메뉴 건너뛰기




Volumn 4, Issue 1, 2015, Pages 1-15

Epigenetic Mechanisms Involved in Huntington's Disease Pathogenesis

Author keywords

DNA methylation; Epigenetics; histone modifications; huntingtin; Huntington's disease; transcription

Indexed keywords

ANTHRACYCLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; BUTYRIC ACID; CHROMOMYCIN; CYTOSKELETON PROTEIN; DNA; DNA METHYLTRANSFERASE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; HUNTINGTIN; METHYLTRANSFERASE INHIBITOR; MITHRAMYCIN; MITOCHONDRIAL PROTEIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A; VORINOSTAT; HISTONE DEACETYLASE; HTT PROTEIN, HUMAN; NERVE PROTEIN;

EID: 84930188561     PISSN: 18796397     EISSN: 18796400     Source Type: Journal    
DOI: 10.3233/JHD-140134     Document Type: Review
Times cited : (43)

References (166)
  • 2
    • 0024450903 scopus 로고
    • The functional anatomy of basal ganglia disorders
    • Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989;12(10):366-75.
    • (1989) Trends Neurosci. , vol.12 , Issue.10 , pp. 366-375
    • Albin, R.L.1    Young, A.B.2    Penney, J.B.3
  • 3
    • 0031044805 scopus 로고    scopus 로고
    • Energy metabolism defects in Huntington's disease and effects of coenzyme Q10
    • Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann Neurol. 1997;41(2):160-5.
    • (1997) Ann Neurol , vol.41 , Issue.2 , pp. 160-165
    • Koroshetz, W.J.1    Jenkins, B.G.2    Rosen, B.R.3    Beal, M.F.4
  • 4
    • 0025885733 scopus 로고
    • Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease
    • Hedreen JC, Peyser CE, Folstein SE, Ross CA. Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neurosci Lett. 1991;133(2):257-61.
    • (1991) Neurosci Lett , vol.133 , Issue.2 , pp. 257-261
    • Hedreen, J.C.1    Peyser, C.E.2    Folstein, S.E.3    Ross, C.A.4
  • 6
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is unstable in Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is unstable in Huntington's disease chromosomes. Cell. 1993;72:971-83.
    • (1993) Cell , vol.72 , pp. 971-983
  • 8
    • 35348877164 scopus 로고    scopus 로고
    • Transcriptional signatures in Huntington's disease
    • Cha JH. Transcriptional signatures in Huntington's disease. Prog Neurobiol. 2007;83(4):228-48.
    • (2007) Prog Neurobiol , vol.83 , Issue.4 , pp. 228-248
    • Cha, J.H.1
  • 11
    • 0037408279 scopus 로고    scopus 로고
    • Transcriptional abnormalities in Huntington disease
    • Sugars KL, Rubinsztein DC. Transcriptional abnormalities in Huntington disease. Trends Genet. 2003;19(5):233-8.
    • (2003) Trends Genet , vol.19 , Issue.5 , pp. 233-238
    • Sugars, K.L.1    Rubinsztein, D.C.2
  • 12
    • 0025363346 scopus 로고
    • Excitotoxic injury of the neostriatum: A model for Huntington's disease
    • DiFiglia M. Excitotoxic injury of the neostriatum: A model for Huntington's disease. Trends Neurosci. 1990;13(7): 286-9.
    • (1990) Trends Neurosci , vol.13 , Issue.7 , pp. 286-289
    • DiFiglia, M.1
  • 14
    • 0032504710 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta Bio Energetics. 1998;1366(1-2):211-23.
    • (1998) Biochim Biophys Acta Bio Energetics , vol.1366 , Issue.1-2 , pp. 211-223
    • Beal, M.F.1
  • 15
    • 0033914747 scopus 로고    scopus 로고
    • Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy
    • Lodi R, Schapira AH, Manners D, Styles P, Wood NW, Taylor DJ, Warner TT. Abnormal in vivo skeletal muscle energy metabolism in Huntington's disease and dentatorubropallidoluysian atrophy. Ann Neurol. 2000;48(1):72-6.
    • (2000) Ann Neurol , vol.48 , Issue.1 , pp. 72-76
    • Lodi, R.1    Schapira, A.H.2    Manners, D.3    Styles, P.4    Wood, N.W.5    Taylor, D.J.6    Warner, T.T.7
  • 18
    • 0033103523 scopus 로고    scopus 로고
    • Caspase-8 is required for cell death induced by expanded polyglutamine repeats
    • Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 1999;22(3):623-33.
