Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula

Journal of Organic Chemistry

Volumn 74, Issue 15, 2009, Pages 5267-5275

  Gutiérrez, Marcelino ^a   Andrianasolo, Eric H ^b   Shin, Won Kyo ^d   Goeger, Douglas E ^b   Yokochi, Alexandre ^c   Schemies, Jörg ^e   Jung, Manfred ^e   France, Dennis ^f   Cornell Kennon, Susan ^f   Lee, Eun ^d   Gerwick, William H ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c Oregon State University   (United States)

^d Seoul National University   (South Korea)

^e UNIVERSITY OF FREIBURG   (Germany)

^f NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL EQUATIONS; CHIRAL HPLC; MADAGASCAR; MARINE CYANOBACTERIUM; NATURAL PRODUCTS; SELECTIVE INHIBITORS; STRUCTURE ELUCIDATION; TOTAL SYNTHESIS;

ACIDS; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS; OPTICAL ROTATION; STEREOCHEMISTRY;

COMPLEXATION;

HYDROLASE INHIBITOR; SIRTUIN 2; TANIKOLIDE DIMER; TANIKOLIDE SECO ACID; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHIRALITY; CYTOTOXICITY; DIMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; LYNGBYA MAJUSCULA; MASS FRAGMENTOGRAPHY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

CYANOBACTERIA; DIMERIZATION; ENZYME INHIBITORS; HUMANS; LACTONES; MADAGASCAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; SIRTUIN 2; STEREOISOMERISM;

EID: 68049096181     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo900578j     Document Type: Article

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