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Volumn 225, Issue 3, 2015, Pages R83-R99

The role of Nrf2 in oxidative stress-induced endothelial injuries

Author keywords

Dysfunction; Endothelial cells; Nrf2; Oxidative stress

Indexed keywords

GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE FYN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 84932110967     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-14-0662     Document Type: Article
Times cited : (324)

References (133)
  • 1
    • 84940165605 scopus 로고    scopus 로고
    • Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat
    • Acar N, Soylu H, Edizer I, Ozbey O, Er H, Akkoyunlu G, Gemici B & Ustunel I 2014 Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat. Acta Histochemica 116 1289-1300. (doi:10.1016/j.acthis.2014.07.012)
    • (2014) Acta Histochemica , vol.116 , pp. 1289-1300
    • Acar, N.1    Soylu, H.2    Edizer, I.3    Ozbey, O.4    Er, H.5    Akkoyunlu, G.6    Gemici, B.7    Ustunel, I.8
  • 2
    • 77951479702 scopus 로고    scopus 로고
    • Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways
    • Afonyushkin T, Oskolkova OV, Philippova M, Resink TJ, Erne P, Binder BR & Bochkov VN 2010 Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arteriosclerosis, Thrombosis, and Vascular Biology 30 1007-1013. (doi:10.1161/ATVBAHA.110.204354)
    • (2010) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.30 , pp. 1007-1013
    • Afonyushkin, T.1    Oskolkova, O.V.2    Philippova, M.3    Resink, T.J.4    Erne, P.5    Binder, B.R.6    Bochkov, V.N.7
  • 4
    • 84903514856 scopus 로고    scopus 로고
    • Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage
    • Anuranjani & Bala M 2014 Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biology 2 832-846. (doi:10.1016/j.redox.2014.02.008)
    • (2014) Redox Biology , vol.2 , pp. 832-846
    • Anuranjani1    Bala, M.2
  • 6
    • 84866607741 scopus 로고    scopus 로고
    • Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease
    • Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, Cohen RA, Pimental D & Loo BV 2013 Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Annals of Medicine 45 17-36. (doi:10.3109/07853890.2011. 645498)
    • (2013) Annals of Medicine , vol.45 , pp. 17-36
    • Bachschmid, M.M.1    Schildknecht, S.2    Matsui, R.3    Zee, R.4    Haeussler, D.5    Cohen, R.A.6    Pimental, D.7    Loo, B.V.8
  • 8
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur JA & Sinclair DA 2006 Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews. Drug Discovery 5 493-506. (doi:10.1038/nrd2060)
    • (2006) Nature Reviews. Drug Discovery , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 11
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
    • Bryan HK, Olayanju A, Goldring CE & Park BK 2013 The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochemical Pharmacology 85 705-717. (doi:10.1016/j.bcp. 2012.11.016)
    • (2013) Biochemical Pharmacology , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 12
    • 84862488588 scopus 로고    scopus 로고
    • Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's
    • Buijsse B, Lee DH, Steffen L, Erickson RR, Luepker RV, Jacobs DR Jr & Holtzman JL 2012 Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's. PLoS ONE 7 e38901. (doi:10.1371/journal.pone.0038901)
    • (2012) PLoS ONE , vol.7 , pp. e38901
    • Buijsse, B.1    Lee, D.H.2    Steffen, L.3    Erickson, R.R.4    Luepker, R.V.5    Jacobs, D.R.6    Holtzman, J.L.7
  • 14
    • 33645420672 scopus 로고    scopus 로고
    • Expression, purification, and in vitro refolding of a humanized singlechain Fv antibody against human CTLA4 (CD152)
    • Chen LH, Huang Q, Wan L, Zeng LY, Li SF, Li YP, Lu XF & Cheng JQ 2006 Expression, purification, and in vitro refolding of a humanized singlechain Fv antibody against human CTLA4 (CD152). Protein Expression and Purification 46 495-502. (doi:10.1016/j.pep.2005.09.002)
    • (2006) Protein Expression and Purification , vol.46 , pp. 495-502
    • Chen, L.H.1    Huang, Q.2    Wan, L.3    Zeng, L.Y.4    Li, S.F.5    Li, Y.P.6    Lu, X.F.7    Cheng, J.Q.8
  • 15
    • 79151485932 scopus 로고    scopus 로고
    • Nrf-2 mediated heme oxygenase-1 expression, an antioxidantindependent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract
    • Chen JS, Huang PH, Wang CH, Lin FY, Tsai HY, Wu TC, Lin SJ & Chen JW 2011 Nrf-2 mediated heme oxygenase-1 expression, an antioxidantindependent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis 214 301-309. (doi:10.1016/j.atherosclerosis.2010.11.010)
    • (2011) Atherosclerosis , vol.214 , pp. 301-309
    • Chen, J.S.1    Huang, P.H.2    Wang, C.H.3    Lin, F.Y.4    Tsai, H.Y.5    Wu, T.C.6    Lin, S.J.7    Chen, J.W.8
  • 16
    • 84875103276 scopus 로고    scopus 로고
    • Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction
    • Chen TM, Li J, Liu L, Fan L, Li XY, Wang YT, Abraham NG & Cao J 2013 Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction. International Journal of Molecular Sciences 14 2684-2706. (doi:10.3390/ijms14022684)
    • (2013) International Journal of Molecular Sciences , vol.14 , pp. 2684-2706
    • Chen, T.M.1    Li, J.2    Liu, L.3    Fan, L.4    Li, X.Y.5    Wang, Y.T.6    Abraham, N.G.7    Cao, J.8
  • 17
    • 84896131117 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression
    • Chen B, Zhang Y, Wang Y, Rao J, Jiang X & Xu Z 2014 Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression. Journal of Steroid Biochemistry and Molecular Biology 143 11-18. (doi:10.1016/j.jsbmb.2014.01.009)
