Mechanism of p300 specific histone acetyltransferase inhibition by small molecules

Journal of Medicinal Chemistry

Volumn 52, Issue 2, 2009, Pages 267-277

  Arif, M ^a   Pradhan, Suman Kalyan ^b   Thanuja, G R ^a   Vedamurthy, B M ^a   Agrawal, Shipra ^c   Dasgupta, Dipak ^b   Kundu, Tapas K ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

^c Institute of Bioinformatics and Applied Biotechnology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GARCINOL; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE INHIBITOR; ISOGARCINOL; LTK 14; PROTEIN P300; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; HISTONE ACETYLTRANSFERASE PCAF; P300-CBP-ASSOCIATED FACTOR; TERPENE;

ARTICLE; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; GARCINIA; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DOCKING; MOLECULAR INTERACTION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; CALORIMETRY; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; KINETICS; SPECTROFLUOROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

CALORIMETRY; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; P300-CBP TRANSCRIPTION FACTORS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; TERPENES;

EID: 60549106446     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800657z     Document Type: Article

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