    • (1999) Neuron , vol.22 , Issue.3 , pp. 623-633
    • Sanchez, I.1    Xu, C.J.2    Juo, P.3    Kakizaka, A.4    Blenis, J.5    Yuan, J.6
  • 20
    • 10744223572 scopus 로고    scopus 로고
    • Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: Analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation
    • Luthi-Carter R, Apostol BL, Dunah AW, DeJohn MM, Farrell LA, Bates GP, Young AB, Standaert DG, Thompson LM, Cha JH. Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: Analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Neurobiol Dis. 2003;14(3):624-36.
    • (2003) Neurobiol Dis , vol.14 , Issue.3 , pp. 624-636
    • Luthi-Carter, R.1    Apostol, B.L.2    Dunah, A.W.3    DeJohn, M.M.4    Farrell, L.A.5    Bates, G.P.6    Young, A.B.7    Standaert, D.G.8    Thompson, L.M.9    Cha, J.H.10
  • 22
    • 0030612119 scopus 로고    scopus 로고
    • Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease
    • Augood SJ, Faull RL, Emson PC. Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease. Ann Neurol. 1997;42(2):215-21.
    • (1997) Ann Neurol , vol.42 , Issue.2 , pp. 215-221
    • Augood, S.J.1    Faull, R.L.2    Emson, P.C.3
  • 24
    • 84929313294 scopus 로고    scopus 로고
    • Transcription, epigenetics and ameliorative strategies in Huntington's disease: A genome-wide perspective
    • Valor LM. Transcription, epigenetics and ameliorative strategies in Huntington's disease: A genome-wide perspective. Mol Neurobiol. 2015;51(1):406-23.
    • (2015) Mol Neurobiol , vol.51 , Issue.1 , pp. 406-423
    • Valor, L.M.1
  • 27
    • 0029895292 scopus 로고    scopus 로고
    • Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease
    • Weeks RA, Piccini P, Harding AE, Brooks DJ. Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann Neurol. 1996;40(1):49-54.
    • (1996) Ann Neurol , vol.40 , Issue.1 , pp. 49-54
    • Weeks, R.A.1    Piccini, P.2    Harding, A.E.3    Brooks, D.J.4
  • 29
    • 0141618325 scopus 로고    scopus 로고
    • Complexin II is essential for normal neurological function in mice
    • Glynn D, Bortnick RA, Morton AJ. Complexin II is essential for normal neurological function in mice. Hum Mol Genet. 2003;12(19):2431-48.
    • (2003) Hum Mol Genet , vol.12 , Issue.19 , pp. 2431-2448
    • Glynn, D.1    Bortnick, R.A.2    Morton, A.J.3
  • 30
    • 10944265363 scopus 로고    scopus 로고
    • Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A
    • Hu H, McCaw EA, Hebb AL, Gomez GT, Denovan-Wright EM. Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A. Eur J Neurosci. 2004;20(12):3351-63.
    • (2004) Eur J Neurosci , vol.20 , Issue.12 , pp. 3351-3363
    • Hu, H.1    McCaw, E.A.2    Hebb, A.L.3    Gomez, G.T.4    Denovan-Wright, E.M.5
  • 31
    • 11244306357 scopus 로고    scopus 로고
    • Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice
    • McCaw EA, Hu H, Gomez GT, Hebb AL, Kelly ME, Denovan-Wright EM. Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice. Eur J Biochem. 2004;271(23-24):4909-20.
    • (2004) Eur J Biochem , vol.271 , Issue.23-24 , pp. 4909-4920
    • McCaw, E.A.1    Hu, H.2    Gomez, G.T.3    Hebb, A.L.4    Kelly, M.E.5    Denovan-Wright, E.M.6
  • 38
    • 77958494144 scopus 로고    scopus 로고
    • The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus
    • Marcora E, Kennedy MB. The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus. Hum Mol Genet. 2010;19(22):4373-84.
    • (2010) Hum Mol Genet , vol.19 , Issue.22 , pp. 4373-4384
    • Marcora, E.1    Kennedy, M.B.2
  • 42
    • 23444458415 scopus 로고
    • Transcriptional activation modulated by homopolymeric glutamine and proline stretches
    • Gerber HP, Seipel K, Georgiev O, Hofferer M, Hug M, Rusconi S, Schaffner W. Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science. 1994;263(5148):808-11.
    • (1994) Science , vol.263 , Issue.5148 , pp. 808-811
    • Gerber, H.P.1    Seipel, K.2    Georgiev, O.3    Hofferer, M.4    Hug, M.5    Rusconi, S.6    Schaffner, W.7
  • 43
    • 0029983147 scopus 로고    scopus 로고
    • Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development
    • Karlin S, Burge C. Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development. Proc Natl Acad Sci U S A. 1996;93(4):1560-5.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.4 , pp. 1560-1565
    • Karlin, S.1    Burge, C.2
  • 44
    • 54849422301 scopus 로고    scopus 로고
    • Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
    • Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JH. Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. J Neurosci. 2008;28(42):10720-33.
