-
1
-
-
0028328817
-
An assay for transforming growth factor-beta using cells transfected with plasminogen activator inhibitor-1 promoterluciferase construct
-
Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rikfin DB (1994) An assay for transforming growth factor-beta using cells transfected with plasminogen activator inhibitor-1 promoterluciferase construct. Anal Biochem 216:276-284.
-
(1994)
Anal Biochem
, vol.216
, pp. 276-284
-
-
Abe, M.1
Harpel, J.G.2
Metz, C.N.3
Nunes, I.4
Loskutoff, D.J.5
Rikfin, D.B.6
-
2
-
-
79953766851
-
Comparison of trypan blue dye exclusion and fluorometric assays for mammalian cell viability determinations
-
Altman SA, Randers L, Rao G (1999) Comparison of trypan blue dye exclusion and fluorometric assays for mammalian cell viability determinations. Biotechnol Prog 9:871-874.
-
(1999)
Biotechnol Prog
, vol.9
, pp. 871-874
-
-
Altman, S.A.1
Randers, L.2
Rao, G.3
-
4
-
-
37249024572
-
Structure and mechanism of lysine-specific demethylase enzymes
-
Anand R, Marmorstein R (2007) Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem 282:35425-35429.
-
(2007)
J Biol Chem
, vol.282
, pp. 35425-35429
-
-
Anand, R.1
Marmorstein, R.2
-
5
-
-
27744479712
-
Modulating molecular chaperone Hsp90 functions through reversible acetylation
-
Aoyagi S, Archer TK (2005) Modulating molecular chaperone Hsp90 functions through reversible acetylation. Trends Cell Biol 15:565-567.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 565-567
-
-
Aoyagi, S.1
Archer, T.K.2
-
6
-
-
60549106446
-
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules
-
Arif M, Pradhan SK, Thanuja GK et al (2009) Mechanism of p300 specific histone acetyltransferase inhibition by small molecules. J Med Chem 52:267-277.
-
(2009)
J Med Chem
, vol.52
, pp. 267-277
-
-
Arif, M.1
Pradhan, S.K.2
Thanuja, G.K.3
-
7
-
-
43749109171
-
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
-
Balasubramanian S, Ramos J, Luo W, Sirisawad M, Verner E, Buggy JJ (2008) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22:1026-1034.
-
(2008)
Leukemia
, vol.22
, pp. 1026-1034
-
-
Balasubramanian, S.1
Ramos, J.2
Luo, W.3
Sirisawad, M.4
Verner, E.5
Buggy, J.J.6
-
8
-
-
4043146501
-
Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
-
Balasubramanyam K, Altaf M, Varier RA et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem 279:33716-33726.
-
(2004)
J Biol Chem
, vol.279
, pp. 33716-33726
-
-
Balasubramanyam, K.1
Altaf, M.2
Varier, R.A.3
-
9
-
-
78651505157
-
Therapeutic potential of activators and inhibitors of sirtuins
-
Balcerczyk A, Pirola L (2010) Therapeutic potential of activators and inhibitors of sirtuins. Biofactors 36:383-393.
-
(2010)
Biofactors
, vol.36
, pp. 383-393
-
-
Balcerczyk, A.1
Pirola, L.2
-
10
-
-
0035694469
-
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
-
Barlev NA, Liu L, Chehab NH et al (2001) Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell 8:1243-1254.
-
(2001)
Mol Cell
, vol.8
, pp. 1243-1254
-
-
Barlev, N.A.1
Liu, L.2
Chehab, N.H.3
-
11
-
-
33845464255
-
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions
-
Bartz SR, Zhang Z, Burchard J et al (2006) Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Mol Cell Biol 26:9377-9386.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 9377-9386
-
-
Bartz, S.R.1
Zhang, Z.2
Burchard, J.3
-
12
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
-
13
-
-
70350524083
-
Resveratrol is not a direct activator of SIRT1 enzyme activity
-
Beher D, Wu J, Cumine S et al (2009) Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des 74:619-624.
-
(2009)
Chem Biol Drug Des
, vol.74
, pp. 619-624
-
-
Beher, D.1
Wu, J.2
Cumine, S.3
-
14
-
-
33846374117
-
Catalytic mechanism of a MYST family histone acetyltransferase
-
Berndsen CE, Albaugh BN, Tan S, Denu JM (2007) Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry 46:623-629.
-
(2007)
Biochemistry
, vol.46
, pp. 623-629
-
-
Berndsen, C.E.1
Albaugh, B.N.2
Tan, S.3
Denu, J.M.4
-
16
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra MT, Smith BC, Denu JM (2005) Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280:17187-17195.
-
(2005)
J Biol Chem
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
17
-
-
55549094833
-
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
-
Bottomley MJ, Lo Surdo P, Di Giovine P et al (2008) Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain. J Biol Chem 283:26694-26704.
-
(2008)
J Biol Chem
, vol.283
, pp. 26694-26704
-
-
Bottomley, M.J.1
Lo Surdo, P.2
Di Giovine, P.3
-
18
-
-
67749124307
-
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole
-
Bowers AA, Greshock TJ, West N et al (2009) Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. J Am Chem Soc 131:2900-2905.
-
(2009)
J Am Chem Soc
, vol.131
, pp. 2900-2905
-
-
Bowers, A.A.1
Greshock, T.J.2
West, N.3
-
19
-
-
0025954615
-
Potent cytodifferentiating agents related to hexamethylenebisacetamide
-
Breslow R, Jursic B, Yan ZF et al (1991) Potent cytodifferentiating agents related to hexamethylenebisacetamide. Proc Natl Acad Sci U S A 88:5542-5546.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 5542-5546
-
-
Breslow, R.1
Jursic, B.2
Yan, Z.F.3
-
20
-
-
77952100365
-
Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides
-
Bressi JC, Jennings AJ, Skene R et al (2010) Exploration of the HDAC2 foot pocket: synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett 20:3142-3145.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 3142-3145
-
-
Bressi, J.C.1
Jennings, A.J.2
Skene, R.3
-
21
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:103-107.
-
(1999)
Nat Genet
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myöhänen, S.3
Herman, J.G.4
Baylin, S.B.5
-
22
-
-
0242660847
-
Total synthesis of the depsipeptide FR-901375
-
Chen Y, Gambs C, Abe Y, Wentworth PJ, Janda KD (2003) Total synthesis of the depsipeptide FR-901375. J Org Chem 68:8902-8905.
-
(2003)
J Org Chem
, vol.68
, pp. 8902-8905
-
-
Chen, Y.1
Gambs, C.2
Abe, Y.3
Wentworth, P.J.4
Janda, K.D.5
-
23
-
-
24344468250
-
NF-CB RelA phosphorylation regulates RelA acetylation
-
Chen L, Williams SA, Mu Y et al (2005) NF-CB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol 25:7966-7975.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7966-7975
-
-
Chen, L.1
Williams, S.A.2
Mu, Y.3
-
24
-
-
40049094942
-
Mammalian DNA methyltransferases: A structural perspective
-
Cheng X, Blumenthal RM (2008) Mammalian DNA methyltransferases: a structural perspective. Structure 16:341-350.
-
(2008)
Structure
, vol.16
, pp. 341-350
-
-
Cheng, X.1
Blumenthal, R.M.2
-
25
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, Kumar C, Gnad F et al (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834-843.
-
(2009)
Science
, vol.325
, pp. 834-843
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
-
26
-
-
0029118592
-
Biological assays for Ras transformation
-
Der CJ, Hall A (eds) Methods in enzymology. Academic, New York
-
Clark GJ, Cox A, Graham SM, Der CJ (1995) Biological assays for Ras transformation. In: Balch WE, Der CJ, Hall A (eds) Methods in enzymology. Academic, New York.
