메뉴 건너뛰기




Volumn 70, Issue 3, 2015, Pages 303-313

Resveratrol encapsulated in novel fusogenic liposomes activates Nrf2 and attenuates oxidative stress in cerebromicrovascular endothelial cells from aged rats

Author keywords

Endothelial; Fusogenic liposomes; Oxidative stress; Polyphenol

Indexed keywords

ANTIOXIDANT; DRUG VEHICLE; LIPOSOME; REACTIVE OXYGEN METABOLITE; RESVERATROL; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

EID: 84942236506     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu029     Document Type: Article
Times cited : (62)

References (83)
  • 1
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 2
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-1122.
    • (2006) Cell. , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 3
    • 63549094179 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
    • Smith JJ, Kenney RD, Gagne DJ, et al. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol. 2009;3:31.
    • (2009) BMC Syst Biol. , vol.3 , pp. 31
    • Smith, J.J.1    Kenney, R.D.2    Gagne, D.J.3
  • 4
    • 34547178903 scopus 로고    scopus 로고
    • Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries
    • Ungvari Z, Orosz Z, Labinskyy N, et al. Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am J Physiol Heart Circ Physiol. 2007;293:H37-H47.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.293 , pp. H37-H47
    • Ungvari, Z.1    Orosz, Z.2    Labinskyy, N.3
  • 5
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8:157-168.
    • (2008) Cell Metab. , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3
  • 6
    • 68149150584 scopus 로고    scopus 로고
    • Resveratrol improves endothelial function: Role of TNF{alpha} and vascular oxidative stress
    • Zhang H, Zhang J, Ungvari Z, Zhang C. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol. 2009;29:1164-1171.
    • (2009) Arterioscler Thromb Vasc Biol. , vol.29 , pp. 1164-1171
    • Zhang, H.1    Zhang, J.2    Ungvari, Z.3    Zhang, C.4
  • 7
    • 0022982012 scopus 로고
    • The diet and 15-year death rate in the seven countries study
    • Keys A, Menotti A, Karvonen MJ, et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol. 1986;124:903-915.
    • (1986) Am J Epidemiol. , vol.124 , pp. 903-915
    • Keys, A.1    Menotti, A.2    Karvonen, M.J.3
  • 8
    • 0032955055 scopus 로고    scopus 로고
    • Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study
    • De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99:779-785.
    • (1999) Circulation , vol.99 , pp. 779-785
    • De Lorgeril, M.1    Salen, P.2    Martin, J.L.3    Monjaud, I.4    Delaye, J.5    Mamelle, N.6
  • 9
    • 51649128211 scopus 로고    scopus 로고
    • Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells
    • Caddeo C, Teskac K, Sinico C, Kristl J. Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells. Int J Pharm. 2008;363:183-191.
    • (2008) Int J Pharm. , vol.363 , pp. 183-191
    • Caddeo, C.1    Teskac, K.2    Sinico, C.3    Kristl, J.4
  • 11
    • 66149107051 scopus 로고    scopus 로고
    • Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice
    • Narayanan NK, Nargi D, Randolph C, Narayanan BA. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009;125:1-8.
    • (2009) Int J Cancer. , vol.125 , pp. 1-8
    • Narayanan, N.K.1    Nargi, D.2    Randolph, C.3    Narayanan, B.A.4
  • 12
    • 43049146486 scopus 로고    scopus 로고
    • Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes
    • Fabris S, Momo F, Ravagnan G, Stevanato R. Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes. Biophys Chem. 2008;135:76-83.
    • (2008) Biophys Chem. , vol.135 , pp. 76-83
    • Fabris, S.1    Momo, F.2    Ravagnan, G.3    Stevanato, R.4
  • 13
    • 33750063974 scopus 로고    scopus 로고
    • Development and evaluation of emulsion-liposome blends for resveratrol delivery
    • Hung CF, Chen JK, Liao MH, Lo HM, Fang JY. Development and evaluation of emulsion-liposome blends for resveratrol delivery. J Nanosci Nanotechnol. 2006;6:2950-2958.
    • (2006) J Nanosci Nanotechnol. , vol.6 , pp. 2950-2958
    • Hung, C.F.1    Chen, J.K.2    Liao, M.H.3    Lo, H.M.4    Fang, J.Y.5
  • 15
    • 84856148283 scopus 로고    scopus 로고
    • Fluorescent lipids: Functional parts of fusogenic liposomes and tools for cell membrane labeling and visualization
    • Kleusch C, Hersch N, Hoffmann B, Merkel R, Csiszár A. Fluorescent lipids: functional parts of fusogenic liposomes and tools for cell membrane labeling and visualization. Molecules. 2012;17:1055-1073.
    • (2012) Molecules. , vol.17 , pp. 1055-1073
    • Kleusch, C.1    Hersch, N.2    Hoffmann, B.3    Merkel, R.4    Csiszár, A.5
  • 16
    • 18844402874 scopus 로고    scopus 로고
    • Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
    • Chen CY, Jang JH, Li MH, Surh YJ. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun. 2005;331:993-1000.
    • (2005) Biochem Biophys Res Commun. , vol.331 , pp. 993-1000
    • Chen, C.Y.1    Jang, J.H.2    Li, M.H.3    Surh, Y.J.4
  • 17
    • 84861865625 scopus 로고    scopus 로고
    • Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: Reversal by resveratrol treatment
    • Csiszar A, Sosnowska D, Wang M, Lakatta EG, Sonntag WE, Ungvari Z. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. J Gerontol A Biol Sci Med Sci. 2012;67:811-820. doi:10.1093/gerona/glr228
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 811-820
    • Csiszar, A.1    Sosnowska, D.2    Wang, M.3    Lakatta, E.G.4    Sonntag, W.E.5    Ungvari, Z.6
  • 18
    • 41549108838 scopus 로고    scopus 로고
    • Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
    • Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008;294:L478-L488.
    • (2008) Am J Physiol Lung Cell Mol Physiol. , vol.294 , pp. L478-L488
    • Kode, A.1    Rajendrasozhan, S.2    Caito, S.3    Yang, S.R.4    Megson, I.L.5    Rahman, I.6
  • 19
    • 48749085399 scopus 로고    scopus 로고
    • Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
    • Rubiolo JA, Mithieux G, Vega FV. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol. 2008;591:66-72.
    • (2008) Eur J Pharmacol. , vol.591 , pp. 66-72
    • Rubiolo, J.A.1    Mithieux, G.2    Vega, F.V.3
  • 20
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010;299:H18-H24.
    • (2010) Am J Physiol Heart Circ Physiol. , vol.299 , pp. H18-H24
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3
  • 21
    • 84878309609 scopus 로고    scopus 로고
    • Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients
    • Tucsek Z, Gautam T, Sonntag WE, et al. Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J Gerontol A Biol Sci Med Sci. 2013;68:652-660.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 652-660
    • Tucsek, Z.1    Gautam, T.2    Sonntag, W.E.3
  • 22
    • 79955068967 scopus 로고    scopus 로고
    • Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
    • Ungvari Z, Bailey-Downs L, Gautam T, et al. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol. 2011;300:H1133-H1140.
    • (2011) Am J Physiol Heart Circ Physiol. , vol.300 , pp. H1133-H1140
    • Ungvari, Z.1    Bailey-Downs, L.2    Gautam, T.3
  • 23
    • 80051484050 scopus 로고    scopus 로고
    • Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta
    • Ungvari Z, Bailey-Downs L, Gautam T, et al. Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci. 2011;66:866-875.
    • (2011) J Gerontol a Biol Sci Med Sci. , vol.66 , pp. 866-875
    • Ungvari, Z.1    Bailey-Downs, L.2    Gautam, T.3
  • 24
    • 33144469523 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
    • Csiszar A, Ahmad M, Smith KE, et al. Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol. 2006;168:629-638.
    • (2006) Am J Pathol. , vol.168 , pp. 629-638
    • Csiszar, A.1    Ahmad, M.2    Smith, K.E.3
  • 25
    • 1842509760 scopus 로고    scopus 로고
    • Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
    • Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol Genomics. 2004;17:21-30.
    • (2004) Physiol Genomics. , vol.17 , pp. 21-30
    • Csiszar, A.1    Ungvari, Z.2    Koller, A.3    Edwards, J.G.4    Kaley, G.5
  • 26
    • 18544384985 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-2 expression in endothelial cells: Role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure
    • Csiszar A, Smith KE, Koller A, Kaley G, Edwards JG, Ungvari Z. Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation. 2005;111:2364-2372.
    • (2005) Circulation , vol.111 , pp. 2364-2372
    • Csiszar, A.1    Smith, K.E.2    Koller, A.3    Kaley, G.4    Edwards, J.G.5    Ungvari, Z.6
  • 27
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
    • (1956) J Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 29
    • 84929258432 scopus 로고    scopus 로고
    • Heart that beats for 500 years: Age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal
    • Sosnowska D, Richardson C, Sonntag WE, Csiszar A, Ungvari Z, Ridgway I A. Heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial animal. J Gerontol A Biol Sci Med Sci. 2013. doi:10.1093/gerona/glt201
    • (2013) J Gerontol a Biol Sci Med Sci.
    • Sosnowska, D.1    Richardson, C.2    Sonntag, W.E.3    Csiszar, A.4    Ungvari, Z.5    Ridgway, I.A.6
  • 30
    • 84908376800 scopus 로고    scopus 로고
    • Obesity in aging exacerbates blood brain barrier disruption, neuroinflammation and oxidative stress in the mouse hippocampus: Effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
    • Tucsek Z, Toth P, Sosnowsk D, et al. Obesity in aging exacerbates blood brain barrier disruption, neuroinflammation and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol Biol Med Sci. 2013. doi:10.1093/gerona/glt177
    • (2013) J Gerontol Biol Med Sci.
    • Tucsek, Z.1    Toth, P.2    Sosnowsk, D.3
  • 31
    • 84885015478 scopus 로고    scopus 로고
    • Basic biology of skeletal aging: Role of stress response pathways
    • Almeida M, O'Brien CA. Basic biology of skeletal aging: role of stress response pathways. J Gerontol A Biol Sci Med Sci. 2013;68:1197-1208.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 1197-1208
    • Almeida, M.1    O'Brien, C.A.2
  • 32
    • 84883048598 scopus 로고    scopus 로고
    • Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging
    • Sinha-Hikim I, Sinha-Hikim AP, Parveen M, et al. Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging. J Gerontol A Biol Sci Med Sci. 2013;68:749-759.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 749-759
    • Sinha-Hikim, I.1    Sinha-Hikim, A.P.2    Parveen, M.3
  • 33
    • 84885007327 scopus 로고    scopus 로고
    • Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1
    • Leiser SF, Fletcher M, Begun A, Kaeberlein M. Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. J Gerontol A Biol Sci Med Sci. 2013;68:1135-1144.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 1135-1144
    • Leiser, S.F.1    Fletcher, M.2    Begun, A.3    Kaeberlein, M.4
  • 34
    • 84876268693 scopus 로고    scopus 로고
    • Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: Is extreme longevity associated with a multistress resistance phenotype?
    • Ungvari Z, Sosnowska D, Mason JB, et al. Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype? J Gerontol A Biol Sci Med Sci. 2013;68:521-529.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 521-529
    • Ungvari, Z.1    Sosnowska, D.2    Mason, J.B.3
  • 35
    • 84875175883 scopus 로고    scopus 로고
    • Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: The giant clam (Tridacna derasa)
    • Ungvari Z, Csiszar A, Sosnowska D, et al. Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). J Gerontol A Biol Sci Med Sci. 2012;68:359-367. doi:10.1093/gerona/gls159
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 359-367
    • Ungvari, Z.1    Csiszar, A.2    Sosnowska, D.3
  • 37
    • 84861025869 scopus 로고    scopus 로고
    • Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: Results from the health aging and body composition study
    • Cesari M, Kritchevsky SB, Nicklas B, et al.; Health ABC study. Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study. J Gerontol A Biol Sci Med Sci. 2012;67:671-676.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 671-676
    • Health ABC study1    Cesari, M.2    Kritchevsky, S.B.3    Nicklas, B.4
  • 38
    • 84866120008 scopus 로고    scopus 로고
    • Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer survivors: Increased apoptosis in Alzheimer's and reduced necrosis in cancer
    • Behrens MI, Silva M, Salech F, et al. Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer survivors: increased apoptosis in Alzheimer's and reduced necrosis in cancer. J Gerontol A Biol Sci Med Sci. 2012;67:1036-1040.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 1036-1040
    • Behrens, M.I.1    Silva, M.2    Salech, F.3
  • 39
    • 84866426621 scopus 로고    scopus 로고
    • Testing the oxidative stress hypothesis of aging in primate fibroblasts: Is there a correlation between species longevity and cellular ROS production?
    • Csiszar A, Podlutsky A, Podlutskaya N, et al. Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci. 2012;67:841-852.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 841-852
    • Csiszar, A.1    Podlutsky, A.2    Podlutskaya, N.3
  • 40
    • 84859077841 scopus 로고    scopus 로고
    • Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: A novel model of vascular aging
    • Bailey-Downs LC, Mitschelen M, Sosnowska D, et al. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:313-329.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 313-329
    • Bailey-Downs, L.C.1    Mitschelen, M.2    Sosnowska, D.3
  • 41
    • 84861059895 scopus 로고    scopus 로고
    • Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: Implications for vascular aging
    • Bailey-Downs LC, Sosnowska D, Toth P, et al. Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:553-564.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 553-564
    • Bailey-Downs, L.C.1    Sosnowska, D.2    Toth, P.3
  • 42
    • 84861087862 scopus 로고    scopus 로고
    • The emerging role of IGF-1 deficiency in cardiovascular aging: Recent advances
    • Ungvari Z, Csiszar A. The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci. 2012;67:599-610. doi:10.1093/gerona/gls072
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 599-610
    • Ungvari, Z.1    Csiszar, A.2
  • 43
    • 77958061482 scopus 로고    scopus 로고
    • Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats
    • Ungvari Z, Gautam T, Koncz P, et al. Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci. 2010;65:1145-1156.
    • (2010) J Gerontol a Biol Sci Med Sci. , vol.65 , pp. 1145-1156
    • Ungvari, Z.1    Gautam, T.2    Koncz, P.3
  • 45
    • 80051504960 scopus 로고    scopus 로고
    • Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal
    • Ungvari Z, Ridgway I, Philipp EE, et al. Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal. J Gerontol A Biol Sci Med Sci. 2011;66:741-750.
    • (2011) J Gerontol a Biol Sci Med Sci. , vol.66 , pp. 741-750
    • Ungvari, Z.1    Ridgway, I.2    Philipp, E.E.3
  • 46
    • 79958292245 scopus 로고    scopus 로고
    • Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: Effects of life span-extending peripubertal GH treatment
    • Ungvari Z, Sosnowska D, Podlutsky A, Koncz P, Sonntag WE, Csiszar A. Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment. J Gerontol A Biol Sci Med Sci. 2011;66:501-510. doi:10.1093/gerona/glr004
    • (2011) J Gerontol a Biol Sci Med Sci. , vol.66 , pp. 501-510
    • Ungvari, Z.1    Sosnowska, D.2    Podlutsky, A.3    Koncz, P.4    Sonntag, W.E.5    Csiszar, A.6
  • 47
    • 36249022195 scopus 로고    scopus 로고
    • Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    • Csiszar A, Labinskyy N, Zhao X, et al. Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity. Aging Cell. 2007;6:783-797.
    • (2007) Aging Cell. , vol.6 , pp. 783-797
    • Csiszar, A.1    Labinskyy, N.2    Zhao, X.3
  • 48
    • 33847032609 scopus 로고    scopus 로고
    • Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging
    • Csiszar A, Labinskyy N, Smith K, Rivera A, Orosz Z, Ungvari Z. Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging. Am J Pathol. 2007;170:388-398.
    • (2007) Am J Pathol. , vol.170 , pp. 388-398
    • Csiszar, A.1    Labinskyy, N.2    Smith, K.3    Rivera, A.4    Orosz, Z.5    Ungvari, Z.6
  • 49
    • 77954214321 scopus 로고    scopus 로고
    • Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy
    • Pepe M, Mamdani M, Zentilin L, et al. Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy. Circ Res. 2010;106:1893-1903.
    • (2010) Circ Res. , vol.106 , pp. 1893-1903
    • Pepe, M.1    Mamdani, M.2    Zentilin, L.3
  • 50
    • 84891616477 scopus 로고    scopus 로고
    • Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: Role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity
    • Ungvari Z, Podlutsky A, Sosnowska D, et al. Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity. J Gerontol A Biol Sci Med Sci. 2013;68:1443-1457.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 1443-1457
    • Ungvari, Z.1    Podlutsky, A.2    Sosnowska, D.3
  • 51
    • 84878292533 scopus 로고    scopus 로고
    • Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice
    • Gesing A, Masternak MM, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A. Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci. 2013;68:639-651.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 639-651
    • Gesing, A.1    Masternak, M.M.2    Lewinski, A.3    Karbownik-Lewinska, M.4    Kopchick, J.J.5    Bartke, A.6
  • 53
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191-196.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 54
    • 67349234999 scopus 로고    scopus 로고
    • Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    • Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med. 2009;46:1589-1597.
    • (2009) Free Radic Biol Med. , vol.46 , pp. 1589-1597
    • Danz, E.D.1    Skramsted, J.2    Henry, N.3    Bennett, J.A.4    Keller, R.S.5
  • 55
    • 46249095235 scopus 로고    scopus 로고
    • SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
    • Miyazaki R, Ichiki T, Hashimoto T, et al. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:1263-1269.
    • (2008) Arterioscler Thromb Vasc Biol. , vol.28 , pp. 1263-1269
    • Miyazaki, R.1    Ichiki, T.2    Hashimoto, T.3
  • 56
    • 74249099068 scopus 로고    scopus 로고
    • Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
    • Gracia-Sancho J, Villarreal G Jr, Zhang Y, García-Cardeña G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2010;85:514-519.
    • (2010) Cardiovasc Res. , vol.85 , pp. 514-519
    • Gracia-Sancho, J.1    Villarreal, G.2    Zhang, Y.3    García-Cardeña, G.4
  • 57
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430:686-689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3
  • 58
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5:493-506.
    • (2006) Nat Rev Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 59
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712-716.
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3
  • 60
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A. 2007;104:7217-7222.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 61
  • 62
    • 78649635403 scopus 로고    scopus 로고
    • Nrf2, a guardian of healthspan and gatekeeper of species longevity
    • Lewis KN, Mele J, Hayes JD, Buffenstein R. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010;50:829-843.
    • (2010) Integr Comp Biol. , vol.50 , pp. 829-843
    • Lewis, K.N.1    Mele, J.2    Hayes, J.D.3    Buffenstein, R.4
  • 63
    • 40749104203 scopus 로고    scopus 로고
    • SKNy worms and long life
    • Jasper H. SKNy worms and long life. Cell. 2008;132:915-916.
    • (2008) Cell. , vol.132 , pp. 915-916
    • Jasper, H.1
  • 64
    • 40649108843 scopus 로고    scopus 로고
    • Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
    • Pearson KJ, Lewis KN, Price NL, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A. 2008;105:2325-2330.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , pp. 2325-2330
    • Pearson, K.J.1    Lewis, K.N.2    Price, N.L.3
  • 65
    • 64249150743 scopus 로고    scopus 로고
    • Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes
    • Collins AR, Lyon CJ, Xia X, et al. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res. 2009;104:e42-e54.
    • (2009) Circ Res. , vol.104 , pp. e42-e54
    • Collins, A.R.1    Lyon, C.J.2    Xia, X.3
  • 66
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh JH, Shenvi SV, Dixon BM, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A. 2004;101:3381-3386.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3
  • 67
    • 79961043903 scopus 로고    scopus 로고
    • Vascular oxidative stress in aging: A homeostatic failure due to dysregulation of NRF2-mediated antioxidant response
    • Ungvari Z, Bailey-Downs L, Sosnowska D, et al. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol. 2011;301:H363-H372.