    • (2014) Journal of Steroid Biochemistry and Molecular Biology , vol.143 , pp. 11-18
    • Chen, B.1    Zhang, Y.2    Wang, Y.3    Rao, J.4    Jiang, X.5    Xu, Z.6
  • 18
    • 78650913154 scopus 로고    scopus 로고
    • Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway
    • Cheng XH, Siow RCM & Mann GE 2011 Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxidants & Redox Signaling 14 469-487. (doi:10.1089/ars.2010.3283)
    • (2011) Antioxidants & Redox Signaling , vol.14 , pp. 469-487
    • Cheng, X.H.1    Siow, R.C.M.2    Mann, G.E.3
  • 19
    • 84890569805 scopus 로고    scopus 로고
    • Two different approaches to restore renal nitric oxide and prevent hypertensioninyoung spontaneouslyhypertensive rats: L-citrulline andnitrate
    • Chien SJ, Lin KM, Kuo HC, Huang CF, Lin YJ, Huang LT & Tain YL 2014 Two different approaches to restore renal nitric oxide and prevent hypertensioninyoung spontaneouslyhypertensive rats: L-citrulline andnitrate. Translational Research 163 43-52. (doi:10.1016/j.trsl.2013.09.008)
    • (2014) Translational Research , vol.163 , pp. 43-52
    • Chien, S.J.1    Lin, K.M.2    Kuo, H.C.3    Huang, C.F.4    Lin, Y.J.5    Huang, L.T.6    Tain, Y.L.7
  • 20
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • Chowdhry S, Zhang Y, McMahon M, Sutherland C, Cuadrado A & Hayes JD 2013 Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 32 3765-3781. (doi:10.1038/onc.2012.388)
    • (2013) Oncogene , vol.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 21
    • 84879690811 scopus 로고    scopus 로고
    • Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway
    • Cimino F, Speciale A, Anwar S, Canali R, Ricciardi E, Virgili F, Trombetta D & Saija A 2013 Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway. Genes & Nutrition 8 391-399. (doi:10.1007/s12263-012-0324-4)
    • (2013) Genes & Nutrition , vol.8 , pp. 391-399
    • Cimino, F.1    Speciale, A.2    Anwar, S.3    Canali, R.4    Ricciardi, E.5    Virgili, F.6    Trombetta, D.7    Saija, A.8
  • 22
    • 84891519567 scopus 로고    scopus 로고
    • Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells
    • Coleman PR, Chang G, Hutas G, Grimshaw M, Vadas MA & Gamble JR 2013 Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging 5 913-924.
    • (2013) Aging , vol.5 , pp. 913-924
    • Coleman, P.R.1    Chang, G.2    Hutas, G.3    Grimshaw, M.4    Vadas, M.A.5    Gamble, J.R.6
  • 23
    • 84879666141 scopus 로고    scopus 로고
    • ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells
    • Cong ZX, Wang HD, Wang JW, Zhou Y, Pan H, Zhang DD & Zhu L 2013 ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells. Oncology Reports 30 715-722. (doi:10.3892/or.2013.2485)
    • (2013) Oncology Reports , vol.30 , pp. 715-722
    • Cong, Z.X.1    Wang, H.D.2    Wang, J.W.3    Zhou, Y.4    Pan, H.5    Zhang, D.D.6    Zhu, L.7
  • 24
    • 84886428586 scopus 로고    scopus 로고
    • Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver
    • Cornejo P, Vargas R & Videla LA 2013 Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver. BioFactors 39 514-521. (doi:10.1002/biof.1094)
    • (2013) BioFactors , vol.39 , pp. 514-521
    • Cornejo, P.1    Vargas, R.2    Videla, L.A.3
  • 26
    • 34848858001 scopus 로고    scopus 로고
    • Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2
    • Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G & Gimbrone MA Jr 2007 Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circulation Research 101 723-733. (doi:10.1161/CIRCRESAHA.107.152942)
    • (2007) Circulation Research , vol.101 , pp. 723-733
    • Dai, G.1    Vaughn, S.2    Zhang, Y.3    Wang, E.T.4    Garcia-Cardena, G.5    Gimbrone, M.A.6
  • 28
    • 0030133352 scopus 로고    scopus 로고
    • Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
    • Darley-Usmar V & Halliwell B 1996 Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmaceutical Research 13 649-662. (doi:10.1023/A:1016079012214)
    • (1996) Pharmaceutical Research , vol.13 , pp. 649-662
    • Darley-Usmar, V.1    Halliwell, B.2
  • 30
    • 80051978810 scopus 로고    scopus 로고
    • Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling
    • Forstermann U & Li H 2011 Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. British Journal of Pharmacology 164 213-223. (doi:10.1111/j.1476-5381.2010.01196.x)
    • (2011) British Journal of Pharmacology , vol.164 , pp. 213-223
    • Forstermann, U.1    Li, H.2
  • 31
    • 84855857730 scopus 로고    scopus 로고
    • Serum oxidative stressinduced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokers
    • Fratta Pasini A, Albiero A, Stranieri C, Cominacini M, Pasini A, Mozzini C, Vallerio P, Cominacini L & Garbin U 2012 Serum oxidative stressinduced repression of Nrf2 and GSH depletion: a mechanism potentially involved in endothelial dysfunction of young smokers. PLoS ONE 7 e30291. (doi:10.1371/journal.pone.0030291)
    • (2012) PLoS ONE , vol.7 , pp. e30291
    • Fratta Pasini, A.1    Albiero, A.2    Stranieri, C.3    Cominacini, M.4    Pasini, A.5    Mozzini, C.6    Vallerio, P.7    Cominacini, L.8    Garbin, U.9
  • 34
    • 31044446194 scopus 로고    scopus 로고
    • Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice
    • Gough PJ, Gomez IG, Wille PT & Raines EW 2006 Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. Journal of Clinical Investigation 116 59-69. (doi:10.1172/JCI25074)
    • (2006) Journal of Clinical Investigation , vol.116 , pp. 59-69
    • Gough, P.J.1    Gomez, I.G.2    Wille, P.T.3    Raines, E.W.4
  • 35
    • 84861014606 scopus 로고    scopus 로고
    • EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes
    • Han SG, Han SS, Toborek M & Hennig B 2012 EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes. Toxicology and Applied Pharmacology 261 181-188. (doi:10.1016/j.taap.2012.03.024)
    • (2012) Toxicology and Applied Pharmacology , vol.261 , pp. 181-188
    • Han, S.G.1    Han, S.S.2    Toborek, M.3    Hennig, B.4
  • 36
    • 79952700675 scopus 로고    scopus 로고
    • Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes
    • He M, Siow RCM, Sugden D, Gao L, Cheng X & Mann GE 2011 Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes. Nutrition, Metabolism, and Cardiovascular Diseases 21 277-285. (doi:10.1016/j.numecd.2009.12.008)
    • (2011) Nutrition, Metabolism, and Cardiovascular Diseases , vol.21 , pp. 277-285
    • He, M.1    Siow, R.C.M.2    Sugden, D.3    Gao, L.4    Cheng, X.5    Mann, G.E.6
  • 37
    • 84871311580 scopus 로고    scopus 로고
    • Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress
    • Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K & Methner A 2012 Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress. Journal of Biological Chemistry 287 42042-42052. (doi:10.1074/jbc.M112.417212)
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 42042-42052
    • Henke, N.1    Albrecht, P.2    Pfeiffer, A.3    Toutzaris, D.4    Zanger, K.5    Methner, A.6
  • 38
    • 84877738587 scopus 로고    scopus 로고
    • Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels
    • Hensen SM, Heldens L, van Enckevort CM, van Genesen ST, Pruijn GJ & Lubsen NH 2013 Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels. Biochimie 95 1245-1251. (doi:10.1016/j.biochi. 2013.01.017)
    • (2013) Biochimie , vol.95 , pp. 1245-1251
    • Hensen, S.M.1    Heldens, L.2    van Enckevort, C.M.3    van Genesen, S.T.4    Pruijn, G.J.5    Lubsen, N.H.6
  • 39
    • 26444588758 scopus 로고    scopus 로고
    • Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity
    • Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD & Bruschi SA 2005 Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicological Sciences 86 354-364. (doi:10.1093/toxsci/kfi205)
    • (2005) Toxicological Sciences , vol.86 , pp. 354-364
    • Ho, H.K.1    White, C.C.2    Fernandez, C.3    Fausto, N.4    Kavanagh, T.J.5    Nelson, S.D.6    Bruschi, S.A.7
  • 40
    • 84880395062 scopus 로고    scopus 로고
    • Genoprotection and genotoxicity of green tea (Camellia sinensis): are they two sides of the same redox coin?
    • Ho CK, Siu-wai C, Siu PM & Benzie IF 2013 Genoprotection and genotoxicity of green tea (Camellia sinensis): are they two sides of the same redox coin?. Redox Report 18 150-154. (doi:10.1179/1351000213Y. 0000000051)
    • (2013) Redox Report , vol.18 , pp. 150-154
    • Ho, C.K.1    Siu-wai, C.2    Siu, P.M.3    Benzie, I.F.4
  • 43
    • 84921831296 scopus 로고    scopus 로고
    • Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFkB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells
    • Huang CS, Lin AH, Yang TC, Liu KL, Chen HW & Lii CK 2015 Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFkB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells. Biochemical Pharmacology 93 352-361. (doi:10.1016/j.bcp.2014.12.005)
    • (2015) Biochemical Pharmacology , vol.93 , pp. 352-361
    • Huang, C.S.1    Lin, A.H.2    Yang, T.C.3    Liu, K.L.4    Chen, H.W.5    Lii, C.K.6
  • 44
    • 84920721006 scopus 로고    scopus 로고
    • Pierisformoside B exhibits neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells via the HO-1/Nrf2-mediated pathway
    • Im NK, Zhou W, Na M & Jeong GS 2015 Pierisformoside B exhibits neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells via the HO-1/Nrf2-mediated pathway. International Immunopharmacology 24 353-360. (doi:10.1016/j.intimp.2014.12.014)
    • (2015) International Immunopharmacology , vol.24 , pp. 353-360
    • Im, N.K.1    Zhou, W.2    Na, M.3    Jeong, G.S.4
  • 46
    • 84890436238 scopus 로고    scopus 로고
    • Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans
    • Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell KT & Makino T 2013b Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radical Biology and Medicine 65 1506-1515. (doi:10.1016/j.freeradbiomed.2012.12.006)
    • (2013) Free Radical Biology and Medicine , vol.65 , pp. 1506-1515
    • Ishikado, A.1    Sono, Y.2    Matsumoto, M.3    Robida-Stubbs, S.4    Okuno, A.5    Goto, M.6    King, G.L.7    Blackwell, K.T.8    Makino, T.9
  • 48
    • 34447526197 scopus 로고    scopus 로고
    • GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
    • Jain AK & Jaiswal AK 2007 GSK-3β acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. Journal of Biological Chemistry 282 16502-16510. (doi:10.1074/jbc.M611336200)
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 16502-16510
    • Jain, A.K.1    Jaiswal, A.K.2
  • 49
    • 1942520367 scopus 로고    scopus 로고
    • Nrf2 signaling in coordinated activation of antioxidant gene expression
    • Jaiswal AK 2004 Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radical Biology & Medicine 36 1199-1207. (doi:10.1016/j.freeradbiomed.2004.02.074)
    • (2004) Free Radical Biology & Medicine , vol.36 , pp. 1199-1207
    • Jaiswal, A.K.1
  • 50
    • 77951199503 scopus 로고    scopus 로고
    • The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