-
(1995)
Balch WE
-
-
Clark, G.J.1
Cox, A.2
Graham, S.M.3
Der, C.J.4
-
27
-
-
0016366116
-
Isolierung und Strukturaufklärung von Chlamydocin
-
Closse A, Huguenin R (1974) Isolierung und Strukturaufklärung von Chlamydocin. Helv Chim Acta 57:533-544.
-
(1974)
Helv Chim Acta
, vol.57
, pp. 533-544
-
-
Closse, A.1
Huguenin, R.2
-
28
-
-
80051599485
-
Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases
-
Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW (2011) Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J Am Chem Soc 133:12474-12477.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 12474-12477
-
-
Cole, K.E.1
Dowling, D.P.2
Boone, M.A.3
Phillips, A.J.4
Christianson, D.W.5
-
29
-
-
35348812522
-
LSD1 and the chemistry of histone demethylation
-
Culhane JC, Cole PA (2007) LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol 11:561-568.
-
(2007)
Curr Opin Chem Biol
, vol.11
, pp. 561-568
-
-
Culhane, J.C.1
Cole, P.A.2
-
30
-
-
77950663978
-
The identification of a novel natural activator of p300 histone acetyltransferase provides new insights into the modulation mechanism of this enzyme
-
Dal Piaz F, Tosco A, Eletto D et al (2010) The identification of a novel natural activator of p300 histone acetyltransferase provides new insights into the modulation mechanism of this enzyme. ChemBioChem 11:818-827.
-
(2010)
ChemBioChem
, vol.11
, pp. 818-827
-
-
Dal Piaz, F.1
Tosco, A.2
Eletto, D.3
-
31
-
-
0037444803
-
Histone deacetylases (HDACs): Characterization of the classical HDAC family
-
De Ruijter AJM, Van Gennip AH, Caron HN, Kemp S, Van Kuilenburg ABP (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737-749.
-
(2003)
Biochem J
, vol.370
, pp. 737-749
-
-
De Ruijter, A.J.M.1
Van Gennip, A.H.2
Caron, H.N.3
Kemp, S.4
Van Kuilenburg, A.B.P.5
-
32
-
-
67650296574
-
Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities
-
Dedesa KJ, Dedesa I, Imescha P, von Buerenb AO, Finka D, Fediera A (2009) Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities. Anticancer Drugs 20:321-333.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 321-333
-
-
Dedesa, K.J.1
Dedesa, I.2
Imescha, P.3
von Buerenb, A.O.4
Finka, D.5
Fediera, A.6
-
33
-
-
0346996870
-
Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation
-
Deng W, Wu KK (2003) Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol 171:6581-6588.
-
(2003)
J Immunol
, vol.171
, pp. 6581-6588
-
-
Deng, W.1
Wu, K.K.2
-
34
-
-
0038813706
-
Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-a-induced cyclooxygenase-2 promoter activation
-
Deng W, Zhu Y, Wu KK (2003) Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-a-induced cyclooxygenase-2 promoter activation. J Biol Chem 278:4770-4777.
-
(2003)
J Biol Chem
, vol.278
, pp. 4770-4777
-
-
Deng, W.1
Zhu, Y.2
Wu, K.K.3
-
35
-
-
79959829510
-
Histone arginine methylation
-
Di Lorenzo A, Bedford MT (2011) Histone arginine methylation. FEBS Lett 585:2024-2031.
-
(2011)
FEBS Lett
, vol.585
, pp. 2024-2031
-
-
Di Lorenzo, A.1
Bedford, M.T.2
-
36
-
-
51549109903
-
Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222
-
Di Micco S, Terracciano S, Bruno I et al (2008) Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222. Bioorg Med Chem 16:8635-8642.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 8635-8642
-
-
Di Micco, S.1
Terracciano, S.2
Bruno, I.3
-
37
-
-
78751506349
-
Catalysis and mechanistic insights into sirtuin activation
-
Dittenhafer-Reed KE, Feldman JL, Denu JM (2011) Catalysis and mechanistic insights into sirtuin activation. ChemBioChem 12:281-289.
-
(2011)
ChemBioChem
, vol.12
, pp. 281-289
-
-
Dittenhafer-reed, K.E.1
Feldman, J.L.2
Denu, J.M.3
-
38
-
-
0036892569
-
Major phase I biotransformation pathways of trichostatin A in rat hepatocytes and in rat and human liver microsomes
-
Elaut G, Torok G, Vinken M et al (2002) Major phase I biotransformation pathways of trichostatin A in rat hepatocytes and in rat and human liver microsomes. Drug Metab Dispos 30:1320-1328.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1320-1328
-
-
Elaut, G.1
Torok, G.2
Vinken, M.3
-
39
-
-
45549083112
-
Constitutive activation of signal transducers and activators of transcription predicts Vorinostat resistance in cutaneous T-cell lymphoma
-
Fantin VR, Loboda A, Paweletz CP et al (2008) Constitutive activation of signal transducers and activators of transcription predicts Vorinostat resistance in cutaneous T-cell lymphoma. Cancer Res 68:3785-3794.
-
(2008)
Cancer Res
, vol.68
, pp. 3785-3794
-
-
Fantin, V.R.1
Loboda, A.2
Paweletz, C.P.3
-
40
-
-
38449122336
-
The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells
-
Fedier A, Dedes KJ, Imesch P, Von Bueren AO, Fink D (2007) The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells. Int J Oncol 31:633-641.
-
(2007)
Int J Oncol
, vol.31
, pp. 633-641
-
-
Fedier, A.1
Dedes, K.J.2
Imesch, P.3
Von Bueren, A.O.4
Fink, D.5
-
41
-
-
65449166411
-
Novel structural insights into Class I and II histone deacetylases
-
Ficner R (2009) Novel structural insights into Class I and II histone deacetylases. Curr Top Med Chem 9:235-240.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 235-240
-
-
Ficner, R.1
-
42
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
Finnin MS, Donigian JR, Cohen A et al (1999) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401:188-193.
-
(1999)
Nature
, vol.401
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
-
43
-
-
49649098602
-
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
-
Frew AJ, Lindemann RK, Martin BP et al (2008) Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist. Proc Natl Acad Sci U S A 105:11317-11322.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 11317-11322
-
-
Frew, A.J.1
Lindemann, R.K.2
Martin, B.P.3
-
44
-
-
0023927992
-
Transformation of diploid human fibroblasts by transfection with the v-sis, PDGF2/c-sis, or T24 H-ras genes
-
Fry DG, Hurlin PJ, Maher VM, McCormick JJ (1988) Transformation of diploid human fibroblasts by transfection with the v-sis, PDGF2/c-sis, or T24 H-ras genes. Mutat Res 199:341-351.
-
(1988)
Mutat Res
, vol.199
, pp. 341-351
-
-
Fry, D.G.1
Hurlin, P.J.2
Maher, V.M.3
McCormick, J.J.4
-
45
-
-
0036735385
-
FK228 (Depsipeptide) as a natural prodrug that inhibits Class I histone deacetylases
-
Furumai R, Matsuyama A, Kobashi N et al (2002) FK228 (Depsipeptide) as a natural prodrug that inhibits Class I histone deacetylases. Cancer Res 62:4916-4921.
-
(2002)
Cancer Res
, vol.62
, pp. 4916-4921
-
-
Furumai, R.1
Matsuyama, A.2
Kobashi, N.3
-
46
-
-
20844444898
-
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
-
George P, Bali P, Annavarapu S et al (2005) Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 105:1768-1776.
