-
1
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S., and Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer 6 (2006) 38-51
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
2
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3 (2002) 415-428
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
3
-
-
0035755974
-
Histone deacetylases and cancer: causes and therapies
-
Marks P., Rifkind R.A., Richon V.M., Breslow R., Miller T., and Kelly W.K. Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 1 (2001) 194-202
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
5
-
-
0035316847
-
Histone acetylation and the cell-cycle in cancer
-
Wang C., Fu M., Mani S., Wadler S., Senderowicz A.M., and Pestell R.G. Histone acetylation and the cell-cycle in cancer. Front. Biosci. 6 (2001) 610-629
-
(2001)
Front. Biosci.
, vol.6
, pp. 610-629
-
-
Wang, C.1
Fu, M.2
Mani, S.3
Wadler, S.4
Senderowicz, A.M.5
Pestell, R.G.6
-
6
-
-
0032546017
-
Role of the histone deacetylase complex in acute promyelocytic leukaemia
-
Lin R.J., Nagy L., Inoue S., Shao W., Miller Jr. W.H., and Evans R.M. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391 (1998) 811-814
-
(1998)
Nature
, vol.391
, pp. 811-814
-
-
Lin, R.J.1
Nagy, L.2
Inoue, S.3
Shao, W.4
Miller Jr., W.H.5
Evans, R.M.6
-
7
-
-
0033305547
-
Nuclear receptor coregulators: cellular and molecular biology
-
McKenna N.J., Lanz R.B., and O'Malley B.W. Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 20 (1999) 321-344
-
(1999)
Endocr. Rev.
, vol.20
, pp. 321-344
-
-
McKenna, N.J.1
Lanz, R.B.2
O'Malley, B.W.3
-
8
-
-
0030923519
-
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
-
Dhordain P., Albagli O., Lin R.J., Ansieau S., Quief S., Leutz A., Kerckaert J.P., Evans R.M., and Leprince D. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94 (1997) 10762-10767
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10762-10767
-
-
Dhordain, P.1
Albagli, O.2
Lin, R.J.3
Ansieau, S.4
Quief, S.5
Leutz, A.6
Kerckaert, J.P.7
Evans, R.M.8
Leprince, D.9
-
9
-
-
1842578986
-
Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis
-
Gregoretti I.V., Lee Y.M., and Goodson H.V. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J. Mol. Biol. 338 (2004) 17-31
-
(2004)
J. Mol. Biol.
, vol.338
, pp. 17-31
-
-
Gregoretti, I.V.1
Lee, Y.M.2
Goodson, H.V.3
-
10
-
-
0036386359
-
Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation
-
Lehrmann H., Pritchard L.L., and Harel-Bellan A. Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv. Cancer Res. 86 (2002) 41-65
-
(2002)
Adv. Cancer Res.
, vol.86
, pp. 41-65
-
-
Lehrmann, H.1
Pritchard, L.L.2
Harel-Bellan, A.3
-
11
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
-
Marks P.A., and Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25 (2007) 84-90
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
12
-
-
39749127166
-
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men
-
Yang X.J., and Seto E. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat. Rev. Mol. Cell. Biol. 9 (2008) 206-218
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 206-218
-
-
Yang, X.J.1
Seto, E.2
-
13
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273 (2000) 793-798
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
15
-
-
34548416641
-
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
-
Boyault C., Zhang Y., Fritah S., Caron C., Gilquin B., Kwon S.H., Garrido C., Yao T.P., Vourc'h C., Matthias P., and Khochbin S. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 (2007) 2172-2181
-
(2007)
Genes Dev.
, vol.21
, pp. 2172-2181
-
-
Boyault, C.1
Zhang, Y.2
Fritah, S.3
Caron, C.4
Gilquin, B.5
Kwon, S.H.6
Garrido, C.7
Yao, T.P.8
Vourc'h, C.9
Matthias, P.10
Khochbin, S.11
-
16
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y., Kovacs J.J., McLaurin A., Vance J.M., Ito A., and Yao T.P. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115 (2003) 727-738
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
17
-
-
44649158252
-
HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions
-
Valenzuela-Fernandez A., Cabrero J.R., Serrador J.M., and Sanchez-Madrid F. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol. 18 (2008) 291-297
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 291-297
-
-
Valenzuela-Fernandez, A.1
Cabrero, J.R.2
Serrador, J.M.3
Sanchez-Madrid, F.4
-
18
-
-
37549010715
-
Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis
-
Gao Y.S., Hubbert C.C., Lu J., Lee Y.S., Lee J.Y., and Yao T.P. Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. Mol. Cell. Biol. 27 (2007) 8637-8647
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8637-8647
-
-
Gao, Y.S.1
Hubbert, C.C.2
Lu, J.3
Lee, Y.S.4
Lee, J.Y.5
Yao, T.P.6
-
19
-
-
34447315270
-
HDAC6 modulates cell motility by altering the acetylation level of cortactin
-
Zhang X., Yuan Z., Zhang Y., Yong S., Salas-Burgos A., Koomen J., Olashaw N., Parsons J.T., Yang X.J., Dent S.R., Yao T.P., Lane W.S., and Seto E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol. Cell 27 (2007) 197-213
-
(2007)
Mol. Cell
, vol.27
, pp. 197-213
-
-
Zhang, X.1
Yuan, Z.2
Zhang, Y.3
Yong, S.4
Salas-Burgos, A.5
Koomen, J.6
Olashaw, N.7
Parsons, J.T.8
Yang, X.J.9
Dent, S.R.10
Yao, T.P.11
Lane, W.S.12
Seto, E.13
-
20
-
-
34547684065
-
HDAC6 at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
-
Boyault C., Sadoul K., Pabion M., and Khochbin S. HDAC6 at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 26 (2007) 5468-5476
-
(2007)
Oncogene
, vol.26
, pp. 5468-5476
-
-
Boyault, C.1
Sadoul, K.2
Pabion, M.3
Khochbin, S.4
-
21
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs J.J., Murphy P.J., Gaillard S., Zhao X., Wu J.T., Nicchitta C.V., Yoshida M., Toft D.O., Pratt W.B., and Yao T.P. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18 (2005) 601-607
-
(2005)
Mol. Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.P.10
-
22
-
-
23844522610
-
Histone deacetylase inhibitors: latest developments, trends and prospects
-
Moradei O., Maroun C.R., Paquin I., and Vaisburg A. Histone deacetylase inhibitors: latest developments, trends and prospects. Curr. Med. Chem. Anticancer Agents 5 (2005) 529-560
-
(2005)
Curr. Med. Chem. Anticancer Agents
, vol.5
, pp. 529-560
-
-
Moradei, O.1
Maroun, C.R.2
Paquin, I.3
Vaisburg, A.4
-
23
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
Richon V.M., Emiliani S., Verdin E., Webb Y., Breslow R., Rifkind R.A., and Marks P.A. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc. Natl. Acad. Sci. USA 95 (1998) 3003-3007
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
Webb, Y.4
Breslow, R.5
Rifkind, R.A.6
Marks, P.A.7
-
24
-
-
23344440655
-
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
-
Carter T.A., Wodicka L.M., Shah N.P., Velasco A.M., Fabian M.A., Treiber D.K., Milanov Z.V., Atteridge C.E., Biggs III W.H., Edeen P.T., Floyd M., Ford J.M., Grotzfeld R.M., Herrgard S., Insko D.E., Mehta S.A., Patel H.K., Pao W., Sawyers C.L., Varmus H., Zarrinkar P.P., and Lockhart D.J. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc. Natl. Acad. Sci. USA 102 (2005) 11011-11016
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11011-11016
-
-
Carter, T.A.1
Wodicka, L.M.2
Shah, N.P.3
Velasco, A.M.4
Fabian, M.A.5
Treiber, D.K.6
Milanov, Z.V.7
Atteridge, C.E.8
Biggs III, W.H.9
Edeen, P.T.10
Floyd, M.11
Ford, J.M.12
Grotzfeld, R.M.13
Herrgard, S.14
Insko, D.E.15
Mehta, S.A.16
Patel, H.K.17
Pao, W.18
Sawyers, C.L.19
Varmus, H.20
Zarrinkar, P.P.21
Lockhart, D.J.22
more..
