-
1
-
-
2942612843
-
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
-
W. An J. Kim R.G. Roeder Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 Cell 117 2004 735 748
-
(2004)
Cell
, vol.117
, pp. 735-748
-
-
An, W.1
Kim, J.2
Roeder, R.G.3
-
2
-
-
40549107989
-
Chromatin Immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo
-
O. Aparicio J.V. Geisberg K. Struhl Chromatin Immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo Curr. Protoc. Cell Biol. 17 2004 7.1 7.23
-
(2004)
Curr. Protoc. Cell Biol.
, vol.17
, pp. 7.1-7.23
-
-
Aparicio, O.1
Geisberg, J.V.2
Struhl, K.3
-
3
-
-
22844432020
-
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in Mdm2 SNP309 homozygous cells
-
N.C. Arva T.R. Gopen K.E. Talbott L.E. Campbell A. Chicas D.E. White G.L. Bond A.J. Levine J. Bargonetti A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in Mdm2 SNP309 homozygous cells J. Biol. Chem. 280 2005 26776 26787
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26776-26787
-
-
Arva, N.C.1
Gopen, T.R.2
Talbott, K.E.3
Campbell, L.E.4
Chicas, A.5
White, D.E.6
Bond, G.L.7
Levine, A.J.8
Bargonetti, J.9
-
4
-
-
0033020147
-
Regulation of p53 function and stability by phosphorylation
-
M. Ashcroft M.H. Kubbutat K.H. Vousden Regulation of p53 function and stability by phosphorylation Mol. Cell. Biol. 19 1999 1751 1758
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1751-1758
-
-
Ashcroft, M.1
Kubbutat, M.H.2
Vousden, K.H.3
-
5
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
M. Ashcroft Y. Taya K.H. Vousden Stress signals utilize multiple pathways to stabilize p53 Mol. Cell. Biol. 20 2000 3224 3233
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
7
-
-
34249299791
-
The complex language of chromatin regulation during transcript
-
S.L. Berger The complex language of chromatin regulation during transcript Nature 447 2007 407 412
-
(2007)
Nature
, vol.447
, pp. 407-412
-
-
Berger, S.L.1
-
8
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
K. Berns E.M. Hijmans J. Mullenders T.R. Brummelkamp A. Velds M. Heimerikx R.M. Kerkhoven M. Madiredjo W. Nijkamp B. Weigelt A large-scale RNAi screen in human cells identifies new components of the p53 pathway Nature 428 2004 431 437
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madiredjo, M.8
Nijkamp, W.9
Weigelt, B.10
-
9
-
-
0033522143
-
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
-
C. Blattner E. Tobiasch M. Litfen H.J. Rahmsdorf P. Herrlich DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation Oncogene 18 1999 1723 1732
-
(1999)
Oncogene
, vol.18
, pp. 1723-1732
-
-
Blattner, C.1
Tobiasch, E.2
Litfen, M.3
Rahmsdorf, H.J.4
Herrlich, P.5
-
10
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
-
C.L. Brooks W. Gu Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation Curr. Opin. Cell Biol. 15 2003 164 171
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
11
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
C.L. Brooks W. Gu p53 ubiquitination: Mdm2 and beyond Mol. Cell 21 2006 307 315
-
(2006)
Mol. Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
12
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
D. Chen N. Kon M. Li W. Zhang J. Qin W. Gu ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor Cell 121 2005 1071 1083
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
Kon, N.2
Li, M.3
Zhang, W.4
Qin, J.5
Gu, W.6
-
13
-
-
34548049032
-
Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation
-
S. Das L. Raj B. Zhao A. Bernstein S.A. Aaronson S.W. Lee Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation Cell 130 2007 624 637
-
(2007)
Cell
, vol.130
, pp. 624-637
-
-
Das, S.1
Raj, L.2
Zhao, B.3
Bernstein, A.4
Aaronson, S.A.5
Lee, S.W.6
-
14
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
D. Dornan I. Wertz H. Shimizu D. Arnott G.D. Frantz P. Dowd K. O'Rourke H. Koeppen V.M. Dixit The ubiquitin ligase COP1 is a critical negative regulator of p53 Nature 429 2004 86 92
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
Arnott, D.4
Frantz, G.D.5
Dowd, P.6
O'Rourke, K.7
Koeppen, H.8
Dixit, V.M.9
-
15
-
-
0033572746
-
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
-
N. Dumaz D.W. Meek Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2 EMBO J. 18 1999 7002 7010
-
(1999)
EMBO J.