-
(2005)
Blood
, vol.105
, pp. 1768-1776
-
-
George, P.1
Bali, P.2
Annavarapu, S.3
-
47
-
-
34447317859
-
Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: Inhibitors of human sirtuins SIRT1 and SIRT2
-
Gey C, Kyrylenko S, Hennig L et al (2007) Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed 46:5219-5222.
-
(2007)
Angew Chem Int Ed
, vol.46
, pp. 5219-5222
-
-
Gey, C.1
Kyrylenko, S.2
Hennig, L.3
-
48
-
-
0042905956
-
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: Defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
-
Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, Davidsen SK (2003) Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol Cancer Ther 2:151-163.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 151-163
-
-
Glaser, K.B.1
Staver, M.J.2
Waring, J.F.3
Stender, J.4
Ulrich, R.G.5
Davidsen, S.K.6
-
49
-
-
28044471827
-
Acetylation and deacetylation of non-histone proteins
-
Glozak MA, Sengupta N, Zhang X, Seto E (2005) Acetylation and deacetylation of non-histone proteins. Gene 363:15-23.
-
(2005)
Gene
, vol.363
, pp. 15-23
-
-
Glozak, M.A.1
Sengupta, N.2
Zhang, X.3
Seto, E.4
-
50
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K et al (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293:876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
51
-
-
1842578986
-
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
-
Gregoretti IV, Lee Y, Goodson HV (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338:17-31.
-
(2004)
J Mol Biol
, vol.338
, pp. 17-31
-
-
Gregoretti, I.V.1
Lee, Y.2
Goodson, H.V.3
-
52
-
-
30644474460
-
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
-
Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:143-145.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 143-145
-
-
Greiner, D.1
Bonaldi, T.2
Eskeland, R.3
Roemer, E.4
Imhof, A.5
-
53
-
-
34249290099
-
Microsporins A and B: New histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solidphase synthesis of microsporin A
-
Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB (2007) Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solidphase synthesis of microsporin A. Tetrahedron 63:6535-6541.
-
(2007)
Tetrahedron
, vol.63
, pp. 6535-6541
-
-
Gu, W.1
Cueto, M.2
Jensen, P.R.3
Fenical, W.4
Silverman, R.B.5
-
54
-
-
68049096181
-
Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula
-
Gutierrez M, Andrianasolo EH, Shin WK et al (2009) Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. J Org Chem 74:5267-5275.
-
(2009)
J Org Chem
, vol.74
, pp. 5267-5275
-
-
Gutierrez, M.1
Andrianasolo, E.H.2
Shin, W.K.3
-
55
-
-
0344640906
-
Domain-selective smallmolecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
-
Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL (2003) Domain-selective smallmolecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A 100:4389-4394.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
56
-
-
1842631408
-
Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
-
Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN (2004) Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 59:177-189.
-
(2004)
Prostate
, vol.59
, pp. 177-189
-
-
Halkidou, K.1
Gaughan, L.2
Cook, S.3
Leung, H.Y.4
Neal, D.E.5
Robson, C.N.6
-
57
-
-
55249098844
-
An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1
-
Hanigan CL, Van Engeland M, De Bruine AP et al (2008) An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. Gastroenterology 135:1654-1664.
-
(2008)
Gastroenterology
, vol.135
, pp. 1654-1664
-
-
Hanigan, C.L.1
Van Engeland, M.2
De Bruine, A.P.3
-
58
-
-
0014725912
-
Isolation and structure elucidation of chaetocin
-
Hauser D, Weber HP, Sigg HP (1970) Isolation and structure elucidation of chaetocin. Helv Chim Acta 53:1061-1073.
-
(1970)
Helv Chim Acta
, vol.53
, pp. 1061-1073
-
-
Hauser, D.1
Weber, H.P.2
Sigg, H.P.3
-
59
-
-
0015792162
-
Isolation and biological activity of Cyl-2, a metabolite of Cylindrocladium scoparium
-
Hirota A, Suzuki A, Suzuki H, Tamura S (1973) Isolation and biological activity of Cyl-2, a metabolite of Cylindrocladium scoparium. Agric Biol Chem 37:643-647.
-
(1973)
Agric Biol Chem
, vol.37
, pp. 643-647
-
-
Hirota, A.1
Suzuki, A.2
Suzuki, H.3
Tamura, S.4
-
60
-
-
34547911052
-
Chemistry of acetyl transfer by histone modifying enzymes: Structure, mechanism and implications for effector design
-
Hodawadekar SC, Marmorstein R (2007) Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design. Oncogene 26:5528-5540.
-
(2007)
Oncogene
, vol.26
, pp. 5528-5540
-
-
Hodawadekar, S.C.1
Marmorstein, R.2
-
61
-
-
84861157767
-
Largazole: From discovery to broad-spectrum therapy
-
Hong J, Luesch H (2012) Largazole: From discovery to broad-spectrum therapy. Nat Prod Rep 29: 449-456.
-
(2012)
Nat Prod Rep
, vol.29
, pp. 449-456
-
-
Hong, J.1
Luesch, H.2
-
62
-
-
38449110249
-
Gene expression profiling induced by histone deacetylase inhibitor, FK228, in human esophageal squamous cancer cells
-
Hoshino I, Hisahiro M, Akutsu Y et al (2007) Gene expression profiling induced by histone deacetylase inhibitor, FK228, in human esophageal squamous cancer cells. Oncol Rep 18:585-592.
-
(2007)
Oncol Rep
, vol.18
, pp. 585-592
-
-
Hoshino, I.1
Hisahiro, M.2
Akutsu, Y.3
-
63
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY et al (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
-
64
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert C, Guardiola A, Shao R et al (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417:455-458.
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
-
65
-
-
33947214077
-
Chaetocin: A promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
-
Isham CR, Tibodeau JD, Jin W, Xu R, Timm MM, Bible KC (2007) Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Blood 109:2579-2588.
-
(2007)
Blood
, vol.109
, pp. 2579-2588
-
-
Isham, C.R.1
Tibodeau, J.D.2
Jin, W.3
Xu, R.4
Timm, M.M.5
Bible, K.C.6
-
66
-
-
0025673805
-
Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents
-
Itazaki H, Nagashima K, Sugita K et al (1990) Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents. J Antibiot 43:1524-1532.
-
(1990)
J Antibiot
, vol.43
, pp. 1524-1532
-
-
Itazaki, H.1
Nagashima, K.2
Sugita, K.3
-
67
-
-
77950229791
-
Total synthesis of (+)-chaetocin and its analogues: Their histone methyltransferase G9a inhibitory activity
-
Iwasa E, Hamashima Y, Fujishiro S et al (2010) Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity. J Am Chem Soc 132:4078-4079.
-
(2010)
J Am Chem Soc
, vol.132
, pp. 4078-4079
-
-
Iwasa, E.1
Hamashima, Y.2
Fujishiro, S.3
-
68
-
-
34548071458
-
Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells
-
Jagadeesh S, Sinha S, Pal BC, Bhattacharya S, Banerjee PP (2007) Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells. Biochem Biophys Res Commun 362:212-217.
-
(2007)
Biochem Biophys Res Commun
, vol.362
, pp. 212-217
-
-
Jagadeesh, S.1
Sinha, S.2
Pal, B.C.3
Bhattacharya, S.4
Banerjee, P.P.5
-
69
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415-428.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
70
-
-
33847065486
-
The epigenomics of cancer
-
Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128:683-692.
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
71
-
-
67650564609
-
Identification of new p53 acetylation sites in COS-1 cells
-
Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL (2009) Identification of new p53 acetylation sites in COS-1 cells. Mol Cell Proteomics 8:1167-1173.
