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Volumn 39, Issue 8, 2014, Pages 813-822

Effects of K-115, a Rho-kinase inhibitor, on aqueous humor dynamics in rabbits

Author keywords

Aqueous humor dynamics; Glaucoma; Intraocular pressure; K 115; ROCK

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANTIHYPERTENSIVE AGENT; CARBON 14; FASUDIL; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; INDOMETACIN; K 115; LATANOPROST; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG; EYE DROPS; ISOQUINOLINE DERIVATIVE; K-115; RHO KINASE; SULFONAMIDE;

EID: 84904348321     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2013.874444     Document Type: Article
Times cited : (94)

References (33)
  • 1
    • 0027399771 scopus 로고
    • Open-angle glaucoma
    • Quigley HA. Open-angle glaucoma. N Engl J Med 1993; 328:1097-1106.
    • (1993) N Engl J Med , vol.328 , pp. 1097-1106
    • Quigley, H.A.1
  • 2
    • 4444279753 scopus 로고    scopus 로고
    • The prevalence of primary open-angle glaucoma in Japanese: The Tajimi Study
    • Iwase A, Suzuki Y, Araie M, Yamamoto T, Abe H, Shirato S, et al. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology 2004;111: 1641-1648.
    • (2004) Ophthalmology , vol.111 , pp. 1641-1648
    • Iwase, A.1    Suzuki, Y.2    Araie, M.3    Yamamoto, T.4    Abe, H.5    Shirato, S.6
  • 3
    • 40049112112 scopus 로고    scopus 로고
    • Normal-tension glaucoma: Is it different from primary open-angle glaucoma?
    • Shields MB. Normal-tension glaucoma: is it different from primary open-angle glaucoma? Curr Opin Ophthalmol 2008;19:85-88.
    • (2008) Curr Opin Ophthalmol , vol.19 , pp. 85-88
    • Shields, M.B.1
  • 4
    • 33746829016 scopus 로고    scopus 로고
    • Causal inference in primary open angle glaucoma: Specific discussion on intraocular pressure
    • Bahrami H. Causal inference in primary open angle glaucoma: specific discussion on intraocular pressure. Ophthalmic Epidemiol 2006;13:283-289.
    • (2006) Ophthalmic Epidemiol , vol.13 , pp. 283-289
    • Bahrami, H.1
  • 5
    • 0038024241 scopus 로고    scopus 로고
    • Rocks: Multifunctional kinases in cell behaviour
    • Riento K, Ridley AJ. Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 2003;4:446-456.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 446-456
    • Riento, K.1    Ridley, A.J.2
  • 6
    • 27844604200 scopus 로고    scopus 로고
    • Rho GTPases and the control of cell behaviour
    • Hall A. Rho GTPases and the control of cell behaviour. Biochem Soc Trans 2005;33:891-895.
    • (2005) Biochem Soc Trans , vol.33 , pp. 891-895
    • Hall, A.1
  • 7
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997;389:990-994.
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1    Ishizaki, T.2    Satoh, H.3    Ono, T.4    Kawahara, T.5    Morishita, T.6
  • 8
    • 41749091574 scopus 로고    scopus 로고
    • Applications for ROCK kinase inhibition
    • Olson MF. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 2008;20:242-248.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 242-248
    • Olson, M.F.1
  • 9
    • 34249694646 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma
    • Rao VP, Epstein DL. Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. Biodrugs 2007;21:167-177.
    • (2007) Biodrugs , vol.21 , pp. 167-177
    • Rao, V.P.1    Epstein, D.L.2
  • 10
    • 17744397579 scopus 로고    scopus 로고
    • Contribution of ROCK in contraction of trabecular meshwork: Proposed mechanism for regulating aqueous outflow in monkey and human eyes
    • Nakajima E, Nakajima T, Minagawa Y, Shearer TR, Azuma M. Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes. J Pharm Sci 2005;94: 701-708.
    • (2005) J Pharm Sci , vol.94 , pp. 701-708
    • Nakajima, E.1    Nakajima, T.2    Minagawa, Y.3    Shearer, T.R.4    Azuma, M.5
  • 11
    • 0035164065 scopus 로고    scopus 로고
    • Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility
    • Honjo M, Tanihara H, Inatani M, Kido N, Sawamura T, Yue BY, et al. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci 2001;42:137-144.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 137-144
