Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70

Toxicology in Vitro

Volumn 29, Issue 3, 2015, Pages 600-608

  Yao, Xiangyang ^a   Bai, Qin ^a   Yan, Dazhong ^b   Li, Guilan ^c   Lü, Chaotian ^a   Xu, Hui ^a  

^a Bengbu College   (China)

^b WUHAN POLYTECHNIC UNIVERSITY   (China)

^c SHANXI AGRICULTURAL UNIVERSITY   (China)

Author keywords

HO 1; HSF1; Hsp70; Nrf2; Solanesol

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CASPASE 3; GLUTATHIONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; HEME OXYGENASE 1; ISOPRENOID; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTATE DEHYDROGENASE; MALONALDEHYDE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; REACTIVE OXYGEN METABOLITE; SOLANESOL; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALCOHOL; ANTIOXIDANT; CENTRAL DEPRESSANT AGENT; NFE2L2 PROTEIN, HUMAN; PROTECTIVE AGENT; TERPENE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; HEAT SHOCK PROTEIN 70 GENE; HO 1 GENE; HUMAN; HUMAN CELL; LIVER CELL; LIVER PROTECTION; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; BIOSYNTHESIS; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; METABOLISM; PATHOLOGY; UPREGULATION;

ANTIOXIDANTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUG-INDUCED LIVER INJURY; ETHANOL; HEME OXYGENASE-1; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LIVER; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTECTIVE AGENTS; TERPENES; UP-REGULATION;

EID: 84922772443     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.01.009     Document Type: Article

References (40)

1. Akerfelt M., Morimoto R.I., Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol. 2010, 11:545-555.
2. Altamirano J., Bataller R. Alcoholic liver disease: pathogenesis and new targets for therapy. Nat. Rev. Gastroenterol. Hepatol. 2011, 8:491-501.
3. Anckar J., Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu. Rev. Biochem. 2011, 80:1089-1115.
4. Bae S.H., Sung S.H., Oh S.Y., Lim J.M., Lee S.K., Park Y.N., Lee H.E., Kang D., Rhee S.G. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 2013, 17:73-84.
5. Barbagallo I., Galvano F., Frigiola A., Cappello F., Riccioni G., Murabito P., D'Orazio N., Torella M., Gazzolo D., Li Volti G. Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases. Antioxid. Redox Signal. 2012, 18:507-521.
6. Cederbaum A.I., Lu Y., Wu D. Role of oxidative stress in alcohol-induced liver injury. Arch. Toxicol. 2009, 83:519-548.
7. Chen M.C., Ye Y.Y., Ji G., Liu J.W. Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. J. Agric. Food Chem. 2010, 58:3330-3335.
8. Davis W., Ronai Z.e., Tew K.D. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J. Pharmacol. Exp. Ther. 2001, 296:1-6.
9. Dey A., Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology 2006, 43:S63-S74.
10. Garrido C., Brunet M., Didelot C., Zermati Y., Schmitt E., Kroemer G. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle 2006, 5:2592-2601.
11. Inoue H., Maeda-Yamamoto M., Nesumi A., Murakami A. Delphinidin-3-O-galactoside protects mouse hepatocytes from (-)-epigallocatechin-3-gallate-induced cytotoxicity via up-regulation of heme oxygenase-1 and heat shock protein 70. Nutr. Res. 2012, 32:357-364.
12. Kampinga H.H., Craig E.A. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat. Rev. Mol. Cell Biol. 2010, 11:579-592.
13. Kaspar J.W., Niture S.K., Jaiswal A.K. Nrf 2:INrf2 (Keap1) signaling in oxidative stress. Free Radic. Biol. Med. 2009, 47:1304-1309.
14. Kensler T.W., Wakabayashi N., Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47:89-116.
15. Keum Y.S., Han Y.H., Liew C., Kim J.H., Xu C., Yuan X., Shakarjian M.P., Chong S., Kong A.N. Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharm. Res. 2006, 23:2586-2594.
16. Komatsu M., Kurokawa H., Waguri S., Taguchi K., Kobayashi A., Ichimura Y., Sou Y.S., Ueno I., Sakamoto A., Tong K.I., Kim M., Nishito Y., Iemura S., Natsume T., Ueno T., Kominami E., Motohashi H., Tanaka K., Yamamoto M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 2010, 12:213-223.
17. Kotipalli K.P., Rao N.C.V., Raj K. Estimation of solanesol in tobacco and non-tobacco plants from Solanaceae family. J. Med. Aroma Plant Sci. 2008, 30:65-68.
18. Leu J.I.J., Pimkina J., Frank A., Murphy M.E., George D.L. A small molecule inhibitor of inducible heat shock protein 70. Mol. Cell 2009, 36:15-27.
19. Li H.Y., Zhong Y.F., Wu S.Y., Shi N. NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells. Chem. Res. Toxicol. 2007, 20:1242-1251.
20. Liu S., Hou W., Yao P., Zhang B., Sun S., Nüssler A.K., Liu L. Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. Toxicol. In Vitro 2010, 24:516-522.
21. Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 2013, 53:401-426.
22. Mayer M.P. Hsp70 chaperone dynamics and molecular mechanism. Trends Biochem. Sci. 2013, 38:507-514.
23. Medina J., Moreno-Otero R. pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs 2005, 65:2445-2461.
24. Niture S.K., Jaiswal A.K. Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation. J. Biol. Chem. 2010, 285:36865-36875.
25. Niture S.K., Jaiswal A.K. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 2011, 286:44542-44556.
26. Niture S.K., Jaiswal A.K. Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis. J. Biol. Chem. 2012, 287:9873-9886.
27. Niture S.K., Khatri R., Jaiswal A.K. Regulation of Nrf2-an update. Free Radic. Biol. Med. 2014, 66:36-44.
28. Nouhi F., Tusi S.K., Abdi A., Khodagholi F. Dietary supplementation with tBHQ, an Nrf2 stabilizer molecule, confers neuroprotection against apoptosis in amyloid beta-injected rat. Neurochem. Res. 2011, 36:870-878.
29. Paine A., Eiz-Vesper B., Blasczyk R., Immenschuh S. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem. Pharmacol. 2010, 80:1895-1903.
30. Peng H.M., Morishima Y., Pratt W.B., Osawa Y. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. J. Biol. Chem. 2012, 287:1556-1565.
31. Rinaldi Tosi M.E., Bocanegra V., Manucha W., Gil Lorenzo A., Valles P.G. The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). Cell Stress Chaperones 2011, 16:57-68.
32. Silver J.T., Noble E.G. Regulation of survival gene hsp70. Cell Stress Chaperones 2012, 17:1-9.
33. Taylor M.A., Fraser P.D. Solanesol: added value from solanaceous waste. Phytochemistry 2011, 72:1323-1327.
34. Trepel J., Mollapour M., Giaccone G., Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat. Rev. Cancer 2010, 10:537-549.
35. Villeneuve N.F., Tian W., Wu T., Sun Z., Lau A., Chapman E., Fang D., Zhang D.D. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Mol. Cell 2013, 51:68-79.
36. Wang A.M., Miyata Y., Klinedinst S., Peng H.M., Chua J.P., Komiyama T., Li X., Morishima Y., Merry D.E., Pratt W.B., Osawa Y., Collins C.A., Gestwicki J.E., Lieberman A.P. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat. Chem. Biol. 2013, 9:112-118.
37. Wang J.-H., Wang C.-J., Gan Y., Du G.-J., Zhao J. Design, synthesis and synergistic effects of novel derivatives of solanesol. Chem. Res. Chin. U 2007, 23:417-420.
38. Yoon Y.J., Kim J.A., Shin K.D., Shin D.S., Han Y.M., Lee Y.J., Lee J.S., Kwon B.M., Han D.C. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J. Biol. Chem. 2011, 286:1737-1747.
39. Zeng T., Zhang C.L., Song F.Y., Zhao X.L., Yu L.H., Zhu Z.P., Xie K.Q. The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. Biochim. Biophys. Acta 2013, 1830:4848-4859.
40. Zhang Y., Ahn Y.H., Benjamin I.J., Honda T., Hicks R.J., Calabrese V., Cole P.A., Dinkova-Kostova A.T. HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem. Biol. 2011, 18:1355-1361.