, vol.18
, pp. 7002-7010
-
-
Dumaz, N.1
Meek, D.W.2
-
16
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
W.S. el-Deiry T. Tokino V.E. Velculescu D.B. Levy R. Parsons J.M. Trent D. Lin W.E. Mercer K.W. Kinzler B. Vogelstein WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
el-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
17
-
-
0034881964
-
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
-
J.M. Espinosa B.M. Emerson Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment Mol. Cell 8 2001 57 69
-
(2001)
Mol. Cell
, vol.8
, pp. 57-69
-
-
Espinosa, J.M.1
Emerson, B.M.2
-
18
-
-
20744448187
-
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
-
L. Feng T. Lin H. Uranishi W. Gu Y. Xu Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity Mol. Cell. Biol. 25 2005 5389 5395
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5389-5395
-
-
Feng, L.1
Lin, T.2
Uranishi, H.3
Gu, W.4
Xu, Y.5
-
19
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
W. Gu R.G. Roeder Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 90 1997 595 606
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
20
-
-
0035868964
-
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
-
A. Ito C.H. Lai X. Zhao S. Saito M.H. Hamilton E. Appella T.P. Yao p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2 EMBO J. 20 2001 1331 1340
-
(2001)
EMBO J.
, vol.20
, pp. 1331-1340
-
-
Ito, A.1
Lai, C.H.2
Zhao, X.3
Saito, S.4
Hamilton, M.H.5
Appella, E.6
Yao, T.P.7
-
21
-
-
0035839136
-
Translating the histone code
-
T. Jenuwein C.D. Allis Translating the histone code Science 293 2001 1074 1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
22
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
S.N. Jones A.E. Roe L.A. Donehower A. Bradley Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 Nature 378 1995 206 208
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
24
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
J.E. Kim J. Chen Z. Lou DBC1 is a negative regulator of SIRT1 Nature 451 2008 583 586
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
25
-
-
33646817028
-
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
-
C.D. Knights J. Catania S. Di Giovanni S. Muratoglu R. Perez A. Swartzbeck A.A. Quong X. Zhang T. Beerman R.G. Pestell M.L. Avantaggiati Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate J. Cell Biol. 173 2006 533 544
-
(2006)
J. Cell Biol.
, vol.173
, pp. 533-544
-
-
Knights, C.D.1
Catania, J.2
Di Giovanni, S.3
Muratoglu, S.4
Perez, R.5
Swartzbeck, A.6
Quong, A.A.7
Zhang, X.8
Beerman, T.9
Pestell, R.G.10
Avantaggiati, M.L.11
-
26
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
K.A. Krummel C.J. Lee F. Toledo G.M. Wahl The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation Proc. Natl. Acad. Sci. USA 102 2005 10188 10193
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
Wahl, G.M.4
-
27
-
-
33749013398
-
Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation
-
R. Kulikov M. Winter C. Blattner Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation J. Biol. Chem. 281 2006 28575 28583
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 28575-28583
-
-
Kulikov, R.1
Winter, M.2
Blattner, C.3
-
28
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
R.P. Leng Y. Lin W. Ma H. Wu B. Lemmers S. Chung J.M. Parant G. Lozano R. Hakem S. Benchimol Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation Cell 112 2003 779 791
-
(2003)
Cell
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
Wu, H.4
Lemmers, B.5
Chung, S.6
Parant, J.M.7
Lozano, G.8
Hakem, R.9
Benchimol, S.10
-
30
-
-
0034676439
-
Deacetylation of p53 modulates its effect on cell growth and apoptosis
-
J. Luo F. Su D. Chen A. Shiloh W. Gu Deacetylation of p53 modulates its effect on cell growth and apoptosis Nature 408 2000 377 381
-