-
(2009)
Mol Cell Proteomics
, vol.8
, pp. 1167-1173
-
-
Joubel, A.1
Chalkley, R.J.2
Medzihradszky, K.F.3
Hondermarck, H.4
Burlingame, A.L.5
-
72
-
-
78751470921
-
Structure and function of mammalian DNA methyltransferases
-
Jurkowska RZ, Jurkowski TP, Jeltsch A (2011) Structure and function of mammalian DNA methyltransferases. ChemBioChem 12:206-222.
-
(2011)
ChemBioChem
, vol.12
, pp. 206-222
-
-
Jurkowska, R.Z.1
Jurkowski, T.P.2
Jeltsch, A.3
-
73
-
-
33750463070
-
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines
-
Kano Y, Akutsu M, Tsunoda S et al (2006) Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. Invest New Drugs 25:31-40.
-
(2006)
Invest New Drugs
, vol.25
, pp. 31-40
-
-
Kano, Y.1
Akutsu, M.2
Tsunoda, S.3
-
74
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao T (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115:727-738.
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.6
-
75
-
-
0037462725
-
Post-activation turn-off of NF-KB-dependent transcription is regulated by acetylation of p65
-
Kiernan R, Bres V, Ng RWM et al (2003) Post-activation turn-off of NF-KB-dependent transcription is regulated by acetylation of p65. J Biol Chem 278:2758-2766.
-
(2003)
J Biol Chem
, vol.278
, pp. 2758-2766
-
-
Kiernan, R.1
Bres, V.2
Ng, R.W.M.3
-
76
-
-
0027378351
-
Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase
-
Kijima M, Yoshida M, Sugita K, Horinouchi S, Beppu T (1993) Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J Biol Chem 268:22429-22435.
-
(1993)
J Biol Chem
, vol.268
, pp. 22429-22435
-
-
Kijima, M.1
Yoshida, M.2
Sugita, K.3
Horinouchi, S.4
Beppu, T.5
-
77
-
-
33847657556
-
Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
-
Kim DH, Shin J, Kwon HJ (2007) Psammaplin A is a natural prodrug that inhibits class I histone deacetylase. Exp Mol Med 39:47-55.
-
(2007)
Exp Mol Med
, vol.39
, pp. 47-55
-
-
Kim, D.H.1
Shin, J.2
Kwon, H.J.3
-
78
-
-
0035361402
-
Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity
-
Komatsu Y, Tomizaki K, Tsukamoto M et al (2001) Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity. Cancer Res 61:4459-4466.
-
(2001)
Cancer Res
, vol.61
, pp. 4459-4466
-
-
Komatsu, Y.1
Tomizaki, K.2
Tsukamoto, M.3
-
79
-
-
0033529565
-
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
-
Kornberg RD, Lorch Y (1999) Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98:285-294.
-
(1999)
Cell
, vol.98
, pp. 285-294
-
-
Kornberg, R.D.1
Lorch, Y.2
-
80
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
81
-
-
78649676706
-
Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells
-
Kuck D, Caulfield T, Lyko F, Medina-Franco JL (2010) Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol Cancer Ther 9:3015-3023.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 3015-3023
-
-
Kuck, D.1
Caulfield, T.2
Lyko, F.3
Medina-franco, J.L.4
-
82
-
-
78649235245
-
Weapons in disguise-activating mechanisms and protecting group chemistry in Nature
-
Kwan JC, Luesch H (2010) Weapons in disguise-activating mechanisms and protecting group chemistry in Nature. Chem Eur J 16:13020-13029.
-
(2010)
Chem Eur J
, vol.16
, pp. 13020-13029
-
-
Kwan, J.C.1
Luesch, H.2
-
83
-
-
0037439085
-
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet
-
Kwon T, Chang JH, Kwak E et al (2003) Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J 22:292-303.
-
(2003)
EMBO J
, vol.22
, pp. 292-303
-
-
Kwon, T.1
Chang, J.H.2
Kwak, E.3
-
84
-
-
0023389780
-
Identification of an acetylation site of Chlamydomonas a-tubulin
-
Ledizet M, Piperno G (1987) Identification of an acetylation site of Chlamydomonas a-tubulin. Proc Natl Acad Sci U S A 84:5720-5724.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5720-5724
-
-
Ledizet, M.1
Piperno, G.2
-
85
-
-
31544441371
-
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
-
Lee WJ, Zhu BT (2006) Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 279:269-277.
-
(2006)
Carcinogenesis
, vol.279
, pp. 269-277
-
-
Lee, W.J.1
Zhu, B.T.2
-
86
-
-
25144507259
-
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
-
Lee WJ, Shim J, Zhu BT (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol 68:1018-1030.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1018-1030
-
-
Lee, W.J.1
Shim, J.2
Zhu, B.T.3
-
87
-
-
77956153243
-
The language of histone crosstalk
-
Lee J, Smith E, Shilatifard A (2010) The language of histone crosstalk. Cell 142:682-685.
-
(2010)
Cell
, vol.142
, pp. 682-685
-
-
Lee, J.1
Smith, E.2
Shilatifard, A.3
-
88
-
-
33847070442
-
The role of chromatin during transcription
-
Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128:707-719.
-
(2007)
Cell
, vol.128
, pp. 707-719
-
-
Li, B.1
Carey, M.2
Workman, J.L.3
-
89
-
-
2442454683
-
Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome
-
Liang G, Lin JCY, Wei V et al (2004) Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A 101:7357-7362.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7357-7362
-
-
Liang, G.1
Lin, J.C.Y.2
Wei, V.3
-
90
-
-
0033168497
-
Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A
-
Lin Y, Fletcher CM, Zhou J, Allis CD, Wagner G (1999) Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A. Nature 400:86-89.
-
(1999)
Nature
, vol.400
, pp. 86-89
-
-
Lin, Y.1
Fletcher, C.M.2
Zhou, J.3
Allis, C.D.4
Wagner, G.5
-
91
-
-
34748837820
-
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells
-
Lina R, Hsu C, Wang Y (2007) Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells. Anticancer Drugs 18:1157-1164.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 1157-1164
-
-
Lina, R.1
Hsu, C.2
Wang, Y.3
-
92
-
-
39149109887
-
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
-
Liu X, Wang L, Zhao K et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature 451:846-850.
-
(2008)
Nature
, vol.451
, pp. 846-850
-
-
Liu, X.1
Wang, L.2
Zhao, K.3
-
93
-
-
65649091667
-
Modulation of DNA methylation by a sesquiterpene lactone parthenolide
-
Liu Z, Liu S, Xie Z et al (2009) Modulation of DNA methylation by a sesquiterpene lactone parthenolide. J Pharmacol Exp Ther 329:505-514.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 505-514
-
-
Liu, Z.1
Liu, S.2
Xie, Z.3
-
94
-
-
78149267515
-
Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor
-
Liu Y, Salvador LA, Byeon S et al (2010) Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J Pharmacol Exp Ther 335:351-361.
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 351-361
-
-
Liu, Y.1
Salvador, L.A.2
Byeon, S.3
-
95
-
-
1842411320
-
Crystal structure of the nucleosome core particle at 2.8 Å resolution
-
Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ (1997) Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389:251-260.
-
(1997)
Nature
, vol.389
, pp. 251-260
-
-
Luger, K.1
Mader, A.W.2
Richmond, R.K.3
Sargent, D.F.4
Richmond, T.J.5
-
96
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
Marks PA, Breslow R (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 25:84-90.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
97
-
-
0022452231
-
The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules
-
Maruta H, Greet K, Rosenbaum JL (1986) The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules. J Cell Biol 103:571-579.