    • (2008) J Neurosci , vol.28 , Issue.42 , pp. 10720-10733
    • Benn, C.L.1    Sun, T.2    Sadri-Vakili, G.3    McFarland, K.N.4    DiRocco, D.P.5    Yohrling, G.J.6    Clark, T.W.7    Bouzou, B.8    Cha, J.H.9
  • 45
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature. 2007; 447(7143):396-8.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 48
    • 80053585923 scopus 로고    scopus 로고
    • Long noncoding RNA and epigenomics
    • Kanduri C. Long noncoding RNA and epigenomics. Adv Exp Med Biol. 2011;722:174-95.
    • (2011) Adv Exp Med Biol , vol.722 , pp. 174-195
    • Kanduri, C.1
  • 49
    • 84959501112 scopus 로고    scopus 로고
    • Cocaine triggers epigenetic alterations in the corticostriatal circuit
    • Sadri-Vakili G. Cocaine triggers epigenetic alterations in the corticostriatal circuit. Brain Res. 2014; pii: S0006-8993(14)01342-0. doi: 10.1016/j.brainres.2014.09.069.
    • (2014) Brain Res
    • Sadri-Vakili, G.1
  • 50
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • Suzuki MM, Bird A. DNA methylation landscapes: Provocative insights from epigenomics. Nat Rev Genet. 2008;9(6):465-76.
    • (2008) Nat Rev Genet , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 51
    • 80051712275 scopus 로고    scopus 로고
    • Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond
    • Guo JU, Su Y, Zhong C, Ming GL, Song H. Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond. Cell Cycle. 2011;10(16):2662-68.
    • (2011) Cell Cycle , vol.10 , Issue.16 , pp. 2662-2668
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 52
    • 84876343136 scopus 로고    scopus 로고
    • Functions of DNA methylation and hydroxymethylation in mammalian development
    • Guibert S, Weber M. Functions of DNA methylation and hydroxymethylation in mammalian development. Curr Top Dev Biol. 2013;104:47-83.
    • (2013) Curr Top Dev Biol , vol.104 , pp. 47-83
    • Guibert, S.1    Weber, M.2
  • 54
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33 Suppl:245-54.
    • (2003) Nat Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 56
    • 77958534051 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome
    • Guerrero-Bosagna C, Settles M, Lucker B, Skinner MK. Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One. 2010;5(9):pii: e13100. doi: 10.1371/journal.pone.0013100.
    • (2010) PLoS One , vol.5 , Issue.9 , pp. e13100
    • Guerrero-Bosagna, C.1    Settles, M.2    Lucker, B.3    Skinner, M.K.4
  • 57
    • 61649126900 scopus 로고    scopus 로고
    • DNA methylation impacts on learning and memory in aging
    • Liu L, van Groen T, Kadish I, Tollefsbol TO. DNA methylation impacts on learning and memory in aging. Neurobiol Aging. 2009;30(4):549-60.
    • (2009) Neurobiol Aging , vol.30 , Issue.4 , pp. 549-560
    • Liu, L.1    Van Groen, T.2    Kadish, I.3    Tollefsbol, T.O.4
  • 59
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • Day JJ, Sweatt JD. DNA methylation and memory formation. Nat Neurosci. 2010;13(11):1319-23.
    • (2010) Nat Neurosci , vol.13 , Issue.11 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 60
    • 84864700183 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological disease
    • Jakovcevski M, Akbarian S. Epigenetic mechanisms in neurological disease. Nat Med. 2012;18(8):1194-204.
    • (2012) Nat Med , vol.18 , Issue.8 , pp. 1194-1204
    • Jakovcevski, M.1    Akbarian, S.2
  • 61
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson KD. DNA methylation and human disease. Nat Rev Genet. 2005;6(8):597-610.
    • (2005) Nat Rev Genet , vol.6 , Issue.8 , pp. 597-610
    • Robertson, K.D.1
  • 62
    • 81955162960 scopus 로고    scopus 로고
    • What have we learned from gene expression profiles in Huntington's disease?
    • Seredenina T, Luthi-Carter R. What have we learned from gene expression profiles in Huntington's disease? Neurobiol Dis. 2012;45(1):83-98.
    • (2012) Neurobiol Dis , vol.45 , Issue.1 , pp. 83-98
    • Seredenina, T.1    Luthi-Carter, R.2
  • 63
    • 77951579326 scopus 로고    scopus 로고
    • Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice
    • Zajac MS, Pang TY, Wong N, Weinrich B, Leang LS, Craig JM, Saffery R, Hannan AJ. Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice. Hippocampus. 2010;20(5):621-36.
    • (2010) Hippocampus , vol.20 , Issue.5 , pp. 621-636
    • Zajac, M.S.1    Pang, T.Y.2    Wong, N.3    Weinrich, B.4    Leang, L.S.5    Craig, J.M.6    Saffery, R.7    Hannan, A.J.8
  • 69
    • 84857331867 scopus 로고    scopus 로고
    • Base-resolution analyses of sequence and parent-of- origin dependentDNAmethylation in the mouse genome
    • Xie W, Barr CL, Kim A, Yue F, LeeAY, Eubanks J, Dempster EL, Ren B. Base-resolution analyses of sequence and parent-of- origin dependentDNAmethylation in the mouse genome. Cell. 2012;148(4):816-31.
    • (2012) Cell , vol.148 , Issue.4 , pp. 816-831
    • Xie, W.1    Barr, C.L.2    Kim, A.3    Yue, F.4    Lee, A.Y.5    Eubanks, J.6    Dempster, E.L.7    Ren, B.8
  • 71
    • 84864129535 scopus 로고    scopus 로고
    • Distribution of 5-hydroxymethylcytosine in different human tissues
    • Li W, Liu M. Distribution of 5-hydroxymethylcytosine in different human tissues. J Nucleic Acids. 2011;2011: 870726.
    • (2011) J Nucleic Acids , vol.2011 , pp. 870726
    • Li, W.1    Liu, M.2
  • 72
    • 80054739563 scopus 로고    scopus 로고
    • The hunt for 5-hydroxymethylcytosine: The sixth base
    • Song CX, He C. The hunt for 5-hydroxymethylcytosine: The sixth base. Epigenomics. 2011;3(5):521-23.
    • (2011) Epigenomics , vol.3 , Issue.5 , pp. 521-523
    • Song, C.X.1    He, C.2
  • 74
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD. The language of covalent histone modifications. Nature. 2000;403(6765):41-5.
    • (2000) Nature , vol.403 , Issue.6765 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 75
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell. 2007;128(4):693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 76
    • 2942518343 scopus 로고    scopus 로고
    • Mapping global histone acetylation patterns to gene expression
    • Kurdistani SK, Tavazoie S, Grunstein M. Mapping global histone acetylation patterns to gene expression. Cell. 2004;117(6):721-33.
    • (2004) Cell , vol.117 , Issue.6 , pp. 721-733
    • Kurdistani, S.K.1    Tavazoie, S.2    Grunstein, M.3
  • 81
    • 80054772539 scopus 로고    scopus 로고
    • Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease
    • Chiu CT, Liu G, Leeds P, Chuang DM. Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease. Neuropsychopharmacology. 2011;36(12):2406-21.
    • (2011) Neuropsychopharmacology , vol.36 , Issue.12 , pp. 2406-2421
    • Chiu, C.T.1    Liu, G.2    Leeds, P.3    Chuang, D.M.4
  • 86
    • 77950794366 scopus 로고    scopus 로고
    • Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease
    • Klevytska AM, Tebbenkamp AT, Savonenko AV, Borchelt DR. Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. J Neuropathol Exp Neurol. 2010;69(4): 396-404.
    • (2010) J Neuropathol Exp Neurol , vol.69 , Issue.4 , pp. 396-404
    • Klevytska, A.M.1    Tebbenkamp, A.T.2    Savonenko, A.V.3    Borchelt, D.R.4
  • 89
    • 84879165605 scopus 로고    scopus 로고
    • Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders
    • Valor LM, Viosca J, Lopez-Atalaya JP, Barco A. Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des. 2013;19(28):5051-64.
    • (2013) Curr Pharm Des , vol.19 , Issue.28 , pp. 5051-5064
    • Valor, L.M.1    Viosca, J.2    Lopez-Atalaya, J.P.3    Barco, A.4
  • 92
    • 84879137604 scopus 로고    scopus 로고
    • Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease
    • Valor LM, Guiretti D, Lopez-Atalaya JP, Barco A. Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. J Neurosci. 2013;33(25):10471-82.
    • (2013) J Neurosci , vol.33 , Issue.25 , pp. 10471-10482
    • Valor, L.M.1    Guiretti, D.2    Lopez-Atalaya, J.P.3    Barco, A.4
  • 93
    • 0033613212 scopus 로고    scopus 로고
    • Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
    • Kazantsev A, Preisinger E, Dranovsky A, Goldgaber D, Housman D. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc Natl Acad Sci U S A. 1999;96(20):11404-09.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.20 , pp. 11404-11409
    • Kazantsev, A.1    Preisinger, E.2    Dranovsky, A.3    Goldgaber, D.4    Housman, D.5
  • 94
    • 4544288380 scopus 로고    scopus 로고
    • Oscillatory entrainment of striatal neurons in freely moving rats
    • Berke JD, Okatan M, Skurski J, Eichenbaum HB. Oscillatory entrainment of striatal neurons in freely moving rats. Neuron. 2004;43(6):883-96.
