-
1
-
-
0038737044
-
Switch-of-function mutants based upon morphology classification of Ras superfamily small GTPases
-
Heo WD, Meyer T. Switch-of-function mutants based upon morphology classification of Ras superfamily small GTPases. Cell. 2003;113:315-328.
-
(2003)
Cell
, vol.113
, pp. 315-328
-
-
Heo, W.D.1
Meyer, T.2
-
2
-
-
0034717136
-
Small guanine nucleotide-binding proteins and myocardial hypertrophy
-
Clerk A, Sugden PH. Small guanine nucleotide-binding proteins and myocardial hypertrophy. Circ Res. 2000;86:1019-1023.
-
(2000)
Circ Res
, vol.86
, pp. 1019-1023
-
-
Clerk, A.1
Sugden, P.H.2
-
3
-
-
0035824897
-
Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy
-
Wu G, Yussman MG, Barrett TJ, Hahn HS, Osinska H, Hilliard GM, Wang X, Toyokawa T, Yatani A, Lynch RA, Robbins J, Dorn GW 2nd. Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy. Circ Res. 2001;89:1130-1137.
-
(2001)
Circ Res
, vol.89
, pp. 1130-1137
-
-
Wu, G.1
Yussman, M.G.2
Barrett, T.J.3
Hahn, H.S.4
Osinska, H.5
Hilliard, G.M.6
Wang, X.7
Toyokawa, T.8
Yatani, A.9
Lynch, R.A.10
Robbins, J.11
Dorn II, G.W.12
-
4
-
-
0036547662
-
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin
-
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T. Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin. J Mol Cell Cardiol. 2002;34:441-453.
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 441-453
-
-
Fahimi-Vahid, M.1
Gosau, N.2
Michalek, C.3
Han, L.4
Jakobs, K.H.5
Schmidt, M.6
Roberts, N.7
Avkiran, M.8
Wieland, T.9
-
5
-
-
3242793344
-
Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy
-
Proud CG. Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy. Cardiovasc Res. 2004;403-413.
-
(2004)
Cardiovasc Res
, pp. 403-413
-
-
Proud, C.G.1
-
6
-
-
0034533691
-
Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists
-
Sugden PH, Clerk A. Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists. Trends Cardiovasc Med. 2000;10:1-8.
-
(2000)
Trends Cardiovasc Med
, vol.10
, pp. 1-8
-
-
Sugden, P.H.1
Clerk, A.2
-
7
-
-
0026778133
-
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70:389-399.
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
8
-
-
0026654125
-
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
-
Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 1992;70:401-410.
-
(1992)
Cell
, vol.70
, pp. 401-410
-
-
Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
-
9
-
-
0842281652
-
Rho and Rac take center stage
-
Burridge K, Wennerberg K. Rho and Rac take center stage. Cell. 2004;167-179.
-
(2004)
Cell
, pp. 167-179
-
-
Burridge, K.1
Wennerberg, K.2
-
10
-
-
0034865456
-
Rho GTPases and cell migration
-
Ridley AJ. Rho GTPases and cell migration. J Cell Sci. 2001;114:2713-2722.
-
(2001)
J Cell Sci
, vol.114
, pp. 2713-2722
-
-
Ridley, A.J.1
-
11
-
-
0032860424
-
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
-
Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem. 1999;68:459-486.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 459-486
-
-
Kaibuchi, K.1
Kuroda, S.2
Amano, M.3
-
12
-
-
0027279176
-
How receptor tyrosine kinases activate Ras
-
Schlessinger J. How receptor tyrosine kinases activate Ras. Trends Biochem Sci. 1993;18:273-275.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 273-275
-
-
Schlessinger, J.1
-
13
-
-
10944244704
-
Rho signaling at a glance
-
Schwartz M. Rho signaling at a glance. J Cell Sci. 2004;117:5457-5458.
-
(2004)
J Cell Sci
, vol.117
, pp. 5457-5458
-
-
Schwartz, M.1
-
14
-
-
0027496730
-
ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells
-
Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem. 1993;268:24535-24538.
-
(1993)
J Biol Chem
, vol.268
, pp. 24535-24538
-
-
Kumagai, N.1
Morii, N.2
Fujisawa, K.3
Nemoto, Y.4
Narumiya, S.5
-
15
-
-
0029125869
-
In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases
-
Aktories K, Just I. In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases. Methods Enzymol. 1995;256:184-206.
-
(1995)
Methods Enzymol
, vol.256
, pp. 184-206
-
-
Aktories, K.1
Just, I.2
-
16
-
-
0033179473
-
Regulation of p21rac activation in human neutrophils
-
Geijsen N, van Delft S, Raaijmakers JA, Lammers JW, Collard JG, Koenderman L, Coffer PJ. Regulation of p21rac activation in human neutrophils. Blood. 1999;94:1121-1130.
-
(1999)
Blood
, vol.94
, pp. 1121-1130
-
-
Geijsen, N.1
Van Delft, S.2
Raaijmakers, J.A.3
Lammers, J.W.4
Collard, J.G.5
Koenderman, L.6
Coffer, P.J.7
-
17
-
-
13444252631
-
GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
-
Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol. 2005;6:167-180.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 167-180
-
-
Rossman, K.L.1
Der, C.J.2
Sondek, J.3
-
18
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: Turning on the switch
-
Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 2002;16:1587-1609.
-
(2002)
Genes Dev
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
19
-
-
0032569051
-
13
-
13. Science. 1998;280:2109-2111.
-
(1998)
Science
, vol.280
, pp. 2109-2111
-
-
Kozasa, T.1
Jiang, X.2
Hart, M.J.3
Sternweis, P.M.4
Singer, W.D.5
Gilman, A.G.6
Bollag, G.7
Sternweis, P.C.8
-
20
-
-
0032568868
-
13
-
13. Science. 1998;280:2112-2114.
-
(1998)
Science
, vol.280
, pp. 2112-2114
-
-
Hart, M.J.1
Jiang, X.2
Kozasa, T.3
Roscoe, W.4
Singer, W.D.5
Gilman, A.G.6
Sternweis, P.C.7
Bollag, G.8
-
21
-
-
0037178831
-
Potent activation of RhoA by Gαq and Gq-coupled receptors
-
Chikumi H, Vazquez-Prado J, Servitja JM, Miyazaki H, Gutkind JS. Potent activation of RhoA by Gαq and Gq-coupled receptors. J Biol Chem. 2002;277:27130-27134.
-
(2002)
J Biol Chem
, vol.277
, pp. 27130-27134
-
-
Chikumi, H.1
Vazquez-Prado, J.2
Servitja, J.M.3
Miyazaki, H.4
Gutkind, J.S.5
-
22
-
-
0036261720
-
Leukemia-associated Rho guanine nucleotide exchange factor promotes Gαq-coupled activation of RhoA
-
Booden MA, Siderovski DP, Der CJ. Leukemia-associated Rho guanine nucleotide exchange factor promotes Gαq-coupled activation of RhoA. Mol Cell Biol. 2002;22:4053-4061.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4053-4061
-
-
Booden, M.A.1
Siderovski, D.P.2
Der, C.J.3
-
24
-
-
15744364175
-
The guanine nucleotide exchange factor p63Rho
-
Lutz S, Freichel-Blomquist A, Yang Y, Ruemenapp U, Jakobs KH, Schmidt M, Wieland T. The guanine nucleotide exchange factor p63Rho. J Biol Chem. 2005;280:11134-11139.
