Rho-associated kinase activity, endothelial function, and cardiovascular risk factors

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 10, 2011, Pages 2353-2359

  Soga, Junko ^a   Noma, Kensuke ^b   Hata, Takaki ^a   Hidaka, Takayuki ^a   Fujii, Yuichi ^a   Idei, Naomi ^a   Fujimura, Noritaka ^a   Mikami, Shinsuke ^a   Maruhashi, Tatsuya ^a   Kihara, Yasuki ^a   Chayama, Kazuaki ^a   Kato, Hitoshi ^c   Liao, James K ^d   Higashi, Yukihito ^b  

^a Department of Cardiovascular Medicine ^*  (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c Ten noz Clinic   (Japan)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

endothelial function; Rho associated kinases; risk factors

Indexed keywords

FASUDIL; GLUCOSE; GLYCERYL TRINITRATE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MYOSIN LIGHT CHAIN; RHO KINASE;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BINDING; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADULT; AGED; BLOOD PRESSURE; BLOTTING, WESTERN; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; HUMANS; HYPEREMIA; JAPAN; LEUKOCYTES; MALE; MIDDLE AGED; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NITROGLYCERIN; PHOSPHORYLATION; PROGNOSIS; PROTEIN KINASE INHIBITORS; REGRESSION ANALYSIS; RHO-ASSOCIATED KINASES; RISK ASSESSMENT; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER, COLOR; ULTRASONOGRAPHY, DOPPLER, PULSED; VASODILATION; VASODILATOR AGENTS; YOUNG ADULT;

EID: 80052966594     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.227892     Document Type: Article

References (38)

1. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994. (Pubitemid 27485693)
2. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science. 1997;275:1308-1311. (Pubitemid 27114159)
3. Hall A. Rho GTPases and the actin cytoskeleton. Science. 1998;279: 509-514. (Pubitemid 28067271)
4. Verdecchia P, Porcellati C, Reboldi G, Gattobigio R, Borgioni C, Pearson TA, Ambrosio G. Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension. Circulation. 2001; 104:2039-2044. (Pubitemid 33027044)
5. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of myosin phosphatase by Rho-associated kinase (Rho-kinase). Science. 1996;273:245-248. (Pubitemid 26285892)
6. Vicari RM, Chaitman B, Keefe D, Smith WB, Chrysant SG, Tonkon MJ, Bittar N, Weiss RJ, Morales-Ballejo H, Thadani U; Fasudil Study Group. Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. J Am Coll Cardiol. 2005;46: 1803-1811. (Pubitemid 41579800)
7. Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A. Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation. 2002;105:1545-1547. (Pubitemid 34297629)
8. Kishi T, Hirooka Y, Masumoto A, Ito K, Kimura Y, Inokuchi K, Tagawa T, Shimokawa H, Takeshita A, Sunagawa K. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. Circulation. 2005;111:2741-2747. (Pubitemid 40791544)
9. Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E; Fasudil Ischemic Stroke Study Group. Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci. 2005;238: 31-39. (Pubitemid 41560951)
10. Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y. Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J Am Coll Cardiol. 2007;49:698-705. (Pubitemid 46205044)
11. Vanhoutte PM. Endothelium and control of vascular function. Hypertension. 1989;13:658-667.
12. Lüscher TF. Imbalance of endothelium-derived relaxing and contracting factors. Am J Hypertens. 1990;3:317-330. (Pubitemid 20215206)
13. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endotheli-um-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27. (Pubitemid 20209468)
14. Linder L, Kiowski W, Buhler FR, Lüscher TF. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation. 1990;81:1762-1767. (Pubitemid 20183824)
15. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Ssaki N, Matsuura H, Kajiyama G, Oshima T. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999;100: 1194-1202. (Pubitemid 29426595)
16. Egashira K, Suzuki S, Hirooka Y, Kai H, Sugimachi M, Imaizumi T, Takeshita A. Impaired endothelium-dependent vasodilation of large epi-cardial and resistance coronary arteries in patients with essential hypertension: different responses to acetylcholine and substance P. Hypertension. 1995;25:201-206.
17. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T, Chayama K. Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med. 2002;346:1954-1962. (Pubitemid 34651355)
18. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterol-emic patients. Circulation. 1993;88:2541-2547. (Pubitemid 23360178)
19. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996;97:22-28. (Pubitemid 26021690)
20. Treasure CB, Klein JL, Weintraub WS, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, Zhang J, Boccuzzi SJ, Cedarholm JC, Alexander RW. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med. 1995;332:481-487.
21. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med. 2000;342:454-460. (Pubitemid 30100232)
22. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
23. Vita JA. Endothelial function and clinical outcome. Heart. 2005;91: 1278-1279. (Pubitemid 41360940)
24. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation. 2005;111:363-368. (Pubitemid 40165345)
25. Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 2004;24:1842-1847. (Pubitemid 39350301)
26. Kataoka C, Egashira K, Inoue S, Takemoto M, Ni W, Koyanagi M, Kitamoto S, Usui M, Kaibuchi K, Shimokawa H, Takeshita A. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension. 2002;39:245-250. (Pubitemid 34165223)
27. American Diabetes Association. Clinical practice recommendations 1999. Diabetes Care. 1999;(suppl 1):S1-S114.
28. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-2497.
29. Wilson PW, Castelli WP, Kannel WB. Coronary risk prediction in adults (the Framingham Heart Study). Am J Cardiol. 1987;59:91G-94G. (Pubitemid 17085552)
30. Rikitake Y, Liao JK. Rho-kinase mediates hyperglycemia-induced plas-minogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005;111:3261-3268. (Pubitemid 40874999)
31. Noma K, Oyama N, Liao JK. Physiological role of ROCKs in the cardiovascular system. Am JPhysiol Cell Physiol. 2006;290:C661-C668.
32. Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK. ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008;118:1632-1644. (Pubitemid 351632368)
33. Sauzeau V, Le Jeune H, Cario-Toumaniantz C, Smolenski A, Lohmann SM, Bertoglio J, Chardin P, Pacaud P, Loirand G. Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensiti-zation of contraction in vascular smooth muscle. J Biol Chem. 2000;275: 21722-21729.
34. Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem. 1998;273: 24266-24271. (Pubitemid 28435775)
35. Sugimoto M, Nakayama M, Goto TM, Amano M, Komori K, Kaibuchi K. Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. Biochem Biophys Res Commun. 2007;361:462-467. (Pubitemid 47187281)
36. Liu PY, Chen JH, Lin LJ, Liao JK. Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol. 2007;49:1619-1624. (Pubitemid 46551629)
37. Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res. 2006;99: 1426-1432. (Pubitemid 44949679)
38. Hidaka T, Hata T, Soga J, Nakamura S, Fujii Y, Idei N, Fujimura N, Nishioka K, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y. Increased leukocyte Rho kinase (ROCK) and endothelial dysfunction in cigarette smokers. Hypertens Res. 2010;33:354-359.