Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5684-5688

  Tessier, Pierre ^a   Smil, David V ^a   Wahhab, Amal ^a   Leit, Silvana ^a   Rahil, Jubrail ^a   Li, Zuomei ^a   Déziel, Robert ^a   Besterman, Jeffrey M ^a  

^a METHYLGENE INC   (Canada)

Author keywords

HDAC class IIa selective inhibitors; HDAC inhibitors; HDAC4 inhibitors; HDAC5 inhibitors; HDAC7 inhibitors

Indexed keywords

HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; N HYDROXY 2,2 DIPHENYLACETAMIDE; N HYDROXY 9H XANTHENE 9 CARBOXAMIDE; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; SUBSTITUTION REACTION;

CELL LINE; DIPHENYLACETIC ACIDS; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHENES;

EID: 69949090550     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.010     Document Type: Article

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