Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells

Biochemical Pharmacology

Volumn 93, Issue 3, 2015, Pages 352-361

  Huang, Chin Shiu ^a,b   Lin, Ai Hsuan ^c   Yang, Ting Chun ^c   Liu, Kai Li ^d   Chen, Haw Wen ^c   Lii, Chong Kuei ^a,c  

^a ASIA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adhesion molecules; Antioxidant defense; Nuclear factor erythroid 2 related factor 2 (Nrf2); Nuclear factor kappaB (NF B); Oxidized LDL; Shikonin

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SHIKONIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; LOW DENSITY LIPOPROTEIN; NAPHTHOQUINONE; NFE2L2 PROTEIN, HUMAN;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING AFFINITY; CELL ADHESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIOXIDANTS; CELL ADHESION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPOPROTEINS, LDL; MONOCYTES; NAPHTHOQUINONES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; UP-REGULATION;

EID: 84921831296     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.12.005     Document Type: Article

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