-
(1986)
J Cell Biol
, vol.103
, pp. 571-579
-
-
Maruta, H.1
Greet, K.2
Rosenbaum, J.L.3
-
98
-
-
0035180541
-
Spiruchostatins A and B, novel gene expressionenhancing substances produced by Pseudomonas sp
-
Masuoka Y, Nagai A, Shin-ya K et al (2001) Spiruchostatins A and B, novel gene expressionenhancing substances produced by Pseudomonas sp. Tetrahedron Lett 42:41-44.
-
(2001)
Tetrahedron Lett
, vol.42
, pp. 41-44
-
-
Masuoka, Y.1
Nagai, A.2
Shin-ya, K.3
-
99
-
-
42949141641
-
Histone deacetylase inhibitors from microorganisms: The Astellas experience
-
Amstutz R, Petersen F (eds), Birkhauser Verlag, Basel
-
Masuoka Y, Shindoh N, Inamura N (2008) Histone deacetylase inhibitors from microorganisms: the Astellas experience. In: Amstutz R, Petersen F (eds) Progress in drug research. Birkhauser Verlag, Basel.
-
(2008)
Progress in drug research
-
-
Masuoka, Y.1
Shindoh, N.2
Inamura, N.3
-
100
-
-
33947239221
-
Molecular insights into azumamide E histone deacetylases inhibitory activity
-
Maulucci N, Chini MG, Di Micco S et al (2007) Molecular insights into azumamide E histone deacetylases inhibitory activity. J Am Chem Soc 129:3007-3012.
-
(2007)
J Am Chem Soc
, vol.129
, pp. 3007-3012
-
-
Maulucci, N.1
Chini, M.G.2
Di Micco, S.3
-
101
-
-
62149098372
-
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives
-
McCulloch MWB, Coombs GS, Banerjee N et al (2009) Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem 17:2189-2198.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2189-2198
-
-
McCulloch, M.W.B.1
Coombs, G.S.2
Banerjee, N.3
-
102
-
-
3042671182
-
Peyssonenynes A and B, novel enediyne oxylipins with DNA methyltransferase inhibitory activity from the red marine alga Peyssonnelia caulifera
-
McPhail KL, France D, Cornell-Kennon S, Gerwick WH (2004) Peyssonenynes A and B, novel enediyne oxylipins with DNA methyltransferase inhibitory activity from the red marine alga Peyssonnelia caulifera. J Nat Prod 67:1010-1013.
-
(2004)
J Nat Prod
, vol.67
, pp. 1010-1013
-
-
McPhail, K.L.1
France, D.2
Cornell-kennon, S.3
Gerwick, W.H.4
-
103
-
-
0344837759
-
Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
-
Min J, Feng Q, Li Z, Zhang Y, Xu R (2003) Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell 112:711-723.
-
(2003)
Cell
, vol.112
, pp. 711-723
-
-
Min, J.1
Feng, Q.2
Li, Z.3
Zhang, Y.4
Xu, R.5
-
104
-
-
0037300444
-
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities
-
Mori H, Urano Y, Abe F et al (2003a) FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities. J Antibiot 56:72-79.
-
(2003)
J Antibiot
, vol.56
, pp. 72-79
-
-
Mori, H.1
Urano, Y.2
Abe, F.3
-
105
-
-
0037300480
-
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). II. Biological activities in animal models
-
Mori H, Abe F, Furukawa S et al (2003b) FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). II. Biological activities in animal models. J Antibiot 56:80-86.
-
(2003)
J Antibiot
, vol.56
, pp. 80-86
-
-
Mori, H.1
Abe, F.2
Furukawa, S.3
-
106
-
-
0037300543
-
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase. III. Structure determination
-
Mori H, Urano Y, Kinoshita T, Yoshimura S, Takase S, Hino M (2003c) FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase. III. Structure determination. J Antibiot 56:181-185.
-
(2003)
J Antibiot
, vol.56
, pp. 181-185
-
-
Mori, H.1
Urano, Y.2
Kinoshita, T.3
Yoshimura, S.4
Takase, S.5
Hino, M.6
-
107
-
-
77953644347
-
Reversal of histone methylation: Biochemical and molecular mechanisms of histone demethylases
-
Mosammaparast N, Shi Y (2010) Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu Rev Biochem 79:155-179.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 155-179
-
-
Mosammaparast, N.1
Shi, Y.2
-
108
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
109
-
-
38449100788
-
Expression profile of class I histone deacetylases in human cancer tissues
-
Nakagawa M, Oda Y, Eguchi T et al (2007) Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 18:769-774.
-
(2007)
Oncol Rep
, vol.18
, pp. 769-774
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
-
110
-
-
0344431240
-
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
-
Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S (1998) FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 241:126-133.
-
(1998)
Exp Cell Res
, vol.241
, pp. 126-133
-
-
Nakajima, H.1
Kim, Y.B.2
Terano, H.3
Yoshida, M.4
Horinouchi, S.5
-
111
-
-
33845199114
-
Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis
-
Nakao Y, Yoshida S, Matsunaga S et al (2006) Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. Angew Chem Int Ed 45:7553-7557.
-
(2006)
Angew Chem Int Ed
, vol.45
, pp. 7553-7557
-
-
Nakao, Y.1
Yoshida, S.2
Matsunaga, S.3
-
112
-
-
33645737411
-
Aggresome disruption: A novel strategy to enhance Bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki ST, Carew JS, Pino MS et al (2006) Aggresome disruption: a novel strategy to enhance Bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res 66:3773-3781.
-
(2006)
Cancer Res
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
-
113
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010. J
-
Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat Prod 75:311-335.
-
(2012)
Nat Prod
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
114
-
-
0035172893
-
A facile and effective screening method for p21WAF1 promoter activators from microbial metabolites
-
Nie L, Ueki M, Kakeya H, Osada H (2001) A facile and effective screening method for p21WAF1 promoter activators from microbial metabolites. J Antibiot 54:783-788.
-
(2001)
J Antibiot
, vol.54
, pp. 783-788
-
-
Nie, L.1
Ueki, M.2
Kakeya, H.3
Osada, H.4
-
115
-
-
70349309607
-
Systemic cell-cycle suppression by apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells
-
Noh JH, Song JH, Eun JW et al (2009) Systemic cell-cycle suppression by apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells. Int J Mol Med 24:205-226.
-
(2009)
Int J Mol Med
, vol.24
, pp. 205-226
-
-
Noh, J.H.1
Song, J.H.2
Eun, J.W.3
-
116
-
-
0033856957
-
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
-
O'Brien J, Wilson I, Orton T, Pognan F (2000) Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 267:5421-5426.
-
(2000)
Eur J Biochem
, vol.267
, pp. 5421-5426
-
-
O'Brien, J.1
Wilson, I.2
Orton, T.3
Pognan, F.4
-
117
-
-
77958126835
-
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance
-
Oh WK, Cho KB, Hien TT et al (2010) Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance. Mol Pharmacol 78:855-864.
-
(2010)
Mol Pharmacol
, vol.78
, pp. 855-864
-
-
Oh, W.K.1
Cho, K.B.2
Hien, T.T.3
-
118
-
-
78751491475
-
Dynamic interplay between histone H3 modifications and protein interpreters: Emerging evidence for a "histone language"
-
Oliver SS, Denu JM (2011) Dynamic interplay between histone H3 modifications and protein interpreters: emerging evidence for a "histone language". ChemBioChem 12:299-307.
-
(2011)
ChemBioChem
, vol.12
, pp. 299-307
-
-
Oliver, S.S.1
Denu, J.M.2
-
119
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Bleasdale JE, Chrunyk B et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285:8340-8345.
