Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

Molecular Cell

Volumn 8, Issue 6, 2001, Pages 1243-1254

  Barlev, Nickolai A ^a   Liu, Lin ^a   Chehab, Nabil H ^a   Mansfield, Kyle ^a   Harris, Kimberly G ^a   Halazonetis, Thanos D ^a   Berger, Shelley L ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA; HISTONE ACETYLTRANSFERASE; PROTEIN CBP; PROTEIN DERIVATIVE; PROTEIN P21; PROTEIN P53; PROTEIN TRRAP; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; CELL CYCLE G1 PHASE; CHROMATIN; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IRRADIATION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STABILITY; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

EID: 0035694469     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00414-2     Document Type: Article

References (52)

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4. The many HATs of transcription coactivators
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14. Mdm2 promotes the rapid degradation of p53
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29. Binding and modulation of p53 by p300/CBP coactivators
30. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
31. Deacetylation of p53 modulates its effect on cell growth and apoptosis
32. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo
33. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
34. The transcriptional coactivators p300 and CBP are histone acetyltransferases
35. Analysis of chromatin structure by in vivo formaldehyde cross-linking
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41. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
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47. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily
48. Surfing the p53 network
49. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
50. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
51. An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants
52. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1