Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 182-189

  Tsounapi, Panagiota ^a   Saito, Motoaki ^a   Kitatani, Kazuyuki ^b   Dimitriadis, Fotios ^a   Ohmasa, Fumiya ^a   Shimizu, Shogo ^a   Kinoshita, Yukako ^a   Takenaka, Atsushi ^a   Satoh, Keisuke ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY HOSPITAL   (Japan)

Author keywords

Aorta; Endothelial dysfunction; eNOS; Fasudil; Rho kinase inhibition; SHR

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; FASUDIL; MESSENGER RNA; MYOSIN LIGHT CHAIN; RHO KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; AORTA DISEASE; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; GENE EXPRESSION; HEART RATE; HYPERTENSION; IN VITRO STUDY; LOW DRUG DOSE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE CONTRACTILITY; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION; WISTAR RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; AORTA; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; MALE; MYOSIN LIGHT CHAINS; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, INBRED SHR; RHO-ASSOCIATED KINASES; RNA, MESSENGER; VASOCONSTRICTION; VASODILATION;

EID: 84864993576     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.016     Document Type: Article

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