메뉴 건너뛰기




Volumn 7, Issue 11, 2010, Pages 637-647

The role of Rho protein signaling in hypertension

Author keywords

[No Author keywords available]

Indexed keywords

RAC1 PROTEIN; RHO FACTOR; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 78049274198     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2010.136     Document Type: Review
Times cited : (138)

References (79)
  • 1
    • 33646763902 scopus 로고    scopus 로고
    • Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand, G., Guerin, P. & Pacaud, P. Rho kinases in cardiovascular physiology and pathophysiology. Circ. Res. 98, 322-334 (2006).
    • (2006) Circ. Res. , vol.98 , pp. 322-334
    • Loirand, G.1    Guerin, P.2    Pacaud, P.3
  • 2
    • 70449445715 scopus 로고    scopus 로고
    • Rho kinase: An important mediator of atherosclerosis and vascular disease
    • Zhou, Q. & Liao, J. K. Rho kinase: an important mediator of atherosclerosis and vascular disease. Curr. Pharm. Des. 15, 3108-3115 (2009).
    • (2009) Curr. Pharm. des , vol.15 , pp. 3108-3115
    • Zhou, Q.1    Liao, J.K.2
  • 3
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions from in vivo studies
    • Heasman, S. J. & Ridley, A. J. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell. Biol. 9, 690-701 (2008).
    • (2008) Nat. Rev. Mol. Cell. Biol. , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 4
    • 69249208550 scopus 로고    scopus 로고
    • Regulation of RhoGEF proteins by G12/13-coupled receptors
    • Siehler, S. Regulation of RhoGEF proteins by G12/13-coupled receptors. Br. J. Pharmacol. 158, 41-49 (2009).
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 41-49
    • Siehler, S.1
  • 5
    • 33749240350 scopus 로고    scopus 로고
    • Coupling receptor tyrosine kinases to Rho GTPases-GEFs what's the link
    • Schiller, M. R. Coupling receptor tyrosine kinases to Rho GTPases-GEFs what's the link. Cell Signal. 18, 1834-1843 (2006).
    • (2006) Cell. Signal , vol.18 , pp. 1834-1843
    • Schiller, M.R.1
  • 6
    • 70249085230 scopus 로고    scopus 로고
    • Rho family GTPases and their regulators in lymphocytes
    • Tybulewicz, V. L. & Henderson, R. B. Rho family GTPases and their regulators in lymphocytes. Nat. Rev. Immunol. 9, 630-644 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 630-644
    • Tybulewicz, V.L.1    Henderson, R.B.2
  • 7
    • 66849101632 scopus 로고    scopus 로고
    • Adhesion signaling-crosstalk between integrins, Src and Rho
    • Huveneers, S. & Danen, E. H. Adhesion signaling-crosstalk between integrins, Src and Rho. J. Cell Sci. 122, 1059-1069 (2009).
    • (2009) J. Cell. Sci. , vol.122 , pp. 1059-1069
    • Huveneers, S.1    Danen, E.H.2
  • 8
    • 73949121819 scopus 로고    scopus 로고
    • Regulation of smooth muscle contraction by small GTPases
    • Puetz, S., Lubomirov, L. T. & Pfitzer, G. Regulation of smooth muscle contraction by small GTPases. Physiology (Bethesda) 24, 342-356 (2009).
    • (2009) Physiology (Bethesda) , vol.24 , pp. 342-356
    • Puetz, S.1    Lubomirov, L.T.2    Pfitzer, G.3
  • 9
    • 0030656619 scopus 로고    scopus 로고
    • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    • Uehata, M. et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389, 990-994 (1997).
    • (1997) Nature , vol.389 , pp. 990-994
    • Uehata, M.1
  • 10
    • 33847003717 scopus 로고    scopus 로고
    • Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling
    • Shirai, H., Autieri, M. & Eguchi, S. Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Curr. Opin. Nephrol. Hypertens. 16, 111-115 (2007).