    • (2004) Neuron , vol.43 , Issue.6 , pp. 883-896
    • Berke, J.D.1    Okatan, M.2    Skurski, J.3    Eichenbaum, H.B.4
  • 96
    • 0038722748 scopus 로고    scopus 로고
    • Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREBbinding protein
    • Taylor JP, Taye AA, Campbell C, Kazemi-Esfarjani P, Fischbeck KH, Min KT. Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREBbinding protein. Genes Dev. 2003;17(12):1463-8.
    • (2003) Genes Dev , vol.17 , Issue.12 , pp. 1463-1468
    • Taylor, J.P.1    Taye, A.A.2    Campbell, C.3    Kazemi-Esfarjani, P.4    Fischbeck, K.H.5    Min, K.T.6
  • 97
    • 84875228213 scopus 로고    scopus 로고
    • Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington's disease
    • Yeh HH, Young D, Gelovani JG, Robinson A, Davidson Y, Herholz K, Mann DM. Histone deacetylase class II and acetylated core histone immunohistochemistry in human brains with Huntington's disease. Brain Res. 2013;1504:16-24.
    • (2013) Brain Res , vol.1504 , pp. 16-24
    • Yeh, H.H.1    Young, D.2    Gelovani, J.G.3    Robinson, A.4    Davidson, Y.5    Herholz, K.6    Mann, D.M.7
  • 99
    • 0742287915 scopus 로고    scopus 로고
    • CRE-mediated transcription is increased in Huntington's disease transgenic mice
    • Obrietan K, Hoyt KR. CRE-mediated transcription is increased in Huntington's disease transgenic mice. J Neurosci. 2004;24(4):791-6.
    • (2004) J Neurosci , vol.24 , Issue.4 , pp. 791-796
    • Obrietan, K.1    Hoyt, K.R.2
  • 100
  • 101
    • 0037090927 scopus 로고    scopus 로고
    • Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice
    • Yu ZX, Li SH, Nguyen HP, Li XJ. Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Hum Mol Genet. 2002;11(8):905-14.
    • (2002) Hum Mol Genet , vol.11 , Issue.8 , pp. 905-914
    • Yu, Z.X.1    Li, S.H.2    Nguyen, H.P.3    Li, X.J.4
  • 103
    • 83755228990 scopus 로고    scopus 로고
    • Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death
    • Choi YJ, Kim SI, Lee JW, Kwon YS, Lee HJ, Kim SS, Chun W. Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death. Mol Cell Neurosci. 2012;49(2):127-37.
    • (2012) Mol Cell Neurosci , vol.49 , Issue.2 , pp. 127-137
    • Choi, Y.J.1    Kim, S.I.2    Lee, J.W.3    Kwon, Y.S.4    Lee, H.J.5    Kim, S.S.6    Chun, W.7
  • 106
    • 12244298155 scopus 로고    scopus 로고
    • Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREBbinding protein
    • Jiang H, Nucifora FC, Jr., Ross CA, DeFranco DB. Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREBbinding protein. Hum Mol Genet. 2003;12(1):1-12.
    • (2003) Hum Mol Genet , vol.12 , Issue.1 , pp. 1-12
    • Jiang, H.1    Nucifora, F.C.2    Ross, C.A.3    DeFranco, D.B.4
  • 108
    • 84873376098 scopus 로고    scopus 로고
    • Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model
    • Quinti L, Chopra V, Rotili D, Valente S, Amore A, Franci G, Meade S, Valenza M, Altucci L, Maxwell MM, Cattaneo E, Hersch S, Mai A, Kazantsev A. Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model. PLoS Curr. 2010;2:pii: RRN1172.
    • (2010) PLoS Curr , vol.2 , pp. RRN1172
    • Quinti, L.1    Chopra, V.2    Rotili, D.3    Valente, S.4    Amore, A.5    Franci, G.6    Meade, S.7    Valenza, M.8    Altucci, L.9    Maxwell, M.M.10    Cattaneo, E.11    Hersch, S.12    Mai, A.13    Kazantsev, A.14
  • 110
    • 84880422675 scopus 로고    scopus 로고
    • Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity
    • Bardai FH, Verma P, Smith C, Rawat V, Wang L, D'Mello SR. Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity. J Neurosci. 2013;33(29):11833-38.
    • (2013) J Neurosci , vol.33 , Issue.29 , pp. 11833-11838
    • Bardai, F.H.1    Verma, P.2    Smith, C.3    Rawat, V.4    Wang, L.5    D'Mello, S.R.6
  • 111
    • 33644830913 scopus 로고    scopus 로고
    • Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity
    • Bates EA, Victor M, Jones AK, Shi Y, Hart AC. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci. 2006;26(10):2830-38.
    • (2006) J Neurosci , vol.26 , Issue.10 , pp. 2830-2838
    • Bates, E.A.1    Victor, M.2    Jones, A.K.3    Shi, Y.4    Hart, A.C.5
  • 112
    • 53249114029 scopus 로고    scopus 로고
    • Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
    • Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet. 2008;17(23):3767-75.
