Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2

Free Radical Biology and Medicine

Volumn 42, Issue 12, 2007, Pages 1797-1806

  Pi, Jingbo ^a,b   Bai, Yushi ^b   Reece, Jeffrey M ^a   Williams, Jason ^a   Liu, Dianxin ^a   Freeman, Michael L ^c   Fahl, William E ^d   Shugar, David ^e   Liu, Jie ^a   Qu, Wei ^a   Collins, Sheila ^b   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Arsenic; CK2; Nrf2; Oxidative stress; Phosphorylation

Indexed keywords

CALCIUM; CALMODULIN; CASEIN KINASE II; PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; COLD; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOLECULAR WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TEMPERATURE DEPENDENCE;

BLOTTING, WESTERN; CALCIUM; CALMODULIN; CASEIN KINASE II; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPRECIPITATION; KERATINOCYTES; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 34248593492     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.03.001     Document Type: Article

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