(2000)
Nature
, vol.408
, pp. 377-381
-
-
Luo, J.1
Su, F.2
Chen, D.3
Shiloh, A.4
Gu, W.5
-
31
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
J. Luo A.Y. Nikolaev S. Imai D. Chen F. Su A. Shiloh L. Guarente W. Gu Negative control of p53 by Sir2alpha promotes cell survival under stress Cell 107 2001 137 148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
34
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
D. Michael M. Oren The p53-Mdm2 module and the ubiquitin system Semin. Cancer Biol. 13 2003 49 58
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
35
-
-
8844232663
-
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
-
N. Minsky M. Oren The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression Mol. Cell 16 2004 631 639
-
(2004)
Mol. Cell
, vol.16
, pp. 631-639
-
-
Minsky, N.1
Oren, M.2
-
36
-
-
0028823020
-
Rescue of early embryonic lethality in Mdm2-deficient mice by deletion of p53
-
R. Montes de Oca Luna D.S. Wagner G. Lozano Rescue of early embryonic lethality in Mdm2-deficient mice by deletion of p53 Nature 378 1995 203 206
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
37
-
-
33745194153
-
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription
-
S. Ohkubo T. Tanaka Y. Taya K. Kitazato C. Prives Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription J. Biol. Chem. 281 2006 16943 16950
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16943-16950
-
-
Ohkubo, S.1
Tanaka, T.2
Taya, Y.3
Kitazato, K.4
Prives, C.5
-
40
-
-
33846551682
-
ASPP: a new family of oncogenes and tumour suppressor genes
-
A. Sullivan X. Lu ASPP: a new family of oncogenes and tumour suppressor genes Br. J. Cancer 96 2007 196 200
-
(2007)
Br. J. Cancer
, vol.96
, pp. 196-200
-
-
Sullivan, A.1
Lu, X.2
-
42
-
-
34547956843
-
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
-
T. Tanaka S. Ohkubo I. Tatsuno C. Prives hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes Cell 130 2007 638 650
-
(2007)
Cell
, vol.130
, pp. 638-650
-
-
Tanaka, T.1
Ohkubo, S.2
Tatsuno, I.3
Prives, C.4
-
43
-
-
33845668241
-
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
-
Y. Tang J. Luo W. Zhang W. Gu Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis Mol. Cell 24 2006 827 839
-
(2006)
Mol. Cell
, vol.24
, pp. 827-839
-
-
Tang, Y.1
Luo, J.2
Zhang, W.3
Gu, W.4
-
44
-
-
11144224782
-
Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
-
T. Thompson C. Tovar H. Yang D. Carvajal B.T. Vu Q. Xu G.M. Wahl D.C. Heimbrook L.T. Vassilev Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis J. Biol. Chem. 279 2004 53015 53022
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53015-53022
-
-
Thompson, T.1
Tovar, C.2
Yang, H.3
Carvajal, D.4
Vu, B.T.5
Xu, Q.6
Wahl, G.M.7
Heimbrook, D.C.8
Vassilev, L.T.9
-
45
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
-
C. Tovar J. Rosinski Z. Filipovic B. Higgins K. Kolinsky H. Hilton X. Zhao B.T. Vu W. Qing K. Packman Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy Proc. Natl. Acad. Sci. USA 103 2006 1888 1893
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
-
46
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
L.T. Vassilev MDM2 inhibitors for cancer therapy Trends Mol. Med. 13 2007 23 31
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
47
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
H. Vaziri S.K. Dessain E. Ng Eaton S.I. Imai R.A. Frye T.K. Pandita L. Guarente R.A. Weinberg hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149 159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
53
-
-
33746012703
-
Mutational analysis of the p53 core domain L1 loop
-
A. Zupnick C. Prives Mutational analysis of the p53 core domain L1 loop J. Biol. Chem. 281 2006 20464 20473
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 20464-20473
-
-
Zupnick, A.1
Prives, C.2
|