-
(2010)
J Biol Chem
, vol.285
, pp. 8340-8345
-
-
Pacholec, M.1
Bleasdale, J.E.2
Chrunyk, B.3
-
121
-
-
0038627550
-
Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
-
Pina IC, Gautschi JT, Wang G et al (2003) Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. J Org Chem 68:3866-3873.
-
(2003)
J Org Chem
, vol.68
, pp. 3866-3873
-
-
Pina, I.C.1
Gautschi, J.T.2
Wang, G.3
-
122
-
-
0023293040
-
Microtubules containing acetylated a-tubulin in mammalian cells in culture
-
Piperno G, LeDizet M, Chang X (1987) Microtubules containing acetylated a-tubulin in mammalian cells in culture. J Cell Biol 104:289-302.
-
(1987)
J Cell Biol
, vol.104
, pp. 289-302
-
-
Piperno, G.1
LeDizet, M.2
Chang, X.3
-
123
-
-
4143083971
-
Regulation at multiple levels of NF-QB-mediated transactivation by protein acetylation
-
Quivy V, Van Lint C (2004) Regulation at multiple levels of NF-QB-mediated transactivation by protein acetylation. Biochem Pharmacol 68:1221-1229.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1221-1229
-
-
Quivy, V.1
Van Lint, C.2
-
124
-
-
0345734267
-
Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells
-
Rahmani M, Yu C, Dai Y et al (2003) Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. Cancer Res 63:8420-8427.
-
(2003)
Cancer Res
, vol.63
, pp. 8420-8427
-
-
Rahmani, M.1
Yu, C.2
Dai, Y.3
-
125
-
-
0000317446
-
A new group of potent inducers of differentiation in murine erythroleukemia cells
-
Reuben RC, Wife RL, Breslow R, Rifkind RA, Marks PA (1976) A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A 73:862-866.
-
(1976)
Proc Natl Acad Sci U S A
, vol.73
, pp. 862-866
-
-
Reuben, R.C.1
Wife, R.L.2
Breslow, R.3
Rifkind, R.A.4
Marks, P.A.5
-
126
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
Richon VM, Webb Y, Merger R et al (1996) Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci U S A 93:5705-5708.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
-
127
-
-
67349095775
-
Development of vorinostat: Current applications and future perspectives for cancer therapy
-
Richon VM, Garcia-Vargas J, Hardwick JS (2009) Development of vorinostat: current applications and future perspectives for cancer therapy. Cancer Lett 280:201-210.
-
(2009)
Cancer Lett
, vol.280
, pp. 201-210
-
-
Richon, V.M.1
Garcia-vargas, J.2
Hardwick, J.S.3
-
128
-
-
42349091446
-
Role of the aggresome pathway in cancer: Targeting histone deacetylase 6-dependent protein degradation
-
Rodriguez-Gonzalez A, Lin T, Ikeda AK, Simms-Waldrip T, Fu C, Sakamoto KM (2008) Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation. Cancer Res 68:2557-2560.
-
(2008)
Cancer Res
, vol.68
, pp. 2557-2560
-
-
Rodriguez-gonzalez, A.1
Lin, T.2
Ikeda, A.K.3
Simms-waldrip, T.4
Fu, C.5
Sakamoto, K.M.6
-
129
-
-
33646354640
-
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
-
Ropero S, Fraga MF, Ballestar E et al (2006) A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet 38:566-569.
-
(2006)
Nat Genet
, vol.38
, pp. 566-569
-
-
Ropero, S.1
Fraga, M.F.2
Ballestar, E.3
-
130
-
-
46249115065
-
Transforming pathways unleashed by a HDAC2 mutation in human cancer
-
Ropero S, Ballestar E, Alaminos M, Arango D, Schwartz S Jr, Esteller M (2008) Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene 27:4008-4012.
-
(2008)
Oncogene
, vol.27
, pp. 4008-4012
-
-
Ropero, S.1
Ballestar, E.2
Alaminos, M.3
Arango, D.4
Schwartz, S.5
Esteller, M.6
-
131
-
-
77953289094
-
Structural basis for sirtuin function: What we know and what we don't
-
Sanders BD, Jackson B, Marmorstein R (2010) Structural basis for sirtuin function: what we know and what we don't. Biochim Biophys Acta 1804:1604-1616.
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 1604-1616
-
-
Sanders, B.D.1
Jackson, B.2
Marmorstein, R.3
-
132
-
-
4644314055
-
Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin A after intraperitoneal administration to mice
-
Sanderson L, Taylor GW, Aboagye EO et al (2004) Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin A after intraperitoneal administration to mice. Drug Metab Dispos 32:1132-1138.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1132-1138
-
-
Sanderson, L.1
Taylor, G.W.2
Aboagye, E.O.3
-
133
-
-
45549095066
-
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
-
Schuetz A, Min J, Allali-Hassani A et al (2008) Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J Biol Chem 283:11355-11363.
-
(2008)
J Biol Chem
, vol.283
, pp. 11355-11363
-
-
Schuetz, A.1
Min, J.2
Allali-hassani, A.3
-
134
-
-
33846014703
-
An acetylation site in the middle domain of Hsp90 regulates chaperone function
-
Scroggins BT, Robzyk K, Wang D et al (2007) An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell 25:151-159.
-
(2007)
Mol Cell
, vol.25
, pp. 151-159
-
-
Scroggins, B.T.1
Robzyk, K.2
Wang, D.3
-
135
-
-
33746035691
-
Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors
-
Shah MH, Binkley P, Chan K et al (2006) Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors. Clin Cancer Res 12:3997-4003.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3997-4003
-
-
Shah, M.H.1
Binkley, P.2
Chan, K.3
-
136
-
-
77956636838
-
Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistance
-
Shao W, Growney JD, Feng Y et al (2010) Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: defining molecular mechanisms of resistance. Int J Cancer 127:2199-2208.
-
(2010)
Int J Cancer
, vol.127
, pp. 2199-2208
-
-
Shao, W.1
Growney, J.D.2
Feng, Y.3
-
138
-
-
0028299638
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination
-
Shigematsu N, Ueda H, Takase S, Tanaka H (1994) FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination. J Antibiot 47:311-314.
-
(1994)
J Antibiot
, vol.47
, pp. 311-314
-
-
Shigematsu, N.1
Ueda, H.2
Takase, S.3
Tanaka, H.4
-
139
-
-
0029347704
-
Synthesis and cellular characterization of the detransformation agent, (-)-depudecin
-
Shimada J, Kwon HJ, Sawamura M, Schreiber S (1995) Synthesis and cellular characterization of the detransformation agent, (-)-depudecin. Chem Biol 2:517-525.
-
(1995)
Chem Biol
, vol.2
, pp. 517-525
-
-
Shimada, J.1
Kwon, H.J.2
Sawamura, M.3
Schreiber, S.4
-
140
-
-
0030569401
-
Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum
-
Singh SB, Zink DL, Polishook JD et al (1996) Apicidins: novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum. Tetrahedron Lett 37:8077-8080.
-
(1996)
Tetrahedron Lett
, vol.37
, pp. 8077-8080
-
-
Singh, S.B.1
Zink, D.L.2
Polishook, J.D.3
-
141
-
-
0035817996
-
Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions
-
Singh SB, Zink DL, Liesch JM et al (2001) Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Org Lett 3:2815-2818.
-
(2001)
Org Lett
, vol.3
, pp. 2815-2818
-
-
Singh, S.B.1
Zink, D.L.2
Liesch, J.M.3
-
142
-
-
85028545574
-
DNA methyltransferase inhibitors
-
Sippl W, Jung M (2009) DNA methyltransferase inhibitors. Methods Princ Med Chem 42:163-183.
