Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the akt activation and pten inactivation in the ischemic penumbra of rat brain

Cellular and Molecular Neurobiology

Volumn 32, Issue 7, 2012, Pages 1187-1197

  Wu, Jianhua ^a   Li, Jianzhe ^b   Hu, Hankun ^a   Liu, Ping ^a   Fang, Yunxiang ^c   Wu, Dongfang ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b RUIKANG HOSPITAL AFFILIATED TO GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral ischemia; Fasudil; Rho kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; FASUDIL; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAD; PROTEIN KINASE B; RHO KINASE; RHO KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; INHIBITION KINETICS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES;

RATTUS;

EID: 84867576648     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-012-9845-z     Document Type: Article

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