-
25
-
-
0003019001
-
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds
-
Tanaka M., Levy J., Terada M., Breslow R., Rifkind R.A., and Marks P.A. Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds. Proc. Natl. Acad. Sci. USA 72 (1975) 1003-1006
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 1003-1006
-
-
Tanaka, M.1
Levy, J.2
Terada, M.3
Breslow, R.4
Rifkind, R.A.5
Marks, P.A.6
-
26
-
-
0000317446
-
A new group of potent inducers of differentiation in murine erythroleukemia cells
-
Reuben R.C., Wife R.L., Breslow R., Rifkind R.A., and Marks P.A. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 73 (1976) 862-866
-
(1976)
Proc. Natl. Acad. Sci. USA
, vol.73
, pp. 862-866
-
-
Reuben, R.C.1
Wife, R.L.2
Breslow, R.3
Rifkind, R.A.4
Marks, P.A.5
-
27
-
-
0025954615
-
Potent cytodifferentiating agents related to hexamethylenebisacetamide
-
Breslow R., Jursic B., Yan Z.F., Friedman E., Leng L., Ngo L., Rifkind R.A., and Marks P.A. Potent cytodifferentiating agents related to hexamethylenebisacetamide. Proc. Natl. Acad. Sci. USA 88 (1991) 5542-5546
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 5542-5546
-
-
Breslow, R.1
Jursic, B.2
Yan, Z.F.3
Friedman, E.4
Leng, L.5
Ngo, L.6
Rifkind, R.A.7
Marks, P.A.8
-
28
-
-
1542588471
-
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
-
Richon V.M., Webb Y., Merger R., Sheppard T., Jursic B., Ngo L., Civoli F., Breslow R., Rifkind R.A., and Marks P.A. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc. Natl. Acad. Sci. USA 93 (1996) 5705-5708
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5705-5708
-
-
Richon, V.M.1
Webb, Y.2
Merger, R.3
Sheppard, T.4
Jursic, B.5
Ngo, L.6
Civoli, F.7
Breslow, R.8
Rifkind, R.A.9
Marks, P.A.10
-
29
-
-
0034665124
-
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo
-
Butler L.M., Agus D.B., Scher H.I., Higgins B., Rose A., Cordon-Cardo C., Thaler H.T., Rifkind R.A., Marks P.A., and Richon V.M. Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 60 (2000) 5165-5170
-
(2000)
Cancer Res.
, vol.60
, pp. 5165-5170
-
-
Butler, L.M.1
Agus, D.B.2
Scher, H.I.3
Higgins, B.4
Rose, A.5
Cordon-Cardo, C.6
Thaler, H.T.7
Rifkind, R.A.8
Marks, P.A.9
Richon, V.M.10
-
30
-
-
21244464349
-
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
-
Kelly W.K., O'Connor O.A., Krug L.M., Chiao J.H., Heaney M., Curley T., MacGregore-Cortelli B., Tong W., Secrist J.P., Schwartz L., Richardson S., Chu E., Olgac S., Marks P.A., Scher H., and Richon V.M. Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J. Clin. Oncol. 23 (2005) 3923-3931
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 3923-3931
-
-
Kelly, W.K.1
O'Connor, O.A.2
Krug, L.M.3
Chiao, J.H.4
Heaney, M.5
Curley, T.6
MacGregore-Cortelli, B.7
Tong, W.8
Secrist, J.P.9
Schwartz, L.10
Richardson, S.11
Chu, E.12
Olgac, S.13
Marks, P.A.14
Scher, H.15
Richon, V.M.16
-
31
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M., Talpur R., Ni X., Zhang C., Hazarika P., Kelly C., Chiao J.H., Reilly J.F., Ricker J.L., Richon V.M., and Frankel S.R. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109 (2007) 31-39
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
Chiao, J.H.7
Reilly, J.F.8
Ricker, J.L.9
Richon, V.M.10
Frankel, S.R.11
-
32
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen E.A., Kim Y.H., Kuzel T.M., Pacheco T.R., Foss F.M., Parker S., Frankel S.R., Chen C., Ricker J.L., Arduino J.M., and Duvic M. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 25 (2007) 3109-3115
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
Kim, Y.H.2
Kuzel, T.M.3
Pacheco, T.R.4
Foss, F.M.5
Parker, S.6
Frankel, S.R.7
Chen, C.8
Ricker, J.L.9
Arduino, J.M.10
Duvic, M.11
-
33
-
-
67349238303
-
a north central cancer treatment group study
-
Phase II trial of vorinostat (SAHA) in recurrent glioblastoma multiforme:, in press
-
E. Galanis, K.A. Jaeckle, M.J. Maurer, J.A. Reid, M. Ames, J.S. Hardwick, J.F. Reilly, A. Loboda, M. Nebozhyn, V.R. Fantin, V.M. Richon, B. Scheithauer, C. Giannini, J. Zweibel, J.C. Buckner, Phase II trial of vorinostat (SAHA) in recurrent glioblastoma multiforme: a north central cancer treatment group study, J. Clin. Oncol., in press.
-
J. Clin. Oncol
-
-
Galanis, E.1
Jaeckle, K.A.2
Maurer, M.J.3
Reid, J.A.4
Ames, M.5
Hardwick, J.S.6
Reilly, J.F.7
Loboda, A.8
Nebozhyn, M.9
Fantin, V.R.10
Richon, V.M.11
Scheithauer, B.12
Giannini, C.13
Zweibel, J.14
Buckner, J.C.15
-
34
-
-
38949096781
-
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
-
Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W.G., Faderl S., Koller C., Morris G., Rosner G., Loboda A., Fantin V.R., Randolph S.S., Hardwick J.S., Reilly J.F., Chen C., Ricker J.L., Secrist J.P., Richon V.M., Frankel S.R., and Kantarjian H.M. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 111 (2008) 1060-1066
-
(2008)
Blood
, vol.111
, pp. 1060-1066
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
Ferrajoli, A.4
Cortes, J.5
Wierda, W.G.6
Faderl, S.7
Koller, C.8
Morris, G.9
Rosner, G.10
Loboda, A.11
Fantin, V.R.12
Randolph, S.S.13
Hardwick, J.S.14
Reilly, J.F.15
Chen, C.16
Ricker, J.L.17
Secrist, J.P.18
Richon, V.M.19
Frankel, S.R.20
Kantarjian, H.M.21
more..