    • (2007) Curr. Opin. Nephrol. Hypertens , vol.16 , pp. 111-115
    • Shirai, H.1    Autieri, M.2    Eguchi, S.3
  • 11
    • 0033605738 scopus 로고    scopus 로고
    • Inhibition of myosin light chain kinase by p21-activated kinase
    • Sanders, L. C., Matsumura, F., Bokoch, G. M. & de Lanerolle, P. Inhibition of myosin light chain kinase by p21-activated kinase. Science 283, 2083-2085 (1999).
    • (1999) Science , vol.283 , pp. 2083-2085
    • Sanders, L.C.1    Matsumura, F.2    Bokoch, G.M.3    De Lanerolle, P.4
  • 12
    • 0038511012 scopus 로고    scopus 로고
    • Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1
    • Wirth, A. et al. Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1. J. Physiol. 549, 489-500 (2003).
    • (2003) J. Physiol. , vol.549 , pp. 489-500
    • Wirth, A.1
  • 13
    • 0034695554 scopus 로고    scopus 로고
    • Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca (2+) sensitivity of smooth muscle contraction
    • Foster, D. B. et al. Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca (2+) sensitivity of smooth muscle contraction. J. Biol. Chem. 275, 1959-1965 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 1959-1965
    • Foster, D.B.1
  • 14
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs, U. & Liao, J. K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J. Biol. Chem. 273, 24266-24271 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 15
    • 5344268785 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection
    • Wolfrum, S. et al. Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler. Thromb. Vasc. Biol. 24, 1842-1847 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 1842-1847
    • Wolfrum, S.1
  • 16
    • 20844459470 scopus 로고    scopus 로고
    • Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: Implications for atherosclerotic endothelial dysfunction
    • Ming, X. F. et al. Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. Circulation 110, 3708-3714 (2004).
    • (2004) Circulation , vol.110 , pp. 3708-3714
    • Ming, X.F.1
  • 17
    • 50949086778 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Racl
    • Sawada, N., Salomone, S., Kim, H. H., Kwiatkowski, D. J. & Liao, J. K. Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Racl. Circ. Res. 103, 360-368 (2008).
    • (2008) Circ. Res. , vol.103 , pp. 360-368
    • Sawada, N.1    Salomone, S.2    Kim, H.H.3    Kwiatkowski, D.J.4    Liao, J.K.5
  • 18
    • 44749092029 scopus 로고    scopus 로고
    • Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac
    • Selvakumar, B., Hess, D. T., Goldschmidt-Clermont, P. J. & Stamler, J. S. Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac. FESS Lett 582, 2195-2202 (2008).
    • (2008) FESS Lett. , vol.582 , pp. 2195-2202
    • Selvakumar, B.1    Hess, D.T.2    Goldschmidt-Clermont, P.J.3    Stamler, J.S.4
  • 19
    • 0034647534 scopus 로고    scopus 로고
    • 2+ sensitization of contraction in vascular smooth muscle
    • 2+ sensitization of contraction in vascular smooth muscle. J. Biol. Chem. 275, 21722-21729 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 21722-21729
    • Sauzeau, V.1
  • 20
    • 74949139625 scopus 로고    scopus 로고
    • The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells
    • Sauzeau, V., Sevilla, M. A., Montero, M. J. & Bustelo, X. R. The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J. Clin. Invest. 120, 315-330 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 315-330
    • Sauzeau, V.1    Sevilla, M.A.2    Montero, M.J.3    Bustelo, X.R.4
  • 21
    • 0036734231 scopus 로고    scopus 로고
    • Baroreceptor reflex pathways and neurotransmitters: 10 years on
    • Pilowsky, P. M. & Goodchild, A. K. Baroreceptor reflex pathways and neurotransmitters: 10 years on. J. Hypertens. 20, 1675-1688 (2002).