    • Jiang T, Huang ZP, Lin YF, Zhang Z, Fang D & Zhang DD 2010 The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes 59 850-860. (doi:10.2337/db09-1342)
    • (2010) Diabetes , vol.59 , pp. 850-860
    • Jiang, T.1    Huang, Z.P.2    Lin, Y.F.3    Zhang, Z.4    Fang, D.5    Zhang, D.D.6
  • 51
    • 0035949615 scopus 로고    scopus 로고
    • Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice
    • Juan SH, Lee TS, Tseng KW, Liou JY, Shyue SK, Wu KK & Chau LY 2001 Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 104 1519-1525. (doi:10.1161/hc3801.095663)
    • (2001) Circulation , vol.104 , pp. 1519-1525
    • Juan, S.H.1    Lee, T.S.2    Tseng, K.W.3    Liou, J.Y.4    Shyue, S.K.5    Wu, K.K.6    Chau, L.Y.7
  • 52
    • 84878785993 scopus 로고    scopus 로고
    • The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer
    • Kansanen E, Kuosmanen SM, Leinonen H & Levonen AL 2013 The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biology 1 45-49. (doi:10.1016/j.redox.2012.10.001)
    • (2013) Redox Biology , vol.1 , pp. 45-49
    • Kansanen, E.1    Kuosmanen, S.M.2    Leinonen, H.3    Levonen, A.L.4
  • 53
    • 77953032816 scopus 로고    scopus 로고
    • Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
    • Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A & Haskell CF 2010 Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. American Journal of Clinical Nutrition 91 1590-1597. (doi:10.3945/ajcn.2009.28641)
    • (2010) American Journal of Clinical Nutrition , vol.91 , pp. 1590-1597
    • Kennedy, D.O.1    Wightman, E.L.2    Reay, J.L.3    Lietz, G.4    Okello, E.J.5    Wilde, A.6    Haskell, C.F.7
  • 56
    • 84873720037 scopus 로고    scopus 로고
    • Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline
    • Koriyama Y, Nakayama Y, Matsugo S & Kato S 2013 Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline. Brain Research 1499 145-157. (doi:10.1016/j.brainres.2012.12.041)
    • (2013) Brain Research , vol.1499 , pp. 145-157
    • Koriyama, Y.1    Nakayama, Y.2    Matsugo, S.3    Kato, S.4
  • 57
    • 84939984048 scopus 로고    scopus 로고
    • The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression
    • Krajka-Kuzniak V, Paluszczak J, Szaefer H & Baer-Dubowska W 2015 The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression. Journal of Physiology and Biochemistry 71 227-238. (doi:10.1007/s13105-015-0401-4)
    • (2015) Journal of Physiology and Biochemistry , vol.71 , pp. 227-238
    • Krajka-Kuzniak, V.1    Paluszczak, J.2    Szaefer, H.3    Baer-Dubowska, W.4
  • 58
    • 84880588789 scopus 로고    scopus 로고
    • Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions
    • Kuang L, Feng J, He G & Jing T 2013 Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions. International Journal of Biological Sciences 9 656-665. (doi:10.7150/ijbs.5887)
    • (2013) International Journal of Biological Sciences , vol.9 , pp. 656-665
    • Kuang, L.1    Feng, J.2    He, G.3    Jing, T.4
  • 60
    • 0035260034 scopus 로고    scopus 로고
    • Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione
    • Kwak MK, Itoh K, Yamamoto M, Sutter TR & Kensler TW 2001 Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Molecular Medicine 7 135-145.
    • (2001) Molecular Medicine , vol.7 , pp. 135-145
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3    Sutter, T.R.4    Kensler, T.W.5
  • 61
    • 79951767414 scopus 로고    scopus 로고
    • Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells
    • Lee SE, Jeong SI, Kim GD, Yang H, Park CS, Jin YH & Park YS 2011 Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. Toxicology Letters 201 240-248. (doi:10.1016/j.toxlet.2011.01.006)
    • (2011) Toxicology Letters , vol.201 , pp. 240-248
    • Lee, S.E.1    Jeong, S.I.2    Kim, G.D.3    Yang, H.4    Park, C.S.5    Jin, Y.H.6    Park, Y.S.7
  • 62
    • 33748752586 scopus 로고    scopus 로고
    • Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
    • Li W, Yu SW & Kong AN 2006 Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. Journal of Biological Chemistry 281 27251-27263. (doi:10.1074/jbc.M602746200)
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 27251-27263
    • Li, W.1    Yu, S.W.2    Kong, A.N.3
  • 63
    • 84863464724 scopus 로고    scopus 로고
    • Activation of Nrf2 is required for upregulation of the pi class of glutathione S-transferase in rat primary hepatocytes with L-methionine starvation
    • Lin AH, Chen HW, Liu CT et al. 2012 Activation of Nrf2 is required for upregulation of the pi class of glutathione S-transferase in rat primary hepatocytes with L-methionine starvation. Journal of Agricultural and Food Chemistry 60 6537-6545. (doi:10.1021/jf301567m)
    • (2012) Journal of Agricultural and Food Chemistry , vol.60 , pp. 6537-6545
    • Lin, A.H.1    Chen, H.W.2    Liu, C.T.3
  • 64
    • 57349116768 scopus 로고    scopus 로고
    • Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
    • Liu H, Dinkova-Kostova AT & Talalay P 2008 Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. PNAS 105 15926-15931. (doi:10.1073/pnas. 0808346105)
    • (2008) PNAS , vol.105 , pp. 15926-15931
    • Liu, H.1    Dinkova-Kostova, A.T.2    Talalay, P.3
  • 65
    • 84874506358 scopus 로고    scopus 로고
    • The effect of transcription factor KLF2 in expression of g-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease
    • Liu XY, Dai AG, Hu RC, Zhu LM & Tan SX 2012 The effect of transcription factor KLF2 in expression of g-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease. Zhongguo Ying Yong Sheng Li Xue Za Zhi 28 173-178.