-
35
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
-
Richon V.M., Sandhoff T.W., Rifkind R.A., and Marks P.A. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl. Acad. Sci. USA 97 (2000) 10014-10019
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
36
-
-
0033604457
-
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
-
Vrana J.A., Decker R.H., Johnson C.R., Wang Z., Jarvis W.D., Richon V.M., Ehinger M., Fisher P.B., and Grant S. Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 18 (1999) 7016-7025
-
(1999)
Oncogene
, vol.18
, pp. 7016-7025
-
-
Vrana, J.A.1
Decker, R.H.2
Johnson, C.R.3
Wang, Z.4
Jarvis, W.D.5
Richon, V.M.6
Ehinger, M.7
Fisher, P.B.8
Grant, S.9
-
37
-
-
33644814867
-
Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action
-
Zhang C., Richon V., Ni X., Talpur R., and Duvic M. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. J. Invest. Dermatol. 125 (2005) 1045-1052
-
(2005)
J. Invest. Dermatol.
, vol.125
, pp. 1045-1052
-
-
Zhang, C.1
Richon, V.2
Ni, X.3
Talpur, R.4
Duvic, M.5
-
38
-
-
0037642133
-
Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5
-
Rascle A., Johnston J.A., and Amati B. Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5. Mol. Cell. Biol. 23 (2003) 4162-4173
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4162-4173
-
-
Rascle, A.1
Johnston, J.A.2
Amati, B.3
-
39
-
-
0037450634
-
STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta
-
Xu M., Nie L., Kim S.H., and Sun X.H. STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta. EMBO J. 22 (2003) 893-904
-
(2003)
EMBO J.
, vol.22
, pp. 893-904
-
-
Xu, M.1
Nie, L.2
Kim, S.H.3
Sun, X.H.4
-
40
-
-
45549083112
-
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma
-
Fantin V.R., Loboda A., Paweletz C.P., Hendrickson R.C., Pierce J.W., Roth J.A., Li L., Gooden F., Korenchuk S., Hou X.S., Harrington E.A., Randolph S., Reilly J.F., Ware C.M., Kadin M.E., Frankel S.R., and Richon V.M. Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. Cancer Res. 68 (2008) 3785-3794
-
(2008)
Cancer Res.
, vol.68
, pp. 3785-3794
-
-
Fantin, V.R.1
Loboda, A.2
Paweletz, C.P.3
Hendrickson, R.C.4
Pierce, J.W.5
Roth, J.A.6
Li, L.7
Gooden, F.8
Korenchuk, S.9
Hou, X.S.10
Harrington, E.A.11
Randolph, S.12
Reilly, J.F.13
Ware, C.M.14
Kadin, M.E.15
Frankel, S.R.16
Richon, V.M.17
-
41
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W., and Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90 (1997) 595-606
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
42
-
-
33749006252
-
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha
-
Qian D.Z., Kachhap S.K., Collis S.J., Verheul H.M., Carducci M.A., Atadja P., and Pili R. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res. 66 (2006) 8814-8821
-
(2006)
Cancer Res.
, vol.66
, pp. 8814-8821
-
-
Qian, D.Z.1
Kachhap, S.K.2
Collis, S.J.3
Verheul, H.M.4
Carducci, M.A.5
Atadja, P.6
Pili, R.7
-
43
-
-
0034899511
-
Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis
-
Williams R.J. Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. Expert Opin. Invest. Drugs 10 (2001) 1571-1573
-
(2001)
Expert Opin. Invest. Drugs
, vol.10
, pp. 1571-1573
-
-
Williams, R.J.1
-
44
-
-
0032168984
-
The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
-
Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., and Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. USA 95 (1998) 10493-10498
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10493-10498
-
-
Ferreira, R.1
Magnaghi-Jaulin, L.2
Robin, P.3
Harel-Bellan, A.4
Trouche, D.5
-
45
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert C., Guardiola A., Shao R., Kawaguchi Y., Ito A., Nixon A., Yoshida M., Wang X.F., and Yao T.P. HDAC6 is a microtubule-associated deacetylase. Nature 417 (2002) 455-458
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
Kawaguchi, Y.4
Ito, A.5
Nixon, A.6
Yoshida, M.7
Wang, X.F.8
Yao, T.P.9
-
46
-
-
52649133274
-
HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
-
Rao R., Fiskus W., Yang Y., Lee P., Joshi R., Fernandez P., Mandawat A., Atadja P., Bradner J.E., and Bhalla K. HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells. Blood 112 (2008) 1886-1893
-
(2008)
Blood
, vol.112
, pp. 1886-1893
-
-
Rao, R.1
Fiskus, W.2
Yang, Y.3
Lee, P.4
Joshi, R.5
Fernandez, P.6
Mandawat, A.7
Atadja, P.8
Bradner, J.E.9
Bhalla, K.10
-
48
-
-
34547864236
-
Histone deacetylase inhibitors: molecular mechanisms of action
-
Xu W.S., Parmigiani R.B., and Marks P.A. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26 (2007) 5541-5552
-
(2007)
Oncogene
, vol.26
, pp. 5541-5552
-
-
Xu, W.S.1
Parmigiani, R.B.2
Marks, P.A.3
-
49
-
-
0035577768
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells
-
Munster P.N., Troso-Sandoval T., Rosen N., Rifkind R., Marks P.A., and Richon V.M. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res. 61 (2001) 8492-8497
-
(2001)
Cancer Res.
, vol.61
, pp. 8492-8497
-
-
Munster, P.N.1
Troso-Sandoval, T.2
Rosen, N.3
Rifkind, R.4
Marks, P.A.5
Richon, V.M.6
-
50
-
-
0035189761
-
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
-
He L.Z., Tolentino T., Grayson P., Zhong S., Warrell Jr. R.P., Rifkind R.A., Marks P.A., Richon V.M., and Pandolfi P.P. Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. J. Clin. Invest. 108 (2001) 1321-1330
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1321-1330
-
-
He, L.Z.1
Tolentino, T.2
Grayson, P.3
Zhong, S.4
Warrell Jr., R.P.5
Rifkind, R.A.6
Marks, P.A.7
Richon, V.M.8
Pandolfi, P.P.9
-
51
-
-
21044449385
-
Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo
-
Eyupoglu I.Y., Hahnen E., Buslei R., Siebzehnrubl F.A., Savaskan N.E., Luders M., Trankle C., Wick W., Weller M., Fahlbusch R., and Blumcke I. Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo. J. Neurochem. 93 (2005) 992-999
-
(2005)
J. Neurochem.
, vol.93
, pp. 992-999
-
-
Eyupoglu, I.Y.1
Hahnen, E.2
Buslei, R.3
Siebzehnrubl, F.A.4
Savaskan, N.E.5
Luders, M.6
Trankle, C.7
Wick, W.8
Weller, M.9
Fahlbusch, R.10
Blumcke, I.11
-
52
-
-
0034297220
-
Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment
-
Huang L., and Pardee A.B. Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment. Mol. Med. 6 (2000) 849-866
-
(2000)
Mol. Med.