    • (2002) J. Hypertens , vol.20 , pp. 1675-1688
    • Pilowsky, P.M.1    Goodchild, A.K.2
  • 22
    • 0038463820 scopus 로고    scopus 로고
    • Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: Possible involvement in neural mechanisms of hypertension
    • Ito, K. et al. Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension. Circ. Res. 92, 1337-1343 (2003).
    • (2003) Circ. Res. , vol.92 , pp. 1337-1343
    • Ito, K.1
  • 23
    • 34250828562 scopus 로고    scopus 로고
    • Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats
    • Nozoe, M. et al. Inhibition of Racl-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats. Hypertension 50, 62-68 (2007).
    • (2007) Hypertension , vol.50 , pp. 62-68
    • Nozoe, M.1
  • 24
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology. XXIII. The angiotensin II receptors
    • de Gasparo, M., Catt, K. J., Inagami, T., Wright, J. W. & Unger, T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 52, 415-472 (2000).
    • (2000) Pharmacol. Rev. , vol.52 , pp. 415-472
    • De Gasparo, M.1    Catt, K.J.2    Inagami, T.3    Wright, J.W.4    Unger, T.5
  • 25
    • 0037423816 scopus 로고    scopus 로고
    • Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
    • Seko, T. et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ. Res. 92, 411-1418 (2003).
    • (2003) Circ. Res. , vol.92 , pp. 411-1418
    • Seko, T.1
  • 26
    • 76249134110 scopus 로고    scopus 로고
    • The Rho exchange factor Arhgefl mediates the effects of angiotensin II on vascular tone and blood pressure
    • Guilluy, C. et al. The Rho exchange factor Arhgefl mediates the effects of angiotensin II on vascular tone and blood pressure. Nat. Med. 16, 183-190 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 183-190
    • Guilluy, C.1
  • 27
    • 33745285003 scopus 로고    scopus 로고
    • Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin ll-induced hypertensive rats
    • Jin, L. et al. Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin ll-induced hypertensive rats. J. Pharmacol. Exp. Ther. 318, 288-295 (2006).
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 288-295
    • Jin, L.1
  • 28
    • 70349235617 scopus 로고    scopus 로고
    • Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor
    • Lohn, M. et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension 54, 676-683 (2009).
    • (2009) Hypertension , vol.54 , pp. 676-683
    • Lohn, M.1
  • 29
    • 0142120102 scopus 로고    scopus 로고
    • Long-term inhibition of Rhokinase suppresses angiotensin ll-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD (P) H oxidase system
    • Higashi, M. et al. Long-term inhibition of Rhokinase suppresses angiotensin ll-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD (P) H oxidase system. Circ. Res. 93, 767-775 (2003).
    • (2003) Circ. Res. , vol.93 , pp. 767-775
    • Higashi, M.1
  • 30
    • 20144366571 scopus 로고    scopus 로고
    • Role of Rho-kinase and p27 in angiotensin ll-induced vascular injury
    • Kanda, T. et al. Role of Rho-kinase and p27 in angiotensin ll-induced vascular injury. Hypertension 45, 724-729 (2005).
    • (2005) Hypertension , vol.45 , pp. 724-729
    • Kanda, T.1
  • 31
    • 0035316139 scopus 로고    scopus 로고
    • Involvement of Rho-kinase in hypertensive vascular disease: A novel therapeutic target in hypertension
    • Mukai, Y. et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J. 15, 1062-1064 (2001).
    • (2001) FASEB J. , vol.15 , pp. 1062-1064
    • Mukai, Y.1
  • 32
    • 34548049282 scopus 로고    scopus 로고
    • Crucial role of Rho-nuclear factor-kappaB axis in angiotensin ll-induced renal injury
    • Ozawa, Y. & Kobori, H. Crucial role of Rho-nuclear factor-kappaB axis in angiotensin ll-induced renal injury. Am. J. Physiol. Renal. Physiol. 293, F100-F109 (2007).
    • (2007) Am. J. Physiol. Renal. Physiol. , vol.293
    • Ozawa, Y.1    Kobori, H.2
  • 33
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman, K. L., Der, C. J. & Sondek, J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180 (2005).
