-
1
-
-
61449147889
-
Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants
-
Abdul-Ghani MA, Jani R, Chavez A, Molina-Carrion M, Tripathy D, and Defronzo RA. Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants. Diabetologia 52: 574-582, 2009.
-
(2009)
Diabetologia
, vol.52
, pp. 574-582
-
-
Abdul-Ghani, M.A.1
Jani, R.2
Chavez, A.3
Molina-Carrion, M.4
Tripathy, D.5
Defronzo, R.A.6
-
2
-
-
0032127734
-
Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis
-
Adams MR, Robinson J, McCredie R, Seale JP, Sorensen KE, Deanfield JE, and Celermajer DS. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol 32: 123-127, 1998.
-
(1998)
J Am Coll Cardiol
, vol.32
, pp. 123-127
-
-
Adams, M.R.1
Robinson, J.2
McCredie, R.3
Seale, J.P.4
Sorensen, K.E.5
Deanfield, J.E.6
Celermajer, D.S.7
-
3
-
-
0033543566
-
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
-
Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, and Cook JL. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274: 26071-26078, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 26071-26078
-
-
Alam, J.1
Stewart, D.2
Touchard, C.3
Boinapally, S.4
Choi, A.M.5
Cook, J.L.6
-
4
-
-
77949770480
-
Nrf2 deletion impairs glucose tolerance and exacerbates hyperglycemia in Type 1 diabetic mice
-
Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, and Klaassen CD. Nrf2 deletion impairs glucose tolerance and exacerbates hyperglycemia in Type 1 diabetic mice. J Pharmacol Exp Ther 333: 140-151, 2010.
-
(2010)
J Pharmacol Exp Ther
, vol.333
, pp. 140-151
-
-
Aleksunes, L.M.1
Reisman, S.A.2
Yeager, R.L.3
Goedken, M.J.4
Klaassen, C.D.5
-
5
-
-
67650523965
-
Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothe-lium exposed to laminar shear stress and impaired by disturbed flow
-
Ali F, Zakkar M, Karu K, Lidington EA, Hamdulay SS, Boyle JJ, Zloh M, Bauer A, Haskard DO, Evans PC, and Mason JC. Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothe-lium exposed to laminar shear stress and impaired by disturbed flow. J Biol Chem 284: 18882-18892, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 18882-18892
-
-
Ali, F.1
Zakkar, M.2
Karu, K.3
Lidington, E.A.4
Hamdulay, S.S.5
Boyle, J.J.6
Zloh, M.7
Bauer, A.8
Haskard, D.O.9
Evans, P.C.10
Mason, J.C.11
-
6
-
-
0342573147
-
Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes
-
Ammar RF Jr., Gutterman DD, Brooks LA, and Dellsperger KC. Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. Cardiovasc Res 47: 595-601, 2000.
-
(2000)
Cardiovasc Res
, vol.47
, pp. 595-601
-
-
Ammar Jr., R.F.1
Gutterman, D.D.2
Brooks, L.A.3
Dellsperger, K.C.4
-
7
-
-
0042626242
-
SKN-1 links C. elegans me-sendodermal specification to a conserved oxidative stress response
-
An JH and Blackwell TK. SKN-1 links C. elegans me-sendodermal specification to a conserved oxidative stress response. Genes Dev 17: 1882- 1893, 2003.
-
(2003)
Genes Dev
, vol.17
, pp. 1882-1893
-
-
An, J.H.1
Blackwell, T.K.2
-
8
-
-
33748645122
-
5-Methyltetrahydrofolate rapidly improves endothelial function and decreases su-peroxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
-
Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H, and Channon KM. 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases su-peroxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 114: 1193-1201, 2006.
-
(2006)
Circulation
, vol.114
, pp. 1193-1201
-
-
Antoniades, C.1
Shirodaria, C.2
Warrick, N.3
Cai, S.4
De Bono, J.5
Lee, J.6
Leeson, P.7
Neubauer, S.8
Ratnatunga, C.9
Pillai, R.10
Refsum, H.11
Channon, K.M.12
-
9
-
-
20444456655
-
Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: Role of mitogen-activated protein kinases and Nrf2
-
Anwar AA, Li FY, Leake DS, Ishii T, Mann GE, and Siow RC. Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radic Biol Med 39: 227-236, 2005.
-
(2005)
Free Radic Biol Med
, vol.39
, pp. 227-236
-
-
Anwar, A.A.1
Li, F.Y.2
Leake, D.S.3
Ishii, T.4
Mann, G.E.5
Siow, R.C.6
-
10
-
-
40549121572
-
Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
-
Apopa PL, He X, and Ma Q. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J Biochem Mol Toxicol 22: 63-76, 2008.
-
(2008)
J Biochem Mol Toxicol
, vol.22
, pp. 63-76
-
-
Apopa, P.L.1
He, X.2
Ma, Q.3
-
11
-
-
35848955430
-
Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis
-
Asija A, Peterson SJ, Stec DE, and Abraham NG. Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis. Antioxid Redox Signal 9: 2065-2074, 2007.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2065-2074
-
-
Asija, A.1
Peterson, S.J.2
Stec, D.E.3
Abraham, N.G.4
-
12
-
-
0037683670
-
Monocyte NADPH ox-idase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: Relationship with oxidative stress
-
Avogaro A, Pagnin E, and Calo L. Monocyte NADPH ox-idase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress. J Clin Endocrinol Metab 88: 1753-1759, 2003.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 1753-1759
-
-
Avogaro, A.1
Pagnin, E.2
Calo, L.3
-
13
-
-
0034458228
-
The NADPH oxidase of endothelial cells
-
Babior BM. The NADPH oxidase of endothelial cells. IUBMB Life 50: 267-269, 2000.
-
(2000)
IUBMB Life
, vol.50
, pp. 267-269
-
-
Babior, B.M.1
-
14
-
-
0024455312
-
Induction of cystine transport activity in human fibroblasts by oxygen
-
Bannai S, Sato H, Ishii T, and Sugita Y. Induction of cystine transport activity in human fibroblasts by oxygen. J Biol Chem 264: 18480-18484, 1989.
-
(1989)
J Biol Chem
, vol.264
, pp. 18480-18484
-
-
Bannai, S.1
Sato, H.2
Ishii, T.3
Sugita, Y.4
-
15
-
-
0032445585
-
Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats
-
Ba̧ star I, Seçkin S, Uysal M, and Aykaç-Toker G. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Res Commun Mol Pathol Pharmacol, 102, 265-272, 1998
-
(1998)
Res Commun Mol Pathol Pharmacol
, vol.102
, pp. 265-272
-
-
Ba̧star I, S.1
-
16
-
-
0037092995
-
Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management
-
Beckman JA, Creager MA, and Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287: 2570-2581, 2002.
-
(2002)
JAMA
, vol.287
, pp. 2570-2581
-
-
Beckman, J.A.1
Creager, M.A.2
Libby, P.3
-
17
-
-
0035656173
-
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappa B
-
Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Kloting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Haring HU, Schleicher E, and Nawroth PP. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50: 2792-2808, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 2792-2808
-
-
Bierhaus, A.1
Schiekofer, S.2
Schwaninger, M.3
Andrassy, M.4
Humpert, P.M.5
Chen, J.6
Hong, M.7
Luther, T.8
Henle, T.9
Kloting, I.10
Morcos, M.11
Hofmann, M.12
Tritschler, H.13
Weigle, B.14
Kasper, M.15
Smith, M.16
Perry, G.17
Schmidt, A.M.18
Stern, D.M.19
Haring, H.U.20
Schleicher, E.21
Nawroth, P.P.22
more..
-
18
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop NA and Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549, 2007.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
19
-
-
0242666198
-
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization=accumulation in the nucleus and tran-scriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
-
Bloom DA and Jaiswal AK. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization=accumulation in the nucleus and tran-scriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 278: 44675-44682, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 44675-44682
-
-
Bloom, D.A.1
Jaiswal, A.K.2
-
20
-
-
1242275127
-
Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
-
Brodsky SV, Gealekman O, Chen J, Zhang F, Togashi N, Crabtree M, Gross SS, Nasjletti A, and Goligorsky MS. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res 94: 377-384, 2004.
-
(2004)
Circ Res
, vol.94
, pp. 377-384
-
-
Brodsky, S.V.1
Gealekman, O.2
Chen, J.3
Zhang, F.4
Togashi, N.5
Crabtree, M.6
Gross, S.S.7
Nasjletti, A.8
Goligorsky, M.S.9
-
21
-
-
0028908348
-
Advanced protein glycosylation in diabetes and aging
-
Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46: 223-234, 1995.
-
(1995)
Annu Rev Med
, vol.46
, pp. 223-234
-
-
Brownlee, M.1
-
22
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
23
-
-
20044376702
-
The pathobiology of diabetic complications: A unifying mechanism
-
Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625, 2005.
-
(2005)
Diabetes
, vol.54
, pp. 1615-1625
-
-
Brownlee, M.1
-
24
-
-
33747412943
-
2-induced apoptosis through functional codependence between HO-1 and AKT
-
2-induced apoptosis through functional codependence between HO-1 and AKT. Arterioscler Thromb Vasc Biol 26: 2027-2034, 2006.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 2027-2034
-
-
Brunt, K.R.1
Fenrich, K.K.2
Kiani, G.3
Tse, M.Y.4
Pang, S.C.5
Ward, C.A.6
Melo, L.G.7
-
25
-
-
0037767747
-
Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothe-lium
-
Buckley BJ, Marshall ZM, and Whorton AR. Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothe-lium. Biochem Biophys Res Commun 307: 973-979, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.307
, pp. 973-979
-
-
Buckley, B.J.1
Marshall, Z.M.2
Whorton, A.R.3
-
26
-
-
1642422773
-
Mitochondrial free radical production and cell signaling
-
Cadenas E. Mitochondrial free radical production and cell signaling. Mol Aspects Med 25: 17-26, 2004.
-
(2004)
Mol Aspects Med
, vol.25
, pp. 17-26
-
-
Cadenas, E.1
-
27
-
-
11844253848
-
Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
-
Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, and Johnson JA. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci USA 102: 244-249, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 244-249
-
-
Calkins, M.J.1
Jakel, R.J.2
Johnson, D.A.3
Chan, K.4
Kan, Y.W.5
Johnson, J.A.6
-
28
-
-
70349233030
-
Hydrogen sulfide mediates cardioprotection through Nrf2 signaling
-
Calvert JW, Jha S, Gundewar S, Elrod JW, Ramachandran A, Pattillo CB, Kevil CG, and Lefer DJ. Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res 105: 365-374, 2009.
-
(2009)
Circ Res
, vol.105
, pp. 365-374
-
-
Calvert, J.W.1
Jha, S.2
Gundewar, S.3
Elrod, J.W.4
Ramachandran, A.5
Pattillo, C.B.6
Kevil, C.G.7
Lefer, D.J.8
-
29
-
-
33745883797
-
NADPH oxidases in cardiovascular health and disease
-
Cave AC, Brewer AC, Narayanapanicker A,RayR,Grieve DJ, Walker S, and Shah AM. NADPH oxidases in cardiovascular health and disease. Antioxid Redox Signal 8: 691-728, 2006.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 691-728
-
-
Cave, A.C.1
Brewer, A.C.2
Narayanapanicker, A.3
Ray, R.4
Grieve, D.J.5
Walker, S.6
Shah, A.M.7
-
30
-
-
0034672595
-
Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein
-
Chan JY and Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta 1517: 19-26, 2000.
-
(2000)
Biochim Biophys Acta
, vol.1517
, pp. 19-26
-
-
Chan, J.Y.1
Kwong, M.2
-
31
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan K, Han XD, and Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98: 4611-4616, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
32
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
Chan K, Lu R, Chang JC, and Kan YW. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943-13948, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
33
-
-
0037101768
-
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and in-ducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
-
Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, and Hayes JD. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and in-ducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem J 365: 405-416, 2002.
-
(2002)
Biochem J
, vol.365
, pp. 405-416
-
-
Chanas, S.A.1
Jiang, Q.2
McMahon, M.3
McWalter, G.K.4
McLellan, L.I.5
Elcombe, C.R.6
Henderson, C.J.7
Wolf, C.R.8
Moffat, G.J.9
Itoh, K.10
Yamamoto, M.11
Hayes, J.D.12
-
34
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B, Sies H, and Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59: 527-605, 1979.
-
(1979)
Physiol Rev
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
35
-
-
0037907756
-
Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain
-
Chang SH, Garcia J, Melendez JA, Kilberg MS, and Agarwal A. Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain. Biochem J 371: 877-885, 2003.
-
(2003)
Biochem J
, vol.371
, pp. 877-885
-
-
Chang, S.H.1
Garcia, J.2
Melendez, J.A.3
Kilberg, M.S.4
Agarwal, A.5
-
36
-
-
52049122423
-
Stress-induced premature senescence of endothelial cells
-
Chen J, Patschan S, and Goligorsky MS. Stress-induced premature senescence of endothelial cells. J Nephrol 21: 337-344, 2008.
-
(2008)
J Nephrol
, vol.21
, pp. 337-344
-
-
Chen, J.1
Patschan, S.2
Goligorsky, M.S.3
-
37
-
-
33646418968
-
Activation of Nrf2=ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
-
Chen XL, Dodd G, Thomas S, Zhang X, Wasserman MA, Rovin BH, and Kunsch C. Activation of Nrf2=ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol 290: H1862-H1870, 2006.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Chen, X.L.1
Dodd, G.2
Thomas, S.3
Zhang, X.4
Wasserman, M.A.5
Rovin, B.H.6
Kunsch, C.7
-
38
-
-
0037428445
-
Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism
-
Chen XL, Varner SE, Rao AS, Grey JY, Thomas S, Cook CK, Wasserman MA, Medford RM, Jaiswal AK, and Kunsch C. Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism. J Biol Chem 278: 703-711, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 703-711
-
-
Chen, X.L.1
Varner, S.E.2
Rao, A.S.3
Grey, J.Y.4
Thomas, S.5
Cook, C.K.6
Wasserman, M.A.7
Medford, R.M.8
Jaiswal, A.K.9
Kunsch, C.10
-
39
-
-
0036664867
-
Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients
-
Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, Charng MJ, Wu TC, Chen LC, Ding YA, Pan WH, Jou YS, and Chau LY. Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111: 1-8, 2002.
-
(2002)
Hum Genet
, vol.111
, pp. 1-8
-
-
Chen, Y.H.1
Lin, S.J.2
Lin, M.W.3
Tsai, H.L.4
Kuo, S.S.5
Chen, J.W.6
Charng, M.J.7
Wu, T.C.8
Chen, L.C.9
Ding, Y.A.10
Pan, W.H.11
Jou, Y.S.12
Chau, L.Y.13
-
40
-
-
11444261268
-
Gene expression profiling of NRF2-mediated protection against oxidative injury
-
DOI 10.1016/j.freeradbiomed.2004.10.013, PII S0891584904008354
-
Cho HY, Reddy SP, Debiase A, Yamamoto M, and Klee-berger SR. Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38: 325-343, 2005. (Pubitemid 40081112)
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.3
, pp. 325-343
-
-
Cho, H.-Y.1
Reddy, S.P.2
DeBiase, A.3
Yamamoto, M.4
Kleeberger, S.R.5
-
41
-
-
72949090169
-
Transforming growth factor-beta1 elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells
-
Churchman AT, Anwar AA, Li FY, Sato H, Ishii T, Mann GE, and Siow RC. Transforming growth factor-beta1 elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells. J Cell Mol Med 13: 2282-2292, 2009.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2282-2292
-
-
Churchman, A.T.1
Anwar, A.A.2
Li, F.Y.3
Sato, H.4
Ishii, T.5
Mann, G.E.6
Siow, R.C.7
-
43
-
-
64249150743
-
Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes
-
Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boy-adjian R, Bikineyeva A, Pratico D, Harrison DG, and Hsueh WA. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 104: e42-e54, 2009.
-
(2009)
Circ Res
, vol.104
-
-
Collins, A.R.1
Lyon, C.J.2
Xia, X.3
Liu, J.Z.4
Tangirala, R.K.5
Yin, F.6
Boy-Adjian, R.7
Bikineyeva, A.8
Pratico, D.9
Harrison, D.G.10
Hsueh, W.A.11
-
44
-
-
33845640469
-
HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism
-
Converso DP, Taille C, Carreras MC, Jaitovich A, Poderoso JJ, and Boczkowski J. HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism. FASEB J 20: 1236-1238, 2006.
-
(2006)
FASEB J
, vol.20
, pp. 1236-1238
-
-
Converso, D.P.1
Taille, C.2
Carreras, M.C.3
Jaitovich, A.4
Poderoso, J.J.5
Boczkowski, J.6
-
45
-
-
65249153029
-
RAGE-induced cytosolic ROS promote mito-chondrial superoxide generation in diabetes
-
Coughlan MT, Thorburn DR, Penfold SA, Laskowski A, Harcourt BE, Sourris KC, Tan AL, Fukami K, Thallas-Bonke V, Nawroth PP, Brownlee M, Bierhaus A, Cooper ME, and Forbes JM. RAGE-induced cytosolic ROS promote mito-chondrial superoxide generation in diabetes. J Am Soc Ne-phrol 20: 742-752, 2009.
-
(2009)
J Am Soc Ne-phrol
, vol.20
, pp. 742-752
-
-
Coughlan, M.T.1
Thorburn, D.R.2
Penfold, S.A.3
Laskowski, A.4
Harcourt, B.E.5
Sourris, K.C.6
Tan, A.L.7
Fukami, K.8
Thallas-Bonke, V.9
Nawroth, P.P.10
Brownlee, M.11
Bierhaus, A.12
Cooper, M.E.13
Forbes, J.M.14
-
46
-
-
70350496588
-
Critical role for tetrahydrobiopterin recycling by di-hydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: Relative importance of the de novo biopterin synthesis versus salvage pathways
-
Crabtree MJ, Tatham AL, Hale AB, Alp NJ, and Channon KM. Critical role for tetrahydrobiopterin recycling by di-hydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. J Biol Chem 284: 28128-28136, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 28128-28136
-
-
Crabtree, M.J.1
Tatham, A.L.2
Hale, A.B.3
Alp, N.J.4
Channon, K.M.5
-
47
-
-
34848858001
-
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase=Akt-dependent activation of Nrf2
-
Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, and Gimbrone MA Jr. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase=Akt-dependent activation of Nrf2. Circ Res 101: 723-733, 2007.
-
(2007)
Circ Res
, vol.101
, pp. 723-733
-
-
Dai, G.1
Vaughn, S.2
Zhang, Y.3
Wang, E.T.4
Garcia-Cardena, G.5
Gimbrone Jr., M.A.6
-
48
-
-
34247598856
-
Endothelial mitochondria: Contributing to vascular function and disease
-
Davidson SM and Duchen MR. Endothelial mitochondria: contributing to vascular function and disease. Circ Res 100: 1128-1141, 2007.
-
(2007)
Circ Res
, vol.100
, pp. 1128-1141
-
-
Davidson, S.M.1
Duchen, M.R.2
-
49
-
-
18844454763
-
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
-
Devling TW, Lindsay CD, McLellan LI, McMahon M, and Hayes JD. Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. Proc Natl Acad Sci USA 102: 7280-7285A, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
-
-
Devling, T.W.1
Lindsay, C.D.2
McLellan, L.I.3
McMahon, M.4
Hayes, J.D.5
-
50
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, and Talalay P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99: 11908-11913, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
51
-
-
52449089630
-
Direct and indirect antioxidant properties of inducers of cytoprotective proteins
-
Dinkova-Kostova AT and Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52 Suppl 1: S128-S138, 2008.
-
(2008)
Mol Nutr Food Res
, vol.52
, Issue.SUPPL. 1
-
-
Dinkova-Kostova, A.T.1
Talalay, P.2
-
52
-
-
0037426373
-
Functional consequences of endothelial nitric oxide synthase uncoupling in congestive cardiac failure
-
Dixon LJ, Morgan DR, Hughes SM, McGrath LT, El-Sher-beeny NA, Plumb RD, Devine A, Leahey W, Johnston GD, and McVeigh GE. Functional consequences of endothelial nitric oxide synthase uncoupling in congestive cardiac failure. Circulation 107: 1725-1728, 2003.
-
(2003)
Circulation
, vol.107
, pp. 1725-1728
-
-
Dixon, L.J.1
Morgan, D.R.2
Hughes, S.M.3
McGrath, L.T.4
El-Sher-Beeny, N.A.5
Plumb, R.D.6
Devine, A.7
Leahey, W.8
Johnston, G.D.9
McVeigh, G.E.10
-
53
-
-
67650229881
-
Nrf2-dependent upregulation of antioxidative enzymes: A novel pathway for proteasome inhibitor-mediated cardioprotection
-
Dreger H, Westphal K, Weller A, Baumann G, Stangl V, Meiners S, and Stangl K. Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res 83: 354-361, 2009.
-
(2009)
Cardiovasc Res
, vol.83
, pp. 354-361
-
-
Dreger, H.1
Westphal, K.2
Weller, A.3
Baumann, G.4
Stangl, V.5
Meiners, S.6
Stangl, K.7
-
54
-
-
85047691537
-
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
-
Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, and Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112: 1049-1057, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 1049-1057
-
-
Du, X.1
Matsumura, T.2
Edelstein, D.3
Rossetti, L.4
Zsengeller, Z.5
Szabo, C.6
Brownlee, M.7
-
55
-
-
70449711686
-
Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice
-
Duan W, Zhang R, Guo Y, Jiang Y, Huang Y, Jiang H, and Li C. Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice. In Vitro Cell Dev Biol Anim 45: 388-397, 2009.
-
(2009)
Vitro Cell Dev Biol Anim
, vol.45
, pp. 388-397
-
-
Duan, W.1
Zhang, R.2
Guo, Y.3
Jiang, Y.4
Huang, Y.5
Jiang, H.6
Li, C.7
-
56
-
-
22544464124
-
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
-
Eggler AL, Liu G, Pezzuto JM, van Breemen RB, and Me-secar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci USA 102: 10070-10075, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10070-10075
-
-
Eggler, A.L.1
Liu, G.2
Pezzuto, J.M.3
Van Breemen, R.B.4
Me-Secar, A.D.5
-
57
-
-
58849155179
-
Vascular endothelial senescence: From mechanisms to pathophysiology
-
Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 106: 326-332, 2009.
-
(2009)
J Appl Physiol
, vol.106
, pp. 326-332
-
-
Erusalimsky, J.D.1
-
58
-
-
0031852094
-
Oxidative stress: Role of mitochondria and protection by glutathione
-
Fernandez-Checa JC, Garcia-Ruiz C, Colell A, Morales A, Mari M, Miranda M, and Ardite E. Oxidative stress: role of mitochondria and protection by glutathione. Biofactors 8: 7-11, 1998.
-
(1998)
Biofactors
, vol.8
, pp. 7-11
-
-
Fernandez-Checa, J.C.1
Garcia-Ruiz, C.2
Colell, A.3
Morales, A.4
Mari, M.5
Miranda, M.6
Ardite, E.7
-
59
-
-
0034626735
-
Oxidants, oxidative stress and the biology of ageing
-
Finkel T and Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 408: 239-247, 2000.
-
(2000)
Nature
, vol.408
, pp. 239-247
-
-
Finkel, T.1
Holbrook, N.J.2
-
60
-
-
44449162751
-
Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies
-
Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 5: 338-349, 2008.
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 338-349
-
-
Forstermann, U.1
-
61
-
-
62349116866
-
Vascular NAD(P) H oxidase activation in diabetes: A double-edged sword in redox signalling
-
Gao L and Mann GE. Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling. Cardiovasc Res 82: 9-20, 2009.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 9-20
-
-
Gao, L.1
Mann, G.E.2
-
62
-
-
57749105450
-
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1= phosphoinositide 3-kinase=Akt-2 pathway
-
Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, and King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1= phosphoinositide 3-kinase=Akt-2 pathway. J Biol Chem 283: 34327-34336, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 34327-34336
-
-
Geraldes, P.1
Yagi, K.2
Ohshiro, Y.3
He, Z.4
Maeno, Y.5
Yamamoto-Hiraoka, J.6
Rask-Madsen, C.7
Chung, S.W.8
Perrella, M.A.9
King, G.L.10
-
63
-
-
23744431987
-
Cardiomyocyte apo-ptosis induced by short-term diabetes requires mitochon-drial GSH depletion
-
Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D, Abrahani A, and Rodrigues B. Cardiomyocyte apo-ptosis induced by short-term diabetes requires mitochon-drial GSH depletion. Am J Physiol Heart Circ Physiol 289: H768-H776, 2005.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.289
-
-
Ghosh, S.1
Pulinilkunnil, T.2
Yuen, G.3
Kewalramani, G.4
An, D.5
Qi, D.6
Abrahani, A.7
Rodrigues, B.8
-
64
-
-
72649107557
-
A key role for mitochondria in endothelial signaling by plasma cysteine=cystine redox potential
-
Go YM, Park H, Koval M, Orr M, Reed M, Liang Y, Smith D, Pohl J, and Jones DP. A key role for mitochondria in endothelial signaling by plasma cysteine=cystine redox potential. Free Radic Biol Med 48: 275-283, 2010.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 275-283
-
-
Go, Y.M.1
Park, H.2
Koval, M.3
Orr, M.4
Reed, M.5
Liang, Y.6
Smith, D.7
Pohl, J.8
Jones, D.P.9
-
65
-
-
77955662758
-
Hyperbaric oxygen induces a cytoprotective and angiogenic response in human micro-vascular endothelial cells
-
Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, and Giardina C. Hyperbaric oxygen induces a cytoprotective and angiogenic response in human micro-vascular endothelial cells. Cell Stress Chaperones 15: 431- 442, 2010.
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 431-442
-
-
Godman, C.A.1
Chheda, K.P.2
Hightower, L.E.3
Perdrizet, G.4
Shin, D.G.5
Giardina, C.6
-
66
-
-
37549066364
-
Endothelial MnSOD over-expression prevents retinal VEGF expression in diabetic mice
-
Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, and Araki E. Endothelial MnSOD over-expression prevents retinal VEGF expression in diabetic mice. Biochem Biophys Res Commun 366: 814-820, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 814-820
-
-
Goto, H.1
Nishikawa, T.2
Sonoda, K.3
Kondo, T.4
Kukidome, D.5
Fujisawa, K.6
Yamashiro, T.7
Motoshima, H.8
Matsumura, T.9
Tsuruzoe, K.10
Araki, E.11
-
67
-
-
0037046214
-
Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
-
Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, and Channon KM. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 105: 1656-1662, 2002.
-
(2002)
Circulation
, vol.105
, pp. 1656-1662
-
-
Guzik, T.J.1
Mussa, S.2
Gastaldi, D.3
Sadowski, J.4
Ratnatunga, C.5
Pillai, R.6
Channon, K.M.7
-
68
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis MC and Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5: 253-295, 2010.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
69
-
-
0027465289
-
The role of oxygen radicals in human disease, with particular reference to the vascular system
-
Halliwell B. The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemos-tasis 23 Suppl 1: 118-126, 1993.
-
(1993)
Haemos-tasis
, vol.23
, Issue.SUPPL. 1
, pp. 118-126
-
-
Halliwell, B.1
-
70
-
-
63849133179
-
Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells
-
Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, and Alevriadou BR. Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther 329: 94-101, 2009.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 94-101
-
-
Han, Z.1
Varadharaj, S.2
Giedt, R.J.3
Zweier, J.L.4
Szeto, H.H.5
Alevriadou, B.R.6
-
71
-
-
8444228527
-
Compartmentation of Nrf-2 redox control: Regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
-
Hansen JM, Watson WH, and Jones DP. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicol Sci 82: 308-317, 2004.
-
(2004)
Toxicol Sci
, vol.82
, pp. 308-317
-
-
Hansen, J.M.1
Watson, W.H.2
Jones, D.P.3
-
72
-
-
33646699095
-
Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase=Akt pathway and the Nrf2 transcription factor in renal cells
-
Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, and Wigmore SJ. Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase=Akt pathway and the Nrf2 transcription factor in renal cells. FEBS J 273: 2345-2356, 2006.
-
(2006)
FEBS J
, vol.273
, pp. 2345-2356
-
-
Harrison, E.M.1
McNally, S.J.2
Devey, L.3
Garden, O.J.4
Ross, J.A.5
Wigmore, S.J.6
-
73
-
-
33750944018
-
Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes
-
Hayashi T, Matsui-Hirai H, Miyazaki-Akita A, Fukatsu A, Funami J, Ding QF, Kamalanathan S, Hattori Y, Ignarro LJ, and Iguchi A. Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Proc Natl Acad Sci USA 103: 17018-17023, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17018-17023
-
-
Hayashi, T.1
Matsui-Hirai, H.2
Miyazaki-Akita, A.3
Fukatsu, A.4
Funami, J.5
Ding, Q.F.6
Kamalanathan, S.7
Hattori, Y.8
Ignarro, L.J.9
Iguchi, A.10
-
74
-
-
0033956744
-
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
-
Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, and Yamamoto M. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28: 33-41, 2000.
-
(2000)
Biochem Soc Trans
, vol.28
, pp. 33-41
-
-
Hayes, J.D.1
Chanas, S.A.2
Henderson, C.J.3
McMahon, M.4
Sun, C.5
Moffat, G.J.6
Wolf, C.R.7
Yamamoto, M.8
-
75
-
-
78649635570
-
Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes
-
He M, Siow RC, Sugden D, Gao L, Cheng X, and Mann GE. Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: a role for Nrf2 in vascular protection in diabetes. Nutr Metab Cardiovasc Dis 2010.
-
(2010)
Nutr Metab Cardiovasc Dis
-
-
He, M.1
Siow, R.C.2
Sugden, D.3
Gao, L.4
Cheng, X.5
Mann, G.E.6
-
76
-
-
25444468046
-
Divergent responses of chondrocytes and endothelial cells to shear stress: Crosstalk among COX-2, the phase 2 response, and apoptosis
-
Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, and Konstantopoulos K. Divergent responses of chondrocytes and endothelial cells to shear stress: crosstalk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci USA 102: 14010-14015, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14010-14015
-
-
Healy, Z.R.1
Lee, N.H.2
Gao, X.3
Goldring, M.B.4
Talalay, P.5
Kensler, T.W.6
Konstantopoulos, K.7
-
77
-
-
70450234994
-
Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: The role of reactive oxygen species (ROS)-, eNOS- and heme oxygenase (HO-1) levels
-
Heiss EH, Schachner D, Werner ER, and Dirsch VM. Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: the role of reactive oxygen species (ROS)-, eNOS- and heme oxygenase (HO-1) levels. J Biol Chem 284: 31579-31586, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 31579-31586
-
-
Heiss, E.H.1
Schachner, D.2
Werner, E.R.3
Dirsch, V.M.4
-
78
-
-
22844450096
-
Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
-
Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Warabi E, Noguchi N, Itoh K, and Yamamoto M. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. J Biol Chem 280: 27244-27250, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 27244-27250
-
-
Hosoya, T.1
Maruyama, A.2
Kang, M.I.3
Kawatani, Y.4
Shibata, T.5
Uchida, K.6
Warabi, E.7
Noguchi, N.8
Itoh, K.9
Yamamoto, M.10
-
79
-
-
34248182498
-
Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice
-
Hu CM, Lin HH, Chiang MT, Chang PF, and Chau LY. Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice. Diabetes 56: 1240-1247, 2007.
-
(2007)
Diabetes
, vol.56
, pp. 1240-1247
-
-
Hu, C.M.1
Lin, H.H.2
Chiang, M.T.3
Chang, P.F.4
Chau, L.Y.5
-
80
-
-
24944557079
-
Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endo-thelial cells
-
Hu T, Ramachandrarao SP, Siva S, Valancius C, Zhu Y, Ma-hadev K, Toh I, Goldstein BJ, Woolkalis M, and Sharma K. Reactive oxygen species production via NADPH oxidase mediates TGF-beta-induced cytoskeletal alterations in endo-thelial cells. Am J Physiol Renal Physiol 289: F816-F825, 2005.
-
(2005)
Am J Physiol Renal Physiol
, vol.289
-
-
Hu, T.1
Ramachandrarao, S.P.2
Siva, S.3
Valancius, C.4
Zhu, Y.5
Ma-Hadev, K.6
Toh, I.7
Goldstein, B.J.8
Woolkalis, M.9
Sharma, K.10
-
81
-
-
0033731182
-
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
-
Huang HC, Nguyen T, and Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci USA 97: 12475-12480, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12475-12480
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
82
-
-
51049094472
-
Oxidative stress-inducible lentiviral vectors for gene therapy
-
Hurttila H, Koponen JK, Kansanen E, Jyrkkanen HK, Kivela A, Kylatie R, Yla-Herttuala S, and Levonen AL. Oxidative stress-inducible lentiviral vectors for gene therapy. Gene Ther 15: 1271-1279, 2008.
-
(2008)
Gene Ther
, vol.15
, pp. 1271-1279
-
-
Hurttila, H.1
Koponen, J.K.2
Kansanen, E.3
Jyrkkanen, H.K.4
Kivela, A.5
Kylatie, R.6
Yla-Herttuala, S.7
Levonen, A.L.8
-
83
-
-
73149085941
-
Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
-
Imhoff BR and Hansen JM. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. Biochem J 424: 491-500, 2009.
-
(2009)
Biochem J
, vol.424
, pp. 491-500
-
-
Imhoff, B.R.1
Hansen, J.M.2
-
84
-
-
76049123402
-
Insulin resistance, li-potoxicity and endothelial dysfunction
-
Imrie H, Abbas A, and Kearney M. Insulin resistance, li-potoxicity and endothelial dysfunction. Biochim Biophys Acta 1801: 320-326, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 320-326
-
-
Imrie, H.1
Abbas, A.2
Kearney, M.3
-
85
-
-
0033765672
-
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxi-dase in cultured vascular cells
-
Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Ut-sumi H, and Nawata H. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxi-dase in cultured vascular cells. Diabetes 49: 1939-1945, 2000.
-
(2000)
Diabetes
, vol.49
, pp. 1939-1945
-
-
Inoguchi, T.1
Li, P.2
Umeda, F.3
Yu, H.Y.4
Kakimoto, M.5
Imamura, M.6
Aoki, T.7
Etoh, T.8
Hashimoto, T.9
Naruse, M.10
Sano, H.11
Ut-Sumi, H.12
Nawata, H.13
-
86
-
-
1642396537
-
Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: Activation by oxidatively modified LDL and 4-hydroxynonenal
-
Ishii T, Itoh K, Ruiz E, Leake DS, Unoki H, Yamamoto M, and Mann GE. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res 94: 609-616, 2004.
-
(2004)
Circ Res
, vol.94
, pp. 609-616
-
-
Ishii, T.1
Itoh, K.2
Ruiz, E.3
Leake, D.S.4
Unoki, H.5
Yamamoto, M.6
Mann, G.E.7
-
87
-
-
0034717329
-
Transcription factor Nrf2 co-ordinately regulates a group of oxidative stress-inducible genes in macrophages
-
Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, and Yamamoto M. Transcription factor Nrf2 co-ordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275: 16023-16029, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 16023-16029
-
-
Ishii, T.1
Itoh, K.2
Takahashi, S.3
Sato, H.4
Yanagawa, T.5
Katoh, Y.6
Bannai, S.7
Yamamoto, M.8
-
88
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, and Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
89
-
-
34447526197
-
GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
-
Jain AK and Jaiswal AK. GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J Biol Chem 282: 16502-16510, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
90
-
-
33744953050
-
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
-
Jain AK and Jaiswal AK. Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J Biol Chem 281: 12132-12142, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 12132-12142
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
91
-
-
47749116455
-
Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: A novel mechanism in Nrf2 activation
-
Jain AK, Mahajan S, and Jaiswal AK. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. J Biol Chem 283: 17712-17720, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 17712-17720
-
-
Jain, A.K.1
Mahajan, S.2
Jaiswal, A.K.3
-
92
-
-
77951808284
-
Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?
-
Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, and Bocchini JA. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal 12: 1333-1337, 2010.
-
(2010)
Antioxid Redox Signal
, vol.12
, pp. 1333-1337
-
-
Jain, S.K.1
Bull, R.2
Rains, J.L.3
Bass, P.F.4
Levine, S.N.5
Reddy, S.6
McVie, R.7
Bocchini, J.A.8
-
93
-
-
33744468523
-
Exercise and hormesis: Activation of cellular antioxidant signaling pathway
-
Ji LL, Gomez-Cabrera MC, and Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci 1067: 425-435, 2006.
-
(2006)
Ann N y Acad Sci
, vol.1067
, pp. 425-435
-
-
Ji, L.L.1
Gomez-Cabrera, M.C.2
Vina, J.3
-
94
-
-
77951199503
-
The protective role of Nrf2 in STZ-induced diabetic ne-phropathy
-
Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, and Zhang DD. The protective role of Nrf2 in STZ-induced diabetic ne-phropathy. Diabetes 59: 850-860, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 850-860
-
-
Jiang, T.1
Huang, Z.2
Lin, Y.3
Zhang, Z.4
Fang, D.5
Zhang, D.D.6
-
95
-
-
0036829579
-
Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses
-
Jones DP, Mody VC Jr., Carlson JL, Lynn MJ, and Sternberg P Jr. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic Biol Med 33: 1290-1300, 2002.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 1290-1300
-
-
Jones, D.P.1
Mody Jr., V.C.2
Carlson, J.L.3
Lynn, M.J.4
Sternberg Jr., P.5
-
96
-
-
34447328075
-
Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase=Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage
-
Kang ES, Woo IS, Kim HJ, Eun SY, Paek KS, Kim HJ, Chang KC, Lee JH, Lee HT, Kim JH, Nishinaka T, Yabe-Nishimura C, and Seo HG. Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase=Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic Biol Med 43: 535-545, 2007.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 535-545
-
-
Kang, E.S.1
Woo, I.S.2
Kim, H.J.3
Eun, S.Y.4
Paek, K.S.5
Kim, H.J.6
Chang, K.C.7
Lee, J.H.8
Lee, H.T.9
Kim, J.H.10
Nishinaka, T.11
Yabe-Nishimura, C.12
Seo, H.G.13
-
97
-
-
1242274394
-
Scaffolding of Keap1 to the actin cytoskele-ton controls the function of Nrf2 as key regulator of cyto-protective phase 2 genes
-
Kang MI, Kobayashi A, Wakabayashi N, Kim SG, and Yamamoto M. Scaffolding of Keap1 to the actin cytoskele-ton controls the function of Nrf2 as key regulator of cyto-protective phase 2 genes. Proc Natl Acad Sci USA 101: 2046-2051, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2046-2051
-
-
Kang, M.I.1
Kobayashi, A.2
Wakabayashi, N.3
Kim, S.G.4
Yamamoto, M.5
-
98
-
-
77950907407
-
Nuclear erythroid factor 2 (Nrf2) mediated proteasome activation delays senescence in human fibroblasts
-
Kapeta S, Chondrogianni N, and Gonos ES. Nuclear erythroid factor 2 (Nrf2) mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 285: 8171-8184, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 8171-8184
-
-
Kapeta, S.1
Chondrogianni, N.2
Gonos, E.S.3
-
99
-
-
0035949502
-
Improved arterial compliance by a novel advanced glycation end-product crosslink breaker
-
Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, and Lakatta EG. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 104: 1464-1470, 2001.
-
(2001)
Circulation
, vol.104
, pp. 1464-1470
-
-
Kass, D.A.1
Shapiro, E.P.2
Kawaguchi, M.3
Capriotti, A.R.4
Scuteri, A.5
Degroof, R.C.6
Lakatta, E.G.7
-
100
-
-
9944255781
-
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
-
Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, and Yamamoto M. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome. Arch Biochem Biophys 433: 342-350, 2005.
-
(2005)
Arch Biochem Biophys
, vol.433
, pp. 342-350
-
-
Katoh, Y.1
Iida, K.2
Kang, M.I.3
Kobayashi, A.4
Mizukami, M.5
Tong, K.I.6
McMahon, M.7
Hayes, J.D.8
Itoh, K.9
Yamamoto, M.10
-
101
-
-
33646178955
-
Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
-
Kim JA, Montagnani M, Koh KK, and Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113: 1888-1904, 2006.
-
(2006)
Circulation
, vol.113
, pp. 1888-1904
-
-
Kim, J.A.1
Montagnani, M.2
Koh, K.K.3
Quon, M.J.4
-
102
-
-
66249147234
-
Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia
-
Kim JY, Cho HJ, Sir JJ,KimBK,HurJ,Youn SW, Yang HM, Jun SI, Park KW, Hwang SJ, Kwon YW, Lee HY, Kang HJ,OhBH, Park YB, and Kim HS. Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia. Cardiovasc Res 82: 550-560, 2009.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 550-560
-
-
Kim, J.Y.1
Cho, H.J.2
Sir, J.J.3
Kim, B.K.4
Hur, J.5
Youn, S.W.6
Yang, H.M.7
Jun, S.I.8
Park, K.W.9
Hwang, S.J.10
Kwon, Y.W.11
Lee, H.Y.12
Kang, H.J.13
Oh, B.H.14
Park, Y.B.15
Kim, H.S.16
-
103
-
-
0037468933
-
Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response
-
Kim YC, Yamaguchi Y, Kondo N, Masutani H, and Yodoi J. Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response. Onco-gene 22: 1860-1865, 2003.
-
(2003)
Onco-gene
, vol.22
, pp. 1860-1865
-
-
Kim, Y.C.1
Yamaguchi, Y.2
Kondo, N.3
Masutani, H.4
Yodoi, J.5
-
104
-
-
0036062227
-
Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes
-
Kim YK, Lee MS, Son SM, Kim IJ, Lee WS, Rhim BY, Hong KW, and Kim CD. Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 51: 522-527, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 522-527
-
-
Kim, Y.K.1
Lee, M.S.2
Son, S.M.3
Kim, I.J.4
Lee, W.S.5
Rhim, B.Y.6
Hong, K.W.7
Kim, C.D.8
-
105
-
-
0141755317
-
Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: Potential role in diabetic nephropathy
-
Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Seno-kuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, and Araki E. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes 52: 2570-2577, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 2570-2577
-
-
Kiritoshi, S.1
Nishikawa, T.2
Sonoda, K.3
Kukidome, D.4
Seno-Kuchi, T.5
Matsuo, T.6
Matsumura, T.7
Tokunaga, H.8
Brownlee, M.9
Araki, E.10
-
106
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, and Yamamoto M. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol 29: 493-502, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
Li, L.2
Iwamoto, N.3
Nakajima-Takagi, Y.4
Kaneko, H.5
Nakayama, Y.6
Eguchi, M.7
Wada, Y.8
Kumagai, Y.9
Yamamoto, M.10
-
107
-
-
20544474751
-
D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes
-
Kruger AL, Peterson S, Turkseven S, Kaminski PM, Zhang FF, Quan S, Wolin MS, and Abraham NG. D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes. Circulation 111: 3126-3134, 2005.
-
(2005)
Circulation
, vol.111
, pp. 3126-3134
-
-
Kruger, A.L.1
Peterson, S.2
Turkseven, S.3
Kaminski, P.M.4
Zhang, F.F.5
Quan, S.6
Wolin, M.S.7
Abraham, N.G.8
-
108
-
-
0038578527
-
Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: Effect of the polyamine metabolite acrolein
-
Kwak MK, Kensler TW, and Casero RA Jr. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem Biophys Res Commun 305: 662-670, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 662-670
-
-
Kwak, M.K.1
Kensler, T.W.2
Casero Jr., R.A.3
-
109
-
-
33646483074
-
The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2- dependent phase II detoxifying genes and alters intracellular glutathione redox
-
Kweon MH, In Park Y, Sung HC, and Mukhtar H. The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2- dependent phase II detoxifying genes and alters intracellular glutathione redox. Free Radic Biol Med 40: 1349-1361, 2006
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 1349-1361
-
-
Kweon, M.H.1
Park, Y.2
Sung, H.C.3
Mukhtar, H.4
-
110
-
-
68349131414
-
Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses
-
Lacraz G, Figeac F, Movassat J, Kassis N, Coulaud J, Galinier A, Leloup C, Bailbe D, Homo-Delarche F, and Portha B. Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses. PLoS ONE 4: e6500, 2009.
-
(2009)
PLoS ONE
, vol.4
-
-
Lacraz, G.1
Figeac, F.2
Movassat, J.3
Kassis, N.4
Coulaud, J.5
Galinier, A.6
Leloup, C.7
Bailbe, D.8
Homo-Delarche, F.9
Portha, B.10
-
111
-
-
56049102574
-
Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose
-
Langston W, Circu ML, and Aw TY. Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Radic Biol Med 45: 1591-1599, 2008.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 1591-1599
-
-
Langston, W.1
Circu, M.L.2
Aw, T.Y.3
-
112
-
-
0035814951
-
En-dothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
-
Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, and Harrison DG. En-dothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 103: 1282-1288, 2001.
-
(2001)
Circulation
, vol.103
, pp. 1282-1288
-
-
Laursen, J.B.1
Somers, M.2
Kurz, S.3
McCann, L.4
Warnholtz, A.5
Freeman, B.A.6
Tarpey, M.7
Fukai, T.8
Harrison, D.G.9
-
113
-
-
41349099837
-
Redox signaling, vascular function, and hypertension
-
Lee MY and Griendling KK. Redox signaling, vascular function, and hypertension. Antioxid Redox Signal 10: 1045-1059, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1045-1059
-
-
Lee, M.Y.1
Griendling, K.K.2
-
114
-
-
75149117017
-
Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
-
Leiser SF and Miller RA. Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol 30: 871-884, 2010.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 871-884
-
-
Leiser, S.F.1
Miller, R.A.2
-
116
-
-
34247204388
-
Nrf2 gene transfer induces an-tioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo
-
Levonen AL, Inkala M, Heikura T, Jauhiainen S, Jyrkkanen HK, Kansanen E, Maatta K, Romppanen E, Turunen P, Ru-tanen J, and Yla-Herttuala S. Nrf2 gene transfer induces an-tioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. Arterioscler Thromb Vasc Biol 27: 741-747, 2007.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 741-747
-
-
Levonen, A.L.1
Inkala, M.2
Heikura, T.3
Jauhiainen, S.4
Jyrkkanen, H.K.5
Kansanen, E.6
Maatta, K.7
Romppanen, E.8
Turunen, P.9
Ru-Tanen, J.10
Yla-Herttuala, S.11
-
117
-
-
30344460537
-
Age affects ERK1=2 and NRF2 signaling in the regulation of GCLC expression
-
Li M, Liu RM, Timblin CR, Meyer SG, Mossman BT, and Fukagawa NK. Age affects ERK1=2 and NRF2 signaling in the regulation of GCLC expression. J Cell Physiol 206: 518-525, 2006.
-
(2006)
J Cell Physiol
, vol.206
, pp. 518-525
-
-
Li, M.1
Liu, R.M.2
Timblin, C.R.3
Meyer, S.G.4
Mossman, B.T.5
Fukagawa, N.K.6
-
118
-
-
34548762437
-
Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice
-
Limon-Pacheco JH, Hernandez NA, Fanjul-Moles ML, and Gonsebatt ME. Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice. Free Radic Biol Med 43: 1335-1347, 2007.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 1335-1347
-
-
Limon-Pacheco, J.H.1
Hernandez, N.A.2
Fanjul-Moles, M.L.3
Gonsebatt, M.E.4
-
119
-
-
34250706879
-
Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2=ARE complex to promote vascular smooth muscle cell survival
-
Liu XM, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, and Durante W. Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2=ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res 75: 381-389, 2007.
-
(2007)
Cardiovasc Res
, vol.75
, pp. 381-389
-
-
Liu, X.M.1
Peyton, K.J.2
Ensenat, D.3
Wang, H.4
Hannink, M.5
Alam, J.6
Durante, W.7
-
120
-
-
12544253089
-
Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival
-
Liu XM, Peyton KJ, Ensenat D, Wang H, Schafer AI, Alam J, and Durante W. Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival. J Biol Chem 280: 872-877, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 872-877
-
-
Liu, X.M.1
Peyton, K.J.2
Ensenat, D.3
Wang, H.4
Schafer, A.I.5
Alam, J.6
Durante, W.7
-
122
-
-
42649130014
-
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
-
Lo SC and Hannink M. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314: 1789-1803, 2008.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1789-1803
-
-
Lo, S.C.1
Hannink, M.2
-
123
-
-
49849099361
-
Heme oxygenase-1 and the vascular bed: From molecular mechanisms to therapeutic opportunities
-
Loboda A, Jazwa A, Grochot-Przeczek A, Rutkowski AJ, Cisowski J, Agarwal A, Jozkowicz A, and Dulak J. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 10: 1767-1812, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1767-1812
-
-
Loboda, A.1
Jazwa, A.2
Grochot-Przeczek, A.3
Rutkowski, A.J.4
Cisowski, J.5
Agarwal, A.6
Jozkowicz, A.7
Dulak, J.8
-
124
-
-
65049089113
-
Regulation of glutathione synthesis
-
Lu SC. Regulation of glutathione synthesis. Mol Aspects Med 30: 42-59, 2009.
-
(2009)
Mol Aspects Med
, vol.30
, pp. 42-59
-
-
Lu, S.C.1
-
125
-
-
67650257495
-
High glucose sensitizes adult cardiomyocytes to ischaemia=reperfusion injury through nitrative thioredoxin inactivation
-
Luan R, Liu S, Yin T, Lau WB, Wang Q, Guo W, Wang H, and Tao L. High glucose sensitizes adult cardiomyocytes to ischaemia=reperfusion injury through nitrative thioredoxin inactivation. Cardiovasc Res 83: 294-302, 2009.
-
(2009)
Cardiovasc Res
, vol.83
, pp. 294-302
-
-
Luan, R.1
Liu, S.2
Yin, T.3
Lau, W.B.4
Wang, Q.5
Guo, W.6
Wang, H.7
Tao, L.8
-
126
-
-
0035856942
-
Mitochondrial function in normal and diabetic beta-cells
-
Maechler P and Wollheim CB. Mitochondrial function in normal and diabetic beta-cells. Nature 414: 807-812, 2001.
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
127
-
-
0030923630
-
The heme oxygenase system: A regulator of second messenger gases
-
Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
-
(1997)
Annu Rev Pharmacol Toxicol
, vol.37
, pp. 517-554
-
-
Maines, M.D.1
-
128
-
-
62249089498
-
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: Protection afforded by dietary iso-flavones
-
Mann GE, Bonacasa B, Ishii T, and Siow RC. Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary iso-flavones. Curr Opin Pharmacol 9: 139-145, 2009.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 139-145
-
-
Mann, G.E.1
Bonacasa, B.2
Ishii, T.3
Siow, R.C.4
-
129
-
-
34250753928
-
Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression
-
Mann GE, Rowlands DJ, Li FY, de Winter P, and Siow RC. Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression. Cardiovasc Res 75: 261-274, 2007.
-
(2007)
Cardiovasc Res
, vol.75
, pp. 261-274
-
-
Mann, G.E.1
Rowlands, D.J.2
Li, F.Y.3
De Winter, P.4
Siow, R.C.5
-
130
-
-
0037207473
-
Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells
-
Mann GE, Yudilevich DL, and Sobrevia L. Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83: 183-252, 2003.
-
(2003)
Physiol Rev
, vol.83
, pp. 183-252
-
-
Mann, G.E.1
Yudilevich, D.L.2
Sobrevia, L.3
-
131
-
-
2942667688
-
Development of insulin resistance and obesity in mice overexpressing cellular glutathione perox-idase
-
McClung JP, Roneker CA, Mu W, Lisk DJ, Langlais P, Liu F, and Lei XG. Development of insulin resistance and obesity in mice overexpressing cellular glutathione perox-idase. Proc Natl Acad Sci USA 101: 8852-8857, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8852-8857
-
-
McClung, J.P.1
Roneker, C.A.2
Mu, W.3
Lisk, D.J.4
Langlais, P.5
Liu, F.6
Lei, X.G.7
-
132
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M, Itoh K, Yamamoto M, and Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278: 21592-21600, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
133
-
-
33846121333
-
Vascular cell senescence: Contribution to atherosclerosis
-
Minamino T and Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res 100: 15-26, 2007.
-
(2007)
Circ Res
, vol.100
, pp. 15-26
-
-
Minamino, T.1
Komuro, I.2
-
134
-
-
0032973663
-
Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy
-
Miyata T, Sugiyama S, Suzuki D, Inagi R, and Kurokawa K. Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy. Kidney Int Suppl 71: S54-S56, 1999.
-
(1999)
Kidney Int Suppl
, vol.71
-
-
Miyata, T.1
Sugiyama, S.2
Suzuki, D.3
Inagi, R.4
Kurokawa, K.5
-
135
-
-
0025883342
-
Nitric oxide: Physiology, pathophysiology, and pharmacology
-
Moncada S, Palmer RM, and Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991.
-
(1991)
Pharmacol Rev
, vol.43
, pp. 109-142
-
-
Moncada, S.1
Palmer, R.M.2
Higgs, E.A.3
-
136
-
-
7244253081
-
Nrf2-Keap1 defines a physiologically important stress response mechanism
-
Motohashi H and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-557, 2004.
-
(2004)
Trends Mol Med
, vol.10
, pp. 549-557
-
-
Motohashi, H.1
Yamamoto, M.2
-
137
-
-
33646417325
-
Induction of mitochondrial ROS production by electrophilic lipids: A new pathway of redox signaling?
-
Murphy MP. Induction of mitochondrial ROS production by electrophilic lipids: a new pathway of redox signaling? Am J Physiol Heart Circ Physiol 290: H1754-H1755, 2006.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Murphy, M.P.1
-
138
-
-
67449135837
-
Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2
-
Naidu S, Vijayan V, Santoso S, Kietzmann T, and Im-menschuh S. Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2. J Immunol 182: 7048-7057, 2009.
-
(2009)
J Immunol
, vol.182
, pp. 7048-7057
-
-
Naidu, S.1
Vijayan, V.2
Santoso, S.3
Kietzmann, T.4
Im-Menschuh, S.5
-
139
-
-
74949102157
-
Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats
-
Ndisang JF, Lane N, Syed N, and Jadhav A. Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 151: 549-560, 2010.
-
(2010)
Endocrinology
, vol.151
, pp. 549-560
-
-
Ndisang, J.F.1
Lane, N.2
Syed, N.3
Jadhav, A.4
-
140
-
-
0033857531
-
The missing link: A single unifying mechanism for diabetic complications
-
Nishikawa T, Edelstein D, and Brownlee M. The missing link: a single unifying mechanism for diabetic complications. Kidney Int Suppl 77: S26-S30, 2000.
-
(2000)
Kidney Int Suppl
, vol.77
-
-
Nishikawa, T.1
Edelstein, D.2
Brownlee, M.3
-
141
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hy-perglycaemic damage
-
Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hy-perglycaemic damage. Nature 404: 787-790, 2000.
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.P.10
Giardino, I.11
Brownlee, M.12
-
142
-
-
14644397287
-
Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene
-
Nishinaka T and Yabe-Nishimura C. Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene. J Pharmacol Sci 97: 43-51, 2005.
-
(2005)
J Pharmacol Sci
, vol.97
, pp. 43-51
-
-
Nishinaka, T.1
Yabe-Nishimura, C.2
-
143
-
-
71449099635
-
Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance
-
Niture SK, Jain AK, and Jaiswal AK. Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci 122: 4452-4464, 2009.
-
(2009)
J Cell Sci
, vol.122
, pp. 4452-4464
-
-
Niture, S.K.1
Jain, A.K.2
Jaiswal, A.K.3
-
144
-
-
33750734665
-
NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglyce-mia-induced brain endothelial cell apoptosis
-
Okouchi M, Okayama N, Alexander JS, and Aw TY. NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglyce-mia-induced brain endothelial cell apoptosis. Curr Neuro-vasc Res 3: 249-261, 2006.
-
(2006)
Curr Neuro-vasc Res
, vol.3
, pp. 249-261
-
-
Okouchi, M.1
Okayama, N.2
Alexander, J.S.3
Aw, T.Y.4
-
145
-
-
70350337363
-
Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apo-ptosis
-
Okouchi M, Okayama N, and Aw TY. Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apo-ptosis. Curr Neurovasc Res 6: 267-278, 2009.
-
(2009)
Curr Neurovasc Res
, vol.6
, pp. 267-278
-
-
Okouchi, M.1
Okayama, N.2
Aw, T.Y.3
-
146
-
-
77649311383
-
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
-
Onken B and Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5: e8758, 2010.
-
(2010)
PLoS ONE
, vol.5
-
-
Onken, B.1
Driscoll, M.2
-
147
-
-
58549094758
-
The pathologic continuum of diabetic vascular disease
-
Orasanu G and Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol 53: S35-S42, 2009.
-
(2009)
J Am Coll Cardiol
, vol.53
-
-
Orasanu, G.1
Plutzky, J.2
-
148
-
-
33748893228
-
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion
-
Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, and Kensler TW. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Arch Bio-chem Biophys 454: 7-15, 2006.
-
(2006)
Arch Bio-chem Biophys
, vol.454
, pp. 7-15
-
-
Osburn, W.O.1
Wakabayashi, N.2
Misra, V.3
Nilles, T.4
Biswal, S.5
Trush, M.A.6
Kensler, T.W.7
-
149
-
-
33846863589
-
Nitric oxide and per-oxynitrite in health and disease
-
Pacher P, Beckman JS, and Liaudet L. Nitric oxide and per-oxynitrite in health and disease. Physiol Rev 87: 315-424, 2007.
-
(2007)
Physiol Rev
, vol.87
, pp. 315-424
-
-
Pacher, P.1
Beckman, J.S.2
Liaudet, L.3
-
150
-
-
34447134863
-
Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
-
Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, and
-
(2007)
Exp Mol Med
, vol.39
, pp. 267-277
-
-
Pae, H.O.1
Jeong, G.S.2
Jeong, S.O.3
Kim, H.S.4
Kim, S.A.5
Kim, Y.C.6
Yoo, S.J.7
Kim, H.D.8
Chung, H.T.9
-
151
-
-
33644649422
-
Hyperoxia stimulates an Nrf2-ARE transcrip-tional response via ROS-EGFR-PI3K-Akt=ERK MAP kinase signaling in pulmonary epithelial cells
-
Papaiahgari S, Zhang Q, Kleeberger SR, Cho HY, and Reddy SP. Hyperoxia stimulates an Nrf2-ARE transcrip-tional response via ROS-EGFR-PI3K-Akt=ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal 8: 43-52, 2006.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 43-52
-
-
Papaiahgari, S.1
Zhang, Q.2
Kleeberger, S.R.3
Cho, H.Y.4
Reddy, S.P.5
-
152
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, and de Cabo R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci USA 105: 2325-2330, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2325-2330
-
-
Pearson, K.J.1
Lewis, K.N.2
Price, N.L.3
Chang, J.W.4
Perez, E.5
Cascajo, M.V.6
Tamashiro, K.L.7
Poosala, S.8
Csiszar, A.9
Ungvari, Z.10
Kensler, T.W.11
Yamamoto, M.12
Egan, J.M.13
Longo, D.L.14
Ingram, D.K.15
Navas, P.16
De Cabo, R.17
-
153
-
-
0038025371
-
Mi-tochondrial dysfunction in the elderly: Possible role in insulin resistance
-
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, and Shulman GI. Mi-tochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300: 1140-1142, 2003.
-
(2003)
Science
, vol.300
, pp. 1140-1142
-
-
Petersen, K.F.1
Befroy, D.2
Dufour, S.3
Dziura, J.4
Ariyan, C.5
Rothman, D.L.6
Dipietro, L.7
Cline, G.W.8
Shulman, G.I.9
-
154
-
-
33744473330
-
Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
-
Piconi L, Quagliaro L, Assaloni R, Da RR, Maier A, Zuodar G, and Ceriello A. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev 22: 198-203, 2006.
-
(2006)
Diabetes Metab Res Rev
, vol.22
, pp. 198-203
-
-
Piconi, L.1
Quagliaro, L.2
Assaloni, R.3
Da, R.R.4
Maier, A.5
Zuodar, G.6
Ceriello, A.7
-
155
-
-
34748904643
-
Translational control of nrf2 protein in activation of antioxi-dant response by oxidants
-
Purdom-Dickinson SE, Sheveleva EV, Sun H, and Chen QM. Translational control of nrf2 protein in activation of antioxi-dant response by oxidants. Mol Pharmacol 72: 1074-1081, 2007.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 1074-1081
-
-
Purdom-Dickinson, S.E.1
Sheveleva, E.V.2
Sun, H.3
Chen, Q.M.4
-
156
-
-
33645770953
-
Mitochondria as signaling organelles in the vascular en-dothelium
-
Quintero M, Colombo SL, Godfrey A, and Moncada S. Mitochondria as signaling organelles in the vascular en-dothelium. Proc Natl Acad Sci USA 103: 5379-5384, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5379-5384
-
-
Quintero, M.1
Colombo, S.L.2
Godfrey, A.3
Moncada, S.4
-
157
-
-
33845742185
-
Mechanisms of disease: En-dothelial dysfunction in insulin resistance and diabetes
-
Rask-Madsen C and King GL. Mechanisms of disease: en-dothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab 3: 46-56, 2007.
-
(2007)
Nat Clin Pract Endocrinol Metab
, vol.3
, pp. 46-56
-
-
Rask-Madsen, C.1
King, G.L.2
-
158
-
-
0037904926
-
Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells
-
Ribeiro MM, Klein D, Pileggi A, Molano RD, Fraker C, Ricordi C, Inverardi L, and Pastori RL. Heme oxygenase-1 fused to a TAT peptide transduces and protects pancreatic beta-cells. Biochem Biophys Res Commun 305: 876-881, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.305
, pp. 876-881
-
-
Ribeiro, M.M.1
Klein, D.2
Pileggi, A.3
Molano, R.D.4
Fraker, C.5
Ricordi, C.6
Inverardi, L.7
Pastori, R.L.8
-
159
-
-
64249099733
-
The permissive role of mito- chondria in the induction of haem oxygenase-1 in endo-thelial cells
-
Ricart KC, Bolisetty S, Johnson MS, Perez J, Agarwal A, Murphy MP, and Landar A. The permissive role of mito- chondria in the induction of haem oxygenase-1 in endo-thelial cells. Biochem J 419: 427-436, 2009.
-
(2009)
Biochem J
, vol.419
, pp. 427-436
-
-
Ricart, K.C.1
Bolisetty, S.2
Johnson, M.S.3
Perez, J.4
Agarwal, A.5
Murphy, M.P.6
Landar, A.7
-
160
-
-
12244297111
-
Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent etha-crynic acid
-
Rizzardini M, Lupi M, Bernasconi S, Mangolini A, and Cantoni L. Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent etha-crynic acid. J Neurol Sci 207: 51-58, 2003.
-
(2003)
J Neurol Sci
, vol.207
, pp. 51-58
-
-
Rizzardini, M.1
Lupi, M.2
Bernasconi, S.3
Mangolini, A.4
Cantoni, L.5
-
161
-
-
0034531564
-
NAD(P)H:quinone oxidoreductase 1 (NQO1): Chemoprotection, bioactivation, gene regulation and genetic polymorphisms
-
Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, and Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129: 77-97, 2000.
-
(2000)
Chem Biol Interact
, vol.129
, pp. 77-97
-
-
Ross, D.1
Kepa, J.K.2
Winski, S.L.3
Beall, H.D.4
Anwar, A.5
Siegel, D.6
-
162
-
-
18244386712
-
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2
-
Sakurai A, Nishimoto M, Himeno S, Imura N, Tsujimoto M, Kunimoto M, and Hara S. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J Cell Phy-siol 203: 529-537, 2005.
-
(2005)
J Cell Phy-siol
, vol.203
, pp. 529-537
-
-
Sakurai, A.1
Nishimoto, M.2
Himeno, S.3
Imura, N.4
Tsujimoto, M.5
Kunimoto, M.6
Hara, S.7
-
163
-
-
33744950387
-
Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phos-phorylation and nuclear exclusion of the transcription factor Nrf2
-
Salazar M, Rojo AI, Velasco D, de Sagarra RM, and Cua-drado A. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phos-phorylation and nuclear exclusion of the transcription factor Nrf2. J Biol Chem 281: 14841-14851, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 14841-14851
-
-
Salazar, M.1
Rojo, A.I.2
Velasco, D.3
De Sagarra, R.M.4
Cua-Drado, A.5
-
164
-
-
0038755458
-
Diabetes and mitochondrial oxidative stress: A study using heart mitochondria from the diabetic Goto-Kakizaki rat
-
Santos DL, Palmeira CM, Seica R, Dias J, Mesquita J, Moreno AJ, and Santos MS. Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat. Mol Cell Biochem 246: 163-170, 2003.
-
(2003)
Mol Cell Biochem
, vol.246
, pp. 163-170
-
-
Santos, D.L.1
Palmeira, C.M.2
Seica, R.3
Dias, J.4
Mesquita, J.5
Moreno, A.J.6
Santos, M.S.7
-
165
-
-
0037160092
-
Electrophile response element-mediated induction of the cystine=glutamate exchange transporter gene expression
-
Sasaki H, Sato H, Kuriyama-Matsumura K, Sato K, Mae-bara K, Wang H, Tamba M, Itoh K, Yamamoto M, and Bannai S. Electrophile response element-mediated induction of the cystine=glutamate exchange transporter gene expression. J Biol Chem 277: 44765-44771, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 44765-44771
-
-
Sasaki, H.1
Sato, H.2
Kuriyama-Matsumura, K.3
Sato, K.4
Mae-Bara, K.5
Wang, H.6
Tamba, M.7
Itoh, K.8
Yamamoto, M.9
Bannai, S.10
-
166
-
-
0029088742
-
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes
-
Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, and Stern D. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. J Clin Invest 96: 1395-1403, 1995.
-
(1995)
J Clin Invest
, vol.96
, pp. 1395-1403
-
-
Schmidt, A.M.1
Hori, O.2
Chen, J.X.3
Li, J.F.4
Crandall, J.5
Zhang, J.6
Cao, R.7
Yan, S.D.8
Brett, J.9
Stern, D.10
-
167
-
-
41349096436
-
Nitric oxide, tetrahydrobiopterin, oxidative stress, and en-dothelial dysfunction in hypertension
-
Schulz E, Jansen T, Wenzel P, Daiber A, and Munzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and en-dothelial dysfunction in hypertension. Antioxid Redox Signal 10: 1115-1126, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1115-1126
-
-
Schulz, E.1
Jansen, T.2
Wenzel, P.3
Daiber, A.4
Munzel, T.5
-
168
-
-
0031728245
-
Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin
-
Sengoelge G, Fodinger M, Skoupy S, Ferrara I, Zangerle C, Rogy M, Horl WH, Sunder-Plassmann G, and Menzel J. Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin. Kidney Int 54: 1637-1651, 1998.
-
(1998)
Kidney Int
, vol.54
, pp. 1637-1651
-
-
Sengoelge, G.1
Fodinger, M.2
Skoupy, S.3
Ferrara, I.4
Zangerle, C.5
Rogy, M.6
Horl, W.H.7
Sunder-Plassmann, G.8
Menzel, J.9
-
169
-
-
20744440945
-
Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
-
Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, and Murphy TH. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J Biol Chem 280: 22925-22936, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 22925-22936
-
-
Shih, A.Y.1
Imbeault, S.2
Barakauskas, V.3
Erb, H.4
Jiang, L.5
Li, P.6
Murphy, T.H.7
-
170
-
-
33947659941
-
Differential expressions of antioxi-dant status in aging rats: The role of transcriptional factor Nrf2 and MAPK signaling pathway
-
Shih PH and Yen GC. Differential expressions of antioxi-dant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway. Biogerontology 8: 71-80, 2007.
-
(2007)
Biogerontology
, vol.8
, pp. 71-80
-
-
Shih, P.H.1
Yen, G.C.2
-
171
-
-
70349140473
-
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide
-
Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, and Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. Eur J Pharmacol 620: 138-144, 2009.
-
(2009)
Eur J Pharmacol
, vol.620
, pp. 138-144
-
-
Shin, S.1
Wakabayashi, J.2
Yates, M.S.3
Wakabayashi, N.4
Dolan, P.M.5
Aja, S.6
Liby, K.T.7
Sporn, M.B.8
Yamamoto, M.9
Kensler, T.W.10
-
172
-
-
74049131523
-
Disruption of the mGsta4 gene increases life span of C57BL mice
-
Singh SP, Niemczyk M, Saini D, Sadovov V, Zimniak L, and Zimniak P. Disruption of the mGsta4 gene increases life span of C57BL mice. J Gerontol A Biol Sci Med Sci 65: 14- 23, 2010.
-
(2010)
J Gerontol A Biol Sci Med Sci
, vol.65
, pp. 14-23
-
-
Singh, S.P.1
Niemczyk, M.2
Saini, D.3
Sadovov, V.4
Zimniak, L.5
Zimniak, P.6
-
173
-
-
33847634280
-
Cardiovascular targets for estrogens and phytoestrogens: Transcriptional regulation of nitric oxide synthase and anti-oxidant defense genes
-
Siow RC, Li FY, Rowlands DJ, de Winter P, and Mann GE. Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and anti-oxidant defense genes. Free Radic Biol Med 42: 909-925, 2007
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 909-925
-
-
Siow, R.C.1
Li, F.Y.2
Rowlands, D.J.3
De Winter, P.4
Mann, G.E.5
-
174
-
-
0033026857
-
Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: Anti-atherogenic actions of bilirubin and carbon monoxide?
-
Siow RC, Sato H, and Mann GE. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res 41: 385-394, 1999.
-
(1999)
Cardiovasc Res
, vol.41
, pp. 385-394
-
-
Siow, R.C.1
Sato, H.2
Mann, G.E.3
-
175
-
-
33644507111
-
Application of sulforaphane: Histopathologi-cal study of intraportal transplanted pancreatic islets into livers of diabetic rats
-
Solowiej E, Solowiej J, Godlewski M, Motyl T, Perkowska-Ptasinska A, Jaskiewicz K, Kasprzycka-Guttman T, and Rowinski W. Application of sulforaphane: histopathologi-cal study of intraportal transplanted pancreatic islets into livers of diabetic rats. Transplant Proc 38: 282-283, 2006.
-
(2006)
Transplant Proc
, vol.38
, pp. 282-283
-
-
Solowiej, E.1
Solowiej, J.2
Godlewski, M.3
Motyl, T.4
Perkowska-Ptasinska, A.5
Jaskiewicz, K.6
Kasprzycka-Guttman, T.7
Rowinski, W.8
-
176
-
-
58549089876
-
Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study
-
Song J, Sumiyoshi S, Nakashima Y, Doi Y, Iida M, Kiyohara Y, and Sueishi K. Overexpression of heme oxygenase-1 in coronary atherosclerosis of Japanese autopsies with diabetes mellitus: Hisayama study. Atherosclerosis 202: 573-581, 2009.
-
(2009)
Atherosclerosis
, vol.202
, pp. 573-581
-
-
Song, J.1
Sumiyoshi, S.2
Nakashima, Y.3
Doi, Y.4
Iida, M.5
Kiyohara, Y.6
Sueishi, K.7
-
177
-
-
21344444333
-
A high-fat diet coordinately down-regulates genes required for mitochondrial oxidative phos-phorylation in skeletal muscle
-
Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, and Smith SR. A high-fat diet coordinately down-regulates genes required for mitochondrial oxidative phos-phorylation in skeletal muscle. Diabetes 54: 1926-1933, 2005.
-
(2005)
Diabetes
, vol.54
, pp. 1926-1933
-
-
Sparks, L.M.1
Xie, H.2
Koza, R.A.3
Mynatt, R.4
Hulver, M.W.5
Bray, G.A.6
Smith, S.R.7
-
178
-
-
0242352418
-
Increased nitric oxide levels as an early sign of premature aging in diabetes
-
Stadler K, Jenei V, von BG, Somogyi A, and Jakus J. Increased nitric oxide levels as an early sign of premature aging in diabetes. Free Radic Biol Med 35: 1240-1251, 2003.
-
(2003)
Free Radic Biol Med
, vol.35
, pp. 1240-1251
-
-
Stadler, K.1
Jenei, V.2
Von Bg Somogyi, A.3
Jakus, J.4
-
179
-
-
0029977757
-
Obesity=insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
-
Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, and Baron AD. Obesity=insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97: 2601-2610, 1996.
-
(1996)
J Clin Invest
, vol.97
, pp. 2601-2610
-
-
Steinberg, H.O.1
Chaker, H.2
Leaming, R.3
Johnson, A.4
Brechtel, G.5
Baron, A.D.6
-
180
-
-
36348947406
-
Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons
-
Storozhevykh TP, Senilova YE, Persiyantseva NA, Pinelis VG, and Pomytkin IA. Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons. BMC Neurosci 8: 84, 2007.
-
(2007)
BMC Neurosci
, vol.8
, pp. 84
-
-
Storozhevykh, T.P.1
Senilova, Y.E.2
Persiyantseva, N.A.3
Pinelis, V.G.4
Pomytkin, I.A.5
-
181
-
-
78650891370
-
Enhanced neointimal hyperplasia and carotid artery remodeling in sequestosome 1 deficient mice
-
Sep 24 [Epub ahead of print]
-
Sugimoto R, Warabi E, Katayanagi S, Sakai S, Uwayama J, Yanagawa T, Watanabe A, Harada H, Kitamura K, No-guchi N, Yoshida H, Siow RC, Mann GE, and Ishii T. Enhanced neointimal hyperplasia and carotid artery remodeling in sequestosome 1 deficient mice. J Cell Mol Med 2009 Sep 24 [Epub ahead of print].
-
(2009)
J Cell Mol Med
-
-
Sugimoto, R.1
Warabi, E.2
Katayanagi, S.3
Sakai, S.4
Uwayama, J.5
Yanagawa, T.6
Watanabe, A.7
Harada, H.8
Kitamura, K.9
No-Guchi, N.10
Yoshida, H.11
Siow, R.C.12
Mann, G.E.13
Ishii, T.14
-
182
-
-
1542723493
-
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
-
Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, and Hagen TM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101: 3381-3386, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3381-3386
-
-
Suh, J.H.1
Shenvi, S.V.2
Dixon, B.M.3
Liu, H.4
Jaiswal, A.K.5
Liu, R.M.6
Hagen, T.M.7
-
183
-
-
33846993042
-
A new activating role for CO in cardiac mitochondrial biogenesis
-
Suliman HB, Carraway MS, Tatro LG, and Piantadosi CA. A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 120: 299-308, 2007.
-
(2007)
J Cell Sci
, vol.120
, pp. 299-308
-
-
Suliman, H.B.1
Carraway, M.S.2
Tatro, L.G.3
Piantadosi, C.A.4
-
184
-
-
1242319573
-
Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network
-
Sun J, Brand M, Zenke Y, Tashiro S, Groudine M, and Ig-arashi K. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci USA 101: 1461-1466, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1461-1466
-
-
Sun, J.1
Brand, M.2
Zenke, Y.3
Tashiro, S.4
Groudine, M.5
Ig-Arashi, K.6
-
185
-
-
56849124834
-
Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-medi-ated atherosclerosis in mice
-
Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gab-rielson KL, Polotsky VY, and Biswal S. Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-medi-ated atherosclerosis in mice. PLoS ONE 3: e3791, 2008.
-
(2008)
PLoS ONE
, vol.3
-
-
Sussan, T.E.1
Jun, J.2
Thimmulappa, R.3
Bedja, D.4
Antero, M.5
Gab-Rielson, K.L.6
Polotsky, V.Y.7
Biswal, S.8
-
186
-
-
37749024370
-
Keap1=Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
-
Sykiotis GP and Bohmann D. Keap1=Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell 14: 76-85, 2008.
-
(2008)
Dev Cell
, vol.14
, pp. 76-85
-
-
Sykiotis, G.P.1
Bohmann, D.2
-
187
-
-
35748959038
-
Hydrogen sulphide and its therapeutic potential
-
Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 6: 917-935, 2007.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 917-935
-
-
Szabo, C.1
-
188
-
-
42449111723
-
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet
-
Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, and Klaassen CD. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther 325: 655-664, 2008.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 655-664
-
-
Tanaka, Y.1
Aleksunes, L.M.2
Yeager, R.L.3
Gyamfi, M.A.4
Esterly, N.5
Guo, G.L.6
Klaassen, C.D.7
-
189
-
-
34248591499
-
Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro
-
Tanito M, Agbaga MP, and Anderson RE. Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro. Free Radic Biol Med 42: 1838-1850, 2007.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 1838-1850
-
-
Tanito, M.1
Agbaga, M.P.2
Anderson, R.E.3
-
190
-
-
1842680838
-
Cardiovascular disease delay in centenarian offspring
-
Terry DF, Wilcox MA, McCormick MA, and Perls TT. Cardiovascular disease delay in centenarian offspring. J Gerontol A Biol Sci Med Sci 59: 385-389, 2004.
-
(2004)
J Gerontol A Biol Sci Med Sci
, vol.59
, pp. 385-389
-
-
Terry, D.F.1
Wilcox, M.A.2
McCormick, M.A.3
Perls, T.T.4
-
191
-
-
49849084827
-
Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities
-
Thomas SR, Witting PK, and Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 10: 1713-1765, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1713-1765
-
-
Thomas, S.R.1
Witting, P.K.2
Drummond, G.R.3
-
192
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulinlike signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, and Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulinlike signaling in C. elegans. Cell 132: 1025-1038, 2008.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
193
-
-
0142248307
-
Senescence-associated cell death of human endo-thelial cells: The role of oxidative stress
-
Unterluggauer H, Hampel B, Zwerschke W, and Jansen-Durr P. Senescence-associated cell death of human endo-thelial cells: the role of oxidative stress. Exp Gerontol 38: 1149-1160, 2003.
-
(2003)
Exp Gerontol
, vol.38
, pp. 1149-1160
-
-
Unterluggauer, H.1
Hampel, B.2
Zwerschke, W.3
Jansen-Durr, P.4
-
194
-
-
0036954803
-
Novel role of gp91(phox)-containing NAD(P)H oxi-dase in vascular endothelial growth factor-induced signaling and angiogenesis
-
Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fuji-moto M, Quinn MT, Pagano PJ, Johnson C, and Alexander RW. Novel role of gp91(phox)-containing NAD(P)H oxi-dase in vascular endothelial growth factor-induced signaling and angiogenesis. Circ Res 91: 1160-1167, 2002.
-
(2002)
Circ Res
, vol.91
, pp. 1160-1167
-
-
Ushio-Fukai, M.1
Tang, Y.2
Fukai, T.3
Dikalov, S.I.4
Ma, Y.5
Fuji-Moto, M.6
Quinn, M.T.7
Pagano, P.J.8
Johnson, C.9
Alexander, R.W.10
-
195
-
-
0024428094
-
Effects of endotheli-um-derived nitric oxide on peripheral arteriolar tone in man
-
Vallance P, Collier J, and Moncada S. Effects of endotheli-um-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2: 997-1000, 1989.
-
(1989)
Lancet
, vol.2
, pp. 997-1000
-
-
Vallance, P.1
Collier, J.2
Moncada, S.3
-
196
-
-
14044249491
-
Expression and localization of NOX2 and NOX4 in primary human endothelial cells
-
Van Buul JD, Fernandez-Borja M, Anthony EC, and Hor-dijk PL. Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal 7: 308-317, 2005.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 308-317
-
-
Van Buul, J.D.1
Fernandez-Borja, M.2
Anthony, E.C.3
Hor-Dijk, P.L.4
-
197
-
-
0033212947
-
Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: Evidence of impaired reactivity to nitroglycerin
-
Vavuranakis M, Stefanadis C, Triandaphyllidi E, Toutouzas K, and Toutouzas P. Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: evidence of impaired reactivity to nitroglycerin. J Am Coll Cardiol 34: 1075-1081, 1999.
-
(1999)
J Am Coll Cardiol
, vol.34
, pp. 1075-1081
-
-
Vavuranakis, M.1
Stefanadis, C.2
Triandaphyllidi, E.3
Toutouzas, K.4
Toutouzas, P.5
-
198
-
-
0029906134
-
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qui-none oxidoreductase1 gene
-
Venugopal R and Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:qui-none oxidoreductase1 gene. Proc Natl Acad Sci USA 93: 14960-14965, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14960-14965
-
-
Venugopal, R.1
Jaiswal, A.K.2
-
199
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, Harada T, Engel JD, and Yamamoto M. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35: 238-245, 2003.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
Harada, T.11
Engel, J.D.12
Yamamoto, M.13
-
200
-
-
45549087514
-
Essential roles of the PI3 kinase=Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE
-
Wang L, Chen Y, Sternberg P, and Cai J. Essential roles of the PI3 kinase=Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest Ophthalmol Vis Sci 49: 1671-1678, 2008.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 1671-1678
-
-
Wang, L.1
Chen, Y.2
Sternberg, P.3
Cai, J.4
-
201
-
-
47549096022
-
Superoxide flashes in single mitochondria
-
Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, and Cheng H. Superoxide flashes in single mitochondria. Cell 134: 279-290, 2008.
-
(2008)
Cell
, vol.134
, pp. 279-290
-
-
Wang, W.1
Fang, H.2
Groom, L.3
Cheng, A.4
Zhang, W.5
Liu, J.6
Wang, X.7
Li, K.8
Han, P.9
Zheng, M.10
Yin, J.11
Wang, W.12
Mattson, M.P.13
Kao, J.P.14
Lakatta, E.G.15
Sheu, S.S.16
Ouyang, K.17
Chen, J.18
Dirksen, R.T.19
Cheng, H.20
more..
-
202
-
-
0034996659
-
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
-
Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, and Wautier JL. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab 280: E685-E694, 2001.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Wautier, M.P.1
Chappey, O.2
Corda, S.3
Stern, D.M.4
Schmidt, A.M.5
Wautier, J.L.6
-
203
-
-
3442893856
-
Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules
-
Winiarska K, Drozak J, Wegrzynowicz M, Fraczyk T, and Bryla J. Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules. Mol Cell Biochem 261: 91-98, 2004.
-
(2004)
Mol Cell Biochem
, vol.261
, pp. 91-98
-
-
Winiarska, K.1
Drozak, J.2
Wegrzynowicz, M.3
Fraczyk, T.4
Bryla, J.5
-
204
-
-
22444433668
-
Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH
-
Wolin MS, Ahmad M, and Gupte SA. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am J Physiol Lung Cell Mol Physiol 289: L159-L173, 2005.
-
(2005)
Am J Physiol Lung Cell Mol Physiol
, vol.289
-
-
Wolin, M.S.1
Ahmad, M.2
Gupte, S.A.3
-
205
-
-
58149352893
-
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
-
Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, and Thornalley PJ. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes 57: 2809-2817, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 2809-2817
-
-
Xue, M.1
Qian, Q.2
Adaikalakoteswari, A.3
Rabbani, N.4
Babaei-Jadidi, R.5
Thornalley, P.J.6
-
206
-
-
36148988058
-
Transgenic expression of antioxi-dant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus
-
Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J, and Miyazaki J. Transgenic expression of antioxi-dant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus. Antioxid Redox Signal 10: 43-49, 2008.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 43-49
-
-
Yamamoto, M.1
Yamato, E.2
Toyoda, S.3
Tashiro, F.4
Ikegami, H.5
Yodoi, J.6
Miyazaki, J.7
-
207
-
-
14644401702
-
Fluid shear stress inhibits vascular inflammation by decreasing thior-edoxin-interacting protein in endothelial cells
-
Yamawaki H, Pan S, Lee RT, and Berk BC. Fluid shear stress inhibits vascular inflammation by decreasing thior-edoxin-interacting protein in endothelial cells. J Clin Invest 115: 733-738, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 733-738
-
-
Yamawaki, H.1
Pan, S.2
Lee, R.T.3
Berk, B.C.4
-
208
-
-
0028304625
-
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors=binding proteins
-
Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, and Stern D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors=binding proteins. J Biol Chem 269: 9889-9897, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 9889-9897
-
-
Yan, S.D.1
Schmidt, A.M.2
Anderson, G.M.3
Zhang, J.4
Brett, J.5
Zou, Y.S.6
Pinsky, D.7
Stern, D.8
-
209
-
-
38349179648
-
Receptor for advanced glycation endproducts (RAGE): A formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging
-
Yan SF, D'Agati V, Schmidt AM, and Ramasamy R. Receptor for advanced glycation endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging. Curr Mol Med 7: 699-710, 2007.
-
(2007)
Curr Mol Med
, vol.7
, pp. 699-710
-
-
Yan, S.F.1
D'Agati, V.2
Schmidt, A.M.3
Ramasamy, R.4
-
210
-
-
42449109476
-
Mechanisms of disease: Advanced glycation end-products and their receptor in inflammation and diabetes complications
-
Yan SF, Ramasamy R, and Schmidt AM. Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 4: 285-293, 2008.
-
(2008)
Nat Clin Pract Endocrinol Metab
, vol.4
, pp. 285-293
-
-
Yan, S.F.1
Ramasamy, R.2
Schmidt, A.M.3
-
211
-
-
2342563763
-
Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes
-
Ye G, Metreveli NS, Donthi RV, Xia S, Xu M, Carlson EC, and Epstein PN. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. Diabetes 53: 1336-1343, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 1336-1343
-
-
Ye, G.1
Metreveli, N.S.2
Donthi, R.V.3
Xia, S.4
Xu, M.5
Carlson, E.C.6
Epstein, P.N.7
-
212
-
-
54449084867
-
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice
-
Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, and Yamamoto M. Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells 13: 1159-1170, 2008.
-
(2008)
Genes Cells
, vol.13
, pp. 1159-1170
-
-
Yoh, K.1
Hirayama, A.2
Ishizaki, K.3
Yamada, A.4
Takeuchi, M.5
Yamagishi, S.6
Morito, N.7
Nakano, T.8
Ojima, M.9
Shimohata, H.10
Itoh, K.11
Takahashi, S.12
Yamamoto, M.13
-
213
-
-
33644552417
-
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
-
Yu T, Robotham JL, and Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci USA 103: 2653-2658, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 2653-2658
-
-
Yu, T.1
Robotham, J.L.2
Yoon, Y.3
-
214
-
-
21344443037
-
Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis
-
Yusuf M, Kwong Huat BT, Hsu A, Whiteman M, Bhatia M, and Moore PK. Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun 333: 1146-1152, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.333
, pp. 1146-1152
-
-
Yusuf, M.1
Kwong Huat, B.T.2
Hsu, A.3
Whiteman, M.4
Bhatia, M.5
Moore, P.K.6
-
215
-
-
73949142348
-
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
-
Zakkar M, Van Der HK, Luong LA, Chaudhury H, Cuhl-mann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, and Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol 29: 1851-1857, 2009.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1851-1857
-
-
Zakkar, M.1
Van Der, H.K.2
Luong, L.A.3
Chaudhury, H.4
Cuhl-Mann, S.5
Hamdulay, S.S.6
Krams, R.7
Edirisinghe, I.8
Rahman, I.9
Carlsen, H.10
Haskard, D.O.11
Mason, J.C.12
Evans, P.C.13
-
216
-
-
38449096208
-
Lower expression of Nrf2 mRNA in older donor livers: A possible contributor to increased ischemia-reperfusion injury?
-
Zaman MB, Leonard MO, Ryan EJ, Nolan NP, Hoti E, Maguire D, Mulcahy H, Traynor O, Taylor CT, Hegarty JE, Geoghegan JG, and O'Farrelly C. Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury? Transplantation 84: 1272-1278, 2007.
-
(2007)
Transplantation
, vol.84
, pp. 1272-1278
-
-
Zaman, M.B.1
Leonard, M.O.2
Ryan, E.J.3
Nolan, N.P.4
Hoti, E.5
Maguire, D.6
Mulcahy, H.7
Traynor, O.8
Taylor, C.T.9
Hegarty, J.E.10
Geoghegan, J.G.11
O'Farrelly, C.12
-
217
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, and Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105: 745-755, 2001.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
218
-
-
33947503436
-
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
-
Zhang HS and Wang SQ. Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. Biochem Pharmacol 73: 1358-1366, 2007.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 1358-1366
-
-
Zhang, H.S.1
Wang, S.Q.2
-
219
-
-
27944437786
-
Activation of the Nrf2=antioxidant response pathway increases IL-8 expression
-
Zhang X, Chen X, Song H, Chen HZ, and Rovin BH. Activation of the Nrf2=antioxidant response pathway increases IL-8 expression. Eur J Immunol 35: 3258-3267, 2005.
-
(2005)
Eur J Immunol
, vol.35
, pp. 3258-3267
-
-
Zhang, X.1
Chen, X.2
Song, H.3
Chen, H.Z.4
Rovin, B.H.5
-
220
-
-
29244479186
-
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
-
Zhao J, Kobori N, Aronowski J, and Dash PK. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393: 108-112, 2006.
-
(2006)
Neurosci Lett
, vol.393
, pp. 108-112
-
-
Zhao, J.1
Kobori, N.2
Aronowski, J.3
Dash, P.K.4
-
221
-
-
34548850603
-
Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
-
Zhao J, Moore AN, Redell JB, and Dash PK. Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. J Neurosci 27: 10240-10248, 2007.
-
(2007)
J Neurosci
, vol.27
, pp. 10240-10248
-
-
Zhao, J.1
Moore, A.N.2
Redell, J.B.3
Dash, P.K.4
-
222
-
-
67949107934
-
Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels
-
Zhong L, Liu Z, Yan R, Johnson S, Zhao Y, Fang X, and Cao D. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Biochem Biophys Res Commun 387: 245-250, 2009.
-
(2009)
Biochem Biophys Res Commun
, vol.387
, pp. 245-250
-
-
Zhong, L.1
Liu, Z.2
Yan, R.3
Johnson, S.4
Zhao, Y.5
Fang, X.6
Cao, D.7
-
223
-
-
20444381360
-
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury
-
Zhu H, Itoh K, Yamamoto M, Zweier JL, and Li Y. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett 579: 3029-3036, 2005.
-
(2005)
FEBS Lett
, vol.579
, pp. 3029-3036
-
-
Zhu, H.1
Itoh, K.2
Yamamoto, M.3
Zweier, J.L.4
Li, Y.5
-
224
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P, Alberti KG, and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414: 782-787, 2001.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
|