Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Nature

Volumn 401, Issue 6749, 1999, Pages 188-193

  Finnin, Michael S ^b   Donigian, Jiii R ^a   Cohen, Alona ^a   Richon, Victoria M ^a   Rifkind, Richard A ^a   Marks, Paul A ^a   Breslow, Ronald ^c   Pavletich, Nikola P ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HYDROXAMIC ACID DERIVATIVE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DEACETYLATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; SEQUENCE HOMOLOGY; THERMOPHILIC BACTERIUM;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; GRAM-NEGATIVE AEROBIC RODS AND COCCI; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS);

EID: 0033539092     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/43710     Document Type: Article

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