메뉴 건너뛰기




Volumn 14, Issue 3, 2011, Pages 469-487

Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: A role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway

Author keywords

[No Author keywords available]

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 78650913154     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2010.3283     Document Type: Review
Times cited : (162)

References (224)
  • 1
    • 61449147889 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants
    • Abdul-Ghani MA, Jani R, Chavez A, Molina-Carrion M, Tripathy D, and Defronzo RA. Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants. Diabetologia 52: 574-582, 2009.
    • (2009) Diabetologia , vol.52 , pp. 574-582
    • Abdul-Ghani, M.A.1    Jani, R.2    Chavez, A.3    Molina-Carrion, M.4    Tripathy, D.5    Defronzo, R.A.6
  • 2
  • 3
    • 0033543566 scopus 로고    scopus 로고
    • Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
    • Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, and Cook JL. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274: 26071-26078, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 26071-26078
    • Alam, J.1    Stewart, D.2    Touchard, C.3    Boinapally, S.4    Choi, A.M.5    Cook, J.L.6
  • 5
    • 67650523965 scopus 로고    scopus 로고
    • Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothe-lium exposed to laminar shear stress and impaired by disturbed flow
    • Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC, and Mason JC. Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothe-lium exposed to laminar shear stress and impaired by disturbed flow. J Biol Chem 284: 18882-18892, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 18882-18892
    • Ali, F.1    Zakkar, M.2    Karu, K.3    Lidington, E.A.4    Hamdulay, S.S.5    Boyle, J.J.6    Zloh, M.7    Bauer, A.8    Haskard, D.O.9    Evans, P.C.10    Mason, J.C.11
  • 6
    • 0342573147 scopus 로고    scopus 로고
    • Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes
    • Ammar RF Jr., Gutterman DD, Brooks LA, and Dellsperger KC. Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. Cardiovasc Res 47: 595-601, 2000.
    • (2000) Cardiovasc Res , vol.47 , pp. 595-601
    • Ammar Jr., R.F.1    Gutterman, D.D.2    Brooks, L.A.3    Dellsperger, K.C.4
  • 7
    • 0042626242 scopus 로고    scopus 로고
    • SKN-1 links C. elegans me-sendodermal specification to a conserved oxidative stress response
    • An JH and Blackwell TK. SKN-1 links C. elegans me-sendodermal specification to a conserved oxidative stress response. Genes Dev 17: 1882- 1893, 2003.
    • (2003) Genes Dev , vol.17 , pp. 1882-1893
    • An, J.H.1    Blackwell, T.K.2
  • 8
    • 33748645122 scopus 로고    scopus 로고
    • 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases su-peroxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    • Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H, and Channon KM. 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases su-peroxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 114: 1193-1201, 2006.
    • (2006) Circulation , vol.114 , pp. 1193-1201
    • Antoniades, C.1    Shirodaria, C.2    Warrick, N.3    Cai, S.4    De Bono, J.5    Lee, J.6    Leeson, P.7    Neubauer, S.8    Ratnatunga, C.9    Pillai, R.10    Refsum, H.11    Channon, K.M.12
  • 9
    • 20444456655 scopus 로고    scopus 로고
    • Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: Role of mitogen-activated protein kinases and Nrf2
    • Anwar AA, Li FY, Leake DS, Ishii T, Mann GE, and Siow RC. Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radic Biol Med 39: 227-236, 2005.
    • (2005) Free Radic Biol Med , vol.39 , pp. 227-236
    • Anwar, A.A.1    Li, F.Y.2    Leake, D.S.3    Ishii, T.4    Mann, G.E.5    Siow, R.C.6
  • 10
    • 40549121572 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
    • Apopa PL, He X, and Ma Q. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J Biochem Mol Toxicol 22: 63-76, 2008.
    • (2008) J Biochem Mol Toxicol , vol.22 , pp. 63-76
    • Apopa, P.L.1    He, X.2    Ma, Q.3
  • 11
    • 35848955430 scopus 로고    scopus 로고
    • Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis
    • Asija A, Peterson SJ, Stec DE, and Abraham NG. Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis. Antioxid Redox Signal 9: 2065-2074, 2007.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 2065-2074
    • Asija, A.1    Peterson, S.J.2    Stec, D.E.3    Abraham, N.G.4
  • 12
    • 0037683670 scopus 로고    scopus 로고
    • Monocyte NADPH ox-idase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: Relationship with oxidative stress
    • Avogaro A, Pagnin E, and Calo L. Monocyte NADPH ox-idase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress. J Clin Endocrinol Metab 88: 1753-1759, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1753-1759
    • Avogaro, A.1    Pagnin, E.2    Calo, L.3
  • 13
    • 0034458228 scopus 로고    scopus 로고
    • The NADPH oxidase of endothelial cells
    • Babior BM. The NADPH oxidase of endothelial cells. IUBMB Life 50: 267-269, 2000.
    • (2000) IUBMB Life , vol.50 , pp. 267-269
    • Babior, B.M.1
  • 14
    • 0024455312 scopus 로고
    • Induction of cystine transport activity in human fibroblasts by oxygen
    • Bannai S, Sato H, Ishii T, and Sugita Y. Induction of cystine transport activity in human fibroblasts by oxygen. J Biol Chem 264: 18480-18484, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 18480-18484
    • Bannai, S.1    Sato, H.2    Ishii, T.3    Sugita, Y.4
  • 15
    • 0032445585 scopus 로고    scopus 로고
    • Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats
    • Ba̧ star I, Seçkin S, Uysal M, and Aykaç-Toker G. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Res Commun Mol Pathol Pharmacol, 102, 265-272, 1998
    • (1998) Res Commun Mol Pathol Pharmacol , vol.102 , pp. 265-272
    • Ba̧star I, S.1
  • 16
    • 0037092995 scopus 로고    scopus 로고
    • Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management
    • Beckman JA, Creager MA, and Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287: 2570-2581, 2002.
    • (2002) JAMA , vol.287 , pp. 2570-2581
    • Beckman, J.A.1    Creager, M.A.2    Libby, P.3
  • 18
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop NA and Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549, 2007.
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 19
    • 0242666198 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization=accumulation in the nucleus and tran-scriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
    • Bloom DA and Jaiswal AK. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization=accumulation in the nucleus and tran-scriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 278: 44675-44682, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 44675-44682
    • Bloom, D.A.1    Jaiswal, A.K.2
  • 21
    • 0028908348 scopus 로고
    • Advanced protein glycosylation in diabetes and aging
    • Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46: 223-234, 1995.
    • (1995) Annu Rev Med , vol.46 , pp. 223-234
    • Brownlee, M.1
  • 22
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 23
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625, 2005.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 25
    • 0037767747 scopus 로고    scopus 로고
    • Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothe-lium
    • Buckley BJ, Marshall ZM, and Whorton AR. Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothe-lium. Biochem Biophys Res Commun 307: 973-979, 2003.
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 973-979
    • Buckley, B.J.1    Marshall, Z.M.2    Whorton, A.R.3
  • 26
    • 1642422773 scopus 로고    scopus 로고
    • Mitochondrial free radical production and cell signaling
    • Cadenas E. Mitochondrial free radical production and cell signaling. Mol Aspects Med 25: 17-26, 2004.