    • Honjo, M.1    Tanihara, H.2    Inatani, M.3    Kido, N.4    Sawamura, T.5    Yue, B.Y.6
  • 12
    • 0035726683 scopus 로고    scopus 로고
    • Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase
    • Waki M, Yoshida Y, Oka T, Azuma M. Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase. Curr Eye Res 2001;22:470-474.
    • (2001) Curr Eye Res , vol.22 , pp. 470-474
    • Waki, M.1    Yoshida, Y.2    Oka, T.3    Azuma, M.4
  • 13
    • 0034905717 scopus 로고    scopus 로고
    • Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes
    • Honjo M, Inatani M, Kido N, Sawamura T, Yue BY, Honda Y, et al. Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch Ophthalmol 2001;119:1171-1178.
    • (2001) Arch Ophthalmol , vol.119 , pp. 1171-1178
    • Honjo, M.1    Inatani, M.2    Kido, N.3    Sawamura, T.4    Yue, B.Y.5    Honda, Y.6
  • 15
    • 34548073671 scopus 로고    scopus 로고
    • Effects of topical administration of Y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys
    • Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M, et al. Effects of topical administration of Y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci 2007;48:3216-3222.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3216-3222
    • Tokushige, H.1    Inatani, M.2    Nemoto, S.3    Sakaki, H.4    Katayama, K.5    Uehata, M.6
  • 16
    • 82455161483 scopus 로고    scopus 로고
    • Ocular hypotensive dose-response efficacy and safety of the rho kinase inhibitor, K-115, in patients with primary open-angle glaucoma and ocular hypertension
    • ARVO E-Abstract 220
    • Tanihara H, Abe H, Kuwayama Y, Yamamoto T, Araie M. Ocular hypotensive dose-response efficacy and safety of the rho kinase inhibitor, K-115, in patients with primary open-angle glaucoma and ocular hypertension. IOVS 2011;52:ARVO E-Abstract 220.
    • (2011) IOVS , vol.52
    • Tanihara, H.1    Abe, H.2    Kuwayama, Y.3    Yamamoto, T.4    Araie, M.5
  • 17
    • 82455221513 scopus 로고    scopus 로고
    • Efficacy and safety of the rho kinase inhibitor, K-115, over 24 hours in patients with primary open-angle glaucoma and ocular hypertension
    • ARVO E-Abstract 216
    • Yamamoto T, Abe H, Kuwayama Y, Tanihara H, Araie M. Efficacy and safety of the rho kinase inhibitor, K-115, over 24 hours in patients with primary open-angle glaucoma and ocular hypertension. IOVS. 2011;52:ARVO E-Abstract 216.
    • (2011) IOVS , vol.52
    • Yamamoto, T.1    Abe, H.2    Kuwayama, Y.3    Tanihara, H.4    Araie, M.5
  • 18
    • 0031956212 scopus 로고    scopus 로고
    • Effects of topical Nipradilol, a, b-blocking agent with a-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation
    • Kanno M, Araie M, Tomita K, Sawanobori K. Effects of topical Nipradilol, a, b-blocking agent with a-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Invest Ophthalmol Vis Sci 1998;39: 736-743.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 736-743
    • Kanno, M.1    Araie, M.2    Tomita, K.3    Sawanobori, K.4
  • 19
    • 0021875993 scopus 로고
    • Uveoscleral outflow following cyclodialysis in the monkey eye using a fluorescent tracer
    • Suguro K, Toris CB, Pederson JE. Uveoscleral outflow following cyclodialysis in the monkey eye using a fluorescent tracer. Invest Ophthalmol Vis Sci 1985;26: 810-813.
    • (1985) Invest Ophthalmol Vis Sci , vol.26 , pp. 810-813
    • Suguro, K.1    Toris, C.B.2    Pederson, J.E.3
  • 21
    • 2042472208 scopus 로고    scopus 로고
    • Ocular hypotensive mechanism of a-, b-blocker (Nipradilol ophthalmic solution)
    • in Japanese
    • Mizuno K. Ocular hypotensive mechanism of a-, b-blocker (Nipradilol ophthalmic solution). Atarashii Ganka (J Eye) 1999;16:529-535. (in Japanese).
    • (1999) Atarashii Ganka (J Eye) , vol.16 , pp. 529-535
    • Mizuno, K.1
  • 22
    • 0000288213 scopus 로고
    • Simultaneous measurement of changing intraocular pressure and outflow facility in the vervet monkey by constant pressure perfusion
    • Barany EH. Simultaneous measurement of changing intraocular pressure and outflow facility in the vervet monkey by constant pressure perfusion. Invest Ophthalmol Vis Sci 1964;3:135-143.
