메뉴 건너뛰기




Volumn 9, Issue 7, 2013, Pages 656-665

Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions

Author keywords

Angiogenesis; Cardiac microvascular endothelial cell; Hypoxia; NF E2 related factor 2

Indexed keywords

HEME OXYGENASE 1; MESSENGER RNA; NFE2L2 PROTEIN, RAT; TRANSCRIPTION FACTOR NRF2; VASCULOTROPIN A;

EID: 84880588789     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5887     Document Type: Article
Times cited : (40)

References (31)
  • 2
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003; 9:653-60.
    • (2003) Nat Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 3
    • 0032894826 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for heart failure
    • Isner JM, Losordo DW. Therapeutic angiogenesis for heart failure. Nat Med. 1999; 5: 491-2.
    • (1999) Nat Med. , vol.5 , pp. 491-492
    • Isner, J.M.1    Losordo, D.W.2
  • 4
    • 2542450436 scopus 로고    scopus 로고
    • Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention
    • Elsman P, van't Hof AW, de Boer MJ, et al. Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J. 2004; 25: 854-8.
    • (2004) Eur Heart J. , vol.25 , pp. 854-858
    • Elsman, P.1    van't Hof, A.W.2    de Boer, M.J.3
  • 6
    • 67650453921 scopus 로고    scopus 로고
    • Targeting the Nrf2 pathway against cardiovascular disease
    • Li J, Ichikawa T, Janicki JS, et al. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets. 2009; 13: 785-94.
    • (2009) Expert Opin Ther Targets. , vol.13 , pp. 785-794
    • Li, J.1    Ichikawa, T.2    Janicki, J.S.3
  • 7
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S, et al. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007; 47: 89-116.
    • (2007) Annu Rev Pharmacol Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 8
    • 67649402187 scopus 로고    scopus 로고
    • The NRF-2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T, Nioi P, Pickett CB, et al. The NRF-2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009; 284: 13291-5.
    • (2009) J Biol Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 9
    • 70350115341 scopus 로고    scopus 로고
    • Nrf2 protects against maladaptive cardiac responses to hemodynamic stress
    • Li J, Ichikawa T, Villacorta L, et al. Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol. 2009; 29:1843-50.
    • (2009) Arterioscler Thromb Vasc Biol. , vol.29 , pp. 1843-1850
    • Li, J.1    Ichikawa, T.2    Villacorta, L.3
  • 10
    • 77954958647 scopus 로고    scopus 로고
    • An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes
    • Li J, Ichikawa T, Jin Y, et al. An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes. J Ethn-opharmacol. 2010; 130: 222-30.
    • (2010) J Ethn-opharmacol. , vol.130 , pp. 222-230
    • Li, J.1    Ichikawa, T.2    Jin, Y.3
  • 11
    • 67650229881 scopus 로고    scopus 로고
    • Nrf2-dependent upregulation of antioxidative enzymes: A novel pathway for proteasome inhibitor-mediated cardioprotection
    • Dreger H, Westphal K, Weller A, et al. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res. 2009; 83: 354-61.
    • (2009) Cardiovasc Res. , vol.83 , pp. 354-361
    • Dreger, H.1    Westphal, K.2    Weller, A.3
  • 12
    • 34848858001 scopus 로고    scopus 로고
    • Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2
    • Dai G, Vaughn S, Zhang Y, et al. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res. 2007; 101: 723-33.
    • (2007) Circ Res. , vol.101 , pp. 723-733
    • Dai, G.1    Vaughn, S.2    Zhang, Y.3
  • 13
    • 77950023482 scopus 로고    scopus 로고
    • Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy
    • Uno K, Prow TW, Bhutto IA, et al. Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy. Exp Eye Res. 2010; 90: 493-500.
    • (2010) Exp Eye Res. , vol.90 , pp. 493-500
    • Uno, K.1    Prow, T.W.2    Bhutto, I.A.3
  • 14
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1a
    • Kim TH, Hur EG, Kang SJ, et al. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1a. Cancer Res. 2011; 71: 2260-75.
    • (2011) Cancer Res. , vol.71 , pp. 2260-2275
    • Kim, T.H.1    Hur, E.G.2    Kang, S.J.3
  • 15
    • 84856756216 scopus 로고    scopus 로고
    • Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer
    • Ma X, Zhang J, Liu S, et al. Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer. Cancer Chemother Pharmacol. 2012; 69: 485-94.
    • (2012) Cancer Chemother Pharmacol. , vol.69 , pp. 485-494
    • Ma, X.1    Zhang, J.2    Liu, S.3
  • 16
    • 79956121323 scopus 로고    scopus 로고
    • Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter
    • Pendyala S, Moitra J, Kalari S, et al. Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter. Free Radic Biol Med. 2011; 50: 1749-59.
    • (2011) Free Radic Biol Med. , vol.50 , pp. 1749-1759
    • Pendyala, S.1    Moitra, J.2    Kalari, S.3
  • 17
    • 77952923001 scopus 로고    scopus 로고
    • Intermittent and sustained hypoxia induce a similar gene expression profile in human aortic endothelial cells
    • Polotsky VY, Savransky V, Bevans-Fonti S, et al. Intermittent and sustained hypoxia induce a similar gene expression profile in human aortic endothelial cells. Physiol Genomics. 2010; 41: 306-14.
