Rho-kinase as a molecular target for insulin resistance and hypertension

FASEB Journal

Volumn 20, Issue 1, 2006, Pages 169-171

  Kanda, Takeshi ^a   Wakino, Shu ^a   Homma, Koichiro ^a   Yoshioka, Kyoko ^a   Tatematsu, Satoru ^a   Hasegawa, Kazuhiro ^a   Takamatsu, Ichiro ^a   Sugano, Naoki ^a   Hayashi, Koichi ^a   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FASUDIL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; NITROPRUSSIDE SODIUM; RHO KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE INTOLERANCE; HYPERTENSION; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE;

ANIMALIA;

EID: 30744440948     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4197fje     Document Type: Article

References (47)

1. Reaven, G. M. (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595-1607
2. DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., and Felber, J. P. (1981) The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000-1007
3. Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S. M., Elton, C. W., and Caro, J. F. (1988) An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486-494
4. de Jongh, R. T., Serne, E. H., Ijzerman, R.G., de Vries, G., and Stehouwer, C. D. (2004) Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation 109, 2529-2535
5. Baron, A. D., Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., and Brechtel, G. (1995) Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J. Clin. Invest. 96, 786-792
6. Jiang, Z. Y., Lin, Y. W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., and King, G. L. (1999) Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 104, 447-457
7. Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., and Mandarino, L. J. (2000) Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J. Clin. Invest. 105, 311-320
8. Kanai, F., Ito, K., Todaka, M., Hayashi, H., Kamohara, S., Ishii, K., Okada, T., Hazeki, O., Ui, M., and Ebina, Y. (1993) Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem. Biophys. Res. Commun. 195, 762-768
9. Zeng, G., Nystrom, F. H., Ravichandran, L. V., Cong, L. N., Kirby, M., Mostowski, H., and Quon, M. J. (2000) Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101, 1539-1545
10. Zick, Y. (2003) Role of Ser/Thr kinases in the uncoupling of insulin signaling. Int. J. Obes. Relat. Metab. Disord. 27, Suppl. 3, S56-S60
11. Riento, K., and Ridley, A. J. (2003) Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4, 446-456
12. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., et al. (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389, 990-994
13. Mukai, Y., Shimokawa, H., Matoba, T., Kandabashi, T., Satoh, S., Hiroki, J., Kaibuchi, K., and Takeshita, A. (2001) Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J. 15, 1062-1064
14. Abe, K., Shimokawa, H., Morikawa, K., Uwatoku, T., Oi, K., Matsumoto, Y., Hattori, T., Nakashima, Y., Kaibuchi, K., Sueishi, K., et al. (2004) Long-term treatment with a Rhokinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ. Res. 94, 385-393
15. Eto, M., Barandier, C., Rathgeb, L., Kozai, T., Joch, H., Yang, Z., and Luscher, T. F. (2001) Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelinconverting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogenactivated protein kinase. Circ. Res. 89, 583-590
16. Begum, N., Sandu, O. A., Ito, M., Lohmann, S. M., and Smolenski, A. (2002) Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J. Biol. Chem. 277, 6214-6222
17. Shimokawa, H., Seto, M., Katsumata, N., Amano, M., Kozai, T., Yamawaki, T., Kuwata, K., Kandabashi, T., Egashira, K., Ikegaki, I., et al. (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc. Res. 43, 1029-1039
18. Dombrowski, L., Roy, D., Marcotte, B., and Marette, A. (1996) A new procedure for the isolation of plasma membranes, T tubules, and internal membranes from skeletal muscle. Am. J. Physiol. 270, E667-E676
19. Wakino, S., Kintscher, U., Liu, Z., Kim, S., Yin, F., Ohba, M., Kuroki, T., Schonthal, A. H., Hsueh, W. A., and Law, R. E. (2001) Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells. J. Biol. Chem. 276, 47,650-47,657
20. Somlyo, A. V., Phelps, C., Dipierro, C., Eto, M., Read, P., Barrett, M., Gibson, J. J., Burnitz, M. C., Myers, C., and Somlyo, A. P. (2003) Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. FASEB J. 17, 223-234
21. Wakino, S., Hayashi, K., Kanda, T., Tatematsu, S., Homma, K., Yoshioka, K., Takamatsu, I., and Saruta, T. (2004) Peroxisome proliferator-activated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2. Circ. Res. 95, e45-e55
22. del Aguila, L. F., Claffey, K. P., and Kirwan, J. P. (1999) TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells. Am. J. Physiol. 276, E849-E855