-
(2005)
J Biol Chem
, vol.280
, pp. 11134-11139
-
-
Lutz, S.1
Freichel-Blomquist, A.2
Yang, Y.3
Ruemenapp, U.4
Jakobs, K.H.5
Schmidt, M.6
Wieland, T.7
-
26
-
-
21744432683
-
GDIs: Central regulatory molecules in Rho GTPase activation
-
DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol. 2005;15:356-363.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 356-363
-
-
DerMardirossian, C.1
Bokoch, G.M.2
-
27
-
-
0038024241
-
Rocks: Multifunctional kinases in cell behaviour
-
Riento K, Ridley AJ. Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol. 2003;4:446-456.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 446-456
-
-
Riento, K.1
Ridley, A.J.2
-
28
-
-
0028980248
-
Involvement of rho in GTPγS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: Inhibition of phosphatase activity
-
Noda M, Yasuda-Fukazawa C, Moriishi K, Kato T, Okuda T, Kurokawa K, Takuwa Y. Involvement of rho in GTPγS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity. FEBS Lett. 1995;367:246-250.
-
(1995)
FEBS Lett
, vol.367
, pp. 246-250
-
-
Noda, M.1
Yasuda-Fukazawa, C.2
Moriishi, K.3
Kato, T.4
Okuda, T.5
Kurokawa, K.6
Takuwa, Y.7
-
29
-
-
9444242736
-
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
-
Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245-248.
-
(1996)
Science
, vol.273
, pp. 245-248
-
-
Kimura, K.1
Ito, M.2
Amano, M.3
Chihara, K.4
Fukata, Y.5
Nakafuku, M.6
Yamamori, B.7
Feng, J.8
Nakano, T.9
Okawa, K.10
Iwamatsu, A.11
Kaibuchi, K.12
-
30
-
-
0030977123
-
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
-
Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation J Biol Chem. 1997;272:12257-12260.
-
(1997)
J Biol Chem
, vol.272
, pp. 12257-12260
-
-
Kureishi, Y.1
Kobayashi, S.2
Amano, M.3
Kimura, K.4
Kanaide, H.5
Nakano, T.6
Kaibuchi, K.7
Ito, M.8
-
32
-
-
2342580708
-
RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
-
Moriki N, Ito M, Seko T, Kureishi Y, Okamoto R, Nakakuki T, Kongo M, Isaka N, Kaibuchi K, Nakano T. RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Hypertens Res. 2004;27:263-270.
-
(2004)
Hypertens Res
, vol.27
, pp. 263-270
-
-
Moriki, N.1
Ito, M.2
Seko, T.3
Kureishi, Y.4
Okamoto, R.5
Nakakuki, T.6
Kongo, M.7
Isaka, N.8
Kaibuchi, K.9
Nakano, T.10
-
33
-
-
0037423816
-
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
-
Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res. 2003;92:411-418.
-
(2003)
Circ Res
, vol.92
, pp. 411-418
-
-
Seko, T.1
Ito, M.2
Kureishi, Y.3
Okamoto, R.4
Moriki, N.5
Onishi, K.6
Isaka, N.7
Hartshorne, D.J.8
Nakano, T.9
-
34
-
-
0030656619
-
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
-
Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
-
(1997)
Nature
, vol.389
, pp. 990-994
-
-
Uehata, M.1
Ishizaki, T.2
Satoh, H.3
Ono, T.4
Kawahara, T.5
Morishita, T.6
Tamakawa, H.7
Yamagami, K.8
Inui, J.9
Maekawa, M.10
Narumiya, S.11
-
35
-
-
9644280885
-
Hypertension and RhoA/Rho-kinase signaling in the vasculature: Highlights from the recent literature
-
Lee DL, Webb RC, Jin L. Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. Hypertension. 2004;44:796-799.
-
(2004)
Hypertension
, vol.44
, pp. 796-799
-
-
Lee, D.L.1
Webb, R.C.2
Jin, L.3
-
36
-
-
0035957574
-
Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension
-
Chrissobolis S, Sobey CG. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension. Circ Res. 2001;88:774-779.
-
(2001)
Circ Res
, vol.88
, pp. 774-779
-
-
Chrissobolis, S.1
Sobey, C.G.2
-
37
-
-
0034983715
-
WASP and WAVE family proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement
-
Takenawa T, Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci. 2001;114:1801-1809.
-
(2001)
J Cell Sci
, vol.114
, pp. 1801-1809
-
-
Takenawa, T.1
Miki, H.2
-
38
-
-
0029913510
-
Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
-
Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem. 1996;271:27225-27228.
-
(1996)
J Biol Chem
, vol.271
, pp. 27225-27228
-
-
Teramoto, H.1
Coso, O.A.2
Miyata, H.3
Igishi, T.4
Miki, T.5
Gutkind, J.S.6
-
39
-
-
0037144667
-
p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I
-
Buscemi N, Foster DB, Neverova I, Van Eyk JE. p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I. Circ Res. 2002;91:509-516.
-
(2002)
Circ Res
, vol.91
, pp. 509-516
-
-
Buscemi, N.1
Foster, D.B.2
Neverova, I.3
Van Eyk, J.E.4
-
40
-
-
1042279545
-
Intracellular localization and functional effects of p21-activated kinase-1 (Pak1) in cardiac myocytes
-
Ke Y, Wang L, Pyle WG, de Tombe PP, Solaro RJ. Intracellular localization and functional effects of p21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res. 2004;94:194-200.
-
(2004)
Circ Res
, vol.94
, pp. 194-200
-
-
Ke, Y.1
Wang, L.2
Pyle, W.G.3
De Tombe, P.P.4
Solaro, R.J.5
-
41
-
-
0141456653
-
Rac regulates cardiovascular superoxide through diverse molecular interactions: More than a binary GTP switch
-
Gregg D, Rauscher FM, Goldschmidt-Clermont PJ. Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch. Am J Physiol Cell Physiol. 2003;285:C723-C734.
-
(2003)
Am J Physiol Cell Physiol
, vol.285
-
-
Gregg, D.1
Rauscher, F.M.2
Goldschmidt-Clermont, P.J.3
-
42
-
-
0029015774
-
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
-
Hill CS, Wynne J, Treisman R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell. 1995;81:1159-1170.
-
(1995)
Cell
, vol.81
, pp. 1159-1170
-
-
Hill, C.S.1
Wynne, J.2
Treisman, R.3
-
43
-
-
0035281564
-
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway
-
Marinissen MJ, Chiariello M, Gutkind JS. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev. 2001;15:535-553.
-
(2001)
Genes Dev
, vol.15
, pp. 535-553
-
-
Marinissen, M.J.1
Chiariello, M.2
Gutkind, J.S.3
-
44
-
-
1842816458
-
The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis
-
Marinissen MJ, Chiariello M, Tanos T, Bernard O, Narumiya S, Gutkind JS. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell. 2004;14:29-41.
-
(2004)
Mol Cell
, vol.14
, pp. 29-41
-
-
Marinissen, M.J.1
Chiariello, M.2
Tanos, T.3
Bernard, O.4
Narumiya, S.5
Gutkind, J.S.6
-
45
-
-
0035887278
-
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA
-
Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev. 2001;15:2702-2719.