    • (2008) Hum Mol Genet , vol.17 , Issue.23 , pp. 3767-3775
    • Pallos, J.1    Bodai, L.2    Lukacsovich, T.3    Purcell, J.M.4    Steffan, J.S.5    Thompson, L.M.6    Marsh, J.L.7
  • 113
    • 66749119970 scopus 로고    scopus 로고
    • Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease
    • Benn CL, Butler R, Mariner L, Nixon J, Moffitt H, Mielcarek M, Woodman B, Bates GP. Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PLoS One. 2009;4(6): e5747.
    • (2009) PLoS One , vol.4 , Issue.6 , pp. e5747
    • Benn, C.L.1    Butler, R.2    Mariner, L.3    Nixon, J.4    Moffitt, H.5    Mielcarek, M.6    Woodman, B.7    Bates, G.P.8
  • 114
    • 84866529842 scopus 로고    scopus 로고
    • SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo
    • Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G. SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One. 2012;7(4): e34805.
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e34805
    • Bobrowska, A.1    Donmez, G.2    Weiss, A.3    Guarente, L.4    Bates, G.5
  • 115
    • 79958064073 scopus 로고    scopus 로고
    • Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease
    • Bobrowska A, Paganetti P, Matthias P, Bates GP. Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS One. 2011;6(6):e20696.
    • (2011) PLoS One , vol.6 , Issue.6 , pp. e20696
    • Bobrowska, A.1    Paganetti, P.2    Matthias, P.3    Bates, G.P.4
  • 116
    • 84856710176 scopus 로고    scopus 로고
    • Genetic knock-down of HDAC3 does not modify diseaserelated phenotypes in a mouse model of Huntington's disease
    • Moumne L, Campbell K, Howland D, Ouyang Y, Bates GP. Genetic knock-down of HDAC3 does not modify diseaserelated phenotypes in a mouse model of Huntington's disease. PLoS One. 2012;7(2):e31080.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e31080
    • Moumne, L.1    Campbell, K.2    Howland, D.3    Ouyang, Y.4    Bates, G.P.5
  • 118
    • 79551532277 scopus 로고    scopus 로고
    • Neuroprotection by histone deacetylase- 7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism
    • MaC, D'Mello SR. Neuroprotection by histone deacetylase- 7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem. 2011;286(6):4819-28.
    • (2011) J Biol Chem , vol.286 , Issue.6 , pp. 4819-4828
    • Mac D'Mello, S.R.1
  • 119
    • 0035370439 scopus 로고    scopus 로고
    • Histone methylation versus histone acetylation: New insights into epigenetic regulation
    • Rice JC, Allis CD. Histone methylation versus histone acetylation: New insights into epigenetic regulation. Curr Opin Cell Biol. 2001;13(3):263-73.
    • (2001) Curr Opin Cell Biol , vol.13 , Issue.3 , pp. 263-273
    • Rice, J.C.1    Allis, C.D.2
  • 120
    • 61349185158 scopus 로고    scopus 로고
    • Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse
    • Brami-Cherrier K, Roze E, Girault JA, Betuing S, Caboche J. Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse. J Neurochem. 2009;108(6):1323-35.
    • (2009) J Neurochem , vol.108 , Issue.6 , pp. 1323-1335
    • Brami-Cherrier, K.1    Roze, E.2    Girault, J.A.3    Betuing, S.4    Caboche, J.5
  • 129
    • 0036173896 scopus 로고    scopus 로고
    • Interaction of Huntington disease protein with transcriptional activator Sp1
    • Li SH, Cheng AL, Zhou H, Lam S, Rao M, Li H, Li XJ. Interaction of Huntington disease protein with transcriptional activator Sp1. Mol Cell Biol. 2002;22(5):1277-87.
    • (2002) Mol Cell Biol , vol.22 , Issue.5 , pp. 1277-1287
    • Li, S.H.1    Cheng, A.L.2    Zhou, H.3    Lam, S.4    Rao, M.5    Li, H.6    Li, X.J.7
  • 134
    • 42049110954 scopus 로고    scopus 로고
    • Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death
    • Roze E, Betuing S, Deyts C, Marcon E, Brami-Cherrier K, Pages C, Humbert S, Merienne K, Caboche J. Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death. FASEB J. 2008;22(4):1083-93.
    • (2008) FASEB J , vol.22 , Issue.4 , pp. 1083-1093
    • Roze, E.1    Betuing, S.2    Deyts, C.3    Marcon, E.4    Brami-Cherrier, K.5    Pages, C.6    Humbert, S.7    Merienne, K.8    Caboche, J.9
  • 135
    • 0348143169 scopus 로고    scopus 로고
    • Chromatin remodeling and neuronal response: Multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons
    • Crosio C, Heitz E, Allis CD, Borrelli E, Sassone-Corsi P. Chromatin remodeling and neuronal response: Multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci. 2003;116(Pt 24):4905-14.
