirzaker RA, Biswas PS, Gupta S, Song L, Bhagat G, and Pernis AB (2012) Ad¬ministration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/ W F1 female mice. Lupus 21:656-661.
    • (2012) Lupus , vol.21 , pp. 656-661
    • Stirzaker, R.A.1    Biswas, P.S.2    Gupta, S.3    Song, L.4    Bhagat, G.5    Pernis, A.B.6
  • 169
    • 77951044950 scopus 로고    scopus 로고
    • Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
    • Stockton RA, Shenkar R, Awad IA, and Ginsberg MH (2010) Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 207:881-896.
    • (2010) J Exp Med , vol.207 , pp. 881-896
    • Stockton, R.A.1    Shenkar, R.2    Awad, I.A.3    Ginsberg, M.H.4
  • 171
    • 34447640943 scopus 로고    scopus 로고
    • A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemor¬rhage
    • discussion 131-132
    • Suzuki Y, Shibuya M, Satoh S, Sugimoto Y, and Takakura K (2007) A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemor¬rhage. Surg Neurol 68:126-131; discussion 131-132.
    • (2007) Surg Neurol , vol.68 , pp. 126-131
    • Suzuki, Y.1    Shibuya, M.2    Satoh, S.3    Sugimoto, Y.4    Takakura, K.5
  • 173
    • 84884595041 scopus 로고    scopus 로고
    • Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension
    • K-115 Clinical Study Group
    • Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, and Araie M; K-115 Clinical Study Group (2013) Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol 156:731-736.
    • (2013) Am J Ophthalmol , vol.156 , pp. 731-736
    • Tanihara, H.1    Inoue, T.2    Yamamoto, T.3    Kuwayama, Y.4    Abe, H.5    Araie, M.6
  • 174
    • 84929395741 scopus 로고    scopus 로고
    • Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: A randomized, open-label, crossover study
    • K-115 Clinical Study Group
    • Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, Suganami H, and Araie M; K-115 Clinical Study Group (2015) Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study. Acta Oph¬thalmol 93:e254-e260.
    • (2015) Acta Oph¬thalmol , vol.93 , pp. e254-e260
    • Tanihara, H.1    Inoue, T.2    Yamamoto, T.3    Kuwayama, Y.4    Abe, H.5    Suganami, H.6    Araie, M.7
  • 176
    • 23844442551 scopus 로고    scopus 로고
    • ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo
    • Thumkeo D, Shimizu Y, Sakamoto S, Yamada S, and Narumiya S (2005) ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo. Genes Cells 10:825-834.
    • (2005) Genes Cells , vol.10 , pp. 825-834
    • Thumkeo, D.1    Shimizu, Y.2    Sakamoto, S.3    Yamada, S.4    Narumiya, S.5
  • 177
    • 84888437392 scopus 로고    scopus 로고
    • Physiological roles ofRho and Rho effectors in mammals
    • Thumkeo D, Watanabe S, and Narumiya S (2013) Physiological roles ofRho and Rho effectors in mammals. Eur J Cell Biol 92:303-315.
    • (2013) Eur J Cell Biol , vol.92 , pp. 303-315
    • Thumkeo, D.1    Watanabe, S.2    Narumiya, S.3
  • 178
    • 34548073671 scopus 로고    scopus 로고
    • Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys
    • Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, and Tanihara H (2007) Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Oph¬thalmol Vis Sci 48:3216-3222.
    • (2007) Invest Oph¬thalmol Vis Sci , vol.48 , pp. 3216-3222
    • Tokushige, H.1    Inatani, M.2    Nemoto, S.3    Sakaki, H.4    Katayama, K.5    Uehata, M.6    Tanihara, H.7
  • 179
    • 84870198515 scopus 로고    scopus 로고
    • Inhibition of rho kinase enhances survival ofdopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease
    • Tonges L, Frank T, Tatenhorst L, Saal KA, Koch JC, Szego EM, Bahr M, Weishaupt JH, and Lingor P (2012) Inhibition of rho kinase enhances survival ofdopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease. Brain 135:3355-3370.