, vol.6
, pp. 849-866
-
-
Huang, L.1
Pardee, A.B.2
-
53
-
-
34250810709
-
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells
-
Kumagai T., Wakimoto N., Yin D., Gery S., Kawamata N., Takai N., Komatsu N., Chumakov A., Imai Y., and Koeffler H.P. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. Int. J. Cancer 121 (2007) 656-665
-
(2007)
Int. J. Cancer
, vol.121
, pp. 656-665
-
-
Kumagai, T.1
Wakimoto, N.2
Yin, D.3
Gery, S.4
Kawamata, N.5
Takai, N.6
Komatsu, N.7
Chumakov, A.8
Imai, Y.9
Koeffler, H.P.10
-
55
-
-
0037589018
-
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
-
Mitsiades N., Mitsiades C.S., Richardson P.G., McMullan C., Poulaki V., Fanourakis G., Schlossman R., Chauhan D., Munshi N.C., Hideshima T., Richon V.M., Marks P.A., and Anderson K.C. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood 101 (2003) 4055-4062
-
(2003)
Blood
, vol.101
, pp. 4055-4062
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
McMullan, C.4
Poulaki, V.5
Fanourakis, G.6
Schlossman, R.7
Chauhan, D.8
Munshi, N.C.9
Hideshima, T.10
Richon, V.M.11
Marks, P.A.12
Anderson, K.C.13
-
56
-
-
0035845541
-
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of bid and production of reactive oxygen species
-
Ruefli A.A., Ausserlechner M.J., Bernhard D., Sutton V.R., Tainton K.M., Kofler R., Smyth M.J., and Johnstone R.W. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of bid and production of reactive oxygen species. Proc. Natl. Acad. Sci. USA 98 (2001) 10833-10838
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10833-10838
-
-
Ruefli, A.A.1
Ausserlechner, M.J.2
Bernhard, D.3
Sutton, V.R.4
Tainton, K.M.5
Kofler, R.6
Smyth, M.J.7
Johnstone, R.W.8
-
57
-
-
12344330351
-
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
-
Sakajiri S., Kumagai T., Kawamata N., Saitoh T., Said J.W., and Koeffler H.P. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp. Hematol. 33 (2005) 53-61
-
(2005)
Exp. Hematol.
, vol.33
, pp. 53-61
-
-
Sakajiri, S.1
Kumagai, T.2
Kawamata, N.3
Saitoh, T.4
Said, J.W.5
Koeffler, H.P.6
-
58
-
-
85047699941
-
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
-
Deroanne C.F., Bonjean K., Servotte S., Devy L., Colige A., Clausse N., Blacher S., Verdin E., Foidart J.M., Nusgens B.V., and Castronovo V. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 21 (2002) 427-436
-
(2002)
Oncogene
, vol.21
, pp. 427-436
-
-
Deroanne, C.F.1
Bonjean, K.2
Servotte, S.3
Devy, L.4
Colige, A.5
Clausse, N.6
Blacher, S.7
Verdin, E.8
Foidart, J.M.9
Nusgens, B.V.10
Castronovo, V.11
-
59
-
-
0037052687
-
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells
-
Ruefli A.A., Bernhard D., Tainton K.M., Kofler R., Smyth M.J., and Johnstone R.W. Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells. Int. J. Cancer 99 (2002) 292-298
-
(2002)
Int. J. Cancer
, vol.99
, pp. 292-298
-
-
Ruefli, A.A.1
Bernhard, D.2
Tainton, K.M.3
Kofler, R.4
Smyth, M.J.5
Johnstone, R.W.6
-
60
-
-
0036323115
-
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors
-
Cohen L.A., Marks P.A., Rifkind R.A., Amin S., Desai D., Pittman B., and Richon V.M. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors. Anticancer Res. 22 (2002) 1497-1504
-
(2002)
Anticancer Res.
, vol.22
, pp. 1497-1504
-
-
Cohen, L.A.1
Marks, P.A.2
Rifkind, R.A.3
Amin, S.4
Desai, D.5
Pittman, B.6
Richon, V.M.7
-
61
-
-
0033367018
-
Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA)
-
Cohen L.A., Amin S., Marks P.A., Rifkind R.A., Desai D., and Richon V.M. Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA). Anticancer Res. 19 (1999) 4999-5005
-
(1999)
Anticancer Res.
, vol.19
, pp. 4999-5005
-
-
Cohen, L.A.1
Amin, S.2
Marks, P.A.3
Rifkind, R.A.4
Desai, D.5
Richon, V.M.6
-
62
-
-
0037236445
-
Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice
-
Desai D., Das A., Cohen L., el-Bayoumy K., and Amin S. Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice. Anticancer Res. 23 (2003) 499-503
-
(2003)
Anticancer Res.
, vol.23
, pp. 499-503
-
-
Desai, D.1
Das, A.2
Cohen, L.3
el-Bayoumy, K.4
Amin, S.5
-
63
-
-
34748877735
-
Inhibition of histone deacetylation: a strategy for tumor radiosensitization
-
Camphausen K., and Tofilon P.J. Inhibition of histone deacetylation: a strategy for tumor radiosensitization. J. Clin. Oncol. 25 (2007) 4051-4056
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 4051-4056
-
-
Camphausen, K.1
Tofilon, P.J.2
-
64
-
-
33846475536
-
Chromatin modifications and DNA double-strand breaks: the current state of play
-
Karagiannis T.C., and El Osta A. Chromatin modifications and DNA double-strand breaks: the current state of play. Leukemia 21 (2007) 195-200
-
(2007)
Leukemia
, vol.21
, pp. 195-200
-
-
Karagiannis, T.C.1
El Osta, A.2
-
65
-
-
33847677760
-
Histone deacetylase inhibitors, but not vincristine, cooperate with radiotherapy to induce cell death in medulloblastoma
-
Kumar K.S., Sonnemann J., Hong l.T., Buurman C., Adler F., Maass M., Volker U., and Beck J.F. Histone deacetylase inhibitors, but not vincristine, cooperate with radiotherapy to induce cell death in medulloblastoma. Anticancer Res. 27 (2007) 465-470
-
(2007)
Anticancer Res.
, vol.27
, pp. 465-470
-
-
Kumar, K.S.1
Sonnemann, J.2
Hong, l.T.3
Buurman, C.4
Adler, F.5
Maass, M.6
Volker, U.7
Beck, J.F.8
-
66
-
-
33646562250
-
Modulation of cellular radiation responses by histone deacetylase inhibitors
-
Karagiannis T.C., and El Osta A. Modulation of cellular radiation responses by histone deacetylase inhibitors. Oncogene 25 (2006) 3885-3893
-
(2006)
Oncogene
, vol.25
, pp. 3885-3893
-
-
Karagiannis, T.C.1
El Osta, A.2
-
67
-
-
33646944722
-
Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation
-
Zhang Y., Adachi M., Zou H., Hareyama M., Imai K., and Shinomura Y. Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 65 (2006) 859-866
-
(2006)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.65
, pp. 859-866
-
-
Zhang, Y.1
Adachi, M.2
Zou, H.3
Hareyama, M.4
Imai, K.5
Shinomura, Y.6
-
68
-
-
17844381019
-
Modulation of radiation response by histone deacetylase inhibition
-
Chinnaiyan P., Vallabhaneni G., Armstrong E., Huang S.M., and Harari P.M. Modulation of radiation response by histone deacetylase inhibition. Int. J. Radiat. Oncol. Biol. Phys. 62 (2005) 223-229
-
(2005)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.62
, pp. 223-229
-
-
Chinnaiyan, P.1
Vallabhaneni, G.2
Armstrong, E.3
Huang, S.M.4
Harari, P.M.5
-
69
-
-
28844502645
-
Rational design and development of radiation-sensitizing histone deacetylase inhibitors
-
Jung M., Kozikowski A., and Dritschilo A. Rational design and development of radiation-sensitizing histone deacetylase inhibitors. Chem. Biodivers. 2 (2005) 1452-1461
-
(2005)
Chem. Biodivers.
