Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug

Nature Biotechnology

Volumn 25, Issue 1, 2007, Pages 84-90

  Marks, Paul A ^a   Breslow, Ronald ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; DRUG APPLICATION; POTENT ANALOGS; TUMOR-BEARING ANIMALS;

ALKYLATION; ANIMAL CELL CULTURE; DRUG PRODUCTS; GROWTH KINETICS; TUMORS;

ENZYME INHIBITION;

3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; ANGIOGENESIS INHIBITOR; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; ARYLBUTYRIC ACID DERIVATIVE; BORTEZOMIB; CAPECITABINE; DEPSIPEPTIDE; DIMETHYL SULFOXIDE; FLAVOPIRIDOL; FLUDARABINE; FLUDARABINE PHOSPHATE; FLUOROURACIL; FR 901228; HEXAMETHYLENEBISACETAMIDE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; IMATINIB; ISOTRETINOIN; LBH 589; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; TRASTUZUMAB; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

ACUTE GRANULOCYTIC LEUKEMIA; ADJUVANT THERAPY; ANOREXIA; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; BREAST TUMOR; CANCER CELL DESTRUCTION; CANCER PATIENT; CANCER RADIOTHERAPY; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL DEATH; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CLINICAL TRIAL; COLON CANCER; COMBINATION CHEMOTHERAPY; CUTANEOUS T CELL LYMPHOMA; DEHYDRATION; DIARRHEA; DOSE RESPONSE; DRUG ACETYLATION; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG TARGETING; DRUG TOLERABILITY; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; FATIGUE; FOOD AND DRUG ADMINISTRATION; HEMATOLOGIC MALIGNANCY; HUMAN; IN VITRO STUDY; KIDNEY CARCINOMA; LARYNX CARCINOMA; LEUKEMIA REMISSION; MESOTHELIOMA; METASTASIS; MONOTHERAPY; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NEUROBLASTOMA; NEUTROPENIA; NONHUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SOLID TUMOR; STRUCTURE ACTIVITY RELATION; THROMBOCYTOPENIA; THYROID CARCINOMA; UNITED STATES; UNSPECIFIED SIDE EFFECT; URINARY TRACT CARCINOMA; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CLINICAL TRIALS; DIMETHYL SULFOXIDE; DRUG DESIGN; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; NEOPLASM PROTEINS; NEOPLASMS; TREATMENT OUTCOME;

ANIMALIA;

EID: 33846122993     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1272     Document Type: Review

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