    • (2012) Zhongguo Ying Yong Sheng Li Xue Za Zhi , vol.28 , pp. 173-178
    • Liu, X.Y.1    Dai, A.G.2    Hu, R.C.3    Zhu, L.M.4    Tan, S.X.5
  • 66
    • 84903723322 scopus 로고    scopus 로고
    • Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells
    • Liu TS, Pei YH, Peng YP, Chen J, Jiang SS & Gong JB 2014 Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells. Journal of Endocrinological Investigation 37 645-651. (doi:10.1007/s40618-014-0086-5)
    • (2014) Journal of Endocrinological Investigation , vol.37 , pp. 645-651
    • Liu, T.S.1    Pei, Y.H.2    Peng, Y.P.3    Chen, J.4    Jiang, S.S.5    Gong, J.B.6
  • 67
    • 84926408618 scopus 로고    scopus 로고
    • Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats
    • Liu Y, Zhang L & Liang J 2015 Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats. Journal of the Neurological Sciences 351 88-92. (doi:10.1016/j.jns.2015.02.045)
    • (2015) Journal of the Neurological Sciences , vol.351 , pp. 88-92
    • Liu, Y.1    Zhang, L.2    Liang, J.3
  • 68
    • 42649130014 scopus 로고    scopus 로고
    • PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
    • Lo SC & Hannink M 2008 PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Experimental Cell Research 314 1789-1803. (doi:10.1016/j.yexcr.2008.02.014)
    • (2008) Experimental Cell Research , vol.314 , pp. 1789-1803
    • Lo, S.C.1    Hannink, M.2
  • 69
    • 84921838788 scopus 로고    scopus 로고
    • Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kB and Nrf2 signaling pathways
    • Mandal A & Bishayee A 2015 Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-kB and Nrf2 signaling pathways. International Journal of Molecular Sciences 16 2426-2445. (doi:10.3390/ijms16022426)
    • (2015) International Journal of Molecular Sciences , vol.16 , pp. 2426-2445
    • Mandal, A.1    Bishayee, A.2
  • 72
    • 84879921918 scopus 로고    scopus 로고
    • Chemical reactivity and biological activity of chalcones and other a,b-unsaturated carbonyl compounds
    • Maydt D, De Spirt S, Muschelknautz C, Stahl W & Müller TJ 2013 Chemical reactivity and biological activity of chalcones and other a,b-unsaturated carbonyl compounds. Xenobiotica 43 711-718. (doi:10.3109/00498254.2012.754112)
    • (2013) Xenobiotica , vol.43 , pp. 711-718
    • Maydt, D.1    De Spirt, S.2    Muschelknautz, C.3    Stahl, W.4    Müller, T.J.5
  • 73
    • 84906331499 scopus 로고    scopus 로고
    • Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression
    • Mishra M, Zhong Q & Kowluru RA 2014 Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. Free Radical Biology & Medicine 75 129-139. (doi:10.1016/j.freeradbiomed.2014.07.001)
    • (2014) Free Radical Biology & Medicine , vol.75 , pp. 129-139
    • Mishra, M.1    Zhong, Q.2    Kowluru, R.A.3
  • 75
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region
    • Moi P, Chan K, Asunis I, Cao A & Kan YW 1994 Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region. PNAS 91 9926-9930. (doi:10.1073/pnas.91.21.9926)
    • (1994) PNAS , vol.91 , pp. 9926-9930
    • Moi, P.1    Chan, K.2    Asunis, I.3    Cao, A.4    Kan, Y.W.5
  • 76
    • 42149160644 scopus 로고    scopus 로고
    • Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus
    • Morin P Jr, Ni Z, McMullen DC & Storey KB 2008 Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus. Molecular and Cellular Biochemistry 312 121-129. (doi:10.1007/s11010-008-9727-3)
    • (2008) Molecular and Cellular Biochemistry , vol.312 , pp. 121-129
    • Morin, P.1    Ni, Z.2    McMullen, D.C.3    Storey, K.B.4
  • 77
    • 84925725109 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals
    • Mozzini C, Garbin U, Stranieri C, Pasini A, Solani E, Tinelli IA, Cominacini L & Fratta Pasini AM 2015 Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals. Free Radical Research 49 244-252. (doi:10.3109/10715762.2014.997229)
    • (2015) Free Radical Research , vol.49 , pp. 244-252
    • Mozzini, C.1    Garbin, U.2    Stranieri, C.3    Pasini, A.4    Solani, E.5    Tinelli, I.A.6    Cominacini, L.7    Fratta Pasini, A.M.8
  • 78
    • 0036711791 scopus 로고    scopus 로고
    • Selective regulation of blood pressure by heme oxygenase-1 in hypertension
    • Ndisang JF, Zhao W & Wang R 2002 Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40 315-321. (doi:10.1161/01.HYP.0000028488.71068.16)
    • (2002) Hypertension , vol.40 , pp. 315-321
    • Ndisang, J.F.1    Zhao, W.2    Wang, R.3
  • 79
    • 30344461640 scopus 로고    scopus 로고
    • The induction of human superoxide dismutase and catalase in vivo: a fundamentallynew approach to antioxidant therapy
    • Nelson SK, Bose SK, Grunwald GK, Myhill P & McCord JM 2006 The induction of human superoxide dismutase and catalase in vivo: a fundamentallynew approach to antioxidant therapy. Free Radical Biology & Medicine 40 341-347. (doi:10.1016/j.freeradbiomed.2005.08.043)
    • (2006) Free Radical Biology & Medicine , vol.40 , pp. 341-347
    • Nelson, S.K.1    Bose, S.K.2    Grunwald, G.K.3    Myhill, P.4    McCord, J.M.5
  • 82
    • 84890553464 scopus 로고    scopus 로고
    • Caffeoylserotonin protects human keratinocyte HaCaT cells against H2O2-induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway
    • Nguyen CN, Kim HE & Lee SG 2013 Caffeoylserotonin protects human keratinocyte HaCaT cells against H2O2-induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway. Phytotherapy Research 27 1810-1818. (doi:10.1002/ptr.4931)
    • (2013) Phytotherapy Research , vol.27 , pp. 1810-1818
    • Nguyen, C.N.1    Kim, H.E.2    Lee, S.G.3
  • 83
    • 28544450507 scopus 로고    scopus 로고
    • The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
    • Nioi P, Nguyen T, Sherratt PJ & Pickett CB 2005 The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Molecular and Cellular Biology 25 10895-10906. (doi:10.1128/MCB.25.24.10895-10906.2005)
    • (2005) Molecular and Cellular Biology , vol.25 , pp. 10895-10906
    • Nioi, P.1    Nguyen, T.2    Sherratt, P.J.3    Pickett, C.B.4
  • 85
    • 0029805130 scopus 로고    scopus 로고
    • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    • Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M & Igarashi K 1996 Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Molecular and Cellular Biology 16 6083-6095. (doi:10.0270-7306/96/$04.0010)
    • (1996) Molecular and Cellular Biology , vol.16 , pp. 6083-6095
    • Oyake, T.1    Itoh, K.2    Motohashi, H.3    Hayashi, N.4    Hoshino, H.5    Nishizawa, M.6    Yamamoto, M.7    Igarashi, K.8
  • 88
  • 89
    • 84873417130 scopus 로고    scopus 로고
    • A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
    • Pickering AM, Staab TA, Tower J, Sieburth D & Davies KJ 2013 A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. Journal of Experimental Biology 216 543-553. (doi:10.1242/jeb.074757)
    • (2013) Journal of Experimental Biology , vol.216 , pp. 543-553
    • Pickering, A.M.1    Staab, T.A.2    Tower, J.3    Sieburth, D.4    Davies, K.J.5
  • 92
    • 84885484473 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?
    • Rochette L, Lorin J, Zeller M, Guilland JC, Lorgis L, Cottin Y & Vergely C 2013 Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?. Pharmacology & Therapeutics 140 239-257. (doi:10.1016/j.pharmthera.2013.07.004)
    • (2013) Pharmacology & Therapeutics , vol.140 , pp. 239-257
    • Rochette, L.1    Lorin, J.2    Zeller, M.3    Guilland, J.C.4    Lorgis, L.5    Cottin, Y.6    Vergely, C.7
  • 93
    • 84864282592 scopus 로고    scopus 로고
    • Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress
    • Rodriguez-Ramiro I, Ramos S, Bravo L, Goya L & Marti{dotless}n MA 2012 Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. European Journal of Nutrition 51 881-892. (doi:10.1007/s00394-011-0269-1)
    • (2012) European Journal of Nutrition , vol.51 , pp. 881-892
    • Rodriguez-Ramiro, I.1    Ramos, S.2    Bravo, L.3    Goya, L.4    Martín, M.A.5
  • 94
    • 31444447800 scopus 로고    scopus 로고
    • Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers
    • Satoh T, Okamoto SI, Cui J, Watanabe Y, Furuta K, Suzuki M, Tohyama K & Lipton SA 2006 Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. PNAS 103 768-773. (doi:10.1073/pnas.0505723102)
    • (2006) PNAS , vol.103 , pp. 768-773
    • Satoh, T.1    Okamoto, S.I.2    Cui, J.3    Watanabe, Y.4    Furuta, K.5    Suzuki, M.6    Tohyama, K.7    Lipton, S.A.8
  • 95
    • 84867581790 scopus 로고    scopus 로고
    • Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
    • Satsu H, Chidachi E, Hiura Y, Ogiwara H, Gondo Y & Shimizu M 2012 Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells. Amino Acids 43 1547-1555. (doi:10.1007/s00726-012-1230-1)
    • (2012) Amino Acids , vol.43 , pp. 1547-1555
    • Satsu, H.1    Chidachi, E.2    Hiura, Y.3    Ogiwara, H.4    Gondo, Y.5    Shimizu, M.6
  • 96
    • 84878009975 scopus 로고    scopus 로고
    • Antioxidantmediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer
    • Singh B, Chatterjee A, Ronghe AM, Bhat NK & Bhat HK 2013 Antioxidantmediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer. BMC Cancer 13 253. (doi:10.1186/1471-2407-13-253)
    • (2013) BMC Cancer , vol.13 , pp. 253
    • Singh, B.1    Chatterjee, A.2    Ronghe, A.M.3    Bhat, N.K.4    Bhat, H.K.5
  • 97
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health - a comprehensive review of human clinical trials
    • Smoliga JM, Baur JA & Hausenblas HA 2011 Resveratrol and health - a comprehensive review of human clinical trials. Molecular Nutrition & Food Research 55 1129-1141. (doi:10.1002/mnfr.201100143)
    • (2011) Molecular Nutrition & Food Research , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 98
    • 58549089876 scopus 로고    scopus 로고
    • Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study
    • Song J, Sumiyoshi S, Nakashima Y, Doi Y, Iida M, Kiyohara Y & Sueishi K 2009 Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study. Atherosclerosis 202 573-581. (doi:10.1016/j.atherosclerosis.2008.05.057)
    • (2009) Atherosclerosis , vol.202 , pp. 573-581
    • Song, J.1    Sumiyoshi, S.2    Nakashima, Y.3    Doi, Y.4    Iida, M.5    Kiyohara, Y.6    Sueishi, K.7
  • 99
    • 84923058292 scopus 로고    scopus 로고
    • Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression
    • Song J, Kang SM, Lee WT, Park KA, Lee KM & Lee JE 2014 Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression. Experimental Neurobiology 23 93-103. (doi:10.5607/en.2014.23.1.93)
    • (2014) Experimental Neurobiology , vol.23 , pp. 93-103
    • Song, J.1    Kang, S.M.2    Lee, W.T.3    Park, K.A.4    Lee, K.M.5    Lee, J.E.6
  • 100
