Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

FASEB Journal

Volumn 20, Issue 7, 2006, Pages 916-925

  Zhang, Ying Min ^a   Bo, Jacqueline ^b   Taffet, George E ^b   Chang, Jiang ^c   Shi, Jianjian ^a   Reddy, Anilkumar K ^b   Michael, Lloyd H ^b   Schneider, Michael D ^b   Entman, Mark L ^b   Schwartz, Robert J ^c   Wei, Lei ^a  

^a INDIANA UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Fibrogenic cytokines; Fibrosis; Hypertrophy; Pressure overload; Rho kinase

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; RHO KINASE; ROCK1 ENZYME; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA2; PROTEIN SERINE THREONINE KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; CARDIOMEGALY; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HEART; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; PRESSURE;

MUS MUSCULUS;

ANIMALS; CARDIOMEGALY; FIBROSIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOTYPE; HEART; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PHENOTYPE; PRESSURE; PROTEIN-SERINE-THREONINE KINASES; VENTRICULAR REMODELING;

EID: 33744473805     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5129com     Document Type: Article

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