Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1506-1515

  Ishikado, Atsushi ^a   Sono, Yoko ^a   Matsumoto, Motonobu ^a   Robida Stubbs, Stacey ^b   Okuno, Aya ^a   Goto, Masashi ^a   King, George L ^b   Keith Blackwell, T ^b   Makino, Taketoshi ^a  

^a Sunstar Inc   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antioxidant enzyme; Caenorhabditis elegans; Free radicals; HUVEC; Nrf2; Oxidative stress; Willow bark extract

Indexed keywords

GLUTATHIONE; HEME OXYGENASE 1; PLANT EXTRACT; PROTEIN P62; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; WILLOW BARK EXTRACT;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BARK; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; GENE INDUCTION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL; WILLOW;

CAENORHABDITIS ELEGANS; SALIX;

3-(4,5-DIMETHYL-2-THIAZOLYL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE; ANTIOXIDANT ENZYME; ANTIOXIDANT RESPONSE ELEMENT; ARE; CAENORHABDITIS ELEGANS; FBS; FETAL BOVINE SERUM; FREE RADICALS; GCLC; GCLM; GFP; GREEN FLUORESCENT PROTEIN; HEME OXYGENASE-1; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HO-1; HPLC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELL; HUVEC; KEAP1; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MTT; NEMATODE GROWTH MEDIUM; NGM; NRF2; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2; OXIDATIVE STRESS; PBS; PHOSPHATE-BUFFERED SALINE; TBHP; TERT-BUTYLHYDROPEROXIDE; WBE; WILLOW BARK EXTRACT; Γ-GLUTAMYLCYSTEINE LIGASE, CATALYTIC SUBUNIT; Γ-GLUTAMYLCYSTEINE LIGASE, MODIFIER SUBUNIT;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; BENZYL ALCOHOLS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARBOXYLIC ESTER HYDROLASES; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUCOSIDES; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMIDAZOLES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLANT BARK; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-MYC; PYRIDINES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SALIX; TRANSCRIPTION FACTORS;

EID: 84890436238     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.12.006     Document Type: Article

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