    • (1964) Invest Ophthalmol Vis Sci , vol.3 , pp. 135-143
    • Barany, E.H.1
  • 23
    • 0028365373 scopus 로고
    • Effects of endothelin-1 on intraocular pressure and aqueous humor dynamics in the rabbit eye
    • Taniguchi T, Okada K, Haque MS, Sugiyama K, Kitazawa Y. Effects of endothelin-1 on intraocular pressure and aqueous humor dynamics in the rabbit eye. Curr Eye Res 1994;13:461-464.
    • (1994) Curr Eye Res , vol.13 , pp. 461-464
    • Taniguchi, T.1    Okada, K.2    Haque, M.S.3    Sugiyama, K.4    Kitazawa, Y.5
  • 24
    • 0032988987 scopus 로고    scopus 로고
    • H-series protein kinase inhibitors and potential clinical applications
    • Ono-Saito N, Niki I, Hidaka H. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther 1999;82:123-131.
    • (1999) Pharmacol Ther , vol.82 , pp. 123-131
    • Ono-Saito, N.1    Niki, I.2    Hidaka, H.3
  • 26
    • 0024848046 scopus 로고
    • Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase
    • Asano T, Suzuki T, Tsuchiya M, Satoh S, Ikegaki I, Shibuya M, et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol 1989;98:1091-1100.
    • (1989) Br J Pharmacol , vol.98 , pp. 1091-1100
    • Asano, T.1    Suzuki, T.2    Tsuchiya, M.3    Satoh, S.4    Ikegaki, I.5    Shibuya, M.6
  • 27
    • 0021751197 scopus 로고
    • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
    • Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 1984;23:5036-5041.
    • (1984) Biochemistry , vol.23 , pp. 5036-5041
    • Hidaka, H.1    Inagaki, M.2    Kawamoto, S.3    Sasaki, Y.4
  • 28
    • 66249123108 scopus 로고    scopus 로고
    • Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK
    • Whitlock NA, Harrison B, Mixon T, Yu XQ, Wilson A, Gerhardt B, et al. Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. J Ocul Pharmacol Ther 2009;25:187-194.
    • (2009) J Ocul Pharmacol Ther , vol.25 , pp. 187-194
    • Whitlock, N.A.1    Harrison, B.2    Mixon, T.3    Yu, X.Q.4    Wilson, A.5    Gerhardt, B.6
  • 29
    • 66849089094 scopus 로고    scopus 로고
    • Topical proparacaine and episcleral venous pressure in the rabbit
    • Zamora DO, Kiel JW. Topical proparacaine and episcleral venous pressure in the rabbit. Invest Ophthalmol Vis Sci 2009;50:2949-2952.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2949-2952
    • Zamora, D.O.1    Kiel, J.W.2
  • 30
    • 0027456591 scopus 로고
    • Selective suppression by bunazosin of alpha-adrenergic agonist evoked elevation of intraocular pressure in sympathectomized rabbit eyes
    • Nishimura K, Kuwayama Y, Matsugi T, Sun N, Shirasawa E. Selective suppression by bunazosin of alpha-adrenergic agonist evoked elevation of intraocular pressure in sympathectomized rabbit eyes. Invest Ophthalmol Vis Sci 1993;34:1761-1766.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 1761-1766
    • Nishimura, K.1    Kuwayama, Y.2    Matsugi, T.3    Sun, N.4    Shirasawa, E.5
  • 31
    • 20444378182 scopus 로고    scopus 로고
    • Roles of the conjunctiva in ocular drug delivery: A review of conjunctival transport mechanisms and their regulation
    • Hosoya K, Lee VH, Kim KJ. Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation. Eur J Pharm Biopharm 2005;60:227-240.
    • (2005) Eur J Pharm Biopharm , vol.60 , pp. 227-240
    • Hosoya, K.1    Lee, V.H.2    Kim, K.J.3
  • 32
    • 0002611505 scopus 로고
    • Ocular pharmacokinetics
    • Sears ML, editor Berlin: Springer-Verlag
    • Maurice DM, Mishima S. Ocular pharmacokinetics. In: Sears ML, editor. Pharmacology of the eye. Berlin: Springer-Verlag; 1984. pp 19-116.
    • (1984) Pharmacology of the Eye , pp. 19-116
    • Maurice, D.M.1    Mishima, S.2
  • 33
    • 31344431612 scopus 로고    scopus 로고
    • Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells
    • Koga T, Koga T, Awai M, Tsutsui J, Yue BY, Tanihara H. Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells. Exp Eye Res 2006;82:362-370.
    • (2006) Exp Eye Res , vol.82 , pp. 362-370
    • Koga, T.1    Koga, T.2    Awai, M.3    Tsutsui, J.4    Yue, B.Y.5    Tanihara, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.