    • (2005) Nat. Rev. Mol. Cell. Biol. , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 34
    • 34447318332 scopus 로고    scopus 로고
    • Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin ll-induced hypertensive rats
    • Hilgers, R. H., Todd, J. Jr & Webb, R. C. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin ll-induced hypertensive rats. J. Hypertens. 25, 1687-1697 (2007).
    • (2007) J. Hypertens , vol.25 , pp. 1687-1697
    • Hilgers, R.H.1    Todd Jr., J.2    Webb, R.C.3
  • 35
    • 33646591530 scopus 로고    scopus 로고
    • Requirement of Racl in the development of cardiac hypertrophy
    • Satoh, M. et al. Requirement of Racl in the development of cardiac hypertrophy. Proc. Natl Acad. Sci. USA 103, 7432-7437 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 7432-7437
    • Satoh, M.1
  • 36
    • 59449102167 scopus 로고    scopus 로고
    • Importance of Racl signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors
    • Rashid, M. et al. Importance of Racl signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors. Circ. J. 73, 361-370 (2009).
    • (2009) Circ. J. , vol.73 , pp. 361-370
    • Rashid, M.1
  • 37
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Racl GTPase
    • Wassmann, S. et al. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Racl GTPase. Mol. Pharmacol. 59, 646-654 (2001).
    • (2001) Mol. Pharmacol. , vol.59 , pp. 646-654
    • Wassmann, S.1
  • 38
    • 77949760277 scopus 로고    scopus 로고
    • Novel aspects of the roles of Racl GTPase in the cardiovascular system
    • Sawada, N., Li, Y. & Liao, J. K. Novel aspects of the roles of Racl GTPase in the cardiovascular system. Curr. Opin. Pharmacol. 10, 116-121 (2010).
    • (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 116-121
    • Sawada, N.1    Li, Y.2    Liao, J.K.3
  • 39
    • 70449725149 scopus 로고    scopus 로고
    • Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-l pathway
    • Vecchione, C. et al. Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-l pathway. Hypertension 54, 1028-1034 (2009).
    • (2009) Hypertension , vol.54 , pp. 1028-1034
    • Vecchione, C.1
  • 40
    • 3343005248 scopus 로고    scopus 로고
    • Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system
    • Zimmerman, M. C., Lazartigues, E., Sharma, R. V. & Davisson, R. L. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ. Res. 95, 210-216 (2004).
    • (2004) Circ. Res. , vol.95 , pp. 210-216
    • Zimmerman, M.C.1    Lazartigues, E.2    Sharma, R.V.3    Davisson, R.L.4
  • 41
    • 4444336724 scopus 로고    scopus 로고
    • Requirement for Racldependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain
    • Zimmerman, M. C. et al. Requirement for Racldependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ. Res. 95, 532-539 (2004).
    • (2004) Circ. Res. , vol.95 , pp. 532-539
    • Zimmerman, M.C.1
  • 42
    • 33846037819 scopus 로고    scopus 로고
    • Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors
    • Sagara, Y. et al. Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors. J. Hypertens. 25, 399-406 (2007).
    • (2007) J. Hypertens , vol.25 , pp. 399-406
    • Sagara, Y.1
  • 43
    • 0035860840 scopus 로고    scopus 로고
    • Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27 (Kip1) expression in the vasculature of hypertensive rats
    • Seasholtz, T. M. et al. Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27 (Kip1) expression in the vasculature of hypertensive rats. Circ. Res. 89, 488-495 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 488-495
    • Seasholtz, T.M.1
  • 44
    • 0035980169 scopus 로고    scopus 로고
    • Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis
    • Ni, W. et al. Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis. Circ. Res. 89, 415-421 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 415-421
    • Ni, W.1
  • 45
    • 18244401416 scopus 로고    scopus 로고
    • Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats
    • Kataoka, C. et al. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 39, 245-250 (2002).
