메뉴 건너뛰기




Volumn 18, Issue 10, 2007, Pages 1157-1164

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells

Author keywords

DNMT; Lung cancer; Metastasis; Mithramycin A

Indexed keywords

DNA METHYLTRANSFERASE; MESSENGER RNA; MITHRAMYCIN; MITHRAMYCIN A; SLIT2 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

EID: 34748837820     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3282a215e9     Document Type: Article
Times cited : (60)

References (48)
  • 1
    • 13644266447 scopus 로고    scopus 로고
    • Dormant hypermethylated tumour suppressor genes: Questions and answers
    • Esteller M. Dormant hypermethylated tumour suppressor genes: questions and answers. J Pathol 2005; 205:172-180.
    • (2005) J Pathol , vol.205 , pp. 172-180
    • Esteller, M.1
  • 2
    • 0242539836 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Momparler RL. Cancer epigenetics. Oncogene 2003; 22:6479-6483.
    • (2003) Oncogene , vol.22 , pp. 6479-6483
    • Momparler, R.L.1
  • 3
    • 0037455915 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer initiation and progression
    • Nephew KP, Huang TH. Epigenetic gene silencing in cancer initiation and progression. Cancer Lett 2003; 190:125-133.
    • (2003) Cancer Lett , vol.190 , pp. 125-133
    • Nephew, K.P.1    Huang, T.H.2
  • 5
    • 3242711153 scopus 로고    scopus 로고
    • 5′ cytosine-phospho-guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer
    • Hsu HS, Wang YC, Tseng RC, Chang JW, Chen JT, Shih CM, et al. 5′ cytosine-phospho-guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer. Clin Cancer Res 2004; 10:4734-4741.
    • (2004) Clin Cancer Res , vol.10 , pp. 4734-4741
    • Hsu, H.S.1    Wang, Y.C.2    Tseng, R.C.3    Chang, J.W.4    Chen, J.T.5    Shih, C.M.6
  • 6
    • 85047688675 scopus 로고    scopus 로고
    • Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
    • Wang YC, Lu YP, Tseng RC, Lin RK, Chang JW, Chen JT, et al. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J Clin Invest 2003; 111:887-895.
    • (2003) J Clin Invest , vol.111 , pp. 887-895
    • Wang, Y.C.1    Lu, Y.P.2    Tseng, R.C.3    Lin, R.K.4    Chang, J.W.5    Chen, J.T.6
  • 7
    • 0037224722 scopus 로고    scopus 로고
    • DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
    • Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 2003; 33:61-65.
    • (2003) Nat Genet , vol.33 , pp. 61-65
    • Robert, M.F.1    Morin, S.2    Beaulieu, N.3    Gauthier, F.4    Chute, I.C.5    Barsalou, A.6
  • 8
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer
    • Lin RK, Hsu HS, Chang JW, Chen CY, Chen JT, Wang YC. Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer. Lung Cancer 2007; 55:205-213.
    • (2007) Lung Cancer , vol.55 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3    Chen, C.Y.4    Chen, J.T.5    Wang, Y.C.6
  • 9
    • 0141995080 scopus 로고    scopus 로고
    • Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas
    • Girault I, Tozlu S, Lidereau R, Bieche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 2003; 9:4415-4422.
    • (2003) Clin Cancer Res , vol.9 , pp. 4415-4422
    • Girault, I.1    Tozlu, S.2    Lidereau, R.3    Bieche, I.4
  • 10
    • 0037598752 scopus 로고    scopus 로고
    • Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    • Saito Y, Kanai Y, Nakagawa T, Sakamoto M, Saito H, Ishii H, et al. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer 2003; 105:527-532.
    • (2003) Int J Cancer , vol.105 , pp. 527-532
    • Saito, Y.1    Kanai, Y.2    Nakagawa, T.3    Sakamoto, M.4    Saito, H.5    Ishii, H.6
  • 11
    • 0036186811 scopus 로고    scopus 로고
    • DNA methyltransferase and demethylase in human prostate cancer
    • Patra SK, Patra A, Zhao H, Dahiya R. DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 2002; 33:163-171.
    • (2002) Mol Carcinog , vol.33 , pp. 163-171
    • Patra, S.K.1    Patra, A.2    Zhao, H.3    Dahiya, R.4
  • 13
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 1994; 91:11797-11801.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 15
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, Mannari R, Thomas D, Faderl S, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004; 103:1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6
  • 16
    • 0017801980 scopus 로고
    • Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine
    • Beisler JA. Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine. J Med Chem 1978; 21:204-208.
    • (1978) J Med Chem , vol.21 , pp. 204-208
