Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Journal of Molecular and Cellular Cardiology

Volumn 44, Issue 3, 2008, Pages 551-560

  Shi, Jianjian ^a   Zhang, Yi Wei ^a,c   Summers, Lelia J ^a   Dorn II, Gerald W ^d   Wei, Lei ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Cardiac dilation; Contractile dysfunction; Pathological cardiac hypertrophy; Rho kinase; ROCK1 knockout mice

Indexed keywords

ADENYLATE CYCLASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA Q; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE; RHO ASSOCIATED COILED COIL CONTAINING PROTEIN KINASE 1; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ELECTROCARDIOGRAM; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; HEART DISEASE; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASODILATATION;

ADENYLATE CYCLASE; ANIMALS; BLOTTING, WESTERN; CARDIOMEGALY; DILATATION, PATHOLOGIC; ECHOCARDIOGRAPHY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HYPERTROPHY, LEFT VENTRICULAR; ISOENZYMES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MODELS, GENETIC; MUSCLE CONTRACTION; RHO-ASSOCIATED KINASES;

MUS; MUS MUSCULUS;

EID: 40849134146     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2007.11.018     Document Type: Article

References (40)

1. Sadoshima J., and Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59 (1997) 551-571
2. Dorn G.W., Robbins II J., and Sugden P.H. Phenotyping hypertrophy: eschew obfuscation. Circ Res 92 (2003) 1171-1175
3. Akhter S.A., Luttrell L.M., Rockman H.A., Iaccarino G., Lefkowitz R.J., and Koch W.J. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science 280 (1998) 574-577
4. Wettschureck N., Rutten H., Zywietz A., Gehring D., Wilkie T.M., Chen J., et al. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med 7 (2001) 1236-1240
5. Adams J.W., Sakata Y., Davis M.G., Sah V.P., Wang Y., Liggett S.B., et al. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A 95 (1998) 10140-10145
6. D'Angelo D.D., Sakata Y., Lorenz J.N., Boivin G.P., Walsh R.A., Liggett S.B., et al. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A 94 (1997) 8121-8126
7. Hahn H.S., Marreez Y., Odley A., Sterbling A., Yussman M.G., Hilty K.C., et al. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circ Res 93 (2003) 1111-1119
8. Tepe N.M., and Liggett S.B. Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. FEBS Lett 458 (1999) 236-240
9. Roth D.M., Gao M.H., Lai N.C., Drumm J., Dalton N., Zhou J.Y., et al. Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 99 (1999) 3099-3102
10. Minamino T., Yujiri T., Terada N., Taffet G.E., Michael L.H., Johnson G.L., et al. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A. 99 (2002) 3866-3871
11. Kobayashi N., Horinaka S., Mita S., Nakano S., Honda T., Yoshida K., et al. Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts. Cardiovasc Res 55 (2002) 757-767
12. Satoh S., Ueda Y., Koyanagi M., Kadokami T., Sugano M., Yoshikawa Y., et al. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. J Mol Cell Cardiol 35 (2003) 59-70
13. Higashi M., Shimokawa H., Hattori T., Hiroki J., Mukai Y., Morikawa K., et al. Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 93 (2003) 767-775
14. Hattori T., Shimokawa H., Higashi M., Hiroki J., Mukai Y., Tsutsui H., et al. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109 (2004) 2234-2239
15. Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 (1997) 990-994
16. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57 (2000) 976-983
17. Breitenlechner C., Gassel M., Hidaka H., Kinzel V., Huber R., Engh R.A., et al. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure (Camb) 11 (2003) 1595-1607
18. Zhang Y.M., Bo J., Taffet G.E., Chang J., Shi J., Reddy A.K., et al. Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J. 20 (2006) 916-925
19. Chang J., Xie M., Shah V.R., Schneider M.D., Entman M.L., Wei L., et al. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A 103 (2006) 14495-14500
20. Rikitake Y., Oyama N., Wang C.Y., Noma K., Satoh M., Kim H.H., et al. Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice. Circulation 112 (2005) 2959-2965
21. Hoshijima M., Sah V.P., Wang Y., Chien K.R., and Brown J.H. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J Biol Chem 273 (1998) 7725-7730
22. Kuwahara K., Saito Y., Nakagawa O., Kishimoto I., Harada M., Ogawa E., et al. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes-possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett 452 (1999) 314-318
23. Wei L. Lysophospholipid signaling in cardiac myocyte hypertrophy. J Mol Cell Cardiol 36 (2004) 465-468
24. Yanazume T., Hasegawa K., Wada H., Morimoto T., Abe M., Kawamura T., et al. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem 277 (2002) 8618-8625
25. Wei L., Taffet G.E., Khoury D.S., Bo J., Li Y., Yatani A., et al. Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. FASEB J 18 (2004) 857-859
26. Soonpaa M.H., and Field L.J. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol 272 (1997) H220-H226
27. Wei L., Imanaka-Yoshida K., Wang L., Zhan S., Schneider M.D., DeMayo F.J., et al. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development 129 (2002) 1705-1714
28. Sakata Y., Hoit B.D., Liggett S.B., Walsh R.A., and Dorn II G.W. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation 97 (1998) 1488-1495
29. Rogers J.H., Tsirka A., Kovacs A., Blumer K.J., Dorn II G.W., and Muslin A.J. RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice. J Mol Cell Cardiol 33 (2001) 209-218
30. Dorn II G.W., Tepe N.M., Lorenz J.N., Koch W.J., and Liggett S.B. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc Natl Acad Sci U S A 96 (1999) 6400-6405
31. Adams J.W., Pagel A.L., Means C.K., Oksenberg D., Armstrong R.C., and Brown J.H. Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ Res 87 (2000) 1180-1187
32. Yussman M.G., Toyokawa T., Odley A., Lynch R.A., Wu G., Colbert M.C., et al. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med 8 (2002) 725-730
33. Hayakawa Y., Chandra M., Miao W., Shirani J., Brown J.H., Dorn II G.W., et al. Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation 108 (2003) 3036-3041
34. Dorn II G.W., Tepe N.M., Wu G., Yatani A., and Liggett S.B. Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. Mol Pharmacol 57 (2000) 278-287
35. Dorn II G.W., and Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest 115 (2005) 527-537
36. Wu G., Toyokawa T., Hahn H., and Dorn II G.W. Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and Galphaq. J Biol Chem 275 (2000) 29927-29930
37. Okumura S., Takagi G., Kawabe J., Yang G., Lee M.C., Hong C., et al. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci U S A 100 (2003) 9986-9990
38. Okumura S., Vatner D.E., Kurotani R., Bai Y., Gao S., Yuan Z., et al. Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Circulation 116 (2007) 1776-1783
39. Takahashi T., Tang T., Lai N.C., Roth D.M., Rebolledo B., Saito M., et al. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation 114 (2006) 388-396
40. Beazely M.A., and Watts V.J. Regulatory properties of adenylate cyclases type 5 and 6: a progress report. Eur J Pharmacol 535 (2006) 1-12