    • (2004) Mol Aspects Med , vol.25 , pp. 17-26
    • Cadenas, E.1
  • 27
    • 11844253848 scopus 로고    scopus 로고
    • Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
    • Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, and Johnson JA. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci USA 102: 244-249, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 244-249
    • Calkins, M.J.1    Jakel, R.J.2    Johnson, D.A.3    Chan, K.4    Kan, Y.W.5    Johnson, J.A.6
  • 30
    • 0034672595 scopus 로고    scopus 로고
    • Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
    • Chan JY and Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta 1517: 19-26, 2000.
    • (2000) Biochim Biophys Acta , vol.1517 , pp. 19-26
    • Chan, J.Y.1    Kwong, M.2
  • 31
    • 0035836698 scopus 로고    scopus 로고
    • An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
    • Chan K, Han XD, and Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98: 4611-4616, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4611-4616
    • Chan, K.1    Han, X.D.2    Kan, Y.W.3
  • 32
    • 0030451213 scopus 로고    scopus 로고
    • NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
    • Chan K, Lu R, Chang JC, and Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943-13948, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13943-13948
    • Chan, K.1    Lu, R.2    Chang, J.C.3    Kan, Y.W.4
  • 33
    • 0037101768 scopus 로고    scopus 로고
    • Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and in-ducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
    • Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, and Hayes JD. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and in-ducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 365: 405-416, 2002.
    • (2002) Biochem J , vol.365 , pp. 405-416
    • Chanas, S.A.1    Jiang, Q.2    McMahon, M.3    McWalter, G.K.4    McLellan, L.I.5    Elcombe, C.R.6    Henderson, C.J.7    Wolf, C.R.8    Moffat, G.J.9    Itoh, K.10    Yamamoto, M.11    Hayes, J.D.12
  • 34
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, and Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605, 1979.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 35
    • 0037907756 scopus 로고    scopus 로고
    • Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain
    • Chang SH, Garcia J, Melendez JA, Kilberg MS, and Agarwal A. Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain. Biochem J 371: 877-885, 2003.
    • (2003) Biochem J , vol.371 , pp. 877-885
    • Chang, S.H.1    Garcia, J.2    Melendez, J.A.3    Kilberg, M.S.4    Agarwal, A.5
  • 36
    • 52049122423 scopus 로고    scopus 로고
    • Stress-induced premature senescence of endothelial cells
    • Chen J, Patschan S, and Goligorsky MS. Stress-induced premature senescence of endothelial cells. J Nephrol 21: 337-344, 2008.
    • (2008) J Nephrol , vol.21 , pp. 337-344
    • Chen, J.1    Patschan, S.2    Goligorsky, M.S.3
  • 40
    • 11444261268 scopus 로고    scopus 로고
    • Gene expression profiling of NRF2-mediated protection against oxidative injury
    • DOI 10.1016/j.freeradbiomed.2004.10.013, PII S0891584904008354
    • Cho HY, Reddy SP, Debiase A, Yamamoto M, and Klee-berger SR. Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38: 325-343, 2005. (Pubitemid 40081112)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.3 , pp. 325-343
    • Cho, H.-Y.1    Reddy, S.P.2    DeBiase, A.3    Yamamoto, M.4    Kleeberger, S.R.5
  • 41
    • 72949090169 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells
    • Churchman AT, Anwar AA, Li FY, Sato H, Ishii T, Mann GE, and Siow RC. Transforming growth factor-beta1 elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells. J Cell Mol Med 13: 2282-2292, 2009.
    • (2009) J Cell Mol Med , vol.13 , pp. 2282-2292
    • Churchman, A.T.1    Anwar, A.A.2    Li, F.Y.3    Sato, H.4    Ishii, T.5    Mann, G.E.6    Siow, R.C.7
  • 44
    • 33845640469 scopus 로고    scopus 로고
    • HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism
    • Converso DP, Taille C, Carreras MC, Jaitovich A, Poderoso JJ, and Boczkowski J. HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism. FASEB J 20: 1236-1238, 2006.
    • (2006) FASEB J , vol.20 , pp. 1236-1238
    • Converso, D.P.1    Taille, C.2    Carreras, M.C.3    Jaitovich, A.4    Poderoso, J.J.5    Boczkowski, J.6
  • 46
    • 70350496588 scopus 로고    scopus 로고
    • Critical role for tetrahydrobiopterin recycling by di-hydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: Relative importance of the de novo biopterin synthesis versus salvage pathways
    • Crabtree MJ, Tatham AL, Hale AB, Alp NJ, and Channon KM. Critical role for tetrahydrobiopterin recycling by di-hydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. J Biol Chem 284: 28128-28136, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 28128-28136
    • Crabtree, M.J.1    Tatham, A.L.2    Hale, A.B.3    Alp, N.J.4    Channon, K.M.5
  • 47
    • 34848858001 scopus 로고    scopus 로고
    • Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase=Akt-dependent activation of Nrf2
    • Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, and Gimbrone MA Jr. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase=Akt-dependent activation of Nrf2. Circ Res 101: 723-733, 2007.
    • (2007) Circ Res , vol.101 , pp. 723-733
    • Dai, G.1    Vaughn, S.2    Zhang, Y.3    Wang, E.T.4    Garcia-Cardena, G.5    Gimbrone Jr., M.A.6
  • 48
    • 34247598856 scopus 로고    scopus 로고
    • Endothelial mitochondria: Contributing to vascular function and disease
    • Davidson SM and Duchen MR. Endothelial mitochondria: contributing to vascular function and disease. Circ Res 100: 1128-1141, 2007.
    • (2007) Circ Res , vol.100 , pp. 1128-1141
    • Davidson, S.M.1    Duchen, M.R.2
  • 50
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, and Talalay P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99: 11908-11913, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6    Yamamoto, M.7    Talalay, P.8
  • 51
    • 52449089630 scopus 로고    scopus 로고
    • Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    • Dinkova-Kostova AT and Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52 Suppl 1: S128-S138, 2008.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Dinkova-Kostova, A.T.1    Talalay, P.2
  • 53
    • 67650229881 scopus 로고    scopus 로고
    • Nrf2-dependent upregulation of antioxidative enzymes: A novel pathway for proteasome inhibitor-mediated cardioprotection
    • Dreger H, Westphal K, Weller A, Baumann G, Stangl V, Meiners S, and Stangl K. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res 83: 354-361, 2009.
    • (2009) Cardiovasc Res , vol.83 , pp. 354-361
    • Dreger, H.1    Westphal, K.2    Weller, A.3    Baumann, G.4    Stangl, V.5    Meiners, S.6    Stangl, K.7
  • 54
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, and Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112: 1049-1057, 2003.
    • (2003) J Clin Invest , vol.112 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengeller, Z.5    Szabo, C.6    Brownlee, M.7
  • 56
    • 22544464124 scopus 로고    scopus 로고
    • Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    • Eggler AL, Liu G, Pezzuto JM, van Breemen RB, and Me-secar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci USA 102: 10070-10075, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10070-10075
    • Eggler, A.L.1    Liu, G.2    Pezzuto, J.M.3    Van Breemen, R.B.4    Me-Secar, A.D.5
  • 57
    • 58849155179 scopus 로고    scopus 로고
    • Vascular endothelial senescence: From mechanisms to pathophysiology
    • Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 106: 326-332, 2009.
    • (2009) J Appl Physiol , vol.106 , pp. 326-332
    • Erusalimsky, J.D.1
  • 59
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T and Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239-247, 2000.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 60
    • 44449162751 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies
    • Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5: 338-349, 2008.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 338-349
    • Forstermann, U.1
  • 61
    • 62349116866 scopus 로고    scopus 로고
    • Vascular NAD(P) H oxidase activation in diabetes: A double-edged sword in redox signalling
    • Gao L and Mann GE. Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling. Cardiovasc Res 82: 9-20, 2009.
    • (2009) Cardiovasc Res , vol.82 , pp. 9-20
    • Gao, L.1    Mann, G.E.2
  • 65
  • 67
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, and Channon KM. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105: 1656-1662, 2002.
    • (2002) Circulation , vol.105 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 68
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis MC and Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5: 253-295, 2010.
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 69
    • 0027465289 scopus 로고
    • The role of oxygen radicals in human disease, with particular reference to the vascular system
    • Halliwell B. The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemos-tasis 23 Suppl 1: 118-126, 1993.
    • (1993) Haemos-tasis , vol.23 , Issue.SUPPL. 1 , pp. 118-126
    • Halliwell, B.1
  • 70
    • 63849133179 scopus 로고    scopus 로고
    • Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells
    • Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, and Alevriadou BR. Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther 329: 94-101, 2009.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 94-101
    • Han, Z.1    Varadharaj, S.2    Giedt, R.J.3    Zweier, J.L.4    Szeto, H.H.5    Alevriadou, B.R.6
  • 71
    • 8444228527 scopus 로고    scopus 로고
    • Compartmentation of Nrf-2 redox control: Regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
    • Hansen JM, Watson WH, and Jones DP. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicol Sci 82: 308-317, 2004.
    • (2004) Toxicol Sci , vol.82 , pp. 308-317
    • Hansen, J.M.1    Watson, W.H.2    Jones, D.P.3
  • 72
    • 33646699095 scopus 로고    scopus 로고
    • Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase=Akt pathway and the Nrf2 transcription factor in renal cells
    • Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, and Wigmore SJ. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase=Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J 273: 2345-2356, 2006.
    • (2006) FEBS J , vol.273 , pp. 2345-2356
    • Harrison, E.M.1    McNally, S.J.2    Devey, L.3    Garden, O.J.4    Ross, J.A.5    Wigmore, S.J.6
  • 74
    • 0033956744 scopus 로고    scopus 로고
    • The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
    • Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, and Yamamoto M. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28: 33-41, 2000.
    • (2000) Biochem Soc Trans , vol.28 , pp. 33-41
    • Hayes, J.D.1    Chanas, S.A.2    Henderson, C.J.3    McMahon, M.4    Sun, C.5    Moffat, G.J.6    Wolf, C.R.7    Yamamoto, M.8
  • 75
    • 78649635570 scopus 로고    scopus 로고
    • Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes
    • He M, Siow RC, Sugden D, Gao L, Cheng X, and Mann GE. Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes. Nutr Metab Cardiovasc Dis 2010.
    • (2010) Nutr Metab Cardiovasc Dis
    • He, M.1    Siow, R.C.2    Sugden, D.3    Gao, L.4    Cheng, X.5    Mann, G.E.6
  • 76
    • 25444468046 scopus 로고    scopus 로고
    • Divergent responses of chondrocytes and endothelial cells to shear stress: Crosstalk among COX-2, the phase 2 response, and apoptosis
    • Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, and Konstantopoulos K. Divergent responses of chondrocytes and endothelial cells to shear stress: crosstalk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci USA 102: 14010-14015, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14010-14015
    • Healy, Z.R.1    Lee, N.H.2    Gao, X.3    Goldring, M.B.4    Talalay, P.5    Kensler, T.W.6    Konstantopoulos, K.7
  • 77
    • 70450234994 scopus 로고    scopus 로고
    • Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: The role of reactive oxygen species (ROS)-, eNOS- and heme oxygenase (HO-1) levels
    • Heiss EH, Schachner D, Werner ER, and Dirsch VM. Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: the role of reactive oxygen species (ROS)-, eNOS- and heme oxygenase (HO-1) levels. J Biol Chem 284: 31579-31586, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 31579-31586
    • Heiss, E.H.1    Schachner, D.2    Werner, E.R.3    Dirsch, V.M.4
  • 79
    • 34248182498 scopus 로고    scopus 로고
    • Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice
    • Hu CM, Lin HH, Chiang MT, Chang PF, and Chau LY. Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice. Diabetes 56: 1240-1247, 2007.
    • (2007) Diabetes , vol.56 , pp. 1240-1247
    • Hu, C.M.1    Lin, H.H.2    Chiang, M.T.3    Chang, P.F.4    Chau, L.Y.5
  • 81
    • 0033731182 scopus 로고    scopus 로고
    • Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
    • Huang HC, Nguyen T, and Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci USA 97: 12475-12480, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12475-12480
    • Huang, H.C.1    Nguyen, T.2    Pickett, C.B.3
  • 83
    • 73149085941 scopus 로고    scopus 로고
    • Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
    • Imhoff BR and Hansen JM. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. Biochem J 424: 491-500, 2009.
    • (2009) Biochem J , vol.424 , pp. 491-500
    • Imhoff, B.R.1    Hansen, J.M.2
  • 84
    • 76049123402 scopus 로고    scopus 로고
    • Insulin resistance, li-potoxicity and endothelial dysfunction
    • Imrie H, Abbas A, and Kearney M. Insulin resistance, li-potoxicity and endothelial dysfunction. Biochim Biophys Acta 1801: 320-326, 2010.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 320-326
    • Imrie, H.1    Abbas, A.2    Kearney, M.3
  • 85
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxi-dase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Ut-sumi H, and Nawata H. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxi-dase in cultured vascular cells. Diabetes 49: 1939-1945, 2000.
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3    Yu, H.Y.4    Kakimoto, M.5    Imamura, M.6    Aoki, T.7    Etoh, T.8    Hashimoto, T.9    Naruse, M.10    Sano, H.11    Ut-Sumi, H.12    Nawata, H.13
  • 86
    • 1642396537 scopus 로고    scopus 로고
    • Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: Activation by oxidatively modified LDL and 4-hydroxynonenal
    • Ishii T, Itoh K, Ruiz E, Leake DS, Unoki H, Yamamoto M, and Mann GE. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res 94: 609-616, 2004.
    • (2004) Circ Res , vol.94 , pp. 609-616
    • Ishii, T.1    Itoh, K.2    Ruiz, E.3    Leake, D.S.4    Unoki, H.5    Yamamoto, M.6    Mann, G.E.7
  • 87
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 co-ordinately regulates a group of oxidative stress-inducible genes in macrophages
    • Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, and Yamamoto M. Transcription factor Nrf2 co-ordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275: 16023-16029, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 16023-16029
    • Ishii, T.1    Itoh, K.2    Takahashi, S.3    Sato, H.4    Yanagawa, T.5    Katoh, Y.6    Bannai, S.7    Yamamoto, M.8
  • 88
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, and Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86, 1999.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6    Yamamoto, M.7
  • 89
    • 34447526197 scopus 로고    scopus 로고
    • GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
    • Jain AK and Jaiswal AK. GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J Biol Chem 282: 16502-16510, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 16502-16510
    • Jain, A.K.1    Jaiswal, A.K.2
  • 90
    • 33744953050 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
    • Jain AK and Jaiswal AK. Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 281: 12132-12142, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 12132-12142
    • Jain, A.K.1    Jaiswal, A.K.2
  • 91
    • 47749116455 scopus 로고    scopus 로고
    • Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: A novel mechanism in Nrf2 activation
    • Jain AK, Mahajan S, and Jaiswal AK. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. J Biol Chem 283: 17712-17720, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 17712-17720
    • Jain, A.K.1    Mahajan, S.2    Jaiswal, A.K.3
  • 92
    • 77951808284 scopus 로고    scopus 로고
    • Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?
    • Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, and Bocchini JA. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal 12: 1333-1337, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1333-1337
    • Jain, S.K.1    Bull, R.2    Rains, J.L.3    Bass, P.F.4    Levine, S.N.5    Reddy, S.6    McVie, R.7    Bocchini, J.A.8
  • 93
    • 33744468523 scopus 로고    scopus 로고
    • Exercise and hormesis: Activation of cellular antioxidant signaling pathway
    • Ji LL, Gomez-Cabrera MC, and Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci 1067: 425-435, 2006.
    • (2006) Ann N y Acad Sci , vol.1067 , pp. 425-435
    • Ji, L.L.1    Gomez-Cabrera, M.C.2    Vina, J.3
  • 94
    • 77951199503 scopus 로고    scopus 로고
    • The protective role of Nrf2 in STZ-induced diabetic ne-phropathy
    • Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, and Zhang DD. The protective role of Nrf2 in STZ-induced diabetic ne-phropathy. Diabetes 59: 850-860, 2010.
    • (2010) Diabetes , vol.59 , pp. 850-860
    • Jiang, T.1    Huang, Z.2    Lin, Y.3    Zhang, Z.4    Fang, D.5    Zhang, D.D.6
  • 95
    • 0036829579 scopus 로고    scopus 로고
    • Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses
    • Jones DP, Mody VC Jr., Carlson JL, Lynn MJ, and Sternberg P Jr. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic Biol Med 33: 1290-1300, 2002.
    • (2002) Free Radic Biol Med , vol.33 , pp. 1290-1300
    • Jones, D.P.1    Mody Jr., V.C.2    Carlson, J.L.3    Lynn, M.J.4    Sternberg Jr., P.5
  • 97
    • 1242274394 scopus 로고    scopus 로고
    • Scaffolding of Keap1 to the actin cytoskele-ton controls the function of Nrf2 as key regulator of cyto-protective phase 2 genes
    • Kang MI, Kobayashi A, Wakabayashi N, Kim SG, and Yamamoto M. Scaffolding of Keap1 to the actin cytoskele-ton controls the function of Nrf2 as key regulator of cyto-protective phase 2 genes. Proc Natl Acad Sci USA 101: 2046-2051, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2046-2051
    • Kang, M.I.1    Kobayashi, A.2    Wakabayashi, N.3    Kim, S.G.4    Yamamoto, M.5
  • 98
    • 77950907407 scopus 로고    scopus 로고
    • Nuclear erythroid factor 2 (Nrf2) mediated proteasome activation delays senescence in human fibroblasts
    • Kapeta S, Chondrogianni N, and Gonos ES. Nuclear erythroid factor 2 (Nrf2) mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 285: 8171-8184, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 8171-8184
    • Kapeta, S.1    Chondrogianni, N.2    Gonos, E.S.3
  • 101
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • Kim JA, Montagnani M, Koh KK, and Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113: 1888-1904, 2006.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 103
    • 0037468933 scopus 로고    scopus 로고
    • Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response
    • Kim YC, Yamaguchi Y, Kondo N, Masutani H, and Yodoi J. Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Onco-gene 22: 1860-1865, 2003.
    • (2003) Onco-gene , vol.22 , pp. 1860-1865
    • Kim, Y.C.1    Yamaguchi, Y.2    Kondo, N.3    Masutani, H.4    Yodoi, J.5
  • 104
    • 0036062227 scopus 로고    scopus 로고
    • Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes
    • Kim YK, Lee MS, Son SM, Kim IJ, Lee WS, Rhim BY, Hong KW, and Kim CD. Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 51: 522-527, 2002.
    • (2002) Diabetes , vol.51 , pp. 522-527
    • Kim, Y.K.1    Lee, M.S.2    Son, S.M.3    Kim, I.J.4    Lee, W.S.5    Rhim, B.Y.6    Hong, K.W.7    Kim, C.D.8
  • 107
    • 20544474751 scopus 로고    scopus 로고
    • D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes
    • Kruger AL, Peterson S, Turkseven S, Kaminski PM, Zhang FF, Quan S, Wolin MS, and Abraham NG. D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes. Circulation 111: 3126-3134, 2005.
    • (2005) Circulation , vol.111 , pp. 3126-3134
    • Kruger, A.L.1    Peterson, S.2    Turkseven, S.3    Kaminski, P.M.4    Zhang, F.F.5    Quan, S.6    Wolin, M.S.7    Abraham, N.G.8
  • 108
    • 0038578527 scopus 로고    scopus 로고
    • Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: Effect of the polyamine metabolite acrolein
    • Kwak MK, Kensler TW, and Casero RA Jr. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem Biophys Res Commun 305: 662-670, 2003.
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 662-670
    • Kwak, M.K.1    Kensler, T.W.2    Casero Jr., R.A.3
  • 109
    • 33646483074 scopus 로고    scopus 로고
    • The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2- dependent phase II detoxifying genes and alters intracellular glutathione redox
    • Kweon MH, In Park Y, Sung HC, and Mukhtar H. The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2- dependent phase II detoxifying genes and alters intracellular glutathione redox. Free Radic Biol Med 40: 1349-1361, 2006
    • (2006) Free Radic Biol Med , vol.40 , pp. 1349-1361
    • Kweon, M.H.1    Park, Y.2    Sung, H.C.3    Mukhtar, H.4
  • 111
    • 56049102574 scopus 로고    scopus 로고
    • Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose
    • Langston W, Circu ML, and Aw TY. Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic Biol Med 45: 1591-1599, 2008.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1591-1599
    • Langston, W.1    Circu, M.L.2    Aw, T.Y.3
  • 112
    • 0035814951 scopus 로고    scopus 로고
    • En-dothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, and Harrison DG. En-dothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103: 1282-1288, 2001.
    • (2001) Circulation , vol.103 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 113
    • 41349099837 scopus 로고    scopus 로고
    • Redox signaling, vascular function, and hypertension
    • Lee MY and Griendling KK. Redox signaling, vascular function, and hypertension. Antioxid Redox Signal 10: 1045-1059, 2008.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1045-1059
    • Lee, M.Y.1    Griendling, K.K.2
  • 114
    • 75149117017 scopus 로고    scopus 로고
    • Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
    • Leiser SF and Miller RA. Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol 30: 871-884, 2010.
    • (2010) Mol Cell Biol , vol.30 , pp. 871-884
    • Leiser, S.F.1    Miller, R.A.2
  • 115
    • 7444224175 scopus 로고    scopus 로고
    • Signaling kinases modulated by 4-hydroxynonenal
    • Leonarduzzi G, Robbesyn F, and Poli G. Signaling kinases modulated by 4-hydroxynonenal. Free Radic Biol Med 37: 1694-1702, 2004.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1694-1702
    • Leonarduzzi, G.1    Robbesyn, F.2    Poli, G.3
  • 118
    • 34548762437 scopus 로고    scopus 로고
    • Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice
    • Limon-Pacheco JH, Hernandez NA, Fanjul-Moles ML, and Gonsebatt ME. Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice. Free Radic Biol Med 43: 1335-1347, 2007.
    • (2007) Free Radic Biol Med , vol.43 , pp. 1335-1347
    • Limon-Pacheco, J.H.1    Hernandez, N.A.2    Fanjul-Moles, M.L.3    Gonsebatt, M.E.4
  • 119
    • 34250706879 scopus 로고    scopus 로고
    • Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2=ARE complex to promote vascular smooth muscle cell survival
    • Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, and Durante W. Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2=ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res 75: 381-389, 2007.
    • (2007) Cardiovasc Res , vol.75 , pp. 381-389
    • Liu, X.M.1    Peyton, K.J.2    Ensenat, D.3    Wang, H.4    Hannink, M.5    Alam, J.6    Durante, W.7
  • 120
    • 12544253089 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival
    • Liu XM, Peyton KJ, Ensenat D, Wang H, Schafer AI, Alam J, and Durante W. Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival. J Biol Chem 280: 872-877, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 872-877
    • Liu, X.M.1    Peyton, K.J.2    Ensenat, D.3    Wang, H.4    Schafer, A.I.5    Alam, J.6    Durante, W.7
  • 122
    • 42649130014 scopus 로고    scopus 로고
    • PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
    • Lo SC and Hannink M. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314: 1789-1803, 2008.
    • (2008) Exp Cell Res , vol.314 , pp. 1789-1803
    • Lo, S.C.1    Hannink, M.2
  • 124
    • 65049089113 scopus 로고    scopus 로고
    • Regulation of glutathione synthesis
    • Lu SC. Regulation of glutathione synthesis. Mol Aspects Med 30: 42-59, 2009.
    • (2009) Mol Aspects Med , vol.30 , pp. 42-59
    • Lu, S.C.1
  • 125
    • 67650257495 scopus 로고    scopus 로고
    • High glucose sensitizes adult cardiomyocytes to ischaemia=reperfusion injury through nitrative thioredoxin inactivation
    • Luan R, Liu S, Yin T, Lau WB, Wang Q, Guo W, Wang H, and Tao L. High glucose sensitizes adult cardiomyocytes to ischaemia=reperfusion injury through nitrative thioredoxin inactivation. Cardiovasc Res 83: 294-302, 2009.
    • (2009) Cardiovasc Res , vol.83 , pp. 294-302
    • Luan, R.1    Liu, S.2    Yin, T.3    Lau, W.B.4    Wang, Q.5    Guo, W.6    Wang, H.7    Tao, L.8
  • 126
    • 0035856942 scopus 로고    scopus 로고
    • Mitochondrial function in normal and diabetic beta-cells
    • Maechler P and Wollheim CB. Mitochondrial function in normal and diabetic beta-cells. Nature 414: 807-812, 2001.
    • (2001) Nature , vol.414 , pp. 807-812
    • Maechler, P.1    Wollheim, C.B.2
  • 127
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 128
    • 62249089498 scopus 로고    scopus 로고
    • Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: Protection afforded by dietary iso-flavones
    • Mann GE, Bonacasa B, Ishii T, and Siow RC. Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary iso-flavones. Curr Opin Pharmacol 9: 139-145, 2009.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 139-145
    • Mann, G.E.1    Bonacasa, B.2    Ishii, T.3    Siow, R.C.4
  • 129
    • 34250753928 scopus 로고    scopus 로고
    • Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression
    • Mann GE, Rowlands DJ, Li FY, de Winter P, and Siow RC. Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression. Cardiovasc Res 75: 261-274, 2007.
    • (2007) Cardiovasc Res , vol.75 , pp. 261-274
    • Mann, G.E.1    Rowlands, D.J.2    Li, F.Y.3    De Winter, P.4    Siow, R.C.5
  • 130
    • 0037207473 scopus 로고    scopus 로고
    • Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells
    • Mann GE, Yudilevich DL, and Sobrevia L. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83: 183-252, 2003.
    • (2003) Physiol Rev , vol.83 , pp. 183-252
    • Mann, G.E.1    Yudilevich, D.L.2    Sobrevia, L.3
  • 131
    • 2942667688 scopus 로고    scopus 로고
    • Development of insulin resistance and obesity in mice overexpressing cellular glutathione perox-idase
    • McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F, and Lei XG. Development of insulin resistance and obesity in mice overexpressing cellular glutathione perox-idase. Proc Natl Acad Sci USA 101: 8852-8857, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8852-8857
    • McClung, J.P.1    Roneker, C.A.2    Mu, W.3    Lisk, D.J.4    Langlais, P.5    Liu, F.6    Lei, X.G.7
  • 132
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • McMahon M, Itoh K, Yamamoto M, and Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278: 21592-21600, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 133
    • 33846121333 scopus 로고    scopus 로고
    • Vascular cell senescence: Contribution to atherosclerosis
    • Minamino T and Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res 100: 15-26, 2007.
    • (2007) Circ Res , vol.100 , pp. 15-26
    • Minamino, T.1    Komuro, I.2
  • 134
    • 0032973663 scopus 로고    scopus 로고
    • Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy
    • Miyata T, Sugiyama S, Suzuki D, Inagi R, and Kurokawa K. Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy. Kidney Int Suppl 71: S54-S56, 1999.
    • (1999) Kidney Int Suppl , vol.71
    • Miyata, T.1    Sugiyama, S.2    Suzuki, D.3    Inagi, R.4    Kurokawa, K.5
  • 135
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada S, Palmer RM, and Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991.
    • (1991) Pharmacol Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 136
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi H and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-557, 2004.
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 137
    • 33646417325 scopus 로고    scopus 로고
    • Induction of mitochondrial ROS production by electrophilic lipids: A new pathway of redox signaling?
    • Murphy MP. Induction of mitochondrial ROS production by electrophilic lipids: a new pathway of redox signaling? Am J Physiol Heart Circ Physiol 290: H1754-H1755, 2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Murphy, M.P.1
  • 138
    • 67449135837 scopus 로고    scopus 로고
    • Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2
    • Naidu S, Vijayan V, Santoso S, Kietzmann T, and Im-menschuh S. Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2. J Immunol 182: 7048-7057, 2009.
    • (2009) J Immunol , vol.182 , pp. 7048-7057
    • Naidu, S.1    Vijayan, V.2    Santoso, S.3    Kietzmann, T.4    Im-Menschuh, S.5
  • 139
    • 74949102157 scopus 로고    scopus 로고
    • Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats
    • Ndisang JF, Lane N, Syed N, and Jadhav A. Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 151: 549-560, 2010.
    • (2010) Endocrinology , vol.151 , pp. 549-560
    • Ndisang, J.F.1    Lane, N.2    Syed, N.3    Jadhav, A.4
  • 140
    • 0033857531 scopus 로고    scopus 로고
    • The missing link: A single unifying mechanism for diabetic complications
    • Nishikawa T, Edelstein D, and Brownlee M. The missing link: a single unifying mechanism for diabetic complications. Kidney Int Suppl 77: S26-S30, 2000.
    • (2000) Kidney Int Suppl , vol.77
    • Nishikawa, T.1    Edelstein, D.2    Brownlee, M.3
  • 142
    • 14644397287 scopus 로고    scopus 로고
    • Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene
    • Nishinaka T and Yabe-Nishimura C. Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene. J Pharmacol Sci 97: 43-51, 2005.
    • (2005) J Pharmacol Sci , vol.97 , pp. 43-51
    • Nishinaka, T.1    Yabe-Nishimura, C.2
  • 143
    • 71449099635 scopus 로고    scopus 로고
    • Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance
    • Niture SK, Jain AK, and Jaiswal AK. Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci 122: 4452-4464, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 4452-4464
    • Niture, S.K.1    Jain, A.K.2    Jaiswal, A.K.3
  • 144
    • 33750734665 scopus 로고    scopus 로고
    • NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglyce-mia-induced brain endothelial cell apoptosis
    • Okouchi M, Okayama N, Alexander JS, and Aw TY. NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglyce-mia-induced brain endothelial cell apoptosis. Curr Neuro-vasc Res 3: 249-261, 2006.
    • (2006) Curr Neuro-vasc Res , vol.3 , pp. 249-261
    • Okouchi, M.1    Okayama, N.2    Alexander, J.S.3    Aw, T.Y.4
  • 145
    • 70350337363 scopus 로고    scopus 로고
    • Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apo-ptosis
    • Okouchi M, Okayama N, and Aw TY. Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apo-ptosis. Curr Neurovasc Res 6: 267-278, 2009.
    • (2009) Curr Neurovasc Res , vol.6 , pp. 267-278
    • Okouchi, M.1    Okayama, N.2    Aw, T.Y.3
  • 146
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken B and Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5: e8758, 2010.
    • (2010) PLoS ONE , vol.5
    • Onken, B.1    Driscoll, M.2
  • 147
    • 58549094758 scopus 로고    scopus 로고
    • The pathologic continuum of diabetic vascular disease
    • Orasanu G and Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol 53: S35-S42, 2009.
    • (2009) J Am Coll Cardiol , vol.53
    • Orasanu, G.1    Plutzky, J.2
  • 148
    • 33748893228 scopus 로고    scopus 로고
    • Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion
    • Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, and Kensler TW. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Bio-chem Biophys 454: 7-15, 2006.
    • (2006) Arch Bio-chem Biophys , vol.454 , pp. 7-15
    • Osburn, W.O.1    Wakabayashi, N.2    Misra, V.3    Nilles, T.4    Biswal, S.5    Trush, M.A.6    Kensler, T.W.7
  • 149
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and per-oxynitrite in health and disease
    • Pacher P, Beckman JS, and Liaudet L. Nitric oxide and per-oxynitrite in health and disease. Physiol Rev 87: 315-424, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 151
    • 33644649422 scopus 로고    scopus 로고
    • Hyperoxia stimulates an Nrf2-ARE transcrip-tional response via ROS-EGFR-PI3K-Akt=ERK MAP kinase signaling in pulmonary epithelial cells
    • Papaiahgari S, Zhang Q, Kleeberger SR, Cho HY, and Reddy SP. Hyperoxia stimulates an Nrf2-ARE transcrip-tional response via ROS-EGFR-PI3K-Akt=ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal 8: 43-52, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 43-52
    • Papaiahgari, S.1    Zhang, Q.2    Kleeberger, S.R.3    Cho, H.Y.4    Reddy, S.P.5
  • 154
    • 33744473330 scopus 로고    scopus 로고
    • Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
    • Piconi L, Quagliaro L, Assaloni R, Da RR, Maier A, Zuodar G, and Ceriello A. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev 22: 198-203, 2006.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 198-203
    • Piconi, L.1    Quagliaro, L.2    Assaloni, R.3    Da, R.R.4    Maier, A.5    Zuodar, G.6    Ceriello, A.7
  • 155
    • 34748904643 scopus 로고    scopus 로고
    • Translational control of nrf2 protein in activation of antioxi-dant response by oxidants
    • Purdom-Dickinson SE, Sheveleva EV, Sun H, and Chen QM. Translational control of nrf2 protein in activation of antioxi-dant response by oxidants. Mol Pharmacol 72: 1074-1081, 2007.
    • (2007) Mol Pharmacol , vol.72 , pp. 1074-1081
    • Purdom-Dickinson, S.E.1    Sheveleva, E.V.2    Sun, H.3    Chen, Q.M.4
  • 156
  • 157
    • 33845742185 scopus 로고    scopus 로고
    • Mechanisms of disease: En-dothelial dysfunction in insulin resistance and diabetes
    • Rask-Madsen C and King GL. Mechanisms of disease: en-dothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 3: 46-56, 2007.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 46-56
    • Rask-Madsen, C.1    King, G.L.2
  • 159
    • 64249099733 scopus 로고    scopus 로고
    • The permissive role of mito- chondria in the induction of haem oxygenase-1 in endo-thelial cells
    • Ricart KC, Bolisetty S, Johnson MS, Perez J, Agarwal A, Murphy MP, and Landar A. The permissive role of mito- chondria in the induction of haem oxygenase-1 in endo-thelial cells. Biochem J 419: 427-436, 2009.
    • (2009) Biochem J , vol.419 , pp. 427-436
    • Ricart, K.C.1    Bolisetty, S.2    Johnson, M.S.3    Perez, J.4    Agarwal, A.5    Murphy, M.P.6    Landar, A.7
  • 160
    • 12244297111 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent etha-crynic acid
    • Rizzardini M, Lupi M, Bernasconi S, Mangolini A, and Cantoni L. Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent etha-crynic acid. J Neurol Sci 207: 51-58, 2003.
    • (2003) J Neurol Sci , vol.207 , pp. 51-58
    • Rizzardini, M.1    Lupi, M.2    Bernasconi, S.3    Mangolini, A.4    Cantoni, L.5
  • 161
    • 0034531564 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1 (NQO1): Chemoprotection, bioactivation, gene regulation and genetic polymorphisms
    • Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, and Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129: 77-97, 2000.
    • (2000) Chem Biol Interact , vol.129 , pp. 77-97
    • Ross, D.1    Kepa, J.K.2    Winski, S.L.3    Beall, H.D.4    Anwar, A.5    Siegel, D.6
  • 162
    • 18244386712 scopus 로고    scopus 로고
    • Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2
    • Sakurai A, Nishimoto M, Himeno S, Imura N, Tsujimoto M, Kunimoto M, and Hara S. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J Cell Phy-siol 203: 529-537, 2005.
    • (2005) J Cell Phy-siol , vol.203 , pp. 529-537
    • Sakurai, A.1    Nishimoto, M.2    Himeno, S.3    Imura, N.4    Tsujimoto, M.5    Kunimoto, M.6    Hara, S.7
  • 163
    • 33744950387 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phos-phorylation and nuclear exclusion of the transcription factor Nrf2
    • Salazar M, Rojo AI, Velasco D, de Sagarra RM, and Cua-drado A. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phos-phorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 281: 14841-14851, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 14841-14851
    • Salazar, M.1    Rojo, A.I.2    Velasco, D.3    De Sagarra, R.M.4    Cua-Drado, A.5
  • 164
    • 0038755458 scopus 로고    scopus 로고
    • Diabetes and mitochondrial oxidative stress: A study using heart mitochondria from the diabetic Goto-Kakizaki rat
    • Santos DL, Palmeira CM, Seica R, Dias J, Mesquita J, Moreno AJ, and Santos MS. Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat. Mol Cell Biochem 246: 163-170, 2003.
    • (2003) Mol Cell Biochem , vol.246 , pp. 163-170
    • Santos, D.L.1    Palmeira, C.M.2    Seica, R.3    Dias, J.4    Mesquita, J.5    Moreno, A.J.6    Santos, M.S.7
  • 166
    • 0029088742 scopus 로고
    • Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes
    • Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, and Stern D. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 96: 1395-1403, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 1395-1403
    • Schmidt, A.M.1    Hori, O.2    Chen, J.X.3    Li, J.F.4    Crandall, J.5    Zhang, J.6    Cao, R.7    Yan, S.D.8    Brett, J.9    Stern, D.10
  • 167
    • 41349096436 scopus 로고    scopus 로고
    • Nitric oxide, tetrahydrobiopterin, oxidative stress, and en-dothelial dysfunction in hypertension
    • Schulz E, Jansen T, Wenzel P, Daiber A, and Munzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and en-dothelial dysfunction in hypertension. Antioxid Redox Signal 10: 1115-1126, 2008.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1115-1126
    • Schulz, E.1    Jansen, T.2    Wenzel, P.3    Daiber, A.4    Munzel, T.5
  • 169
    • 20744440945 scopus 로고    scopus 로고
    • Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
    • Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, and Murphy TH. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J Biol Chem 280: 22925-22936, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 22925-22936
    • Shih, A.Y.1    Imbeault, S.2    Barakauskas, V.3    Erb, H.4    Jiang, L.5    Li, P.6    Murphy, T.H.7
  • 170
    • 33947659941 scopus 로고    scopus 로고
    • Differential expressions of antioxi-dant status in aging rats: The role of transcriptional factor Nrf2 and MAPK signaling pathway
    • Shih PH and Yen GC. Differential expressions of antioxi-dant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway. Biogerontology 8: 71-80, 2007.
    • (2007) Biogerontology , vol.8 , pp. 71-80
    • Shih, P.H.1    Yen, G.C.2
  • 173
    • 33847634280 scopus 로고    scopus 로고
    • Cardiovascular targets for estrogens and phytoestrogens: Transcriptional regulation of nitric oxide synthase and anti-oxidant defense genes
    • Siow RC, Li FY, Rowlands DJ, de Winter P, and Mann GE. Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and anti-oxidant defense genes. Free Radic Biol Med 42: 909-925, 2007
    • (2007) Free Radic Biol Med , vol.42 , pp. 909-925
    • Siow, R.C.1    Li, F.Y.2    Rowlands, D.J.3    De Winter, P.4    Mann, G.E.5
  • 174
    • 0033026857 scopus 로고    scopus 로고
    • Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: Anti-atherogenic actions of bilirubin and carbon monoxide?
    • Siow RC, Sato H, and Mann GE. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res 41: 385-394, 1999.
    • (1999) Cardiovasc Res , vol.41 , pp. 385-394
    • Siow, R.C.1    Sato, H.2    Mann, G.E.3
  • 176
    • 58549089876 scopus 로고    scopus 로고
    • Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study
    • Song J, Sumiyoshi S, Nakashima Y, Doi Y, Iida M, Kiyohara Y, and Sueishi K. Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study. Atherosclerosis 202: 573-581, 2009.
    • (2009) Atherosclerosis , vol.202 , pp. 573-581
    • Song, J.1    Sumiyoshi, S.2    Nakashima, Y.3    Doi, Y.4    Iida, M.5    Kiyohara, Y.6    Sueishi, K.7
  • 177
    • 21344444333 scopus 로고    scopus 로고
    • A high-fat diet coordinately down-regulates genes required for mitochondrial oxidative phos-phorylation in skeletal muscle
    • Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, and Smith SR. A high-fat diet coordinately down-regulates genes required for mitochondrial oxidative phos-phorylation in skeletal muscle. Diabetes 54: 1926-1933, 2005.
    • (2005) Diabetes , vol.54 , pp. 1926-1933
    • Sparks, L.M.1    Xie, H.2    Koza, R.A.3    Mynatt, R.4    Hulver, M.W.5    Bray, G.A.6    Smith, S.R.7
  • 178
    • 0242352418 scopus 로고    scopus 로고
    • Increased nitric oxide levels as an early sign of premature aging in diabetes
    • Stadler K, Jenei V, von BG, Somogyi A, and Jakus J. Increased nitric oxide levels as an early sign of premature aging in diabetes. Free Radic Biol Med 35: 1240-1251, 2003.
    • (2003) Free Radic Biol Med , vol.35 , pp. 1240-1251
    • Stadler, K.1    Jenei, V.2    Von Bg Somogyi, A.3    Jakus, J.4
  • 179
    • 0029977757 scopus 로고    scopus 로고
    • Obesity=insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, and Baron AD. Obesity=insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97: 2601-2610, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 180
    • 36348947406 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons
    • Storozhevykh TP, Senilova YE, Persiyantseva NA, Pinelis VG, and Pomytkin IA. Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons. BMC Neurosci 8: 84, 2007.
    • (2007) BMC Neurosci , vol.8 , pp. 84
    • Storozhevykh, T.P.1    Senilova, Y.E.2    Persiyantseva, N.A.3    Pinelis, V.G.4    Pomytkin, I.A.5
  • 182
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, and Hagen TM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101: 3381-3386, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.4    Jaiswal, A.K.5    Liu, R.M.6    Hagen, T.M.7
  • 183
    • 33846993042 scopus 로고    scopus 로고
    • A new activating role for CO in cardiac mitochondrial biogenesis
    • Suliman HB, Carraway MS, Tatro LG, and Piantadosi CA. A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 120: 299-308, 2007.
    • (2007) J Cell Sci , vol.120 , pp. 299-308
    • Suliman, H.B.1    Carraway, M.S.2    Tatro, L.G.3    Piantadosi, C.A.4
  • 184
    • 1242319573 scopus 로고    scopus 로고
    • Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network
    • Sun J, Brand M, Zenke Y, Tashiro S, Groudine M, and Ig-arashi K. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci USA 101: 1461-1466, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1461-1466
    • Sun, J.1    Brand, M.2    Zenke, Y.3    Tashiro, S.4    Groudine, M.5    Ig-Arashi, K.6
  • 186
    • 37749024370 scopus 로고    scopus 로고
    • Keap1=Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    • Sykiotis GP and Bohmann D. Keap1=Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell 14: 76-85, 2008.
    • (2008) Dev Cell , vol.14 , pp. 76-85
    • Sykiotis, G.P.1    Bohmann, D.2
  • 187
    • 35748959038 scopus 로고    scopus 로고
    • Hydrogen sulphide and its therapeutic potential
    • Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6: 917-935, 2007.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 917-935
    • Szabo, C.1
  • 189
    • 34248591499 scopus 로고    scopus 로고
    • Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro
    • Tanito M, Agbaga MP, and Anderson RE. Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radic Biol Med 42: 1838-1850, 2007.
    • (2007) Free Radic Biol Med , vol.42 , pp. 1838-1850
    • Tanito, M.1    Agbaga, M.P.2    Anderson, R.E.3
  • 191
    • 49849084827 scopus 로고    scopus 로고
    • Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities
    • Thomas SR, Witting PK, and Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 10: 1713-1765, 2008.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1713-1765
    • Thomas, S.R.1    Witting, P.K.2    Drummond, G.R.3
  • 193
    • 0142248307 scopus 로고    scopus 로고
    • Senescence-associated cell death of human endo-thelial cells: The role of oxidative stress
    • Unterluggauer H, Hampel B, Zwerschke W, and Jansen-Durr P. Senescence-associated cell death of human endo-thelial cells: the role of oxidative stress. Exp Gerontol 38: 1149-1160, 2003.
    • (2003) Exp Gerontol , vol.38 , pp. 1149-1160
    • Unterluggauer, H.1    Hampel, B.2    Zwerschke, W.3    Jansen-Durr, P.4
  • 195
    • 0024428094 scopus 로고
    • Effects of endotheli-um-derived nitric oxide on peripheral arteriolar tone in man
    • Vallance P, Collier J, and Moncada S. Effects of endotheli-um-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2: 997-1000, 1989.
    • (1989) Lancet , vol.2 , pp. 997-1000
    • Vallance, P.1    Collier, J.2    Moncada, S.3
  • 197
    • 0033212947 scopus 로고    scopus 로고
    • Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: Evidence of impaired reactivity to nitroglycerin
    • Vavuranakis M, Stefanadis C, Triandaphyllidi E, Toutouzas K, and Toutouzas P. Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: evidence of impaired reactivity to nitroglycerin. J Am Coll Cardiol 34: 1075-1081, 1999.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 1075-1081
    • Vavuranakis, M.1    Stefanadis, C.2    Triandaphyllidi, E.3    Toutouzas, K.4    Toutouzas, P.5
  • 198
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qui-none oxidoreductase1 gene
    • Venugopal R and Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qui-none oxidoreductase1 gene. Proc Natl Acad Sci USA 93: 14960-14965, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 200
    • 45549087514 scopus 로고    scopus 로고
    • Essential roles of the PI3 kinase=Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE
    • Wang L, Chen Y, Sternberg P, and Cai J. Essential roles of the PI3 kinase=Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest Ophthalmol Vis Sci 49: 1671-1678, 2008.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1671-1678
    • Wang, L.1    Chen, Y.2    Sternberg, P.3    Cai, J.4
  • 203
    • 3442893856 scopus 로고    scopus 로고
    • Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules
    • Winiarska K, Drozak J, Wegrzynowicz M, Fraczyk T, and Bryla J. Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules. Mol Cell Biochem 261: 91-98, 2004.
    • (2004) Mol Cell Biochem , vol.261 , pp. 91-98
    • Winiarska, K.1    Drozak, J.2    Wegrzynowicz, M.3    Fraczyk, T.4    Bryla, J.5
  • 204
    • 22444433668 scopus 로고    scopus 로고
    • Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH
    • Wolin MS, Ahmad M, and Gupte SA. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am J Physiol Lung Cell Mol Physiol 289: L159-L173, 2005.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289
    • Wolin, M.S.1    Ahmad, M.2    Gupte, S.A.3
  • 205
    • 58149352893 scopus 로고    scopus 로고
    • Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
    • Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, and Thornalley PJ. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes 57: 2809-2817, 2008.
    • (2008) Diabetes , vol.57 , pp. 2809-2817
    • Xue, M.1    Qian, Q.2    Adaikalakoteswari, A.3    Rabbani, N.4    Babaei-Jadidi, R.5    Thornalley, P.J.6
  • 206
    • 36148988058 scopus 로고    scopus 로고
    • Transgenic expression of antioxi-dant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus
    • Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J, and Miyazaki J. Transgenic expression of antioxi-dant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus. Antioxid Redox Signal 10: 43-49, 2008.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 43-49
    • Yamamoto, M.1    Yamato, E.2    Toyoda, S.3    Tashiro, F.4    Ikegami, H.5    Yodoi, J.6    Miyazaki, J.7
  • 207
    • 14644401702 scopus 로고    scopus 로고
    • Fluid shear stress inhibits vascular inflammation by decreasing thior-edoxin-interacting protein in endothelial cells
    • Yamawaki H, Pan S, Lee RT, and Berk BC. Fluid shear stress inhibits vascular inflammation by decreasing thior-edoxin-interacting protein in endothelial cells. J Clin Invest 115: 733-738, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 733-738
    • Yamawaki, H.1    Pan, S.2    Lee, R.T.3    Berk, B.C.4
  • 208
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors=binding proteins
    • Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, and Stern D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors=binding proteins. J Biol Chem 269: 9889-9897, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.M.3    Zhang, J.4    Brett, J.5    Zou, Y.S.6    Pinsky, D.7    Stern, D.8
  • 209
    • 38349179648 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (RAGE): A formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging
    • Yan SF, D'Agati V, Schmidt AM, and Ramasamy R. Receptor for advanced glycation endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging. Curr Mol Med 7: 699-710, 2007.
    • (2007) Curr Mol Med , vol.7 , pp. 699-710
    • Yan, S.F.1    D'Agati, V.2    Schmidt, A.M.3    Ramasamy, R.4
  • 210
    • 42449109476 scopus 로고    scopus 로고
    • Mechanisms of disease: Advanced glycation end-products and their receptor in inflammation and diabetes complications
    • Yan SF, Ramasamy R, and Schmidt AM. Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 4: 285-293, 2008.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 285-293
    • Yan, S.F.1    Ramasamy, R.2    Schmidt, A.M.3
  • 213
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Yu T, Robotham JL, and Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci USA 103: 2653-2658, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 214
    • 21344443037 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis
    • Yusuf M, Kwong Huat BT, Hsu A, Whiteman M, Bhatia M, and Moore PK. Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun 333: 1146-1152, 2005.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 1146-1152
    • Yusuf, M.1    Kwong Huat, B.T.2    Hsu, A.3    Whiteman, M.4    Bhatia, M.5    Moore, P.K.6
  • 218
    • 33947503436 scopus 로고    scopus 로고
    • Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
    • Zhang HS and Wang SQ. Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. Biochem Pharmacol 73: 1358-1366, 2007.
    • (2007) Biochem Pharmacol , vol.73 , pp. 1358-1366
    • Zhang, H.S.1    Wang, S.Q.2
  • 219
    • 27944437786 scopus 로고    scopus 로고
    • Activation of the Nrf2=antioxidant response pathway increases IL-8 expression
    • Zhang X, Chen X, Song H, Chen HZ, and Rovin BH. Activation of the Nrf2=antioxidant response pathway increases IL-8 expression. Eur J Immunol 35: 3258-3267, 2005.
    • (2005) Eur J Immunol , vol.35 , pp. 3258-3267
    • Zhang, X.1    Chen, X.2    Song, H.3    Chen, H.Z.4    Rovin, B.H.5
  • 220
    • 29244479186 scopus 로고    scopus 로고
    • Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
    • Zhao J, Kobori N, Aronowski J, and Dash PK. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393: 108-112, 2006.
    • (2006) Neurosci Lett , vol.393 , pp. 108-112
    • Zhao, J.1    Kobori, N.2    Aronowski, J.3    Dash, P.K.4
  • 221
    • 34548850603 scopus 로고    scopus 로고
    • Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    • Zhao J, Moore AN, Redell JB, and Dash PK. Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci 27: 10240-10248, 2007.
    • (2007) J Neurosci , vol.27 , pp. 10240-10248
    • Zhao, J.1    Moore, A.N.2    Redell, J.B.3    Dash, P.K.4
  • 222
    • 67949107934 scopus 로고    scopus 로고
    • Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels
    • Zhong L, Liu Z, Yan R, Johnson S, Zhao Y, Fang X, and Cao D. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Biochem Biophys Res Commun 387: 245-250, 2009.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 245-250
    • Zhong, L.1    Liu, Z.2    Yan, R.3    Johnson, S.4    Zhao, Y.5    Fang, X.6    Cao, D.7
  • 223
    • 20444381360 scopus 로고    scopus 로고
    • Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury
    • Zhu H, Itoh K, Yamamoto M, Zweier JL, and Li Y. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett 579: 3029-3036, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 3029-3036
    • Zhu, H.1    Itoh, K.2    Yamamoto, M.3    Zweier, J.L.4    Li, Y.5
  • 224
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet P, Alberti KG, and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.