    • Beisler, J.A.1
  • 17
    • 33646595937 scopus 로고    scopus 로고
    • Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: A National Cancer Institute of Canada Clinical Trials Group investigational new drug study
    • Winquist E, Knox J, Ayoub JP, Wood L, Wainman N, Reid GK, et al. Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs 2006; 24:159-167.
    • (2006) Invest New Drugs , vol.24 , pp. 159-167
    • Winquist, E.1    Knox, J.2    Ayoub, J.P.3    Wood, L.4    Wainman, N.5    Reid, G.K.6
  • 18
    • 0142231968 scopus 로고    scopus 로고
    • Structure and function of 'metalloantibiotics'
    • Ming LJ. Structure and function of 'metalloantibiotics'. Med Res Rev 2003; 23:697-762.
    • (2003) Med Res Rev , vol.23 , pp. 697-762
    • Ming, L.J.1
  • 19
    • 0028500719 scopus 로고
    • Interaction of mithramycin with isolated GC and CG sites
    • Carpenter ML, Cassidy SA, Fox KR. Interaction of mithramycin with isolated GC and CG sites. J Mol Recognit 1994; 7:189-197.
    • (1994) J Mol Recognit , vol.7 , pp. 189-197
    • Carpenter, M.L.1    Cassidy, S.A.2    Fox, K.R.3
  • 20
    • 0022429777 scopus 로고
    • Investigations into the sequence-selective binding of mithramycin and related ligands to DNA
    • Fox KR, Howarth NR. Investigations into the sequence-selective binding of mithramycin and related ligands to DNA. Nucleic Acids Res 1985; 13:8695-8714.
    • (1985) Nucleic Acids Res , vol.13 , pp. 8695-8714
    • Fox, K.R.1    Howarth, N.R.2
  • 22
    • 0037260759 scopus 로고    scopus 로고
    • The diagnosis and management of hypercalcaemia
    • Koh LK. The diagnosis and management of hypercalcaemia. Ann Acad Med Singapore 2003; 32:129-139.
    • (2003) Ann Acad Med Singapore , vol.32 , pp. 129-139
    • Koh, L.K.1
  • 23
    • 0028925590 scopus 로고
    • Long-term follow-up of stage III testicular carcinoma treated with mithramycin (plicamycin)
    • Kennedy BJ, Torkelson JL. Long-term follow-up of stage III testicular carcinoma treated with mithramycin (plicamycin). Med Pediatr Oncol 1995; 24:327-328.
    • (1995) Med Pediatr Oncol , vol.24 , pp. 327-328
    • Kennedy, B.J.1    Torkelson, J.L.2
  • 24
    • 0022891311 scopus 로고
    • Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea
    • Koller CA, Miller DM. Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea. N Engl J Med 1986; 315:1433-1438.
    • (1986) N Engl J Med , vol.315 , pp. 1433-1438
    • Koller, C.A.1    Miller, D.M.2
  • 25
    • 2942559254 scopus 로고    scopus 로고
    • The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF)
    • Duverger V, Murphy AM, Sheehan D, England K, Cotter TG, Hayes I, et al. The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). Br J Cancer 2004; 90:2025-2031.
    • (2004) Br J Cancer , vol.90 , pp. 2025-2031
    • Duverger, V.1    Murphy, A.M.2    Sheehan, D.3    England, K.4    Cotter, T.G.5    Hayes, I.6
  • 27
    • 0038164676 scopus 로고    scopus 로고
    • Inhibition of c-src transcription by mithramycin: Structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target
    • Remsing LL, Bahadori HR, Carbone GM, McGuffie EM, Catapano CV, Rohr J. Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target. Biochemistry 2003; 42:8313-8324.
    • (2003) Biochemistry , vol.42 , pp. 8313-8324
    • Remsing, L.L.1    Bahadori, H.R.2    Carbone, G.M.3    McGuffie, E.M.4    Catapano, C.V.5    Rohr, J.6
  • 28
    • 0031226737 scopus 로고    scopus 로고
    • Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
    • Chu YW, Yang PC, Yang SC, Shyu YC, Hendrix MJ, Wu R, et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997; 17:353-360.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 353-360
    • Chu, Y.W.1    Yang, P.C.2    Yang, S.C.3    Shyu, Y.C.4    Hendrix, M.J.5    Wu, R.6
  • 30
    • 0037108922 scopus 로고    scopus 로고
    • SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers
    • Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER, et al. SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res 2002; 62:5874-5880.
    • (2002) Cancer Res , vol.62 , pp. 5874-5880
    • Dallol, A.1    Da Silva, N.F.2    Viacava, P.3    Minna, J.D.4    Bieche, I.5    Maher, E.R.6
  • 31
    • 18644384743 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: Loss of expression correlates with poor prognosis
    • Darnton SJ, Hardie LJ, Muc RS, Wild CP, Casson AG. Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: loss of expression correlates with poor prognosis. Int J Cancer 2005; 115:351-358.