-
(2001)
Genes Dev
, vol.15
, pp. 2702-2719
-
-
Charron, F.1
Tsimiklis, G.2
Arcand, M.3
Robitaille, L.4
Liang, Q.5
Molkentin, J.D.6
Meloche, S.7
Nemer, M.8
-
46
-
-
9144268981
-
RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of IκB kinase β and phosphorylation of RelA/p65
-
Anwar KN, Fazal F, Malik AB, Rahman A. RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of IκB kinase β and phosphorylation of RelA/p65. J Immunol. 2004;173:6965-6972.
-
(2004)
J Immunol
, vol.173
, pp. 6965-6972
-
-
Anwar, K.N.1
Fazal, F.2
Malik, A.B.3
Rahman, A.4
-
47
-
-
0038446034
-
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: Effects on tumor growth and therapeutic consequences
-
Benitah SA, Valeron PF, Lacal JC. ROCK and nuclear factor-kappaB- dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Mol Biol Cell. 2003;14:3041-3054.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3041-3054
-
-
Benitah, S.A.1
Valeron, P.F.2
Lacal, J.C.3
-
48
-
-
0031910828
-
The Rho family G proteins play a critical role in muscle differentiation
-
Takano H, Komuro I, Oka T, Shiojima I, Hiroi Y, Mizuno T, Yazaki Y. The Rho family G proteins play a critical role in muscle differentiation. Mol Cell Biol. 1998;18:1580-1589.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1580-1589
-
-
Takano, H.1
Komuro, I.2
Oka, T.3
Shiojima, I.4
Hiroi, Y.5
Mizuno, T.6
Yazaki, Y.7
-
49
-
-
20444420893
-
An expression screen reveals modulators of class II histone deacetylase phosphorylation
-
Chang S, Bezprozvannaya S, Li S, Olson EN. An expression screen reveals modulators of class II histone deacetylase phosphorylation. Proc Natl Acad Sci U S A. 2005;102:8120-8125.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 8120-8125
-
-
Chang, S.1
Bezprozvannaya, S.2
Li, S.3
Olson, E.N.4
-
50
-
-
0032563677
-
"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium
-
Sugden PH, Clerk A. "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res. 1998;83:345-352.
-
(1998)
Circ Res
, vol.83
, pp. 345-352
-
-
Sugden, P.H.1
Clerk, A.2
-
51
-
-
0034282394
-
Angiotensin II initiates tyrosine kinase pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase
-
Murasawa S, Matsubara H, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Kitabayashi I, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Iba S, Iwasaka T. Angiotensin II initiates tyrosine kinase pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. J Biol Chem. 2000;275:26856-26863.
-
(2000)
J Biol Chem
, vol.275
, pp. 26856-26863
-
-
Murasawa, S.1
Matsubara, H.2
Mori, Y.3
Masaki, H.4
Tsutsumi, Y.5
Shibasaki, Y.6
Kitabayashi, I.7
Tanaka, Y.8
Fujiyama, S.9
Koyama, Y.10
Fujiyama, A.11
Iba, S.12
Iwasaka, T.13
-
52
-
-
0035090134
-
Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter
-
He Q, LaPointe MC. Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter. Hypertension. 2001;37:478-484.
-
(2001)
Hypertension
, vol.37
, pp. 478-484
-
-
He, Q.1
LaPointe, M.C.2
-
53
-
-
0035186999
-
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
-
Takemoto M, Node K, Nakagami H, Liao Y, Grimm M, Takemoto Y, Kitakaze M, Liao JK. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J Clin Invest. 2001;108:1429-1437.
-
(2001)
J Clin Invest
, vol.108
, pp. 1429-1437
-
-
Takemoto, M.1
Node, K.2
Nakagami, H.3
Liao, Y.4
Grimm, M.5
Takemoto, Y.6
Kitakaze, M.7
Liao, J.K.8
-
54
-
-
0037516859
-
Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes
-
Teramoto H, Malek RL, Behbahani B, Castellone MD, Lee NH, Gutkind JS. Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes. Oncogene. 2003;22:2689-2697.
-
(2003)
Oncogene
, vol.22
, pp. 2689-2697
-
-
Teramoto, H.1
Malek, R.L.2
Behbahani, B.3
Castellone, M.D.4
Lee, N.H.5
Gutkind, J.S.6
-
55
-
-
0032537819
-
Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
-
Olson MF, Paterson HF, Marshall CJ. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature. 1998;394:295-299.
-
(1998)
Nature
, vol.394
, pp. 295-299
-
-
Olson, M.F.1
Paterson, H.F.2
Marshall, C.J.3
-
57
-
-
12344329603
-
Rho Signaling in vascular diseases
-
Seasholtz TM, Brown JH. Rho Signaling in vascular diseases. Mol Interv. 2004;4:348-357.
-
(2004)
Mol Interv
, vol.4
, pp. 348-357
-
-
Seasholtz, T.M.1
Brown, J.H.2
-
58
-
-
0028181770
-
1-adrenergic stimulation
-
1- adrenergic stimulation. J Biol Chem. 1994;269:13490-13496.
-
(1994)
J Biol Chem
, vol.269
, pp. 13490-13496
-
-
Lamorte, V.J.1
Thorburn, J.2
Absher, D.3
Spiegel, A.M.4
Brown, J.H.5
Chien, K.R.6
Feramisco, J.R.7
Knowlton, K.U.8
-
59
-
-
0033015220
-
Gq signaling in cardiac adaptation and maladaptation
-
Dorn GW, Brown JH. Gq signaling in cardiac adaptation and maladaptation. Trends in Cardiovasc Med. 1999;9:26-34.
-
(1999)
Trends in Cardiovasc Med
, vol.9
, pp. 26-34
-
-
Dorn, G.W.1
Brown, J.H.2
-
60
-
-
0032543959
-
q signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure
-
q signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A. 1998;95:10140-10145.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 10140-10145
-
-
Adams, J.W.1
Sakata, Y.2
Davis, M.G.3
Sah, V.P.4
Wang, Y.5
Liggett, S.B.6
Chien, K.R.7
Brown, J.H.8
Dorn, G.W.9
-
61
-
-
0036843158
-
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death
-
Bueno OF, Molkentin JD. Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res. 2002;91:776-781.
-
(2002)
Circ Res
, vol.91
, pp. 776-781
-
-
Bueno, O.F.1
Molkentin, J.D.2
-
62
-
-
16844379390
-
Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes
-
Clerk A, Sugden PH. Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. Biochem Cell Biol. 2004;82:603-609.
-
(2004)
Biochem Cell Biol
, vol.82
, pp. 603-609
-
-
Clerk, A.1
Sugden, P.H.2
-
63
-
-
0037110460
-
1-adrenergic receptor-induced cardiac hypertrophy
-
1- adrenergic receptor-induced cardiac hypertrophy. Circ Res. 2002;91:961-969.
-
(2002)
Circ Res
, vol.91
, pp. 961-969
-
-
Maruyama, Y.1
Nishida, M.2
Sugimoto, Y.3
Tanabe, S.4
Turner, J.H.5
Kozasa, T.6
Wada, T.7
Nagao, T.8
Kurose, H.9
-
64
-
-
0037040943
-
Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy
-
Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem. 2002;277:8618-8625.
-
(2002)
J Biol Chem
, vol.277
, pp. 8618-8625
-
-
Yanazume, T.1
Hasegawa, K.2
Wada, H.3
Morimoto, T.4
Abe, M.5
Kawamura, T.6
Sasayama, S.7
-
65
-
-
0030893060
-
MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells
-
Thorburn J, Xu S, Thorburn A. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J. 1997;16:1888-1900.
