Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation

ACS Chemical Biology

Volumn 9, Issue 4, 2014, Pages 1015-1024

  Zhang, Huifang M ^a   Dai, Huanqin ^b   Hanson, Paul J ^a   Li, Huidong ^c   Guo, Hui ^b,d   Ye, Xin ^a   Hemida, Maged G ^a   Wang, Luoqiang ^b,e   Tong, Yaojun ^b,d   Qiu, Ye ^a   Liu, Selina ^a   Wang, Fengping ^a,f   Song, Fuhang ^b   Zhang, Buchang ^e   Wang, Jian Guo ^c   Zhang, Li Xin ^b,e   Yang, Decheng ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c NANKAI UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e ANHUI UNIVERSITY   (China)

^f HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GLUTAMATE CYSTEINE LIGASE MODIFIER SUBUNIT; ID 146; ID 45; ID 48; ID 52; INITIATION FACTOR; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4G; ISATIN DERIVATIVE; LIGASE; MESSENGER RNA; PKR LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE; PROTEIN KINASE; PROTEINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ISATIN; PERK KINASE; PROTEIN KINASE R;

ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; COXSACKIE VIRUS B3; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENDOPLASMIC RETICULUM STRESS; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSLATION INITIATION; TRANSLATION REGULATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; VIRUS CELL INTERACTION; VIRUS PARTICLE; VIRUS PLAQUE; VIRUS REPLICATION; X RAY DIFFRACTION; BIOLOGICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; PROTEIN SYNTHESIS; SYNTHESIS; WESTERN BLOTTING;

ANTIVIRAL AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HUMANS; ISATIN; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; PROTEIN BIOSYNTHESIS; VIRUS REPLICATION;

EID: 84899102437     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400775z     Document Type: Article

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