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM & Hagen TM 2004 Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. PNAS 101 3381-3386. (doi:10.1073/pnas.0400282101)
    • (2004) PNAS , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.4    Jaiswal, A.K.5    Liu, R.M.6    Hagen, T.M.7
  • 101
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh YJ, Kundu JK & Na HK 2008 Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Medica 74 1526-1539. (doi:10.1055/s-0028-1088302)
    • (2008) Planta Medica , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 102
    • 56849124834 scopus 로고    scopus 로고
    • Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice
    • Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gabrielson KL, Polotsky VY & Biswal S 2008 Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE 3 e3791. (doi:10.1371/journal.pone.0003791)
    • (2008) PLoS ONE , vol.3 , pp. e3791
    • Sussan, T.E.1    Jun, J.2    Thimmulappa, R.3    Bedja, D.4    Antero, M.5    Gabrielson, K.L.6    Polotsky, V.Y.7    Biswal, S.8
  • 104
    • 79958255513 scopus 로고    scopus 로고
    • Mechanism of the Nrf2/Keap1/ARE signaling system
    • Tkachev VO, Menshchikova EB & Zenkov NK 2011 Mechanism of the Nrf2/Keap1/ARE signaling system. Biochemistry 76 407-422. (doi:10.1134/s0006297911040031)
    • (2011) Biochemistry , vol.76 , pp. 407-422
    • Tkachev, V.O.1    Menshchikova, E.B.2    Zenkov, N.K.3
  • 109
    • 84882936506 scopus 로고    scopus 로고
    • Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance
    • Ushida Y & Talalay P 2013 Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance. Alcohol and Alcoholism 48 526-534. (doi:10.1093/alcalc/agt063)
    • (2013) Alcohol and Alcoholism , vol.48 , pp. 526-534
    • Ushida, Y.1    Talalay, P.2
  • 113
    • 58149086400 scopus 로고    scopus 로고
    • Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement protandim
    • Velmurugan K, Alam J, McCord JM & Pugazhenthi S 2009 Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement protandim. Free Radical Biology & Medicine 46 430-440. (doi:10.1016/j.freeradbiomed.2008.10.050)
    • (2009) Free Radical Biology & Medicine , vol.46 , pp. 430-440
    • Velmurugan, K.1    Alam, J.2    McCord, J.M.3    Pugazhenthi, S.4
  • 114
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K & Förstermann U 2002 Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106 1652-1658. (doi:10.1161/01.CIR.0000029925.18593.5C)
    • (2002) Circulation , vol.106 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3    Anderson, H.4    Li, H.5    Witte, K.6    Förstermann, U.7
  • 115
    • 84922759380 scopus 로고    scopus 로고
    • Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors
    • Wang W, Wang J, Li N, Zhang X, Zhao W, Li J & Si Y 2015a Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors. Bioorganic & Medicinal Chemistry Letters 25 1078-1081. (doi:10.1016/j. bmcl.2015.01.009)
    • (2015) Bioorganic & Medicinal Chemistry Letters , vol.25 , pp. 1078-1081
    • Wang, W.1    Wang, J.2    Li, N.3    Zhang, X.4    Zhao, W.5    Li, J.6    Si, Y.7
  • 116
    • 84911895830 scopus 로고    scopus 로고
    • Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-kB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine
    • Wang B, Feng L, Jiang WD, Wu P, Kuang SY, Jiang J, Tang L, Tang WN, Zhang YA, Liu Y et al. 2015b Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-kB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine. Aquatic Toxicology 158 125-137. (doi:10.1016/j.aquatox.2014.10.025)
    • (2015) Aquatic Toxicology , vol.158 , pp. 125-137
    • Wang, B.1    Feng, L.2    Jiang, W.D.3    Wu, P.4    Kuang, S.Y.5    Jiang, J.6    Tang, L.7    Tang, W.N.8    Zhang, Y.A.9    Liu, Y.10
  • 117
    • 84921473737 scopus 로고    scopus 로고
    • Green tea polyphenol (K)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: responses of major antioxidant enzymes and the Nrf2 rescue pathway
    • Wang D, Wang Y, Wan X, Yang CS & Zhang J 2015c Green tea polyphenol (K)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: responses of major antioxidant enzymes and the Nrf2 rescue pathway. Toxicology and Applied Pharmacology 283 65-74. (doi:10.1016/j.taap. 2014.12.018)
    • (2015) Toxicology and Applied Pharmacology , vol.283 , pp. 65-74
    • Wang, D.1    Wang, Y.2    Wan, X.3    Yang, C.S.4    Zhang, J.5
  • 118
    • 84950170835 scopus 로고    scopus 로고
    • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
    • Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I & Berry NM 2011 Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutrition, Metabolism, and Cardiovascular Diseases 21 851-856. (doi:10. 1016/j.numecd.2010.03.003)
    • (2011) Nutrition, Metabolism, and Cardiovascular Diseases , vol.21 , pp. 851-856
    • Wong, R.H.1    Howe, P.R.2    Buckley, J.D.3    Coates, A.M.4    Kunz, I.5    Berry, N.M.6
  • 119
    • 84863763926 scopus 로고    scopus 로고
    • Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver
    • Wu KC, Cui JY & Klaassen CD 2012 Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS ONE 7 e39006. (doi:10.1371/journal.pone.0039006)
    • (2012) PLoS ONE , vol.7 , pp. e39006
    • Wu, K.C.1    Cui, J.Y.2    Klaassen, C.D.3
  • 122
    • 84922772443 scopus 로고    scopus 로고
    • Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70