-
(2009)
Methods Princ Med Chem
, vol.42
, pp. 163-183
-
-
Sippl, W.1
Jung, M.2
-
143
-
-
59349115177
-
Chemical mechanisms of histone lysine and arginine modifications
-
Smith BC, Denu JM (2009) Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta 1789:45-57.
-
(2009)
Biochim Biophys Acta
, vol.1789
, pp. 45-57
-
-
Smith, B.C.1
Denu, J.M.2
-
144
-
-
3142562372
-
Structural snapshots of human HDAC8 provide insights into the Class I histone deacetylases
-
Somoza JR, Skene RJ, Katz BA et al (2004) Structural snapshots of human HDAC8 provide insights into the Class I histone deacetylases. Structure 12:1325-1334.
-
(2004)
Structure
, vol.12
, pp. 1325-1334
-
-
Somoza, J.R.1
Skene, R.J.2
Katz, B.A.3
-
145
-
-
21044447215
-
Increased expression of histone deacetylase 2 is found in human gastric cancer
-
Song J, Noh JH, Lee JH et al (2005) Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS 113:264-268.
-
(2005)
APMIS
, vol.113
, pp. 264-268
-
-
Song, J.1
Noh, J.H.2
Lee, J.H.3
-
146
-
-
70349780606
-
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
-
Spannhoff A, Hauser A, Heinke R, Sippl W, Jung M (2009) The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors. ChemMedChem 42:1568-1582.
-
(2009)
ChemMedChem
, vol.42
, pp. 1568-1582
-
-
Spannhoff, A.1
Hauser, A.2
Heinke, R.3
Sippl, W.4
Jung, M.5
-
147
-
-
0016334991
-
Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptide
-
Stähelin H, Trippmacher A (1974) Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptide. Eur J Cancer 103:801-808.
-
(1974)
Eur J Cancer
, vol.103
, pp. 801-808
-
-
Stähelin, H.1
Trippmacher, A.2
-
148
-
-
51149102710
-
Trypan blue exclusion test of cell viability
-
A.3B.1-A.3B.2
-
Strober W (2001) Trypan blue exclusion test of cell viability. Curr Protoc Immunol Appendix 3:A.3B.1-A.3B.2.
-
(2001)
Curr Protoc Immunol Appendix
, vol.3
-
-
Strober, W.1
-
149
-
-
0003019001
-
Induction of erythroid differentiation in murine virus infected erythroleukemia cells by highly polar compounds
-
Tanaka M, Levy J, Terada M, Breslow R, Rifkind RA, Marks PA (1975) Induction of erythroid differentiation in murine virus infected erythroleukemia cells by highly polar compounds. Proc Natl Acad Sci U S A 72:1003-1006.
-
(1975)
Proc Natl Acad Sci U S A
, vol.72
, pp. 1003-1006
-
-
Tanaka, M.1
Levy, J.2
Terada, M.3
Breslow, R.4
Rifkind, R.A.5
Marks, P.A.6
-
150
-
-
43049163953
-
Acetylation is indispensable for p53 activation
-
Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008) Acetylation is indispensable for p53 activation. Cell 133:612-626.
-
(2008)
Cell
, vol.133
, pp. 612-626
-
-
Tang, Y.1
Zhao, W.2
Chen, Y.3
Zhao, Y.4
Gu, W.5
-
151
-
-
0033603555
-
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator
-
Tanner KG, Trievel RC, Kuoi M et al (1999) Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator. J Biol Chem 274:18157-18160.
-
(1999)
J Biol Chem
, vol.274
, pp. 18157-18160
-
-
Tanner, K.G.1
Trievel, R.C.2
Kuoi, M.3
-
152
-
-
39049135494
-
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp
-
Taori K, Paul VJ, Luesch H (2008) Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc 130:1806-1807.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 1806-1807
-
-
Taori, K.1
Paul, V.J.2
Luesch, H.3
-
153
-
-
0029795991
-
Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function
-
Taunton J, Collins JL, Schreiber SL (1996a) Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. J Am Chem Soc 118:10412-10422.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 10412-10422
-
-
Taunton, J.1
Collins, J.L.2
Schreiber, S.L.3
-
154
-
-
0029932598
-
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
-
Taunton J, Hassig CA, Schreiber SL (1996b) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
-
(1996)
Science
, vol.272
, pp. 408-411
-
-
Taunton, J.1
Hassig, C.A.2
Schreiber, S.L.3
-
155
-
-
77955661449
-
Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation
-
Teng Y, Iuchi K, Iwasa E et al (2010) Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation. Bioorg Med Chem Lett 20:5085-5088.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 5085-5088
-
-
Teng, Y.1
Iuchi, K.2
Iwasa, E.3
-
156
-
-
69949090550
-
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
-
Tessier P, Smil DV, Wahhab A et al (2009) Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett 19:5684-5688.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5684-5688
-
-
Tessier, P.1
Smil, D.V.2
Wahhab, A.3
-
157
-
-
79953127793
-
Next generation histone deacetylase inhibitors: The answer to the search for optimized epigenetic therapies?
-
Thaler F, Minucci S (2011) Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? Expert Opin Drug Discov 6:393-404.
-
(2011)
Expert Opin Drug Discov
, vol.6
, pp. 393-404
-
-
Thaler, F.1
Minucci, S.2
-
158
-
-
64549104648
-
The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase
-
Tibodeau JD, Benson LM, Isham CR, Owen WG, Bible KC (2009) The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal 11:1097-1106.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 1097-1106
-
-
Tibodeau, J.D.1
Benson, L.M.2
Isham, C.R.3
Owen, W.G.4
Bible, K.C.5
-
159
-
-
0028258610
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity
-
Ueda H, Nakajima H, Hori Y et al (1994a) FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot 47:301-310.
-
(1994)
J Antibiot
, vol.47
, pp. 301-310
-
-
Ueda, H.1
Nakajima, H.2
Hori, Y.3
-
160
-
-
0028267278
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968 III. Antitumor activities on experimental tumors in mice
-
Ueda H, Manda T, Matsumoto S et al (1994b) FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968 III. Antitumor activities on experimental tumors in mice. J Antibiot 47:315-324.
-
(1994)
J Antibiot
, vol.47
, pp. 315-324
-
-
Ueda, H.1
Manda, T.2
Matsumoto, S.3
-
161
-
-
0035698217
-
New trichostatin derivative, trichostatin RK, from Streptomyces sp. RK98-A74
-
Uekia M, Teruya T, Nie L, Usamib R, Yoshida M, Osada H (2001) New trichostatin derivative, trichostatin RK, from Streptomyces sp. RK98-A74. J Antibiot 54:1093-1095.
-
(2001)
J Antibiot
, vol.54
, pp. 1093-1095
-
-
Uekia, M.1
Teruya, T.2
Nie, L.3
Usamib, R.4
Yoshida, M.5
Osada, H.6
-
162
-
-
0020519166
-
Studies on WF-3161, a new antitumor antibiotic
-
Umehara K, Nakahara K, Kiyoto S et al (1983) Studies on WF-3161, a new antitumor antibiotic. J Antibiot 36:478-483.
-
(1983)
J Antibiot
, vol.36
, pp. 478-483
-
-
Umehara, K.1
Nakahara, K.2
Kiyoto, S.3
-
163
-
-
6344222799
-
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
-
Vannini A, Volpari C, Filocamo G et al (2004) Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc Natl Acad Sci U S A 101:15064-15069.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15064-15069
-
-
Vannini, A.1
Volpari, C.2
Filocamo, G.3
-
164
-
-
32944478995
-
Sulforhodamine B assay and chemosensitivity
-
Voigt W (2005) Sulforhodamine B assay and chemosensitivity. Methods Mol Med 110:39-48.