    • (2003) J Cell Sci , vol.116 , Issue.24 , pp. 4905-4914
    • Crosio, C.1    Heitz, E.2    Allis, C.D.3    Borrelli, E.4    Sassone-Corsi, P.5
  • 136
    • 33645059712 scopus 로고    scopus 로고
    • Histone modifications in kainate-induced status epilepticus
    • Sng JC, Taniura H, Yoneda Y. Histone modifications in kainate-induced status epilepticus. Eur J Neurosci. 2006;23(5):1269-82.
    • (2006) Eur J Neurosci , vol.23 , Issue.5 , pp. 1269-1282
    • Sng, J.C.1    Taniura, H.2    Yoneda, Y.3
  • 137
    • 3042589127 scopus 로고    scopus 로고
    • Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures
    • Tsankova NM, Kumar A, Nestler EJ. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci. 2004;24(24):5603-10.
    • (2004) J Neurosci , vol.24 , Issue.24 , pp. 5603-5610
    • Tsankova, N.M.1    Kumar, A.2    Nestler, E.J.3
  • 138
    • 79957509694 scopus 로고    scopus 로고
    • Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: Role on chromatin remodeling at the PGC-1-alpha promoter
    • Martin E, Betuing S, Pages C, Cambon K, Auregan G, Deglon N, Roze E, Caboche J. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: Role on chromatin remodeling at the PGC-1-alpha promoter. Hum Mol Genet. 2011;20(12):2422-34.
    • (2011) Hum Mol Genet , vol.20 , Issue.12 , pp. 2422-2434
    • Martin, E.1    Betuing, S.2    Pages, C.3    Cambon, K.4    Auregan, G.5    Deglon, N.6    Roze, E.7    Caboche, J.8
  • 140
    • 62849122468 scopus 로고    scopus 로고
    • DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates
    • Illuzzi J, Yerkes S, Parekh-Olmedo H, Kmiec EB. DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates. J Neurosci Res. 2009;87(3):733-47.
    • (2009) J Neurosci Res , vol.87 , Issue.3 , pp. 733-747
    • Illuzzi, J.1    Yerkes, S.2    Parekh-Olmedo, H.3    Kmiec, E.B.4
  • 141
    • 84867477363 scopus 로고    scopus 로고
    • Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of gamma- H2AX andDNAdamage responses in Huntington's disease
    • Jeon GS, Kim KY, Hwang YJ, Jung MK, An S, Ouchi M, Ouchi T, Kowall N, Lee J, Ryu H. Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of gamma- H2AX andDNAdamage responses in Huntington's disease. Mol Neurobiol. 2012;45(3):550-63.
    • (2012) Mol Neurobiol , vol.45 , Issue.3 , pp. 550-563
    • Jeon, G.S.1    Kim, K.Y.2    Hwang, Y.J.3    Jung, M.K.4    An, S.5    Ouchi, M.6    Ouchi, T.7    Kowall, N.8    Lee, J.9    Ryu, H.10
  • 142
    • 84870575235 scopus 로고    scopus 로고
    • Histone H2A variants in nucleosomes and chromatin: More or less stable?
    • Bonisch C, Hake SB. Histone H2A variants in nucleosomes and chromatin: More or less stable? Nucleic Acids Res. 2012;40(21):10719-41.
    • (2012) Nucleic Acids Res , vol.40 , Issue.21 , pp. 10719-10741
    • Bonisch, C.1    Hake, S.B.2
  • 144
    • 84863302006 scopus 로고    scopus 로고
    • Shaping the landscape: Mechanistic consequences of ubiquitin modification of chromatin
    • Braun S, Madhani HD. Shaping the landscape: Mechanistic consequences of ubiquitin modification of chromatin. EMBO Rep. 2012;13(7):619-30.
    • (2012) EMBO Rep , vol.13 , Issue.7 , pp. 619-630
    • Braun, S.1    Madhani, H.D.2
  • 145
    • 65249165505 scopus 로고    scopus 로고
    • The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease
    • Bett JS, Benn CL, Ryu KY, Kopito RR, Bates GP. The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease. J Cell Mol Med. 2009;13(8B):2645-57.
    • (2009) J Cell Mol Med , vol.13 B , Issue.8 , pp. 2645-2657
    • Bett, J.S.1    Benn, C.L.2    Ryu, K.Y.3    Kopito, R.R.4    Bates, G.P.5
  • 146
    • 43049168861 scopus 로고    scopus 로고
    • Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation
    • Kim MO, Chawla P, Overland RP, Xia E, Sadri-Vakili G, Cha JH. Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation. J Neurosci. 2008;28(15):3947-57.
    • (2008) J Neurosci , vol.28 , Issue.15 , pp. 3947-3957
    • Kim, M.O.1    Chawla, P.2    Overland, R.P.3    Xia, E.4    Sadri-Vakili, G.5    Cha, J.H.6
  • 150
    • 84886234157 scopus 로고    scopus 로고
    • Epigenetic mechanisms of neurodegeneration in Huntington's disease
    • Lee J, Hwang YJ, Kim KY, Kowall NW, Ryu H. Epigenetic mechanisms of neurodegeneration in Huntington's disease. Neurotherapeutics. 2013;10(4):664-76.
    • (2013) Neurotherapeutics , vol.10 , Issue.4 , pp. 664-676
    • Lee, J.1    Hwang, Y.J.2    Kim, K.Y.3    Kowall, N.W.4    Ryu, H.5
  • 151
    • 84920374074 scopus 로고    scopus 로고
    • HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation
    • Jia H, Morris CD, Williams RM, Loring JF, Thomas EA. HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation. Proc Natl Acad Sci U S A. 2015;112(1):E56-64.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.1 , pp. E56-E64
    • Jia, H.1    Morris, C.D.2    Williams, R.M.3    Loring, J.F.4    Thomas, E.A.5
  • 152
    • 69849093083 scopus 로고    scopus 로고
    • Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (HDAC) inhibitors
    • Thomas EA. Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (HDAC) inhibitors. Mol Neurobiol. 2009;40(1):33-45.
    • (2009) Mol Neurobiol , vol.40 , Issue.1 , pp. 33-45
    • Thomas, E.A.1
  • 153
    • 84901505786 scopus 로고    scopus 로고
    • Involvement of HDAC1 and HDAC3 in the pathology of polyglutamine disorders: Therapeutic implications for selective HDAC1/HDAC3 inhibitors
    • Thomas EA. Involvement of HDAC1 and HDAC3 in the pathology of polyglutamine disorders: Therapeutic implications for selective HDAC1/HDAC3 inhibitors. Pharmaceuticals (Basel). 2014;7(6):634-61.
    • (2014) Pharmaceuticals (Basel) , vol.7 , Issue.6 , pp. 634-661
    • Thomas, E.A.1
  • 154
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: Molecular mechanisms of action. Oncogene. 2007;26(37):5541-52.
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 155
    • 84870378784 scopus 로고    scopus 로고
    • Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitinproteasomal and autophagy systems
    • Jia H, Kast RJ, Steffan JS, Thomas EA. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitinproteasomal and autophagy systems. Hum Mol Genet. 2012;21(24):5280-93.
    • (2012) Hum Mol Genet , vol.21 , Issue.24 , pp. 5280-5293
    • Jia, H.1    Kast, R.J.2    Steffan, J.S.3    Thomas, E.A.4
  • 159
    • 84884960688 scopus 로고    scopus 로고
    • Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition
    • Lopez-Atalaya JP, Ito S, Valor LM, Benito E, Barco A. Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. Nucleic Acids Res. 2013;41(17):8072-84.
    • (2013) Nucleic Acids Res , vol.41 , Issue.17 , pp. 8072-8084
    • Lopez-Atalaya, J.P.1    Ito, S.2    Valor, L.M.3    Benito, E.4    Barco, A.5
  • 164
    • 34047175919 scopus 로고    scopus 로고
    • Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
    • Dompierre JP, Godin JD, Charrin BC, Cordelieres FP, King SJ, Humbert S, Saudou F. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci. 2007;27(13):3571-83.
    • (2007) J Neurosci , vol.27 , Issue.13 , pp. 3571-3583
    • Dompierre, J.P.1    Godin, J.D.2    Charrin, B.C.3    Cordelieres, F.P.4    King, S.J.5    Humbert, S.6    Saudou, F.7
  • 165
    • 28644433087 scopus 로고    scopus 로고
    • Normal huntingtin function: An alternative approach to Huntington's disease
    • Cattaneo E, Zuccato C, Tartari M. Normal huntingtin function: An alternative approach to Huntington's disease. Nat Rev Neurosci. 2005;6(12):919-30.
    • (2005) Nat Rev Neurosci , vol.6 , Issue.12 , pp. 919-930
    • Cattaneo, E.1    Zuccato, C.2    Tartari, M.3
  • 166
    • 84877802471 scopus 로고    scopus 로고
    • Anthracyclines still prove effective in anticancer therapy
    • Piekarski M, Jelinska A. Anthracyclines still prove effective in anticancer therapy. Mini Rev Med Chem. 2013;13(5):627-34.
    • (2013) Mini Rev Med Chem , vol.13 , Issue.5 , pp. 627-634
    • Piekarski, M.1    Jelinska, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.