-
(1997)
EMBO J
, vol.16
, pp. 1888-1900
-
-
Thorburn, J.1
Xu, S.2
Thorburn, A.3
-
66
-
-
0029658495
-
1- adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways
-
1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways. J Biol Chem. 1996;271:31185-31190.
-
(1996)
J Biol Chem
, vol.271
, pp. 31185-31190
-
-
Sah, V.P.1
Hoshijima, M.2
Chien, K.R.3
Brown, J.H.4
-
67
-
-
0033005291
-
The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiomyocytes - Possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy
-
Kuwahara K, Saito Y, Nakagawa O, Kishimoto I, Harada M, Ogawa E, Miyamoto Y, Hamanaka I, Kajiyama N, Takahashi N, Izumi T, Kawakami R, Tamura N, Ogawa Y, Nakao K. The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiomyocytes - possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett. 1999;452:314-318.
-
(1999)
FEBS Lett
, vol.452
, pp. 314-318
-
-
Kuwahara, K.1
Saito, Y.2
Nakagawa, O.3
Kishimoto, I.4
Harada, M.5
Ogawa, E.6
Miyamoto, Y.7
Hamanaka, I.8
Kajiyama, N.9
Takahashi, N.10
Izumi, T.11
Kawakami, R.12
Tamura, N.13
Ogawa, Y.14
Nakao, K.15
-
68
-
-
0032489871
-
Angiotensin II activates RhoA in cardiac myocytes: A critical role of RhoA in angiotensin II-induced premyofibril formation
-
Aoki H, Izumo S, Sadoshima J. Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res. 1998;82:666-676.
-
(1998)
Circ Res
, vol.82
, pp. 666-676
-
-
Aoki, H.1
Izumo, S.2
Sadoshima, J.3
-
69
-
-
0032031590
-
Ras and Rho are required for Gαq-induced hypertrophic gene expression in neonatal rat cardiac myocytes
-
Hines WA, Thorburn A. Ras and Rho are required for Gαq-induced hypertrophic gene expression in neonatal rat cardiac myocytes. J Mol Cell Cardiol. 1998;30:485-494.
-
(1998)
J Mol Cell Cardiol
, vol.30
, pp. 485-494
-
-
Hines, W.A.1
Thorburn, A.2
-
70
-
-
0032571395
-
The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes: Involvement of Rho kinase
-
Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes: involvement of Rho kinase. J Biol Chem. 1998;273:7725-7730.
-
(1998)
J Biol Chem
, vol.273
, pp. 7725-7730
-
-
Hoshijima, M.1
Sah, V.P.2
Wang, Y.3
Chien, K.R.4
Brown, J.H.5
-
71
-
-
0033081753
-
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
-
Ren X-D, Kiosses WB, Schwartz MA. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 1999;18:578-585.
-
(1999)
EMBO J
, vol.18
, pp. 578-585
-
-
Ren, X.-D.1
Kiosses, W.B.2
Schwartz, M.A.3
-
72
-
-
0035141242
-
Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1
-
Clerk A, Pham FH, Fuller SJ, Sahai E, Aktories K, Marais R, Marshall C, Sugden PH. Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol. 2001;21:1173-1184.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1173-1184
-
-
Clerk, A.1
Pham, F.H.2
Fuller, S.J.3
Sahai, E.4
Aktories, K.5
Marais, R.6
Marshall, C.7
Sugden, P.H.8
-
73
-
-
1842815880
-
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho
-
Hilal-Dandan R, Means CK, Gustafsson AB, Morissette MR, Adams JW, Brunton LL, Heller BJ. Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cellular Cardiol. 2004;36:481-493.
-
(2004)
J Mol Cellular Cardiol
, vol.36
, pp. 481-493
-
-
Hilal-Dandan, R.1
Means, C.K.2
Gustafsson, A.B.3
Morissette, M.R.4
Adams, J.W.5
Brunton, L.L.6
Heller, B.J.7
-
74
-
-
20744448925
-
Gα12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes
-
Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, Takagahara S, Turner JH, Kozasa T, Kobayashi H, Sato Y, Kawanishi T, Inoue R, Nagao T, Kurose H. Gα12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem. 2005;280:18434-18441.
-
(2005)
J Biol Chem
, vol.280
, pp. 18434-18441
-
-
Nishida, M.1
Tanabe, S.2
Maruyama, Y.3
Mangmool, S.4
Urayama, K.5
Nagamatsu, Y.6
Takagahara, S.7
Turner, J.H.8
Kozasa, T.9
Kobayashi, H.10
Sato, Y.11
Kawanishi, T.12
Inoue, R.13
Nagao, T.14
Kurose, H.15
-
75
-
-
14644426000
-
Receptors coupled to heterotrimeric G proteins of the G12 family
-
Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends Pharmacol Sci. 2005;26:146-154.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 146-154
-
-
Riobo, N.A.1
Manning, D.R.2
-
76
-
-
0032587451
-
13 stimulates gene expression and increases cell size in cultured neonatal rat ventricular myocytes
-
13 stimulates gene expression and increases cell size in cultured neonatal rat ventricular myocytes. Cardiovasc Res. 1999;42:140-148.
-
(1999)
Cardiovasc Res
, vol.42
, pp. 140-148
-
-
Finn, S.G.1
Plonk, S.G.2
Fuller, S.J.3
-
78
-
-
0025217676
-
Stretching cardiac myocytes stimulates protooncogene expression
-
Komuro I, Kaida T, Shibazaki Y, Kurabayashi M, Katoh Y, Hoh E, Takaku F, Yazaki Y. Stretching cardiac myocytes stimulates protooncogene expression. J Biol Chem. 1990;265:3595-3598.
-
(1990)
J Biol Chem
, vol.265
, pp. 3595-3598
-
-
Komuro, I.1
Kaida, T.2
Shibazaki, Y.3
Kurabayashi, M.4
Katoh, Y.5
Hoh, E.6
Takaku, F.7
Yazaki, Y.8
-
79
-
-
0029090205
-
Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes
-
Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Mizuno T, Takano H, Hiroi Y, Ueki K, Tobe K. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest. 1995;96:438-446.
-
(1995)
J Clin Invest
, vol.96
, pp. 438-446
-
-
Yamazaki, T.1
Komuro, I.2
Kudoh, S.3
Zou, Y.4
Shiojima, I.5
Mizuno, T.6
Takano, H.7
Hiroi, Y.8
Ueki, K.9
Tobe, K.10
-
80
-
-
0033525546
-
Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes
-
Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Zhu W, Kadowaki T, Yazaki Y. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circ Res. 1999;84:458-466.
-
(1999)
Circ Res
, vol.84
, pp. 458-466
-
-
Aikawa, R.1
Komuro, I.2
Yamazaki, T.3
Zou, Y.4
Kudoh, S.5
Zhu, W.6
Kadowaki, T.7
Yazaki, Y.8
-
81
-
-
0042733080
-
Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: Cytoskeletal regulation of ERK translocation
-
Kawamura S, Miyamoto S, Brown JH. Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem. 2003;278:31111-31117.
-
(2003)
J Biol Chem
, vol.278
, pp. 31111-31117
-
-
Kawamura, S.1
Miyamoto, S.2
Brown, J.H.3
-
82
-
-
0035816691
-
Differential usage of signal transduction pathways defines two types of serum response factor target gene
-
Gineitis D, Treisman R. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J Biol Chem. 2001;276:24531-24539.
