Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

Hypertension

Volumn 38, Issue 6, 2001, Pages 1307-1310

  Masumoto, Akihiro ^a   Hirooka, Yoshitaka ^a   Shimokawa, Hiroaki ^a   Hironaga, Kiyoshi ^a   Setoguchi, Soko ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Blood flow; Hypertension, essential; Muscle, smooth, vascular; Vascular resistance

Indexed keywords

CALCIUM ION; ENZYME INHIBITOR; FASUDIL; NITROPRUSSIDE SODIUM; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FOREARM BLOOD FLOW; HUMAN; HYPERTENSION; MALE; PATHOGENESIS; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; SYSTEMIC VASCULAR RESISTANCE; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0035679020     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/hy1201.096541     Document Type: Article

References (16)

1. Signal transduction by G-proteins, rho-kinase and phosphatase to smooth muscle and non-muscle myosin II
2. 2+- sensitization of coronary artery contraction in genetically hypertensive rats: Evidence for altered signal transduction in the coronary smooth muscle cells
3. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
4. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
5. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
6. Regulation of cytoskeletons and cell adhesions by the Rho family GTPases in mammalian cells
7. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
8. Inhibition of myosin phosphatase by up-regulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β
9. Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension
10. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase
11. Specificity and mechanism of action of some commonly used protein kinase inhibitors
12. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
13. Cellular and molecular mechanism for coronary artery spasm: Lessons from animal models
14. Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients
15. Gene transfer of dominant negative Rho-kinase suppresses neointimal formation after balloon injury in pigs
16. Adenovirus-mediated transfer of dominant-negative Rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo