Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 10, 2004, Pages 1842-1847

  Wolfrum, Sebastian ^a,b   Dendorfer, Andreas ^b   Rikitake, Yoshiyuki ^a   Stalker, Timothy J ^c   Gong, Yulan ^c   Scalia, Rosario ^c   Dominiak, Peter ^b   Liao, James K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Endothelium; Infarction; Inflammation; Ischemia reperfusion; Nitric oxide

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; FASUDIL; HYDROXYFASUDIL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RHO KINASE; SERINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CATTLE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; MESENTERY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REPERFUSION INJURY; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARDIOVASCULAR SYSTEM; ENZYME ACTIVATION; HEART DISEASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; VASCULAR DISEASES;

EID: 5344268785     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000142813.33538.82     Document Type: Article

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