, vol.2
, pp. 1452-1461
-
-
Jung, M.1
Kozikowski, A.2
Dritschilo, A.3
-
70
-
-
33748360764
-
Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci
-
Munshi A., Tanaka T., Hobbs M.L., Tucker S.L., Richon V.M., and Meyn R.E. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol. Cancer Ther. 5 (2006) 1967-1974
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 1967-1974
-
-
Munshi, A.1
Tanaka, T.2
Hobbs, M.L.3
Tucker, S.L.4
Richon, V.M.5
Meyn, R.E.6
-
71
-
-
33645226815
-
Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells
-
Sonnemann J., Kumar K.S., Heesch S., Muller C., Hartwig C., Maass M., Bader P., and Beck J.F. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. Int. J. Oncol. 28 (2006) 755-766
-
(2006)
Int. J. Oncol.
, vol.28
, pp. 755-766
-
-
Sonnemann, J.1
Kumar, K.S.2
Heesch, S.3
Muller, C.4
Hartwig, C.5
Maass, M.6
Bader, P.7
Beck, J.F.8
-
72
-
-
0032530486
-
DNA damage activates p53 through a phosphorylation-acetylation cascade
-
Sakaguchi K., Herrera J.E., Saito S., Miki T., Bustin M., Vassilev A., Anderson C.W., and Appella E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12 (1998) 2831-2841
-
(1998)
Genes Dev.
, vol.12
, pp. 2831-2841
-
-
Sakaguchi, K.1
Herrera, J.E.2
Saito, S.3
Miki, T.4
Bustin, M.5
Vassilev, A.6
Anderson, C.W.7
Appella, E.8
-
73
-
-
0033615547
-
Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
-
Kim G.D., Choi Y.H., Dimtchev A., Jeong S.J., Dritschilo A., and Jung M. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J. Biol. Chem. 274 (1999) 31127-31130
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31127-31130
-
-
Kim, G.D.1
Choi, Y.H.2
Dimtchev, A.3
Jeong, S.J.4
Dritschilo, A.5
Jung, M.6
-
74
-
-
0030798245
-
Histone acetylation in chromatin structure and transcription
-
Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 389 (1997) 349-352
-
(1997)
Nature
, vol.389
, pp. 349-352
-
-
Grunstein, M.1
-
75
-
-
0032030770
-
Histone acetylation and transcriptional regulatory mechanisms
-
Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12 (1998) 599-606
-
(1998)
Genes Dev.
, vol.12
, pp. 599-606
-
-
Struhl, K.1
-
76
-
-
0242610850
-
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA
-
Kim M.S., Blake M., Baek J.H., Kohlhagen G., Pommier Y., and Carrier F. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 63 (2003) 7291-7300
-
(2003)
Cancer Res.
, vol.63
, pp. 7291-7300
-
-
Kim, M.S.1
Blake, M.2
Baek, J.H.3
Kohlhagen, G.4
Pommier, Y.5
Carrier, F.6
-
77
-
-
34447315913
-
Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid
-
Rikiishi H., Shinohara F., Sato T., Sato Y., Suzuki M., and Echigo S. Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. Int. J. Oncol. 30 (2007) 1181-1188
-
(2007)
Int. J. Oncol.
, vol.30
, pp. 1181-1188
-
-
Rikiishi, H.1
Shinohara, F.2
Sato, T.3
Sato, Y.4
Suzuki, M.5
Echigo, S.6
-
78
-
-
16544379283
-
Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid
-
Marchion D.C., Bicaku E., Daud A.I., Richon V., Sullivan D.M., and Munster P.N. Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid. J. Cell. Biochem. 92 (2004) 223-237
-
(2004)
J. Cell. Biochem.
, vol.92
, pp. 223-237
-
-
Marchion, D.C.1
Bicaku, E.2
Daud, A.I.3
Richon, V.4
Sullivan, D.M.5
Munster, P.N.6
-
79
-
-
18744408483
-
The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells
-
Ocker M., Alajati A., Ganslmayer M., Zopf S., Luders M., Neureiter D., Hahn E.G., Schuppan D., and Herold C. The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J. Cancer Res. Clin. Oncol. 131 (2005) 385-394
-
(2005)
J. Cancer Res. Clin. Oncol.
, vol.131
, pp. 385-394
-
-
Ocker, M.1
Alajati, A.2
Ganslmayer, M.3
Zopf, S.4
Luders, M.5
Neureiter, D.6
Hahn, E.G.7
Schuppan, D.8
Herold, C.9
-
80
-
-
28544432910
-
Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta
-
Marchion D.C., Bicaku E., Turner J.G., Daud A.I., Sullivan D.M., and Munster P.N. Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. Clin. Cancer Res. 11 (2005) 8467-8475
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8467-8475
-
-
Marchion, D.C.1
Bicaku, E.2
Turner, J.G.3
Daud, A.I.4
Sullivan, D.M.5
Munster, P.N.6
-
81
-
-
34250696097
-
Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
-
Ramalingam S.S., Parise R.A., Ramanathan R.K., Lagattuta T.F., Musguire L.A., Stoller R.G., Potter D.M., Argiris A.E., Zwiebel J.A., Egorin M.J., and Belani C.P. Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies. Clin. Cancer Res. 13 (2007) 3605-3610
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3605-3610
-
-
Ramalingam, S.S.1
Parise, R.A.2
Ramanathan, R.K.3
Lagattuta, T.F.4
Musguire, L.A.5
Stoller, R.G.6
Potter, D.M.7
Argiris, A.E.8
Zwiebel, J.A.9
Egorin, M.J.10
Belani, C.P.11
-
82
-
-
31344446955
-
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
-
Gore S.D. Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies. Nat. Clin. Pract. Oncol. 2 (2005) S30-S35
-
(2005)
Nat. Clin. Pract. Oncol.
, vol.2
-
-
Gore, S.D.1
-
83
-
-
0037068312
-
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
-
Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 21 (2002) 5427-5440
-
(2002)
Oncogene
, vol.21
, pp. 5427-5440
-
-
Esteller, M.1
-
84
-
-
0035799382
-
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications
-
Santini V., Kantarjian H.M., and Issa J.P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann. Intern. Med. 134 (2001) 573-586
-
(2001)
Ann. Intern. Med.