    • (2002) Hypertension , vol.39 , pp. 245-250
    • Kataoka, C.1
  • 46
    • 33745439004 scopus 로고    scopus 로고
    • The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice
    • Williams, J., Bogwu, J. & Oyekan, A. The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice. J. Hypertens. 24, 1429-1436 (2006).
    • (2006) J. Hypertens , vol.24 , pp. 1429-1436
    • Williams, J.1    Bogwu, J.2    Oyekan, A.3
  • 47
    • 0842332607 scopus 로고    scopus 로고
    • Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition
    • Ito, K. et al. Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition. Hypertension 43, 156-162 (2004).
    • (2004) Hypertension , vol.43 , pp. 156-162
    • Ito, K.1
  • 48
    • 77951841400 scopus 로고    scopus 로고
    • RhoA-Rho kinase signaling mediates endothelium-and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction
    • Denniss, S. G., Jeffery, A. J. & Rush, J. W. RhoA-Rho kinase signaling mediates endothelium-and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction. Am. J. Physiol. Heart Circ. Physiol. 298, H1391-H1405 (2010).
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298
    • Denniss, S.G.1    Jeffery, A.J.2    Rush, J.W.3
  • 49
    • 2342580708 scopus 로고    scopus 로고
    • RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
    • Moriki, N. et al. RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Hypertens. Res. 27, 263-270 (2004).
    • (2004) Hypertens. Res. , vol.27 , pp. 263-270
    • Moriki, N.1
  • 50
    • 5444222639 scopus 로고    scopus 로고
    • Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats
    • Ying, Z., Jin, L., Dorrance, A. M. & Webb, R. C. Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats. Am. J. Hypertens. 17, 981-985 (2004).
    • (2004) Am. J. Hypertens , vol.17 , pp. 981-985
    • Ying, Z.1    Jin, L.2    Dorrance, A.M.3    Webb, R.C.4
  • 51
    • 38149015451 scopus 로고    scopus 로고
    • Aproteomic analysis of aorta from spontaneously hypertensive rat: RhoGDI alpha upregulation by angiotensin ll via AT (1) receptor
    • Bian, Y. L. et al. Aproteomic analysis of aorta from spontaneously hypertensive rat: RhoGDI alpha upregulation by angiotensin ll via AT (1) receptor. Eur. J. Cell. Biol. 87, 101-110 (2008).
    • (2008) Eur. J. Cell. Biol. , vol.87 , pp. 101-110
    • Bian, Y.L.1
  • 52
    • 34848915063 scopus 로고    scopus 로고
    • Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats
    • Kumai, T. et al. Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats. Life Sci. 81, 1193-1198 (2007).
    • (2007) Life Sci. , vol.81 , pp. 1193-1198
    • Kumai, T.1
  • 53
    • 23244443751 scopus 로고    scopus 로고
    • Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats
    • Ito, K. et al. Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats. Hypertension 46, 360-365 (2005).
    • (2005) Hypertension , vol.46 , pp. 360-365
    • Ito, K.1
  • 54
    • 16444365371 scopus 로고    scopus 로고
    • Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats
    • Ito, K., Hirooka, Y., Kimura, Y., Shimokawa, H. & Takeshita, A. Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats. Clin. Exp. Hypertens. 27, 269-277 (2005).
    • (2005) Clin. Exp. Hypertens , vol.27 , pp. 269-277
    • Ito, K.1    Hirooka, Y.2    Kimura, Y.3    Shimokawa, H.4    Takeshita, A.5
  • 55
    • 34547945446 scopus 로고    scopus 로고
    • Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
    • Ishimaru, K. et al. Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats. J. Cardiovasc. Pharmacol. 50, 187-194 (2007).
    • (2007) J. Cardiovasc. Pharmacol. , vol.50 , pp. 187-194
    • Ishimaru, K.1
  • 56
    • 0035742442 scopus 로고    scopus 로고
    • Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats
    • Weber, D. S. & Webb, R. C. Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats. Pharmacology 63, 129-133 (2001).