    • (2010) Physiol Genomics. , vol.41 , pp. 306-314
    • Polotsky, V.Y.1    Savransky, V.2    Bevans-Fonti, S.3
  • 18
    • 0029128161 scopus 로고
    • A new simple method for isolation of micro-vascular endothelial cells avoiding both chemical and mechanical injuries
    • Chen SF, Fei X, Li SH, et al. A new simple method for isolation of micro-vascular endothelial cells avoiding both chemical and mechanical injuries. Microvasc Res. 1995; 50: 119-28.
    • (1995) Microvasc Res. , vol.50 , pp. 119-128
    • Chen, S.F.1    Fei, X.2    Li, S.H.3
  • 19
    • 84855794830 scopus 로고    scopus 로고
    • Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells
    • Wang L, Chen Q, Li G, et al. Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells. Peptides. 2012; 33: 92-100.
    • (2012) Peptides. , vol.33 , pp. 92-100
    • Wang, L.1    Chen, Q.2    Li, G.3
  • 20
    • 77955053268 scopus 로고    scopus 로고
    • Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells
    • Kuang CY, Yu Y, Guo RW, et al. Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells. Biochem Biophys Res Commun. 2010; 398: 315-20.
    • (2010) Biochem Biophys Res Commun. , vol.398 , pp. 315-320
    • Kuang, C.Y.1    Yu, Y.2    Guo, R.W.3
  • 21
    • 79954520207 scopus 로고    scopus 로고
    • PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells
    • Feng J, Zhang P, Chen X, et al. PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells. J Cell Biochem. 2011; 112: 1524-31.
    • (2011) J Cell Biochem. , vol.112 , pp. 1524-1531
    • Feng, J.1    Zhang, P.2    Chen, X.3
  • 22
    • 79952990726 scopus 로고    scopus 로고
    • Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia
    • Sethy NK, Singh M, Kumar R, et al. Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia. Funct Integr Genomics. 2011;11:119-37.
    • (2011) Funct Integr Genomics. , vol.11 , pp. 119-137
    • Sethy, N.K.1    Singh, M.2    Kumar, R.3
  • 23
    • 67649670106 scopus 로고    scopus 로고
    • Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    • Yang C, Zhang X, Fan H, et al. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res. 2009; 1282:133-41.
    • (2009) Brain Res. , vol.1282 , pp. 133-141
    • Yang, C.1    Zhang, X.2    Fan, H.3
  • 24
    • 0021717225 scopus 로고
    • Mechanisms of neovascularization Vascular sprouting can occur without proliferation of endothelial cells
    • Sholley MM, Ferguson GP, Seibel HR, et al. Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Lab Invest, 1984; 51: 624-634.
    • (1984) Lab Invest , vol.51 , pp. 624-634
    • Sholley, M.M.1    Ferguson, G.P.2    Seibel, H.R.3
  • 25
    • 84875364553 scopus 로고    scopus 로고
    • Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia
    • Ashino T, Yamamoto M, Yoshida T, et al. Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia. Arterioscler Thromb Vasc Biol, 2013; 33:760-768.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 760-768
    • Ashino, T.1    Yamamoto, M.2    Yoshida, T.3
  • 26
    • 84866346444 scopus 로고    scopus 로고
    • Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: Implications for microvascular aging
    • Valcarcel-Ares MN, Gautam T, Warrington JP, et al. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:821-29.
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 821-829
    • Valcarcel-Ares, M.N.1    Gautam, T.2    Warrington, J.P.3
  • 27
    • 77951479702 scopus 로고    scopus 로고
    • Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism novel point of convergence between electrophilic and unfolded protein stress pathways
    • Afonyushkin T, Oskolkova OV, Philippova M, et al. Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol. 2010; 30: 1007-13.
    • (2010) Arterioscler Thromb Vasc Biol. , vol.30 , pp. 1007-1013
    • Afonyushkin, T.1    Oskolkova, O.V.2    Philippova, M.3
  • 28
    • 0027468890 scopus 로고
    • Isolation and characterization of human and rat cardiac microvascular endothelial cells
    • Nishida M, Carley WW, Gerritsen ME, et al. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am J Physiol. 1993; 264: H639-52.
    • (1993) Am J Physiol. , vol.264
    • Nishida, M.1    Carley, W.W.2    Gerritsen, M.E.3
  • 29
    • 42349109815 scopus 로고    scopus 로고
    • Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice
    • Tongers J, Knapp JW, Korf M, et al. Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice. Cardiovasc Res. 2008; 78: 294-300.
    • (2008) Cardiovasc Res. , vol.78 , pp. 294-300
    • Tongers, J.1    Knapp, J.W.2    Korf, M.3
  • 30
    • 77950494559 scopus 로고    scopus 로고
    • Arsenic promotes angiogenesis in vitro via a heme oxygenase-1 dependent mechanism
    • Meng D, Wang X, Chang Q, et al. Arsenic promotes angiogenesis in vitro via a heme oxygenase-1 dependent mechanism. Toxicol Appl Pharmacol. 2010; 244: 291-9.
    • (2010) Toxicol Appl Pharmacol. , vol.244 , pp. 291-299
    • Meng, D.1    Wang, X.2    Chang, Q.3
  • 31
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara, N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004; 25: 581-611.
    • (2004) Endocr Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.