, vol.134
, pp. 573-586
-
-
Santini, V.1
Kantarjian, H.M.2
Issa, J.P.3
-
85
-
-
0842322916
-
Enhancement of antineoplastic action of 5-aza-2â²-deoxycytidine by phenylbutyrate on L1210 leukemic cells
-
Lemaire M., Momparler L.F., Farinha N.J., Bernstein M., and Momparler R.L. Enhancement of antineoplastic action of 5-aza-2â²-deoxycytidine by phenylbutyrate on L1210 leukemic cells. Leuk. Lymphoma 45 (2004) 147-154
-
(2004)
Leuk. Lymphoma
, vol.45
, pp. 147-154
-
-
Lemaire, M.1
Momparler, L.F.2
Farinha, N.J.3
Bernstein, M.4
Momparler, R.L.5
-
86
-
-
0037400558
-
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2â²-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells
-
Shaker S., Bernstein M., Momparler L.F., and Momparler R.L. Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2â²-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. Leuk. Res. 27 (2003) 437-444
-
(2003)
Leuk. Res.
, vol.27
, pp. 437-444
-
-
Shaker, S.1
Bernstein, M.2
Momparler, L.F.3
Momparler, R.L.4
-
87
-
-
16544369848
-
Antineoplastic action of 5-aza-2â²-deoxycytidine (Dacogen) and depsipeptide on Raji lymphoma cells
-
Shaker S., Bernstein M., and Momparler R.L. Antineoplastic action of 5-aza-2â²-deoxycytidine (Dacogen) and depsipeptide on Raji lymphoma cells. Oncol. Rep. 11 (2004) 1253-1256
-
(2004)
Oncol. Rep.
, vol.11
, pp. 1253-1256
-
-
Shaker, S.1
Bernstein, M.2
Momparler, R.L.3
-
88
-
-
20344394418
-
Antileukemia activity of the combination of 5-aza-2â²-deoxycytidine with valproic acid
-
Yang H., Hoshino K., Sanchez-Gonzalez B., Kantarjian H., and Garcia-Manero G. Antileukemia activity of the combination of 5-aza-2â²-deoxycytidine with valproic acid. Leuk. Res. 29 (2005) 739-748
-
(2005)
Leuk. Res.
, vol.29
, pp. 739-748
-
-
Yang, H.1
Hoshino, K.2
Sanchez-Gonzalez, B.3
Kantarjian, H.4
Garcia-Manero, G.5
-
89
-
-
52949085309
-
A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: a New York cancer consortium study
-
(ASCO Meeting Abstracts)
-
Silverman L.R., Verma A., Odchimar-Reissig R., Cozza A., Najfeld V., Licht J.D., and Zwiebel J.A. A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: a New York cancer consortium study. J. Clin. Oncol. 26 (2008) 7000 (ASCO Meeting Abstracts)
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 7000
-
-
Silverman, L.R.1
Verma, A.2
Odchimar-Reissig, R.3
Cozza, A.4
Najfeld, V.5
Licht, J.D.6
Zwiebel, J.A.7
-
90
-
-
33645737411
-
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki S.T., Carew J.S., Pino M.S., Highshaw R.A., Andtbacka R.H., Dunner Jr. K., Pal A., Bornmann W.G., Chiao P.J., Huang P., Xiong H., Abbruzzese J.L., and McConkey D.J. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res. 66 (2006) 3773-3781
-
(2006)
Cancer Res.
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner Jr., K.6
Pal, A.7
Bornmann, W.G.8
Chiao, P.J.9
Huang, P.10
Xiong, H.11
Abbruzzese, J.L.12
McConkey, D.J.13
-
91
-
-
53049110009
-
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
-
Nawrocki S.T., Carew J.S., Maclean K.H., Courage J.F., Huang P., Houghton J.A., Cleveland J.L., Giles F.J., and McConkey D.J. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood 112 (2008) 2917-2926
-
(2008)
Blood
, vol.112
, pp. 2917-2926
-
-
Nawrocki, S.T.1
Carew, J.S.2
Maclean, K.H.3
Courage, J.F.4
Huang, P.5
Houghton, J.A.6
Cleveland, J.L.7
Giles, F.J.8
McConkey, D.J.9
-
92
-
-
38049126172
-
Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma
-
Heider U., von Metzler I., Kaiser M., Rosche M., Sterz J., Rotzer S., Rademacher J., Jakob C., Fleissner C., Kuckelkorn U., Kloetzel P.M., and Sezer O. Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma. Eur. J. Haematol. 80 (2008) 133-142
-
(2008)
Eur. J. Haematol.
, vol.80
, pp. 133-142
-
-
Heider, U.1
von Metzler, I.2
Kaiser, M.3
Rosche, M.4
Sterz, J.5
Rotzer, S.6
Rademacher, J.7
Jakob, C.8
Fleissner, C.9
Kuckelkorn, U.10
Kloetzel, P.M.11
Sezer, O.12
-
93
-
-
34249993174
-
SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor bortezomib
-
Emanuele S., Lauricella M., Carlisi D., Vassallo B., D'Anneo A., Di Fazio P., Vento R., and Tesoriere G. SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor bortezomib. Apoptosis 12 (2007) 1327-1338
-
(2007)
Apoptosis
, vol.12
, pp. 1327-1338
-
-
Emanuele, S.1
Lauricella, M.2
Carlisi, D.3
Vassallo, B.4
D'Anneo, A.5
Di Fazio, P.6
Vento, R.7
Tesoriere, G.8
-
94
-
-
2542523228
-
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
-
Pei X.Y., Dai Y., and Grant S. Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin. Cancer Res. 10 (2004) 3839-3852
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3839-3852
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
95
-
-
0242493856
-
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571
-
Yu C., Rahmani M., Conrad D., Subler M., Dent P., and Grant S. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood 102 (2003) 3765-3774
-
(2003)
Blood
, vol.102
, pp. 3765-3774
-
-
Yu, C.1
Rahmani, M.2
Conrad, D.3
Subler, M.4
Dent, P.5
Grant, S.6
-
96
-
-
42449114035
-
Multiple myeloma
-
Kyle R.A., and Rajkumar S.V. Multiple myeloma. Blood 111 (2008) 2962-2972
-
(2008)
Blood
, vol.111
, pp. 2962-2972
-
-
Kyle, R.A.1
Rajkumar, S.V.2
-
97
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P., Pranpat M., Bradner J., Balasis M., Fiskus W., Guo F., Rocha K., Kumaraswamy S., Boyapalle S., Atadja P., Seto E., and Bhalla K. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280 (2005) 26729-26734
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
Balasis, M.4
Fiskus, W.5
Guo, F.6
Rocha, K.7
Kumaraswamy, S.8
Boyapalle, S.9
Atadja, P.10
Seto, E.11
Bhalla, K.12
-
98
-
-
0345734267
-
Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells
-
Rahmani M., Yu C., Dai Y., Reese E., Ahmed W., Dent P., and Grant S. Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. Cancer Res. 63 (2003) 8420-8427
-
(2003)
Cancer Res.