-
(2001)
J Biol Chem
, vol.276
, pp. 24531-24539
-
-
Gineitis, D.1
Treisman, R.2
-
83
-
-
0035808389
-
Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization
-
Mack CP, Somlyo AV, Hautmann M, Somlyo AP, Owens GK. Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization. J Biol Chem. 2001;276:341-347.
-
(2001)
J Biol Chem
, vol.276
, pp. 341-347
-
-
Mack, C.P.1
Somlyo, A.V.2
Hautmann, M.3
Somlyo, A.P.4
Owens, G.K.5
-
84
-
-
0032549013
-
Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation
-
Alberts AS, Geneste O, Treisman R. Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell. 1998;92:475-487.
-
(1998)
Cell
, vol.92
, pp. 475-487
-
-
Alberts, A.S.1
Geneste, O.2
Treisman, R.3
-
85
-
-
0012265697
-
The RhoA Rho kinase pathway regulates nuclear localization of serum response factor
-
Lui HW, Halayko AJ, Fernandes DJ, Harmon GS, McCauley JA, Kocieniewski P, McConville J, Fu Y, Forsythe SM, Kogut P, Bellam S, Dowell M, Churchill J, Lesso H, Kassiri K, Mitchell RW, Hershenson MB, Camoretti-Mercado B, Sloway J. The RhoA Rho kinase pathway regulates nuclear localization of serum response factor. Am J Respir Cell Mol Biol. 2003;29:39-47.
-
(2003)
Am J Respir Cell Mol Biol
, vol.29
, pp. 39-47
-
-
Lui, H.W.1
Halayko, A.J.2
Fernandes, D.J.3
Harmon, G.S.4
McCauley, J.A.5
Kocieniewski, P.6
McConville, J.7
Fu, Y.8
Forsythe, S.M.9
Kogut, P.10
Bellam, S.11
Dowell, M.12
Churchill, J.13
Lesso, H.14
Kassiri, K.15
Mitchell, R.W.16
Hershenson, M.B.17
Camoretti-Mercado, B.18
Sloway, J.19
-
86
-
-
0032515147
-
RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation
-
Wei L, Zhou W, Croissant JD, Johansen F-E, Prywes R, Balasubramanayam A, Schwartz RJ. RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation. J Biol Chem. 1998;273:30287-30294.
-
(1998)
J Biol Chem
, vol.273
, pp. 30287-30294
-
-
Wei, L.1
Zhou, W.2
Croissant, J.D.3
Johansen, F.-E.4
Prywes, R.5
Balasubramanayam, A.6
Schwartz, R.J.7
-
87
-
-
0033946118
-
The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element
-
Morissette MR, Sah VP, Glembotski CC, Brown JH. The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element. Am J Physiol. 2000;278:H1769-H1774.
-
(2000)
Am J Physiol
, vol.278
-
-
Morissette, M.R.1
Sah, V.P.2
Glembotski, C.C.3
Brown, J.H.4
-
88
-
-
23644456010
-
SRF-dependent gene expression in isolated cardiomyocytes: Regulation of genes involved in cardiac hypertrophy
-
Nelson TJ, Balza R Jr, Xiao Q, Misra RP. SRF-dependent gene expression in isolated cardiomyocytes: regulation of genes involved in cardiac hypertrophy. J Mol Cell Cardiol. 2005;39:479-489.
-
(2005)
J Mol Cell Cardiol
, vol.39
, pp. 479-489
-
-
Nelson, T.J.1
Balza Jr., R.2
Xiao, Q.3
Misra, R.P.4
-
89
-
-
0031864579
-
The small GTP-binding protein Rho potentiates AP-1 transcription in T cells
-
Chang J-H, Pratt JC, Sawasdikosol S, Kapeller R, Burakoff SJ. The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. Mol Cell Biol. 1998;18:4986-4993.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4986-4993
-
-
Chang, J.-H.1
Pratt, J.C.2
Sawasdikosol, S.3
Kapeller, R.4
Burakoff, S.J.5
-
90
-
-
0035811062
-
Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
-
Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, Lin A. Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proc Natl Acad Sci U S A. 2001;98:6668-6673.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 6668-6673
-
-
Purcell, N.H.1
Tang, G.2
Yu, C.3
Mercurio, F.4
DiDonato, J.A.5
Lin, A.6
-
91
-
-
0036487320
-
Involvement of reactive oxygen species-mediated NF-κB activation in TNF-α-induced cardiomyocyte hypertrophy
-
Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsumura Y, Ueno H, Tada M, Hori M. Involvement of reactive oxygen species-mediated NF-κB activation in TNF-α-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2002;34:233-240.
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 233-240
-
-
Higuchi, Y.1
Otsu, K.2
Nishida, K.3
Hirotani, S.4
Nakayama, H.5
Yamaguchi, O.6
Matsumura, Y.7
Ueno, H.8
Tada, M.9
Hori, M.10
-
92
-
-
0041828937
-
Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?
-
Purcell NH, Molkentin JD. Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy? Circulation. 2003;108:638-640.
-
(2003)
Circulation
, vol.108
, pp. 638-640
-
-
Purcell, N.H.1
Molkentin, J.D.2
-
93
-
-
0032694585
-
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure
-
Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW, RossJ Jr, Chien KR, Brown JH. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J Clin Invest. 1999;103:1627-1634.
-
(1999)
J Clin Invest
, vol.103
, pp. 1627-1634
-
-
Sah, V.P.1
Minamisawa, S.2
Tam, S.P.3
Wu, T.H.4
Dorn, G.W.5
Ross Jr., J.6
Chien, K.R.7
Brown, J.H.8
-
95
-
-
0032511197
-
The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel
-
Cachero TG, Morielli AD, Peralta EG. The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. Cell. 1998;93:1077-1085.
-
(1998)
Cell
, vol.93
, pp. 1077-1085
-
-
Cachero, T.G.1
Morielli, A.D.2
Peralta, E.G.3
-
97
-
-
0036336506
-
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation
-
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002;129:1705-1714.
-
(2002)
Development
, vol.129
, pp. 1705-1714
-
-
Wei, L.1
Imanaka-Yoshida, K.2
Wang, L.3
Zhan, S.4
Schneider, M.D.5
DeMayo, F.J.6
Schwartz, R.J.7
-
98
-
-
4644288506
-
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved
-
Wei L, Taffet GE, Khoury DS, Bo J, Li Y, Yatani A, Delaughter MC, Klevitsky R, Hewett TE, Robbins J, Michael LH, Schneider MD, Entman ML, Schwartz RJ. Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved. FASEB J. 2004;18:857-859.
-
(2004)
FASEB J
, vol.18
, pp. 857-859
-
-
Wei, L.1
Taffet, G.E.2
Khoury, D.S.3
Bo, J.4
Li, Y.5
Yatani, A.6
Delaughter, M.C.7
Klevitsky, R.8
Hewett, T.E.9
Robbins, J.10
Michael, L.H.11
Schneider, M.D.12
Entman, M.L.13
Schwartz, R.J.14
-
99
-
-
0034125425
-
Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling
-
Takakura A, Miyoshi J, Ishizaki H, Tanaka M, Togawa A, Nishizawa Y, Yoshida H, Nishikawa S, Takai Y. Involvement of a small GTP-binding protein (G protein) regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling. Mol Biol Cell. 2000;11:1875-1886.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 1875-1886
-
-
Takakura, A.1
Miyoshi, J.2
Ishizaki, H.3
Tanaka, M.4
Togawa, A.5
Nishizawa, Y.6
Yoshida, H.7
Nishikawa, S.8
Takai, Y.9
-
100
-
-
0033531237
-
A balancing of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival
-
Moorman J, Luu D, Wickham J, Bobak D, Hahn CS. A balancing of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene. 1999;18:47-57.