    • (2012) Brain , vol.135 , pp. 3355-3370
    • Tonges, L.1    Frank, T.2    Tatenhorst, L.3    Saal, K.A.4    Koch, J.C.5    Szego, E.M.6    Bahr, M.7    Weishaupt, J.H.8    Lingor, P.9
  • 180
    • 84912028581 scopus 로고    scopus 로고
    • New approaches to the design and discovery of therapies to prevent erectile dysfunction
    • Toque HA and Caldwell RW (2014) New approaches to the design and discovery of therapies to prevent erectile dysfunction. Expert Opin Drug Discov 9: 1447-1469.
    • (2014) Expert Opin Drug Discov , vol.9 , pp. 1447-1469
    • Toque, H.A.1    Caldwell, R.W.2
  • 181
    • 33750289641 scopus 로고    scopus 로고
    • ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epi¬thelial tumor cells
    • Torka R, Thuma F, Herzog V, and Kirfel G (2006) ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epi¬thelial tumor cells. Exp Cell Res 312:3857-3871.
    • (2006) Exp Cell Res , vol.312 , pp. 3857-3871
    • Torka, R.1    Thuma, F.2    Herzog, V.3    Kirfel, G.4
  • 185
    • 84886448486 scopus 로고    scopus 로고
    • Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke
    • Vesterinen HM, Currie GL, Carter S, Mee S, Watzlawick R, Egan KJ, Macleod MR, and Sena ES (2013) Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke. Syst Rev 2:33.
    • (2013) Syst Rev , vol.2 , pp. 33
    • Vesterinen, H.M.1    Currie, G.L.2    Carter, S.3    Mee, S.4    Watzlawick, R.5    Egan, K.J.6    Macleod, M.R.7    Sena, E.S.8
  • 188
    • 84885025560 scopus 로고    scopus 로고
    • Rho/Rho-associated kinase pathway in glaucoma (Review)
    • Wang J, Liu X, and Zhong Y (2013) Rho/Rho-associated kinase pathway in glaucoma (Review). Int J Oncol 43:1357-1367.
    • (2013) Int J Oncol , vol.43 , pp. 1357-1367
    • Wang, J.1    Liu, X.2    Zhong, Y.3
  • 189
    • 61949299083 scopus 로고    scopus 로고
    • ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells
    • Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X, and Surks HK (2009) ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. Circ Res 104:531-540.
    • (2009) Circ Res , vol.104 , pp. 531-540
    • Wang, Y.1    Zheng, X.R.2    Riddick, N.3    Bryden, M.4    Baur, W.5    Zhang, X.6    Surks, H.K.7
  • 191
    • 0037092045 scopus 로고    scopus 로고
    • The GTP binding proteins Gem and Rad are negative regulators of the Rho¬Rho kinase pathway
    • Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, and Kelly K (2002) The GTP binding proteins Gem and Rad are negative regulators of the Rho¬Rho kinase pathway. J Cell Biol 157:291-302.
    • (2002) J Cell Biol , vol.157 , pp. 291-302
    • Ward, Y.1    Yap, S.F.2    Ravichandran, V.3    Matsumura, F.4    Ito, M.5    Spinelli, B.6    Kelly, K.7
  • 192
    • 84892410718 scopus 로고    scopus 로고
    • Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: A systematic review and meta-analysis
    • Watzlawick R, Sena ES, Dirnagl U, Brommer B, Kopp MA, Macleod MR, Howells DW, and Schwab JM (2014) Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis. JAMA Neurol 71:91-99.
    • (2014) JAMA Neurol , vol.71 , pp. 91-99
    • Watzlawick, R.1    Sena, E.S.2    Dirnagl, U.3    Brommer, B.4    Kopp, M.A.5    Macleod, M.R.6    Howells, D.W.7    Schwab, J.M.8
  • 194
    • 54449095663 scopus 로고    scopus 로고
    • Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases
    • Wen W, Liu W, Yan J, and Zhang M (2008) Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinases. J Biol Chem 283:26263-26273.
    • (2008) J Biol Chem , vol.283 , pp. 26263-26273
    • Wen, W.1    Liu, W.2    Yan, J.3    Zhang, M.4
  • 197
    • 66149095045 scopus 로고    scopus 로고
    • Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor in¬vasion
    • Wong CCL, Wong CM, Tung EKK, Man K, and Ng iOL (2009) Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor in¬vasion. Hepatology 49:1583-1594.
