Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells

Molecular Nutrition and Food Research

Volumn 57, Issue 2, 2013, Pages 249-259

  Zhai, Xiaohan ^a   Lin, Musen ^a   Zhang, Feng ^a   Hu, Yan ^a   Xu, Xiaomei ^a   Li, Yubing ^a   Liu, Kexin ^a   Ma, Xiaochi ^a   Tian, Xiaofeng ^a   Yao, Jihong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

ERK1 2; Gesnitein; Nrf2; Oxidative stress; PKC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; FLAVONOID; GENISTEIN; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; MESSENGER RNA; NFE2L2 PROTEIN, HUMAN; PROTEIN KINASE C; PROTOPORPHYRIN; PROTOPORPHYRIN ZINC; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL STRAIN CACO 2; DRUG ANTAGONISM; DRUG DETOXIFICATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIOXIDANTS; BUTHIONINE SULFOXIMINE; CACO-2 CELLS; FLAVONOIDS; GENE EXPRESSION; GENISTEIN; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; METABOLIC DETOXICATION, PHASE II; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN KINASE C; PROTOPORPHYRINS; RNA, MESSENGER; UP-REGULATION;

EID: 84872766433     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200536     Document Type: Article

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