Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

Journal of Biological Chemistry

Volumn 283, Issue 39, 2008, Pages 26694-26704

  Bottomley, Matthew J ^a   Lo Surdo, Paola Lo ^a   Di Giovine, Paolo Di ^a   Cirillo, Agostino ^a   Scarpelli, Rita ^a   Ferrigno, Federica ^a   Jones, Philip ^a   Neddermann, Petra ^a   De Francesco, Raffaele ^a   Steinkühler, Christian ^a   Gallinari, Paola ^a   Carfí, Andrea ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; GENE EXPRESSION; LAWS AND LEGISLATION; ZINC;

ACTIVE SITES; BINDING DOMAINS; BIOLOGICAL SUBSTRATES; CATALYTIC DOMAINS; ENZYMATIC ACTIVITIES; FREE STRUCTURES; HISTONE DEACETYLASE; HISTONE DEACETYLASES; MOLECULAR BASES; SELECTIVE INHIBITORS; SPECIFIC INHIBITORS; ZINC IONS;

DATA STRUCTURES;

HISTONE DEACETYLASE 4; LYSINE; ZINC ION; HDAC4 PROTEIN, HUMAN; HISTONE DEACETYLASE; REPRESSOR PROTEIN; ZINC;

ACETYLATION; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; IMMUNOPRECIPITATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CELL LINE; CHEMISTRY; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETYLATION; BINDING SITES; CELL LINE; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CRYSTALLOGRAPHY, X-RAY; HISTONE DEACETYLASES; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; ZINC;

EID: 55549094833     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803514200     Document Type: Article

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