, vol.63
, pp. 8420-8427
-
-
Rahmani, M.1
Yu, C.2
Dai, Y.3
Reese, E.4
Ahmed, W.5
Dent, P.6
Grant, S.7
-
99
-
-
15744402283
-
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change
-
Rahmani M., Reese E., Dai Y., Bauer C., Kramer L.B., Huang M., Jove R., Dent P., and Grant S. Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change. Mol. Pharmacol. 67 (2005) 1166-1176
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 1166-1176
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Kramer, L.B.5
Huang, M.6
Jove, R.7
Dent, P.8
Grant, S.9
-
100
-
-
33846839622
-
Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation
-
Marrocco D.L., Tilley W.D., Bianco-Miotto T., Evdokiou A., Scher H.I., Rifkind R.A., Marks P.A., Richon V.M., and Butler L.M. Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation. Mol. Cancer Ther. 6 (2007) 51-60
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 51-60
-
-
Marrocco, D.L.1
Tilley, W.D.2
Bianco-Miotto, T.3
Evdokiou, A.4
Scher, H.I.5
Rifkind, R.A.6
Marks, P.A.7
Richon, V.M.8
Butler, L.M.9
-
101
-
-
35348961982
-
Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cells and blocks tamoxifen-induced proliferation of uterine cells
-
Hodges-Gallagher L., Valentine C.D., Bader S.E., and Kushner P.J. Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cells and blocks tamoxifen-induced proliferation of uterine cells. Breast Cancer Res. Treat. 105 (2007) 297-309
-
(2007)
Breast Cancer Res. Treat.
, vol.105
, pp. 297-309
-
-
Hodges-Gallagher, L.1
Valentine, C.D.2
Bader, S.E.3
Kushner, P.J.4
-
102
-
-
67349116060
-
SAHA, a deacetylase inhibitor, induces apoptosis in cutaneous T-cell lymphoma cells and is synergistic with 5-Aza-2 deoxycytidine
-
(American Society of Hematology Annual Meeting Abstract)
-
Zhang C., Ni X., Talpur R., Richon V., and Duvic M. SAHA, a deacetylase inhibitor, induces apoptosis in cutaneous T-cell lymphoma cells and is synergistic with 5-Aza-2 deoxycytidine. Blood 102 (2003) (American Society of Hematology Annual Meeting Abstract)
-
(2003)
Blood
, vol.102
-
-
Zhang, C.1
Ni, X.2
Talpur, R.3
Richon, V.4
Duvic, M.5
-
103
-
-
6344229760
-
Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species
-
Denlinger C.E., Rundall B.K., and Jones D.R. Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species. J. Thorac. Cardiovasc. Surg. 128 (2004) 740-748
-
(2004)
J. Thorac. Cardiovasc. Surg.
, vol.128
, pp. 740-748
-
-
Denlinger, C.E.1
Rundall, B.K.2
Jones, D.R.3
-
104
-
-
9144220841
-
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications
-
Mitsiades C.S., Mitsiades N.S., McMullan C.J., Poulaki V., Shringarpure R., Hideshima T., Akiyama M., Chauhan D., Munshi N., Gu X., Bailey C., Joseph M., Libermann T.A., Richon V.M., Marks P.A., and Anderson K.C. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proc. Natl. Acad. Sci. USA 101 (2004) 540-545
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 540-545
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Shringarpure, R.5
Hideshima, T.6
Akiyama, M.7
Chauhan, D.8
Munshi, N.9
Gu, X.10
Bailey, C.11
Joseph, M.12
Libermann, T.A.13
Richon, V.M.14
Marks, P.A.15
Anderson, K.C.16
-
105
-
-
24344473755
-
Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2
-
Bali P., Pranpat M., Swaby R., Fiskus W., Yamaguchi H., Balasis M., Rocha K., Wang H.G., Richon V., and Bhalla K. Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2. Clin. Cancer Res. 11 (2005) 6382-6389
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 6382-6389
-
-
Bali, P.1
Pranpat, M.2
Swaby, R.3
Fiskus, W.4
Yamaguchi, H.5
Balasis, M.6
Rocha, K.7
Wang, H.G.8
Richon, V.9
Bhalla, K.10
-
106
-
-
0036050151
-
Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)
-
Almenara J., Rosato R., and Grant S. Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Leukemia 16 (2002) 1331-1343
-
(2002)
Leukemia
, vol.16
, pp. 1331-1343
-
-
Almenara, J.1
Rosato, R.2
Grant, S.3
-
107
-
-
4844224868
-
Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol
-
Gao N., Dai Y., Rahmani M., Dent P., and Grant S. Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. Mol. Pharmacol. 66 (2004) 956-963
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 956-963
-
-
Gao, N.1
Dai, Y.2
Rahmani, M.3
Dent, P.4
Grant, S.5
-
108
-
-
37549040614
-
Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells
-
Mitchell C., Park M.A., Zhang G., Yacoub A., Curiel D.T., Fisher P.B., Roberts J.D., Grant S., and Dent P. Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells. Mol. Cancer Ther. 6 (2007) 3101-3112
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 3101-3112
-
-
Mitchell, C.1
Park, M.A.2
Zhang, G.3
Yacoub, A.4
Curiel, D.T.5
Fisher, P.B.6
Roberts, J.D.7
Grant, S.8
Dent, P.9
-
109
-
-
34347226747
-
Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
-
Lillehammer T., Engesaeter B.O., Prasmickaite L., Maelandsmo G.M., Fodstad O., and Engebraaten O. Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines. J. Gene Med. 9 (2007) 440-451
-
(2007)
J. Gene Med.
, vol.9
, pp. 440-451
-
-
Lillehammer, T.1
Engesaeter, B.O.2
Prasmickaite, L.3
Maelandsmo, G.M.4
Fodstad, O.5
Engebraaten, O.6
-
110
-
-
4344666663
-
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
-
Nakata S., Yoshida T., Horinaka M., Shiraishi T., Wakada M., and Sakai T. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23 (2004) 6261-6271
-
(2004)
Oncogene
, vol.23
, pp. 6261-6271
-
-
Nakata, S.1
Yoshida, T.2
Horinaka, M.3
Shiraishi, T.4
Wakada, M.5
Sakai, T.6
-
111
-
-
0142057138
-
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition
-
Rahmani M., Yu C., Reese E., Ahmed W., Hirsch K., Dent P., and Grant S. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene 22 (2003) 6231-6242
-
(2003)
Oncogene
, vol.22
, pp. 6231-6242
-
-
Rahmani, M.1
Yu, C.2
Reese, E.3
Ahmed, W.4
Hirsch, K.5
Dent, P.6
Grant, S.7
-
112
-
-
2942584501
-
Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells
-
Rosato R.R., Almenara J.A., Dai Y., and Grant S. Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells. Mol. Cancer Ther. 2 (2003) 1273-1284
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 1273-1284
-
-
Rosato, R.R.1
Almenara, J.A.2
Dai, Y.3
Grant, S.4
-
113
-
-
22744437647
-
HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma
-
Singh T.R., Shankar S., and Srivastava R.K. HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma. Oncogene 24 (2005) 4609-4623
-
(2005)
Oncogene
, vol.24
, pp. 4609-4623
-
-
Singh, T.R.1
Shankar, S.2
Srivastava, R.K.3
-
114
-
-
15244343927
-
Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines
-
Sonnemann J., Gange J., Kumar K.S., Muller C., Bader P., and Beck J.F. Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. Invest. New Drugs 23 (2005) 99-109
-
(2005)
Invest. New Drugs
, vol.23
, pp. 99-109
-
-
Sonnemann, J.1
Gange, J.2
Kumar, K.S.3
Muller, C.4
Bader, P.5
Beck, J.F.6
-
115
-
-
26944440597
-
Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells
-
Yu C., Dasmahapatra G., Dent P., and Grant S. Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells. Leukemia 19 (2005) 1579-1589
-
(2005)
Leukemia
, vol.19
, pp. 1579-1589
-
-
Yu, C.1
Dasmahapatra, G.2
Dent, P.3
Grant, S.4
-
116
-
-
15944406971
-
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
-
Rahmani M., Reese E., Dai Y., Bauer C., Payne S.G., Dent P., Spiegel S., and Grant S. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res. 65 (2005) 2422-2432
-
(2005)
Cancer Res.