23. Matsuda, H., Hayashi, K., Arakawa, K., Naitoh, M., Kubota, E., Honda, M., Matsumoto, A., Suzuki, H., Yamamoto, T., Kajiya, F., et al. (1999) Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: role of intrarenal bradykinin. J. Am. Soc. Nephrol. 10, 2272-2282
24. Yamamoto, T., Hayashi, K., Matsuda, H., Kubota, E., Tanaka, H., Ogasawara, Y., Nakamoto, H., Suzuki, H., Saruta, T., and Kajiya, F. (2001) In vivo visualization of angiotensin II- and tubuloglomerular feedback-mediated renal vasoconstriction. Kidney Int. 60, 364-369
25. Hori, H., Sasaoka, T., Ishihara, H., Wada, T., Murakami, S., Ishiki, M., and Kobayashi, M. (2002) Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice. Diabetes 51, 2387-2394
26. Plante, G. E., Perreault, M., Lanthier, A., Marette, A., and Maheux, P. (2003) Reduction of endothelial NOS and bradykinin-induced extravasation of macromolecules in skeletal muscle of the fructose-fed rat model. Cardiovasc. Res. 59, 963-970
27. Hayashi, K., Epstein, M., and Loutzenhiser, R. (1989) Pressure-induced vasoconstriction of renal microvessels in normotensive and hypertensive rats. Studies in the isolated perfused hydronephrotic kidney. Circ. Res. 65, 1475-1484
28. Gong, M. C., Fujihara, H., Somlyo, A. V., and Somlyo, A. P. (1997) Translocation of rhoA associated with Ca2+ sensitization of smooth muscle. J. Biol. Chem. 272, 10,704-10,709
29. Levin, B. E., Triscari, J., and Sullivan, A. C. (1980) Abnormal sympatho- adrenal function and plasma catecholamines in obese Zucker rats. Pharmacol. Biochem. Behav. 13, 107-113
30. Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A., Dunaif, A., and White, M. F. (2001) Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J. Clin. Invest. 107, 181-189
31. Hanna, A. N., Berthiaume, L. G., Kikuchi, Y., Begg, D., Bourgoin, S., and Brindley, D. N. (2001) Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase. Mol. Biol. Cell 12, 3618-3630
32. Karnam, P., Standaert, M. L., Galloway, L., and Farese, R. V. (1997) Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes. Apparent involvement of phosphatidylinositol 3-kinase. J. Biol. Chem. 272, 6136-6140
33. Duplain, H., Burcelin, R., Sartori, C., Cook, S., Egli, M., Lepori, M., Vollenweider, P., Pedrazzini, T., Nicod, P., Thorens, B., et al. (2001) Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 104, 342-345
34. Sandu, O. A., Ragolia, L., and Begum, N. (2000) Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation. Diabetes 49, 2178-2189
35. Fujiwara, K., Hayashi, K., Matsuda, H., Kubota, E., Honda, M., Ozawa, Y., and Saruta, T. (1999) Altered pressure-natriuresis in obese Zucker rats. Hypertension 33, 1470-1475
36. Sordella, R., Classon, M., Hu, K. Q., Matheson, S. F., Brouns, M. R., Fine, B., Zhang, L., Takami, H., Yamada, Y., and Settleman, J. (2002) Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2, 553-565
37. Cheung, A. T., Ree, D., Kolls, J. K., Fuselier, J., Coy, D. H., and Bryer-Ash, M. (1998) An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNFalpha. Endocrinology 139, 4928-4935
38. Nicholls, D. G., and Locke, R. M. (1984) Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64
39. Lowell, B. B., and Spiegelman, B. M. (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660
40. Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., and Flier, J. S. (1993) Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742
41. Emilsson, V., Summers, R. J., Hamilton, S., Liu, Y. L., and Cawthorne, M. A. (1998) The effects of the beta3-adrenoceptor agonist BRL 35135 on UCP isoform mRNA expression. Biochem. Biophys. Res. Commun. 252, 450-454
42. Masaki, T., Yoshimatsu, H., Chiba, S., and Sakata, T. (2000) Impaired response of UCP family to cold exposure in diabetic (db/db) mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R1305-R1309
43. Valverde, A. M., Arribas, M., Mur, C., Navarro, P., Pons, S., Cassard-Doulcier, A. M., Kahn, C. R., and Benito, M. (2003) Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J. Biol. Chem. 278, 10,221-10,231
44. Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., and Baron, A. D. (1996) Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J. Clin. Invest. 97, 2601-2610
45. Williams, S. B., Cusco, J. A., Roddy, M. A., Johnstone, M. T., and Creager, M. A. (1996) Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J. Am. Coll. Cardiol. 27, 567-574
46. Bolz, S. S., Vogel, L., Sollinger, D., Derwand, R., de Wit, C., Loirand, G., and Pohl, U. (2003) Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation 107, 3081-3087
47. Rask-Madsen, C., Dominguez, H., Ihlemann, N., Hermann, T., Kober, L., and Torp-Pedersen, C. (2003) Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 108, 1815-1821