    • (2001) Pharmacology , vol.63 , pp. 129-133
    • Weber, D.S.1    Webb, R.C.2
  • 57
    • 2442652728 scopus 로고    scopus 로고
    • Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension
    • Wehrwein, E. A., Northcott, C. A., Loberg, R. D. & Watts, S. W. Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension. J. Pharmacol. Exp. Ther. 309, 1011-1019 (2004).
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 1011-1019
    • Wehrwein, E.A.1    Northcott, C.A.2    Loberg, R.D.3    Watts, S.W.4
  • 58
    • 38049017120 scopus 로고    scopus 로고
    • G12-G13-LARG-mediated signaling in vascular smooth muscle is required for saltinduced hypertension
    • Wirth, A. et al. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for saltinduced hypertension. Nat Med. 14, 64-68 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 64-68
    • Wirth, A.1
  • 59
    • 68049127802 scopus 로고    scopus 로고
    • Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: A microarray analysis
    • Benter, I. F., Canatan, H., Benboubetra, M., Yousif, M. H. & Akhtar, S. Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis. Vascul. Pharmacol. 51, 101-109 (2009).
    • (2009) Vascul. Pharmacol. , vol.51 , pp. 101-109
    • Benter, I.F.1    Canatan, H.2    Benboubetra, M.3    Yousif, M.H.4    Akhtar, S.5
  • 60
    • 33744996300 scopus 로고    scopus 로고
    • Long-term administration of rhokinase inhibitor ameliorates renal damage in malignant hypertensive rats
    • Ishikawa, Y. et al. Long-term administration of rhokinase inhibitor ameliorates renal damage in malignant hypertensive rats. Hypertension 47, 1075-1083 (2006).
    • (2006) Hypertension , vol.47 , pp. 1075-1083
    • Ishikawa, Y.1
  • 61
    • 33746539611 scopus 로고    scopus 로고
    • Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury
    • Sun, G. P. et al. Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury. J. Am. Soc. Nephrol. 17, 2193-2201 (2006).
    • (2006) J. Am. Soc. Nephrol , vol.17 , pp. 2193-2201
    • Sun, G.P.1
  • 62
    • 56549093414 scopus 로고    scopus 로고
    • Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells
    • Diah, S. et al. Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells. Exp. Cell Res. 314, 3654-3662 (2008).
    • (2008) Exp. Cell. Res. , vol.314 , pp. 3654-3662
    • Diah, S.1
  • 63
    • 77950510305 scopus 로고    scopus 로고
    • Mineralocorticoid receptors, saltsensitive hypertension, and metabolic syndrome
    • Fujita, T. Mineralocorticoid receptors, saltsensitive hypertension, and metabolic syndrome. Hypertension 55, 813-818 (2010).
    • (2010) Hypertension , vol.55 , pp. 813-818
    • Fujita, T.1
  • 64
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by Racl GTPase: Implication in proteinuric kidney disease
    • Shibata, S. et al. Modification of mineralocorticoid receptor function by Racl GTPase: implication in proteinuric kidney disease. Nat. Med. 14, 1370-1376 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1370-1376
    • Shibata, S.1
  • 65
    • 27744466333 scopus 로고    scopus 로고
    • Decreased perivascular fibrosis but not cardiac hypertrophy in R0CK1± haploinsufficient mice
    • Rikitake, Y. et al. Decreased perivascular fibrosis but not cardiac hypertrophy in R0CK1± haploinsufficient mice. Circulation 112, 2959-2965 (2005).
    • (2005) Circulation , vol.112 , pp. 2959-2965
    • Rikitake, Y.1
  • 66
    • 33744473805 scopus 로고    scopus 로고
    • Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis
    • Zhang, Y. M. et al. Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J. 20, 916-925 (2006).
