Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5085-5088

  Teng, Yuou ^a,b   Iuchi, Katsuya ^a,b   Iwasa, Eriko ^a,b,c   Fujishiro, Shinya ^b,d   Hamashima, Yoshitaka ^b   Dodo, Kosuke ^a,b   Sodeoka, Mikiko ^a,b,c,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b RIKEN   (Japan)

^c SAITAMA UNIVERSITY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase; Dithiodiketopiperazine

Indexed keywords

ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CHAETOCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; PIPERAZINES; STEREOISOMERISM;

CHAETOMIUM; FUNGI;

EID: 77955661449     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.032     Document Type: Article

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