    • (2009) Hepatology , vol.49 , pp. 1583-1594
    • Wong, C.1    Wong, C.M.2    Tung, E.3    Man, K.4    Ng, I.5
  • 198
    • 84867576648 scopus 로고    scopus 로고
    • Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain
    • Wu J, Li J, Hu H, Liu P, Fang Y, and Wu D (2012) Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain. Cell Mol Neurobiol 32:1187-1197.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 1187-1197
    • Wu, J.1    Li, J.2    Hu, H.3    Liu, P.4    Fang, Y.5    Wu, D.6
  • 199
    • 0037040943 scopus 로고    scopus 로고
    • Rho/ROCK pathway contributes to the activation of ex¬tracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy
    • Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, and Sasayama S (2002) Rho/ROCK pathway contributes to the activation of ex¬tracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem 277:8618-8625.
    • (2002) J Biol Chem , vol.277 , pp. 8618-8625
    • Yanazume, T.1    Hasegawa, K.2    Wada, H.3    Morimoto, T.4    Abe, M.5    Kawamura, T.6    Sasayama, S.7
  • 200
    • 84860910365 scopus 로고    scopus 로고
    • Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1
    • Yang X, Li Q, Lin X, Ma Y, Yue X, Tao Z, Wang F, Mckeehan WL, Wei L, and Schwartz RJ, et al. (2012) Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J26:2105-2116.
    • (2012) FASEB , vol.J26 , pp. 2105-2116
    • Yang, X.1    Li, Q.2    Lin, X.3    Ma, Y.4    Yue, X.5    Tao, Z.6    Wang, F.7    McKeehan, W.L.8    Wei, L.9    Schwartz, R.J.10
  • 201
    • 84874266181 scopus 로고    scopus 로고
    • Prevention ofdiabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout
    • Yao L, Chandra S, Toque HA, Bhatta A, Rojas M, Caldwell RB, and Caldwell RW (2013) Prevention ofdiabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout. Cardiovasc Res 97:509-519.
    • (2013) Cardiovasc Res , vol.97 , pp. 509-519
    • Yao, L.1    Chandra, S.2    Toque, H.A.3    Bhatta, A.4    Rojas, M.5    Caldwell, R.B.6    Caldwell, R.W.7
  • 202
    • 23744480002 scopus 로고    scopus 로고
    • The Rho kinases i and ii reg¬ulate different aspects of myosin ii activity
    • Yoneda A, Multhaupt HA, and Couchman JR (2005) The Rho kinases i and ii reg¬ulate different aspects of myosin ii activity. J Cell Biol 170:443-453.
    • (2005) J Cell Biol , vol.170 , pp. 443-453
    • Yoneda, A.1    Multhaupt, H.A.2    Couchman, J.R.3
  • 205
    • 84895173553 scopus 로고    scopus 로고
    • Gene variations of ROCKs and risk of ischaemic stroke: The Women’s Genome Health Study
    • Zee RY, Wang QM, Chasman Di, Ridker PM, and Liao JK (2014) Gene variations of ROCKs and risk of ischaemic stroke: the Women’s Genome Health Study. Clin Sci (Lond) 126:829-835.
    • (2014) Clin Sci (Lond) , vol.126 , pp. 829-835
    • Zee, R.Y.1    Wang, Q.M.2    Di, C.3    Ridker, P.M.4    Liao, J.K.5
  • 207
  • 208
    • 70449445715 scopus 로고    scopus 로고
    • Rho kinase: An important mediator of atherosclerosis and vascular disease
    • Zhou Q and Liao JK (2009) Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr Pharm Des 15:3108-3115.
    • (2009) Curr Pharm Des , vol.15 , pp. 3108-3115
    • Zhou, Q.1    Liao, J.K.2
  • 209
    • 84868205077 scopus 로고    scopus 로고
    • Rho-associated coiled-coil-containing kinase 2 de¬ficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis
    • Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, and Moser M, et al. (2012) Rho-associated coiled-coil-containing kinase 2 de¬ficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation 126:2236-2247.
    • (2012) Circulation , vol.126 , pp. 2236-2247
    • Zhou, Q.1    Mei, Y.2    Shoji, T.3    Han, X.4    Kaminski, K.5    Oh, G.T.6    Ongusaha, P.P.7    Zhang, K.8    Schmitt, H.9    Moser, M.10


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