Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

Life Sciences

Volumn 69, Issue 12, 2001, Pages 1441-1453

  Satoh, Shin Ichi ^a,b   Utsunomiya, Tatsuma ^a   Tsurui, Kazuyuki ^a   Kobayashi, Teruki ^a   Ikegaki, Ichiro ^a   Sasaki, Yasuo ^a   Asano, Toshio ^a  

^a ASAHI KASEI CORPORATION   (Japan)

^b ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Cerebral ischemia; Hydroxy fasudil; Neuroprotection; Pharmacokinetics; Rho kinase inhibitor

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; DRUG METABOLITE; FASUDIL; HYDROXYFASUDIL; POTASSIUM CHLORIDE; PROSTAGLANDIN F2; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CELL DAMAGE; CELL LOSS; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG EFFECT; ENZYME INHIBITION; FEMALE; GERBIL; HEMODYNAMICS; MALE; MICROEMBOLISM; MIDDLE CEREBRAL ARTERY; NERVE CELL NECROSIS; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PATHOGENESIS; RAT; STROKE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBRAL ARTERIES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GERBILLINAE; HEMODYNAMIC PROCESSES; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAPERITONEAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; METHACRYLATES; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NEUROPROTECTIVE AGENTS; PROTEIN-SERINE-THREONINE KINASES; RATS; REGIONAL BLOOD FLOW; REPERFUSION INJURY;

CANIS FAMILIARIS; GERBILLINAE;

EID: 0035838950     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01229-2     Document Type: Article

References (27)

1. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
2. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells
3. Rho-kinase in human neutrophils: A role in signaling for myosin light chain phosphorylation and cell migration
4. Signal transduction and regulation in smooth muscle
5. A protein kinase inhibitor, Fasudil (AT-877): A novel approach to signal transduction therapy
6. Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle
7. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
8. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage
9. Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction
10. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
11. Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
12. Blockade of intracellular actions of calcium may protect against ischaemic damage to the gerbil brain
13. Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877
14. Neuroprotective properties of a protein kinase inhibitor against ischaemia-induced neuronal damage in rats and gerbils
15. Mechanism of action of a novel anivasospasm drug, HA1077
16. 2+ antagonist and vasodilator, on chronic cerebral vasospasm
17. Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm
18. Fasudil, a protein kinase inhibitor, prevents the development of endothelial injury and neutrophil infiltration in a two-haemorrhage canine model
19. The effects of HA1077 on the cerebral circulation after subarachnoid haemorrhage in dogs
20. The effects of HA1077, a novel protein kinase inhibitor, on reductions of cerebral blood flow and glucose metabolism following acute and/or chronic bilateral carotid artery ligation in Wistar rats
21. Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity
22. Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage
23. Bright and dark sides of nitric oxide in ischemic brain injury
24. Molecular and biochemical events within the brain subjected to cerebral ischemia (Targets for therapeutic intervention)
25. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase
26. Endothelin: A potential modulator of cerebral vasospasm
27. Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils