4-Hydroxy Hexenal Derived from Docosahexaenoic Acid Protects Endothelial Cells via Nrf2 Activation

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Ishikado, Atsushi ^a,d   Morino, Katsutaro ^a   Nishio, Yoshihiko ^b   Nakagawa, Fumiyuki ^a,c   Mukose, Atsushi ^a   Sono, Yoko ^d   Yoshioka, Nagisa ^c   Kondo, Keiko ^a   Sekine, Osamu ^a   Yoshizaki, Takeshi ^a   Ugi, Satoshi ^a   Uzu, Takashi ^a   Kawai, Hiromichi ^a   Makino, Taketoshi ^d   Okamura, Tomio ^a   Yamamoto, Masayuki ^e   Kashiwagi, Atsunori ^a   Maegawa, Hiroshi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c JCL Bioassay Corporation Miyahara   (Japan)

^d Sunstar Inc   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY HEXENAL; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; HEME OXYGENASE 1; ICOSAPENTAENOIC ACID; MESSENGER RNA; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN P62; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR RESPONSE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ACTIVITY; GENE TARGETING; HEART PROTECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALDEHYDES; ANIMALS; ANTIOXIDANTS; AORTA; BODY WEIGHT; CYTOPROTECTION; DIET; DNA DAMAGE; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPID PEROXIDATION; MALE; MICE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; VASODILATION;

EID: 84880724830     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069415     Document Type: Article

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