    • (2011) Am J Physiol Heart Circ Physiol. , vol.301 , pp. H363-H372
    • Ungvari, Z.1    Bailey-Downs, L.2    Sosnowska, D.3
  • 69
    • 84866346444 scopus 로고    scopus 로고
    • Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: Implications for microvascular aging
    • Valcarcel-Ares MN, Gautam T, Warrington JP, et al. Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:821-829.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 821-829
    • Valcarcel-Ares, M.N.1    Gautam, T.2    Warrington, J.P.3
  • 70
    • 48349110303 scopus 로고    scopus 로고
    • A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    • Barger JL, Kayo T, Vann JM, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One. 2008;3:e2264.
    • (2008) PLoS One. , vol.3 , pp. e2264
    • Barger, J.L.1    Kayo, T.2    Vann, J.M.3
  • 71
    • 79961092644 scopus 로고    scopus 로고
    • Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice
    • Jackson JR, Ryan MJ, Alway SE. Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. J Gerontol A Biol Sci Med Sci. 2011;66:751-764.
    • (2011) J Gerontol a Biol Sci Med Sci. , vol.66 , pp. 751-764
    • Jackson, J.R.1    Ryan, M.J.2    Alway, S.E.3
  • 73
    • 79955125211 scopus 로고    scopus 로고
    • Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome
    • Labbé A, Garand C, Cogger VC, et al. Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci. 2011;66:264-278.
    • (2011) J Gerontol a Biol Sci Med Sci. , vol.66 , pp. 264-278
    • Labbé, A.1    Garand, C.2    Cogger, V.C.3
  • 74
    • 84856171338 scopus 로고    scopus 로고
    • Challenges of translating basic research into therapeutics: Resveratrol as an example
    • Smoliga JM, Vang O, Baur JA. Challenges of translating basic research into therapeutics: resveratrol as an example. J Gerontol A Biol Sci Med Sci. 2012;67:158-167.
    • (2012) J Gerontol a Biol Sci Med Sci. , vol.67 , pp. 158-167
    • Smoliga, J.M.1    Vang, O.2    Baur, J.A.3
  • 76
    • 84871876229 scopus 로고    scopus 로고
    • Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
    • Strong R, Miller RA, Astle CM, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2013;68:6-16.
    • (2013) J Gerontol a Biol Sci Med Sci. , vol.68 , pp. 6-16
    • Strong, R.1    Miller, R.A.2    Astle, C.M.3
  • 77
    • 46449096453 scopus 로고    scopus 로고
    • Age-related alterations in reactivity of cerebral arterioles: Role of oxidative stress
    • Mayhan WG, Arrick DM, Sharpe GM, Sun H. Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Microcirculation. 2008;15:225-236.
    • (2008) Microcirculation , vol.15 , pp. 225-236
    • Mayhan, W.G.1    Arrick, D.M.2    Sharpe, G.M.3    Sun, H.4
  • 79
    • 36248935988 scopus 로고    scopus 로고
    • Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain
    • Park L, Anrather J, Girouard H, Zhou P, Iadecola C. Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J Cereb Blood Flow Metab. 2007;27:1908-1918.
    • (2007) J Cereb Blood Flow Metab. , vol.27 , pp. 1908-1918
    • Park, L.1    Anrather, J.2    Girouard, H.3    Zhou, P.4    Iadecola, C.5
  • 81
    • 79953321373 scopus 로고    scopus 로고
    • Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats
    • Wang Y, Xu H, Fu Q, Ma R, Xiang J. Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats. J Neurol Sci. 2011;304:29-34.
    • (2011) J Neurol Sci. , vol.304 , pp. 29-34
    • Wang, Y.1    Xu, H.2    Fu, Q.3    Ma, R.4    Xiang, J.5
  • 83
    • 78049475228 scopus 로고    scopus 로고
    • Effects of resveratrol on membrane biophysical properties: Relevance for its pharmacological effects
    • Brittes J, Lúcio M, Nunes C, Lima JL, Reis S. Effects of resveratrol on membrane biophysical properties: relevance for its pharmacological effects. Chem Phys Lipids. 2010;163:747-754.
    • (2010) Chem Phys Lipids. , vol.163 , pp. 747-754
    • Brittes, J.1    Lúcio, M.2    Nunes, C.3    Lima, J.L.4    Reis, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.