, vol.65
, pp. 2422-2432
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Payne, S.G.5
Dent, P.6
Spiegel, S.7
Grant, S.8
-
117
-
-
20744449274
-
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
-
Dai Y., Rahmani M., Dent P., and Grant S. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Mol. Cell. Biol. 25 (2005) 5429-5444
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5429-5444
-
-
Dai, Y.1
Rahmani, M.2
Dent, P.3
Grant, S.4
-
118
-
-
33846327942
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer
-
Arnold N.B., Arkus N., Gunn J., and Korc M. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer. Clin. Cancer Res. 13 (2007) 18-26
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 18-26
-
-
Arnold, N.B.1
Arkus, N.2
Gunn, J.3
Korc, M.4
-
119
-
-
24344498688
-
Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer
-
Rundall B.K., Denlinger C.E., and Jones D.R. Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer. Surgery 138 (2005) 360-367
-
(2005)
Surgery
, vol.138
, pp. 360-367
-
-
Rundall, B.K.1
Denlinger, C.E.2
Jones, D.R.3
-
120
-
-
36749055778
-
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro
-
Sonnemann J., Bumbul B., and Beck J.F. Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro. Mol. Cancer Ther. 6 (2007) 2976-2984
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2976-2984
-
-
Sonnemann, J.1
Bumbul, B.2
Beck, J.F.3
-
121
-
-
41549151359
-
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA)
-
Spiller S.E., Ditzler S.H., Pullar B.J., and Olson J.M. Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA). J. Neurooncol. 87 (2008) 133-141
-
(2008)
J. Neurooncol.
, vol.87
, pp. 133-141
-
-
Spiller, S.E.1
Ditzler, S.H.2
Pullar, B.J.3
Olson, J.M.4
-
122
-
-
58149144779
-
Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells
-
Fiskus W., Wang Y., Joshi R., Rao R., Yang Y., Chen J., Kolhe R., Balusu R., Eaton K., Lee P., Ustun C., Jillella A., Buser C.A., Peiper S., and Bhalla K. Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Clin. Cancer Res. 14 (2008) 6106-6115
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6106-6115
-
-
Fiskus, W.1
Wang, Y.2
Joshi, R.3
Rao, R.4
Yang, Y.5
Chen, J.6
Kolhe, R.7
Balusu, R.8
Eaton, K.9
Lee, P.10
Ustun, C.11
Jillella, A.12
Buser, C.A.13
Peiper, S.14
Bhalla, K.15
-
123
-
-
0038620379
-
Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells
-
Nimmanapalli R., Fuino L., Stobaugh C., Richon V., and Bhalla K. Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Blood 101 (2003) 3236-3239
-
(2003)
Blood
, vol.101
, pp. 3236-3239
-
-
Nimmanapalli, R.1
Fuino, L.2
Stobaugh, C.3
Richon, V.4
Bhalla, K.5
-
124
-
-
0038066488
-
Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells
-
Yu C., Rahmani M., Almenara J., Subler M., Krystal G., Conrad D., Varticovski L., Dent P., and Grant S. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells. Cancer Res. 63 (2003) 2118-2126
-
(2003)
Cancer Res.
, vol.63
, pp. 2118-2126
-
-
Yu, C.1
Rahmani, M.2
Almenara, J.3
Subler, M.4
Krystal, G.5
Conrad, D.6
Varticovski, L.7
Dent, P.8
Grant, S.9
-
125
-
-
33750303818
-
Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells
-
Fiskus W., Pranpat M., Balasis M., Bali P., Estrella V., Kumaraswamy S., Rao R., Rocha K., Herger B., Lee F., Richon V., and Bhalla K. Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin. Cancer Res. 12 (2006) 5869-5878
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5869-5878
-
-
Fiskus, W.1
Pranpat, M.2
Balasis, M.3
Bali, P.4
Estrella, V.5
Kumaraswamy, S.6
Rao, R.7
Rocha, K.8
Herger, B.9
Lee, F.10
Richon, V.11
Bhalla, K.12
-
126
-
-
34547161973
-
Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation
-
Dasmahapatra G., Yerram N., Dai Y., Dent P., and Grant S. Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation. Clin. Cancer Res. 13 (2007) 4280-4290
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 4280-4290
-
-
Dasmahapatra, G.1
Yerram, N.2
Dai, Y.3
Dent, P.4
Grant, S.5
-
127
-
-
53549119055
-
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
-
Park M.A., Zhang G., Martin A.P., Hamed H., Mitchell C., Hylemon P.B., Graf M., Rahmani M., Ryan K., Liu X., Spiegel S., Norris J., Fisher P.B., Grant S., and Dent P. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol. Ther. 7 (2008) 1648-1662
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1648-1662
-
-
Park, M.A.1
Zhang, G.2
Martin, A.P.3
Hamed, H.4
Mitchell, C.5
Hylemon, P.B.6
Graf, M.7
Rahmani, M.8
Ryan, K.9
Liu, X.10
Spiegel, S.11
Norris, J.12
Fisher, P.B.13
Grant, S.14
Dent, P.15
-
128
-
-
53049109359
-
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation
-
Zhang G., Park M.A., Mitchell C., Hamed H., Rahmani M., Martin A.P., Curiel D.T., Yacoub A., Graf M., Lee R., Roberts J.D., Fisher P.B., Grant S., and Dent P. Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation. Clin. Cancer Res. 14 (2008) 5385-5399
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5385-5399
-
-
Zhang, G.1
Park, M.A.2
Mitchell, C.3
Hamed, H.4
Rahmani, M.5
Martin, A.P.6
Curiel, D.T.7
Yacoub, A.8
Graf, M.9
Lee, R.10
Roberts, J.D.11
Fisher, P.B.12
Grant, S.13
Dent, P.14
-
129
-
-
40849137934
-
Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells
-
Seo S.K., Jin H.O., Lee H.C., Woo S.H., Kim E.S., Yoo D.H., Lee S.J., An S., Rhee C.H., Hong S.I., Choe T.B., and Park I.C. Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells. Mol. Pharmacol. 73 (2008) 1005-1012
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 1005-1012
-
-
Seo, S.K.1
Jin, H.O.2
Lee, H.C.3
Woo, S.H.4
Kim, E.S.5
Yoo, D.H.6
Lee, S.J.7
An, S.8
Rhee, C.H.9
Hong, S.I.10
Choe, T.B.11
Park, I.C.12
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