Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis

Circulation

Volumn 126, Issue 18, 2012, Pages 2236-2247

  Zhou, Qian ^a,b   Mei, Yu ^a   Shoji, Takuhito ^a   Han, Xinbing ^a,c   Kaminski, Karol ^a   Oh, Goo Taeg ^a,d   Ongusaha, Pat P ^a,e   Zhang, Kunzhong ^a   Schmitt, Hannah ^b   Moser, Martin ^b   Bode, Christoph ^b   Liao, James K ^a,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Ewha Womans University   (South Korea)

^e UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

atherogenesis; atherosclerosis; macrophage; Rho kinase; Rho associated kinases

Indexed keywords

ABC TRANSPORTER A1; CD36 ANTIGEN; CHOLESTEROL; CHOLESTEROL ESTERASE; GAMMA INTERFERON; LIVER X RECEPTOR ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RHO ASSOCIATED COILED COIL CONTAINING KINASE 2; RHO KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CHOLESTEROL DIET; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FOAM CELL; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; AORTA; AORTIC DISEASES; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BONE MARROW TRANSPLANTATION; CHOLESTEROL; CHOLESTEROL, DIETARY; FOAM CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPROTEINS, LDL; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; PPAR GAMMA; RADIATION CHIMERA; RECEPTORS, LDL; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84868205077     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.086041     Document Type: Article

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