A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Nature Genetics

Volumn 38, Issue 5, 2006, Pages 566-569

  Ropero, Santiago ^a   Fraga, Mario F ^a   Ballestar, Esteban ^a   Hamelin, Richard ^b   Yamamoto, Hiroyuki ^c   Boix Chornet, Manuel ^a   Caballero, Rosalia ^a   Alaminos, Miguel ^a   Setien, Fernando ^a   Paz, Maria F ^a   Herranz, Michel ^a   Palacios, Jose ^a   Arango, Diego ^d   Orntoft, Torben F ^e   Aaltonen, Lauri A ^f   Schwartz Jr , Simó ^d   Esteller, Manel ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b FONDATION JEAN DAUSSET CEPH   (France)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 2;

APOPTOSIS; ARTICLE; CELL CYCLE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FRAMESHIFT MUTATION; GENE; GENE MUTATION; HDAC2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, CAPILLARY; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; REPRESSOR PROTEINS; RNA, SMALL INTERFERING;

EID: 33646354640     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1773     Document Type: Article

References (20)

1. Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428 (2002).
2. Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143-153 (2004).
3. Fraga, M.F. et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37, 391-400 (2005).
4. Seligson, D.B. et al. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435, 1262-1266 (2005).
5. Jenuwein, T. & Allis, C.D. Translating the histone code. Science 293, 1074-1080 (2001).
6. Bannister, A.J. & Kouzarides, T. Histone methylation: recognizing the methyl mark. Methods Enzymol. 376, 269-288 (2004).
7. Gayther, S.A. et al. Mutations truncating the EP300 acetylase in human cancers. Nat. Genet. 24, 300-303 (2000).
8. Ionov, Y., Matsui, S. & Cowell, J.K. A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability. Proc. Natl. Acad. Sci. USA 101, 1273-1278 (2004).
9. Lynch, H.T. & de la Chapelle, A. Hereditary colorectal cancer. N. Engl. J. Med. 348, 919-932 (2003).
10. Herman, J.G. et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95, 6870-6875 (1998).
11. Markowitz, S. et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268, 1336-1338 (1995).
12. Rampino, N. et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275, 967-969 (1997).
13. Marks, P.A. & Jiang, X. Histone deacetylase inhibitors in programmed cell death and cancer therapy. Cell Cycle 4, 549-551 (2005).
14. Archer, S.Y., Meng, S., Shei, A. & Hodin, R.A. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc. Natl. Acad. Sci. USA 95, 6791-6796 (1998).
15. Myzak, M.C. et al. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice. FASEB J. 20, 506-508 (2006).
16. Lagger, G. et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 21, 2672-2681 (2002).
17. Wang, D.F., Helquist, P., Wiech, N.L. & Wiest, O. Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases. J. Med. Chem. 48, 6936-6947 (2005).
18. Turner, B.M. & Fellows, G. Specific antibodies reveal ordered and cell-cycle-related use of histone-H4 acetylation sites in mammalian cells. Eur. J. Biochem. 179, 131-139 (1989).
19. Fraga, M.F. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 102, 10604-10609 (2005).
20. Espada, J. et al. Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J. Biol. Chem. 279, 37175-37184 (2004).