    • Yao X, Bai Q, Yan D, Li G, Lü C & Xu H 2015 Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70. Toxicology in Vitro 29 600-608. (doi:10.1016/j. tiv.2015.01.009)
    • (2015) Toxicology in Vitro , vol.29 , pp. 600-608
    • Yao, X.1    Bai, Q.2    Yan, D.3    Li, G.4    Lü, C.5    Xu, H.6
  • 123
    • 84910010311 scopus 로고    scopus 로고
    • Oroxylin A exerts antiinflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation
    • Ye M, Wang Q, Zhang W, Li Z, Wang Y & Hu R 2014 Oroxylin A exerts antiinflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation. Biochemistry and Cell Biology 92 337-348. (doi:10.1139/bcb-2014-0030)
    • (2014) Biochemistry and Cell Biology , vol.92 , pp. 337-348
    • Ye, M.1    Wang, Q.2    Zhang, W.3    Li, Z.4    Wang, Y.5    Hu, R.6
  • 124
    • 84939932976 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
    • Yu Y, Bai F, Liu Y, Yang Y, Yuan Q, Zou D, Qu S, Tian G, Song L, Zhang T et al. 2015 Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. Molecular and Cellular Biochemistry 403 287-299. (doi:10.1007/s11010-015-2358-6)
    • (2015) Molecular and Cellular Biochemistry , vol.403 , pp. 287-299
    • Yu, Y.1    Bai, F.2    Liu, Y.3    Yang, Y.4    Yuan, Q.5    Zou, D.6    Qu, S.7    Tian, G.8    Song, L.9    Zhang, T.10
  • 125
    • 84872766433 scopus 로고    scopus 로고
    • Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells
    • Zhai X, Lin M, Zhang F, Hu Y, Xu X, Li Y, Liu K, Ma X, Tian X & Yao J 2013 Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells. Molecular Nutrition & Food Research 57 249-259. (doi:10.1002/mnfr.201200536)
    • (2013) Molecular Nutrition & Food Research , vol.57 , pp. 249-259
    • Zhai, X.1    Lin, M.2    Zhang, F.3    Hu, Y.4    Xu, X.5    Li, Y.6    Liu, K.7    Ma, X.8    Tian, X.9    Yao, J.10
  • 127
    • 84870396636 scopus 로고    scopus 로고
    • Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart
    • Zhang X, Xiao Z, Yao J, Zhao G, Fa X & Niu J 2013 Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart. Molecular and Cellular Biochemistry 372 169-179. (doi:10.1007/s11010-012-1458-9)
    • (2013) Molecular and Cellular Biochemistry , vol.372 , pp. 169-179
    • Zhang, X.1    Xiao, Z.2    Yao, J.3    Zhao, G.4    Fa, X.5    Niu, J.6
  • 128
    • 84907817553 scopus 로고    scopus 로고
    • The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCRF1/Nrf1b; both are also inhibited by the small dominant-negative Nrf1g/d isoforms that down-regulate ARE-battery gene expression
    • Zhang Y, Qiu L, Li S et al. 2014a The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCRF1/Nrf1b; both are also inhibited by the small dominant-negative Nrf1g/d isoforms that down-regulate ARE-battery gene expression. PLoS ONE 9 e109159. (doi:10.1371/journal.pone.0109159)
    • (2014) PLoS ONE , vol.9 , pp. e109159
    • Zhang, Y.1    Qiu, L.2    Li, S.3
  • 129
    • 84899102437 scopus 로고    scopus 로고
    • Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of Cap-independent translation
    • Zhang HM, Dai H, Hanson PJ, Li H, Guo H, Ye X, Hemida MG, Wang L, Tong Y, Qiu Y et al. 2014b Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of Cap-independent translation. ACS Chemical Biology 9 1015-1024. (doi:10.1021/cb400775z)
    • (2014) ACS Chemical Biology , vol.9 , pp. 1015-1024
    • Zhang, H.M.1    Dai, H.2    Hanson, P.J.3    Li, H.4    Guo, H.5    Ye, X.6    Hemida, M.G.7    Wang, L.8    Tong, Y.9    Qiu, Y.10
  • 130
    • 84878804327 scopus 로고    scopus 로고
    • Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy
    • Zhong Q, Mishra M & Kowluru RA 2013 Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Investigative Ophthalmology & Visual Science 54 3941-3948. (doi:10.1167/iovs.13-11598)
    • (2013) Investigative Ophthalmology & Visual Science , vol.54 , pp. 3941-3948
    • Zhong, Q.1    Mishra, M.2    Kowluru, R.A.3
  • 131
    • 84875617631 scopus 로고    scopus 로고
    • Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway
    • Zhou HG, Liu L, Zhang Y, Huang YY, Tao YH, Zhang S, Su JJ, Tang YP, Guo ZL, Hu RM et al. 2013 Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway. CNS Neuroscience & Therapeutics 19 252-261. (doi:10.1111/cns.12068)
    • (2013) CNS Neuroscience & Therapeutics , vol.19 , pp. 252-261
    • Zhou, H.G.1    Liu, L.2    Zhang, Y.3    Huang, Y.Y.4    Tao, Y.H.5    Zhang, S.6    Su, J.J.7    Tang, Y.P.8    Guo, Z.L.9    Hu, R.M.10
  • 132
    • 41549129055 scopus 로고    scopus 로고
    • Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress
    • Zhu H, Jia ZQ, Zhang L, Yamamoto M, Misra HP, Trush MA & Li Y 2008 Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress. Experimental Biology and Medicine 233 463-474. (doi:10.3181/0711-RM-304)
    • (2008) Experimental Biology and Medicine , vol.233 , pp. 463-474
    • Zhu, H.1    Jia, Z.Q.2    Zhang, L.3    Yamamoto, M.4    Misra, H.P.5    Trush, M.A.6    Li, Y.7
  • 133
    • 84897668774 scopus 로고    scopus 로고
    • Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway
    • Zuo X, Tian C, Zhao N et al. 2014 Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway. BMC Research Notes 7 120. (doi:10.1186/1756-0500-7-120)
    • (2014) BMC Research Notes , vol.7 , pp. 120
    • Zuo, X.1    Tian, C.2    Zhao, N.3


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