-
(1999)
Oncogene
, vol.18
, pp. 47-57
-
-
Moorman, J.1
Luu, D.2
Wickham, J.3
Bobak, D.4
Hahn, C.S.5
-
101
-
-
0033552910
-
Anti-apoptotic function of Rac in hematopoietic cells
-
Nishida K, Kaziro Y, Satoh T. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene. 1999;18:407-415.
-
(1999)
Oncogene
, vol.18
, pp. 407-415
-
-
Nishida, K.1
Kaziro, Y.2
Satoh, T.3
-
102
-
-
0028036684
-
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
-
Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell. 1994;79:507-513.
-
(1994)
Cell
, vol.79
, pp. 507-513
-
-
Chong, L.D.1
Traynor-Kaplan, A.2
Bokoch, G.M.3
Schwartz, M.A.4
-
103
-
-
20244379418
-
Regulation of PTEN by Rho small GTPases
-
Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nat Cell Biol. 2005;7:399-404.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 399-404
-
-
Li, Z.1
Dong, X.2
Wang, Z.3
Liu, W.4
Deng, N.5
Ding, Y.6
Tang, L.7
Hla, T.8
Zeng, R.9
Li, L.10
Wu, D.11
-
104
-
-
0037050260
-
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB
-
Murga C, Zohar M, Teramoto H, Gutkind JS. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene. 2002;21:207-216.
-
(2002)
Oncogene
, vol.21
, pp. 207-216
-
-
Murga, C.1
Zohar, M.2
Teramoto, H.3
Gutkind, J.S.4
-
105
-
-
3042549659
-
RhoA controls myoblast survival by inducing the phosphatidylinositol 3-kinase-Akt signaling pathway
-
Reuveny M, Heller H, Bengal E. RhoA controls myoblast survival by inducing the phosphatidylinositol 3-kinase-Akt signaling pathway. FEBS Lett. 2004;569:129-134.
-
(2004)
FEBS Lett
, vol.569
, pp. 129-134
-
-
Reuveny, M.1
Heller, H.2
Bengal, E.3
-
106
-
-
0036045056
-
Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts
-
Kobayashi N, Horinaka S, Mita S, Nakano S, Honda T, Yoshida K, Kobayashi T, Matsuoka H. Critical role of Rho-kinase pathway for cardiac performance and remodeling in failing rat hearts. Cardiovasc Res. 2002;55:757-767.
-
(2002)
Cardiovasc Res
, vol.55
, pp. 757-767
-
-
Kobayashi, N.1
Horinaka, S.2
Mita, S.3
Nakano, S.4
Honda, T.5
Yoshida, K.6
Kobayashi, T.7
Matsuoka, H.8
-
107
-
-
0037214686
-
Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure
-
Satoh S, Ueda Y, Koyanagi M, Kadokami T, Sugano M, Yoshikawa Y, Makino N. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. J Mol Cell Cardiol. 2003;35:59-70.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 59-70
-
-
Satoh, S.1
Ueda, Y.2
Koyanagi, M.3
Kadokami, T.4
Sugano, M.5
Yoshikawa, Y.6
Makino, N.7
-
108
-
-
2442509844
-
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
-
Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation. 2004;109:2234-2239.
-
(2004)
Circulation
, vol.109
, pp. 2234-2239
-
-
Hattori, T.1
Shimokawa, H.2
Higashi, M.3
Hiroki, J.4
Mukai, Y.5
Tsutsui, H.6
Kaibuchi, K.7
Takeshita, A.8
-
110
-
-
5344268785
-
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection
-
Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P, Liao JK. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 2004;24:1842-1847.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1842-1847
-
-
Wolfrum, S.1
Dendorfer, A.2
Rikitake, Y.3
Stalker, T.J.4
Gong, Y.5
Scalia, R.6
Dominiak, P.7
Liao, J.K.8
-
111
-
-
1142297518
-
Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury
-
Bao W, Hu E, Tao L, Boyce R, Mirabile R, Thudium DT, Ma XL, Willette RN, Yue TL. Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury. Cardiovasc Res. 2004;61:548-558.
-
(2004)
Cardiovasc Res
, vol.61
, pp. 548-558
-
-
Bao, W.1
Hu, E.2
Tao, L.3
Boyce, R.4
Mirabile, R.5
Thudium, D.T.6
Ma, X.L.7
Willette, R.N.8
Yue, T.L.9
-
112
-
-
1342302820
-
Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA
-
Porter KE, Turner NA, O'Regan DJ, Balmforth AJ, Ball SG. Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovasc Res. 2004;61:745-755.
-
(2004)
Cardiovasc Res
, vol.61
, pp. 745-755
-
-
Porter, K.E.1
Turner, N.A.2
O'Regan, D.J.3
Balmforth, A.J.4
Ball, S.G.5
-
113
-
-
0032167411
-
A requirement for the Rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy
-
Pracyk JB, Tanaka K, Hegland D, Kim K-S, Sethi R, Rovira II, Blazinda DR, Lee L, Bruder JT, Kovesdi I, Goldschmidt-Clermont PJ, Irani K, Finkel T. A requirement for the Rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J Clin Invest. 1998;102:929-937.
-
(1998)
J Clin Invest
, vol.102
, pp. 929-937
-
-
Pracyk, J.B.1
Tanaka, K.2
Hegland, D.3
Kim, K.-S.4
Sethi, R.5
Rovira, I.I.6
Blazinda, D.R.7
Lee, L.8
Bruder, J.T.9
Kovesdi, I.10
Goldschmidt-Clermont, P.J.11
Irani, K.12
Finkel, T.13
-
114
-
-
0035861968
-
Reactive oxygen species in mechanical stress-induced cardiac hypertrophy
-
Aikawa R, Nagai T, Tanaka M, Zou Y, Ishihara T, Tanako H, Hasegawa H, Azakawa H, Mizukami M, Nagai R, Komuro I. Reactive oxygen species in mechanical stress-induced cardiac hypertrophy. Biochem Biophys Res Commun. 2001;289:901-907.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 901-907
-
-
Aikawa, R.1
Nagai, T.2
Tanaka, M.3
Zou, Y.4
Ishihara, T.5
Tanako, H.6
Hasegawa, H.7
Azakawa, H.8
Mizukami, M.9
Nagai, R.10
Komuro, I.11
-
115
-
-
24144471786
-
Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells
-
Zuo L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander RW. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2005;25:1824-1830.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1824-1830
-
-
Zuo, L.1
Ushio-Fukai, M.2
Ikeda, S.3
Hilenski, L.4
Patrushev, N.5
Alexander, R.W.6
-
116
-
-
3042818863
-
Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation
-
Dougherty CJ, Kubasiak LA, Frazier DP, Li H, Xiong W-C, Bishopric NH, Webster KA. Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation. FASEB J. 2004;18:1060-1070.
-
(2004)
FASEB J
, vol.18
, pp. 1060-1070
-
-
Dougherty, C.J.1
Kubasiak, L.A.2
Frazier, D.P.3
Li, H.4
Xiong, W.-C.5
Bishopric, N.H.6
Webster, K.A.7
-
117
-
-
20744441519
-
Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts
-
Fujii T, Onohara N, Maruyama Y, Tanabe S, Kobayashi H, Fukutomi M, Nagamatsu Y, Nishihara N, Inoue R, Sumimoto H, Shibasaki F, Nagao T, Nishida M, Kurose H. Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. J Biol Chem. 2005;280:23041-23047.