    • (2006) FASEB J. , vol.20 , pp. 916-925
    • Zhang, Y.M.1
  • 67
    • 0038450313 scopus 로고    scopus 로고
    • Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death
    • Thumkeo, D. et al. Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol. Cell. Biol. 23, 5043-5055 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5043-5055
    • Thumkeo, D.1
  • 68
    • 33947115378 scopus 로고    scopus 로고
    • Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice
    • Sauzeau, V., Jerkic, M., Lopez-Novoa, J. M. & Bustelom, X. R. Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice. Mol. Biol. Cell 18, 943-952 (2007).
    • (2007) Mol. Biol. Cell. , vol.18 , pp. 943-952
    • Sauzeau, V.1    Jerkic, M.2    Lopez-Novoa, J.M.3    Bustelom, X.R.4
  • 69
    • 33745929899 scopus 로고    scopus 로고
    • Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction
    • Sauzeau, V. et al. Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nat. Med. 12, 841-845 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 841-845
    • Sauzeau, V.1
  • 70
    • 33845457599 scopus 로고    scopus 로고
    • Hypertension caused by transgenic overexpression of Racl
    • Hassanain, H. H. et al. Hypertension caused by transgenic overexpression of Racl. Antioxid. Redox Signal. 9, 91-100 (2007).
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 91-100
    • Hassanain, H.H.1
  • 71
    • 0035679020 scopus 로고    scopus 로고
    • Possible involvement of Rhokinase in the pathogenesis of hypertension in humans
    • Masumoto, A. et al. Possible involvement of Rhokinase in the pathogenesis of hypertension in humans. Hypertension 38, 1307-1310 (2001).
    • (2001) Hypertension , vol.38 , pp. 1307-1310
    • Masumoto, A.1
  • 72
    • 20344383268 scopus 로고    scopus 로고
    • Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure
    • Kishi, T. et al. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. Circulation 111, 2741-2747 (2005).
    • (2005) Circulation , vol.111 , pp. 2741-2747
    • Kishi, T.1
  • 73
    • 33846842317 scopus 로고    scopus 로고
    • Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness
    • Noma, K. et al. Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J. Am. Coll. Cardiol. 49, 698-705 (2007).
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 698-705
    • Noma, K.1
  • 74
    • 33646164662 scopus 로고    scopus 로고
    • Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: Role of heredity
    • Seasholtz, T. M. et al. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension 47, 937-947 (2006).
    • (2006) Hypertension , vol.47 , pp. 937-947
    • Seasholtz, T.M.1
  • 75
    • 55449105596 scopus 로고    scopus 로고
    • Amajor haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: The HYPGENE study
    • Rankinen, T. et al. Amajor haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study. Hypertens. Res. 31, 1651-1657 (2008).
    • (2008) Hypertens. Res. , vol.31 , pp. 1651-1657
    • Rankinen, T.1
  • 76
    • 53849089211 scopus 로고    scopus 로고
    • Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension
    • Oka, M., Fagan, K. A., Jones, P. L. & McMurtry, I. F. Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension. Br. J. Pharmacol. 155, 444-454 (2008).
    • (2008) Br. J. Pharmacol. , vol.155 , pp. 444-454
    • Oka, M.1    Fagan, K.A.2    Jones, P.L.3    McMurtry, I.F.4
  • 77
    • 14244260105 scopus 로고    scopus 로고
    • Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
    • Fukumoto, Y. et al. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 91, 391-392 (2005).
    • (2005) Heart , vol.91 , pp. 391-392
    • Fukumoto, Y.1
  • 78
    • 77950921360 scopus 로고    scopus 로고
    • Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension
    • Fujita, H. et al. Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart Vessels 25, 144-149 (2010).
    • (2010) Heart Vessels , vol.25 , pp. 144-149
    • Fujita, H.1
  • 79
    • 67449105737 scopus 로고    scopus 로고
    • RhoA and Rho kinase activation in human pulmonary hypertension: Role of 5-HT signaling
    • Guilluy, C. et al. RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. Am. J. Respir. Crit. Care Med. 179, 1151-1158 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 1151-1158
    • Guilluy, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.