    • (2005) Int J Cancer , vol.115 , pp. 351-358
    • Darnton, S.J.1    Hardie, L.J.2    Muc, R.S.3    Wild, C.P.4    Casson, A.G.5
  • 32
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001; 97:1172-1179.
    • (2001) Blood , vol.97 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3    Akashi, K.4    Fukumaki, Y.5    Niho, Y.6
  • 33
    • 31044432347 scopus 로고    scopus 로고
    • Selective regulation of MMP and TIMP mRNA levels in tree shrew sclera during minus lens compensation and recovery
    • Siegwart JT Jr, Norton TT. Selective regulation of MMP and TIMP mRNA levels in tree shrew sclera during minus lens compensation and recovery. Invest Ophthalmol Vis Sci 2005; 46:3484-3492.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3484-3492
    • Siegwart Jr, J.T.1    Norton, T.T.2
  • 34
    • 3242876311 scopus 로고    scopus 로고
    • BLAST: At the core of a powerful and diverse set of sequence analysis tools
    • McGinnis S, Madden TL. BLAST: at the core of a powerful and diverse set of sequence analysis tools. Nucleic Acids Res 2004; 32:W20-W25.
    • (2004) Nucleic Acids Res , vol.32
    • McGinnis, S.1    Madden, T.L.2
  • 35
    • 0035863850 scopus 로고    scopus 로고
    • Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA
    • Dong A, Yoder JA, Zhang X, Zhou L, Bestor TH, Cheng X. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res 2001; 29:439-448.
    • (2001) Nucleic Acids Res , vol.29 , pp. 439-448
    • Dong, A.1    Yoder, J.A.2    Zhang, X.3    Zhou, L.4    Bestor, T.H.5    Cheng, X.6
  • 36
    • 0029068629 scopus 로고
    • The crystal structure of HaeIII methyltransferase convalently complexed to DNA: An extrahelical cytosine and rearranged base pairing
    • Reinisch KM, Chen L, Verdine GL, Lipscomb WN. The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell 1995; 82:143-153.
    • (1995) Cell , vol.82 , pp. 143-153
    • Reinisch, K.M.1    Chen, L.2    Verdine, G.L.3    Lipscomb, W.N.4
  • 37
  • 41
    • 0034084855 scopus 로고    scopus 로고
    • The three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: Evidence for an interaction between the E saccharides
    • Keniry MA, Owen EA, Shafer RH. The three-dimensional structure of the 4:1 mithramycin:d(ACCCGGGT)(2) complex: evidence for an interaction between the E saccharides. Biopolymers 2000; 54:104-114.
    • (2000) Biopolymers , vol.54 , pp. 104-114
    • Keniry, M.A.1    Owen, E.A.2    Shafer, R.H.3
  • 42
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B, Boy RG, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 2005; 65:6305-6311.
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Boy, R.G.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6
  • 43
    • 0036318310 scopus 로고    scopus 로고
    • Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins
    • Kishikawa S, Murata T, Kimura H, Shiota K, Yokoyama KK. Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins. Eur J Biochem 2002; 269:2961-2970.
    • (2002) Eur J Biochem , vol.269 , pp. 2961-2970
    • Kishikawa, S.1    Murata, T.2    Kimura, H.3    Shiota, K.4    Yokoyama, K.K.5
  • 44
    • 11244325724 scopus 로고    scopus 로고
    • Inhibition of p53-mediated transcriptional responses by mithramycin A
    • Koutsodontis G, Kardassis D. Inhibition of p53-mediated transcriptional responses by mithramycin A. Oncogene 2004; 23:9190-9200.
    • (2004) Oncogene , vol.23 , pp. 9190-9200
    • Koutsodontis, G.1    Kardassis, D.2
  • 45
    • 0030778285 scopus 로고    scopus 로고
    • Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis
    • Faraldo ML, Rodrigo I, Behrens J, Birchmeier W, Cano A. Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis. Mol Carcinog 1997; 20:33-47.
    • (1997) Mol Carcinog , vol.20 , pp. 33-47
    • Faraldo, M.L.1    Rodrigo, I.2    Behrens, J.3    Birchmeier, W.4    Cano, A.5
  • 47
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea A, Fraga MF, Espada J, Esteller M. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res 2003; 63:4984-4989.
    • (2003) Cancer Res , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 48
    • 18944383889 scopus 로고    scopus 로고
    • 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    • Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 2005; 25:4727-4741.
    • (2005) Mol Cell Biol , vol.25 , pp. 4727-4741
    • Ghoshal, K.1    Datta, J.2    Majumder, S.3    Bai, S.4    Kutay, H.5    Motiwala, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.