Induction of NAD(P)H: Quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells

Amino Acids

Volumn 43, Issue 4, 2012, Pages 1547-1555

  Satsu, Hideo ^a   Chidachi, Emi ^a   Hiura, Yuto ^a   Ogiwara, Haru ^a   Gondo, Yusuke ^a   Shimizu, Makoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cysteine; Intestinal epithelial cell; NAD(P)H:quinone oxidoreductase 1 (NQO1); Nuclear factor erythroid 2 related factor 2 (Nrf2)

Indexed keywords

CYSTEINE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; BINDING SITES; CELL LINE; CELL NUCLEUS; CYSTEINE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; INTESTINAL MUCOSA; INTESTINES; MICE; MUTATION; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS;

MUS;

EID: 84867581790     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1230-1     Document Type: Article

References (27)

1. Baker DH, Czarnecki-Maulden GL (1987) Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities. J Nutr 117:1003-1010
2. Bauchart-Thevret C, Stoll B, Burrin DG (2009) Intestinal metabolism of sulfur amino acids. Nutr Res Rev 22:175-187
3. Begleiter A, Sivananthan K, Curphey TJ, Bird RP (2003) Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats. Cancer Epidemiol Biomarkers Prev 12:566-572
4. Begleiter A, Hewitt D, Maksymiuk AW, Ross DA, Bird RP (2006) ANAD(P)H:quinone oxidoreductase 1 polymorphism is Arisk factor for human colon cancer. Cancer Epidemiol Biomarkers Prev 15:2422-2426
5. Begleiter A, Sivananthan K, Lefas GM, Maksymiuk AW, Bird RP (2009) Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats. Oncol Rep 21:1559-1565
6. Carriere V, Chambaz J, Rousset M (2001) Intestinal responses to xenobiotics. Toxicol In Vitro 15:373-378
7. Dinkova-Kostova AT, Fahey JW, Talalay P (2004) Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1). Methods Enzymol 382:423-448
8. Giles NM, Giles GI, Jacob C (2003) Multiple roles of cysteine in biocatalysis. Biochem Biophys Res Commun 300:1-4
9. Hong F, Sekhar KR, Freeman ML, Liebler DC (2005a) Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem 280:31768-31775
10. Hong F, Freeman ML, Liebler DC (2005b) Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol 18:1917-1926
11. Keum YS, Han YH, Liew C, Kim JH, Xu C, Yuan X, Shakarjian MP, Chong S, Kong AN (2006) Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by Aphenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharm Res 23:2586-2594
12. Kim CJ, Kovacs-Nolan J, Yang C, Archbold T, Fan MZ, Mine Y (2009) l-Cysteine supplementation attenuates local inflammation and restores gut homeostasis in Aporcine model of colitis. Biochim Biophys Acta 1790:1161-1169
13. Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M (2006) Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 26:221-229
14. Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M (2009) The antioxidant defense system Keap1-Nrf2 comprises Amultiple sensing mechanism for responding to Awide range of chemical compounds. Mol Cell Biol 29:493-502
15. Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB (2007) Sites of alkylation of human Keap1 by natural chemoprevention agents. J Am Soc Mass Spectrom 18:2226-2232
16. Moran JA, Dahl EL, Mulcahy RT (2002) Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. Biochem J 361:371-377
17. Nguyen T, Rushmore TH, Pickett CB (1994) Transcriptional regulation of Arat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-Acetate. J Biol Chem 269:13656-13662
18. Nioi P, Hayes JD (2004) Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res 555:149-171
19. Prochaska HJ, Santamaria AB (1988) Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: Ascreening assay for anticarcinogenic enzyme inducers. Anal Biochem 169:328-336
20. Ross D, Siegel D (2004) NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Methods Enzymol 382:115-144
21. Satsu H, Hiura Y, Mochizuki K, Hamada M, Shimizu M (2008) Activation of the pregnane X receptor and induction of MDR1 by dietary phytochemicals. J Agric Food Chem 56:5366-5373
22. Shin HS, Zhao Z, Satsu H, Totsuka M, Shimizu M (2011) Synergistic effect of tumor necrosis factor-Alpha and hydrogen peroxide on the induction of IL-8 production in human intestinal Caco-2 cells. Inflammation 34:440-447
23. Stipanuk MH (2004) Role of the liver in regulation of body cysteine and taurine levels: Abrief review. Neurochem Res 29:105-110
24. Talalay P (2000) Chemoprotection against cancer by induction of phase 2 enzymes. Biofactors 12:5-11
25. Tanigawa S, Fujii M, Hou DX (2007) Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin. Free Radic Biol Med 42:1690-1703
26. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203
27. Xu C, Li CY, Kong AN (2005) Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 28:249-268