-
(2005)
J Biol Chem
, vol.280
, pp. 23041-23047
-
-
Fujii, T.1
Onohara, N.2
Maruyama, Y.3
Tanabe, S.4
Kobayashi, H.5
Fukutomi, M.6
Nagamatsu, Y.7
Nishihara, N.8
Inoue, R.9
Sumimoto, H.10
Shibasaki, F.11
Nagao, T.12
Nishida, M.13
Kurose, H.14
-
118
-
-
0345258510
-
Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes
-
Sabri A, Hughie HH, Lucchesi PA. Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxid Redox Signal. 2003;5:731-740.
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 731-740
-
-
Sabri, A.1
Hughie, H.H.2
Lucchesi, P.A.3
-
119
-
-
0345258505
-
Oxidative stress-induced signal transduction pathways in cardiac myocytes: Involvement of ROS in heart diseases
-
Takano H, Zou Y, Hasegawa H, Akazawa H, Nagai T, Komuro I. Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases. Antioxid Redox Signal. 2003;5:789-794.
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 789-794
-
-
Takano, H.1
Zou, Y.2
Hasegawa, H.3
Akazawa, H.4
Nagai, T.5
Komuro, I.6
-
120
-
-
0141924553
-
A novel pleiotropic effect of statins: Prevention of cardiac hypertrophy by cholesterol-independent mechanisms
-
Nakagami H, Jensen KS, Liao JK. A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms. Ann Med. 2003;35:398-403.
-
(2003)
Ann Med
, vol.35
, pp. 398-403
-
-
Nakagami, H.1
Jensen, K.S.2
Liao, J.K.3
-
121
-
-
0032080913
-
Protection from reoxygenation injury by inhibition of rac1
-
Kim KS, Takeda K, Sethi R, Pracyk JB, Tanaka K, Zhou YF, Yu ZX, Ferrans VJ, Bruder JT, Kovesdi I, Irani K, Goldschmidt-Clermont P, Finkel T. Protection from reoxygenation injury by inhibition of rac1. J Clin Invest. 1998;101:1821-1826.
-
(1998)
J Clin Invest
, vol.101
, pp. 1821-1826
-
-
Kim, K.S.1
Takeda, K.2
Sethi, R.3
Pracyk, J.B.4
Tanaka, K.5
Zhou, Y.F.6
Yu, Z.X.7
Ferrans, V.J.8
Bruder, J.T.9
Kovesdi, I.10
Irani, K.11
Goldschmidt-Clermont, P.12
Finkel, T.13
-
122
-
-
0038146887
-
Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: Role of PI3-K and Akt kinase upon rac1
-
Ozaki M, Haga S, Zhang HQ, Irani K, Suzuki S. Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1. Cell Death Differ. 2003;10:508-515.
-
(2003)
Cell Death Differ
, vol.10
, pp. 508-515
-
-
Ozaki, M.1
Haga, S.2
Zhang, H.Q.3
Irani, K.4
Suzuki, S.5
-
123
-
-
0035514402
-
Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism
-
Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, Aird W. Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. FASEB J. 2001;15:2548-2550.
-
(2001)
FASEB J
, vol.15
, pp. 2548-2550
-
-
Abid, M.R.1
Tsai, J.C.2
Spokes, K.C.3
Deshpande, S.S.4
Irani, K.5
Aird, W.6
-
124
-
-
0036199909
-
Impact of HMG CoA reductase inhibition on small GTPases in the heart
-
Laufs U, Kilter H, Konkol C, Wassmann, Bohm M, Nickenig G. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res. 2002;53:911-920.
-
(2002)
Cardiovasc Res
, vol.53
, pp. 911-920
-
-
Laufs, U.1
Kilter, H.2
Konkol, C.3
Wassmann4
Bohm, M.5
Nickenig, G.6
-
125
-
-
3342948524
-
Statins inhibit beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes via a Rac1-dependent mechanism
-
Ito M, Adachi T, Pimentel DR, Ido Y, Colucci WS. Statins inhibit beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes via a Rac1-dependent mechanism. Circulation. 2004;110:412-418.
-
(2004)
Circulation
, vol.110
, pp. 412-418
-
-
Ito, M.1
Adachi, T.2
Pimentel, D.R.3
Ido, Y.4
Colucci, W.S.5
-
126
-
-
0038080961
-
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B
-
Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Hikoso S, Kashiwase K, Takeda T, Watanabe T, Mano T, Matsumura Y, Ueno H, Hori M. The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B. J Biol Chem. 2003;278:20770-20777.
-
(2003)
J Biol Chem
, vol.278
, pp. 20770-20777
-
-
Higuchi, Y.1
Otsu, K.2
Nishida, K.3
Hirotani, S.4
Nakayama, H.5
Yamaguchi, O.6
Hikoso, S.7
Kashiwase, K.8
Takeda, T.9
Watanabe, T.10
Mano, T.11
Matsumura, Y.12
Ueno, H.13
Hori, M.14
-
127
-
-
17644379381
-
Functional effects of Rho-kinase-dependent phosphorylation of specific sites on cardiac troponin
-
Vahebi S, Kobayashi T, Warren CM, de Tombe PP, Solaro RJ. Functional effects of Rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res. 2005;96:740-747.
-
(2005)
Circ Res
, vol.96
, pp. 740-747
-
-
Vahebi, S.1
Kobayashi, T.2
Warren, C.M.3
De Tombe, P.P.4
Solaro, R.J.5
-
128
-
-
0037566957
-
Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes
-
Nagai T, Tanaka-Ishiwata M, Aikawa R, Ishihara H, Zhu W, Yazaki Y, Nagai R, Komuro I. Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes. Biochem Biophys Res Commun. 2003;305:806-810.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 806-810
-
-
Nagai, T.1
Tanaka-Ishiwata, M.2
Aikawa, R.3
Ishihara, H.4
Zhu, W.5
Yazaki, Y.6
Nagai, R.7
Komuro, I.8
-
129
-
-
3042774131
-
Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts. Role in redox signaling
-
Zuo L, Ushio-Fukai M, Hilenski LL, Alexander W. Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts. Role in redox signaling. Arterioscler Thromb Vasc Biol. 2004;24:1223-1228.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1223-1228
-
-
Zuo, L.1
Ushio-Fukai, M.2
Hilenski, L.L.3
Alexander, W.4
-
130
-
-
0030040856
-
The ras-related GTPase Rac1 binds tubulin
-
Best A, Ahmed S, Kozma R, Lim L. The ras-related GTPase Rac1 binds tubulin. J Biol Chem. 1996;271:3756-3762.
-
(1996)
J Biol Chem
, vol.271
, pp. 3756-3762
-
-
Best, A.1
Ahmed, S.2
Kozma, R.3
Lim, L.4
-
131
-
-
0035178210
-
Cell motility: Can Rho GTPases and microtubules point the way?
-
Wittmann T, Waterman-Storer CM. Cell motility: can Rho GTPases and microtubules point the way? J Cell Sci. 2001;114:3795-3803.