-
(2005)
Methods Mol Med
, vol.110
, pp. 39-48
-
-
Voigt, W.1
-
165
-
-
0038491354
-
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305
-
Wang Y, Tsay Y, Chin-Ming Tan B, Lo W, Lee S (2003) Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. J Biol Chem 278:25568-25576.
-
(2003)
J Biol Chem
, vol.278
, pp. 25568-25576
-
-
Wang, Y.1
Tsay, Y.2
Chin-ming Tan, B.3
Lo, W.4
Lee, S.5
-
166
-
-
0037253808
-
A fluorogenic histone deacetylase assay well suited for high-throughput activity screening
-
Wegener D, Wirsching F, Riester D, Schwienhorst A (2003) A fluorogenic histone deacetylase assay well suited for high-throughput activity screening. Chem Biol 10:61-68.
-
(2003)
Chem Biol
, vol.10
, pp. 61-68
-
-
Wegener, D.1
Wirsching, F.2
Riester, D.3
Schwienhorst, A.4
-
167
-
-
34147198467
-
Synthetic lethal screen identification of chemosensitizer loci in cancer cells
-
Whitehurst AW, Bodemann BO, Cardenas J et al (2007) Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446:815-819.
-
(2007)
Nature
, vol.446
, pp. 815-819
-
-
Whitehurst, A.W.1
Bodemann, B.O.2
Cardenas, J.3
-
168
-
-
33744956666
-
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
-
Wilson AJ, Byun DS, Popova N et al (2006) Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J Biol Chem 281:13548-13558.
-
(2006)
J Biol Chem
, vol.281
, pp. 13548-13558
-
-
Wilson, A.J.1
Byun, D.S.2
Popova, N.3
-
169
-
-
61849144810
-
HDAC family: What are the cancer relevant targets?
-
Witt O, Deubzer HE, Oehme I (2009) HDAC family: what are the cancer relevant targets? Cancer Lett 277:8-21.
-
(2009)
Cancer Lett
, vol.277
, pp. 8-21
-
-
Witt, O.1
Deubzer, H.E.2
Oehme, I.3
-
170
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood JG, Rogina B, Lavu S et al (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430:686-689.
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
-
171
-
-
0037421847
-
Structure and catalytic mechanism of the human histone methyltransferase SET7/9
-
Xiao B, Jing C, Wilson JR et al (2003) Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421:652-656.
-
(2003)
Nature
, vol.421
, pp. 652-656
-
-
Xiao, B.1
Jing, C.2
Wilson, J.R.3
-
172
-
-
23044440043
-
Chemoresistance to depsipeptide FK228 [(E)-(1 S, 4 S, 10 S, 21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines
-
Xiao JJ, Huang Y, Dai Z et al (2005) Chemoresistance to depsipeptide FK228 [(E)-(1 S, 4 S, 10 S, 21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. J Pharmacol Exp Ther 314:467-475.
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 467-475
-
-
Xiao, J.J.1
Huang, Y.2
Dai, Z.3
-
173
-
-
66449099052
-
p53 acetylation is crucial for its transcriptionindependent proapoptotic functions
-
Yamaguchi H, Woods NT, Piluso LG et al (2009) p53 acetylation is crucial for its transcriptionindependent proapoptotic functions. J Biol Chem 284:11171-11183.
-
(2009)
J Biol Chem
, vol.284
, pp. 11171-11183
-
-
Yamaguchi, H.1
Woods, N.T.2
Piluso, L.G.3
-
174
-
-
34249881352
-
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
-
Yang M, Culhane JC, Szewczuk LM et al (2007) Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol 14:535-539.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 535-539
-
-
Yang, M.1
Culhane, J.C.2
Szewczuk, L.M.3
-
175
-
-
49649108912
-
Role of acetylation and extracellular location of heat shock protein 90A in tumor cell invasion
-
Yang Y, Rao R, Shen J et al (2008) Role of acetylation and extracellular location of heat shock protein 90A in tumor cell invasion. Cancer Res 68:4833-4842.
-
(2008)
Cancer Res
, vol.68
, pp. 4833-4842
-
-
Yang, Y.1
Rao, R.2
Shen, J.3
-
176
-
-
46049100010
-
Total synthesis and molecular target of largazole, a histone deacetylase inhibitor
-
Ying Y, Taori K, Kim H, Hong J, Luesch H (2008) Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc 130:8455-8459.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 8455-8459
-
-
Ying, Y.1
Taori, K.2
Kim, H.3
Hong, J.4
Luesch, H.5
-
177
-
-
0024996768
-
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
-
Yoshida M, Kijima M, Akita M, Beppu T (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265:17174-17179.
-
(1990)
J Biol Chem
, vol.265
, pp. 17174-17179
-
-
Yoshida, M.1
Kijima, M.2
Akita, M.3
Beppu, T.4
-
178
-
-
0024265086
-
Phase I trial and clinical pharmacological evaluation of hexamethylene bisacetamide administration by ten-day continuous intravenous infusion at twenty-eight-day intervals
-
Young CW, Fanucchi MP, Walsh TD et al (1988) Phase I trial and clinical pharmacological evaluation of hexamethylene bisacetamide administration by ten-day continuous intravenous infusion at twenty-eight-day intervals. Cancer Res 48:7304-7309.
-
(1988)
Cancer Res
, vol.48
, pp. 7304-7309
-
-
Young, C.W.1
Fanucchi, M.P.2
Walsh, T.D.3
-
179
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan Z, Guan Y, Chatterjee D, Chin YE (2005) Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307:269-273.
-
(2005)
Science
, vol.307
, pp. 269-273
-
-
Yuan, Z.1
Guan, Y.2
Chatterjee, D.3
Chin, Y.E.4
-
180
-
-
78649329125
-
Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans
-
Zarse K, Schmeisser S, Birringer M, Falk E, Schmoll D, Ristow M (2010) Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. Horm Metab Res 42:837-839.
-
(2010)
Horm Metab Res
, vol.42
, pp. 837-839
-
-
Zarse, K.1
Schmeisser, S.2
Birringer, M.3
Falk, E.4
Schmoll, D.5
Ristow, M.6
-
181
-
-
0037904754
-
Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides
-
Zhang X, Cheng X (2003) Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure 11:509-520.
-
(2003)
Structure
, vol.11
, pp. 509-520
-
-
Zhang, X.1
Cheng, X.2
-
182
-
-
0042164227
-
Structural basis for the product specificity of histone lysine methyltransferases
-
Zhang X, Yang Z, Khan SI et al (2003a) Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell 12:177-185.
-
(2003)
Mol Cell
, vol.12
, pp. 177-185
-
-
Zhang, X.1
Yang, Z.2
Khan, S.I.3
-
183
-
-
0037416151
-
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
-
Zhang Y, Li N, Caron C et al (2003b) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J 22:1168-1179.
-
(2003)
EMBO J
, vol.22
, pp. 1168-1179
-
-
Zhang, Y.1
Li, N.2
Caron, C.3
-
184
-
-
33645230001
-
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21Waf1/Cip1
-
Zhao Y, Lu S, Wu L et al (2006) Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21Waf1/Cip1. Mol Cell Biol 26:2782-2790.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2782-2790
-
-
Zhao, Y.1
Lu, S.2
Wu, L.3
-
185
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S, Xu W, Wenqing J et al (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327:1000-1004.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Wenqing, J.3
|