-
(2001)
J Cell Sci
, vol.114
, pp. 3795-3803
-
-
Wittmann, T.1
Waterman-Storer, C.M.2
-
132
-
-
0032585635
-
Rac1 is required for the formation of three germ layers during gastrulation
-
Sugihara K, Nakatsuji N, Nakamura K, Nakao K, Hashimoto R, Otani H, Sakagami H, Kondo H, Nozawa S, Aiba A, Katsuki M. Rac1 is required for the formation of three germ layers during gastrulation. Oncogene. 1998;17:3427-3433.
-
(1998)
Oncogene
, vol.17
, pp. 3427-3433
-
-
Sugihara, K.1
Nakatsuji, N.2
Nakamura, K.3
Nakao, K.4
Hashimoto, R.5
Otani, H.6
Sakagami, H.7
Kondo, H.8
Nozawa, S.9
Aiba, A.10
Katsuki, M.11
-
133
-
-
0034120364
-
Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active Rac1
-
Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Price RL, Schaefer E, Yager K. Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active Rac1. J Clin Invest. 2000;105:875-886.
-
(2000)
J Clin Invest
, vol.105
, pp. 875-886
-
-
Sussman, M.A.1
Welch, S.2
Walker, A.3
Klevitsky, R.4
Hewett, T.E.5
Price, R.L.6
Schaefer, E.7
Yager, K.8
-
134
-
-
0141668894
-
Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src
-
Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind JS. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem. 2003;278:34339-34346.
-
(2003)
J Biol Chem
, vol.278
, pp. 34339-34346
-
-
Servitja, J.M.1
Marinissen, M.J.2
Sodhi, A.3
Bustelo, X.R.4
Gutkind, J.S.5
-
135
-
-
28144458158
-
Myocardial subproteomic analysis of a constitutively active Rac1 expressing transgenic mouse with lethal myocardial hypertrophy
-
Buscemi N, Murray C, Doherty-Kirby A, Lajoie G, Sussman MA, Van Eyk JE. Myocardial subproteomic analysis of a constitutively active Rac1 expressing transgenic mouse with lethal myocardial hypertrophy. Am J Physiol Heart Circ Physiol. 2005;289:H2325-H2333.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.289
-
-
Buscemi, N.1
Murray, C.2
Doherty-Kirby, A.3
Lajoie, G.4
Sussman, M.A.5
Van Eyk, J.E.6
-
136
-
-
0029781555
-
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
-
Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest. 1996;98:1253-1260.
-
(1996)
J Clin Invest
, vol.98
, pp. 1253-1260
-
-
Yen, H.C.1
Oberley, T.D.2
Vichitbandha, S.3
Ho, Y.S.4
St Clair, D.K.5
-
137
-
-
19344364055
-
MnSOD in mouse heart: Acute responses to ischemic preconditioning and ischemia-reperfusion injury
-
Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005;288:H2986-H2994.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Jin, Z.Q.1
Zhou, H.Z.2
Cecchini, G.3
Gray, M.O.4
Karliner, J.S.5
-
138
-
-
33644585112
-
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium
-
Sam F, Kerstetter DL, Pimental DR, Mulukutla S, Tabaee A, Bristow MR, Colucci WS, Sawyer DB. Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. J Card Failure. 2005;11:473-480.
-
(2005)
J Card Failure
, vol.11
, pp. 473-480
-
-
Sam, F.1
Kerstetter, D.L.2
Pimental, D.R.3
Mulukutla, S.4
Tabaee, A.5
Bristow, M.R.6
Colucci, W.S.7
Sawyer, D.B.8
-
139
-
-
0141841614
-
Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment
-
Maack C, Kartes T, Kilter H, chafers HJ, Nickenig G, Bohm M, Laufs U. Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment. Circulation. 2003;108:1567-1574.
-
(2003)
Circulation
, vol.108
, pp. 1567-1574
-
-
Maack, C.1
Kartes, T.2
Kilter, H.3
Chafers, H.J.4
Nickenig, G.5
Bohm, M.6
Laufs, U.7
-
140
-
-
0037109099
-
Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation
-
Indolfi C, Di Lorenzo E, Perrino C, Stingone AM, Curcio A, Torella D, Cittadini A, Cardone L, Coppola C, Cavuto L, Arcucci O, Sacca L, Avvedimento EV, Chiariello M. Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation. Circulation. 2002;106:2118-2124.
-
(2002)
Circulation
, vol.106
, pp. 2118-2124
-
-
Indolfi, C.1
Di Lorenzo, E.2
Perrino, C.3
Stingone, A.M.4
Curcio, A.5
Torella, D.6
Cittadini, A.7
Cardone, L.8
Coppola, C.9
Cavuto, L.10
Arcucci, O.11
Sacca, L.12
Avvedimento, E.V.13
Chiariello, M.14
-
141
-
-
23344440434
-
Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy
-
Senthil V, Chen SN, Tsybouleva N, Halder, Tripti, Nagueh SF, Willerson JT, Roberts R, Marian AJ. Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res. 2005;97:285-292.
-
(2005)
Circ Res
, vol.97
, pp. 285-292
-
-
Senthil, V.1
Chen, S.N.2
Tsybouleva, N.3
Halder4
Tripti5
Nagueh, S.F.6
Willerson, J.T.7
Roberts, R.8
Marian, A.J.9
-
142
-
-
33644694919
-
Rho GTPases, statins, and nitric oxide
-
Rikitake Y, Liao JK. Rho GTPases, statins, and nitric oxide. Circ Res. 2005;97:1232-1235.
-
(2005)
Circ Res
, vol.97
, pp. 1232-1235
-
-
Rikitake, Y.1
Liao, J.K.2
-
143
-
-
5444271645
-
Statin therapy for cardiac hypertrophy and heart failure
-
Liao JK. Statin therapy for cardiac hypertrophy and heart failure. J Investig Med. 2004;52:248-253.
-
(2004)
J Investig Med
, vol.52
, pp. 248-253
-
-
Liao, J.K.1
-
145
-
-
0038446797
-
A dual role of the GTPase Rac in cardiac differentiation of stem cells
-
Puceat M, Travo P, Quinn MT, Fort. A dual role of the GTPase Rac in cardiac differentiation of stem cells. Mol Biol Cell. 2003;14:2781-2792.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 2781-2792
-
-
Puceat, M.1
Travo, P.2
Quinn, M.T.3
Fort4
-
146
-
-
14044263538
-
Vang12 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract
-
Phillips HN, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ. Vang12 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005;96:292-299.
-
(2005)
Circ Res
, vol.96
, pp. 292-299
-
-
Phillips, H.N.1
Murdoch, J.N.2
Chaudhry, B.3
Copp, A.J.4
Henderson, D.J.5
-
147
-
-
0033615966
-
Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
-
Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J Cell Biol. 1999;147:1009-1021.
-
(1999)
J Cell Biol
, vol.147
, pp. 1009-1021
-
-
Sander, E.E.1
Ten Klooster, J.P.2
Van Delft, S.3
Van Der Kammen, R.A.4
Collard, J.G.5
-
148
-
-
19044390915
-
Rac1 / Cdc42 and Rho GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
-
Wang G, Beier F. Rac1 / Cdc42 and Rho GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J Bone Miner Res. 2005;20:1022-1031.
-
(2005)
J Bone Miner Res
, vol.20
, pp. 1022-1031
-
-
Wang, G.1
Beier, F.2
-
149
-
-
0036067142
-
Knocked out by Rho/Rac T-cell biology
-
Bustelo XR. Knocked out by Rho/Rac T-cell biology. Histol Histopathol. 2002;17:871-875.
-
(2002)
Histol Histopathol
, vol.17
, pp. 871-875
-
-
Bustelo, X.R.1
|