Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin

Journal of Biological Chemistry

Volumn 288, Issue 49, 2013, Pages 35604-35616

  Wu, Shuai ^a   Zheng, Shui Di ^b   Huang, Hong Ling ^a   Yan, Li Chong ^a   Yin, Xiao Fei ^a   Xu, Hai Neng ^a   Zhang, Kang Jian ^a   Gui, Jing Hua ^b   Chu, Liang ^a   Liu, Xin Yuan ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TUMORS;

ANTITUMOR EFFECT; AUTOPHAGIC DEGRADATION; HISTONE DEACETYLASES; MUTANT HUNTINGTIN; NEURAL CELLS; TUMOR CELLS; VALPROIC ACID;

LITHIUM;

HISTONE DEACETYLASE 1; HUNTINGTIN; LITHIUM SALT; MESSENGER RNA; MUTANT PROTEIN; VALPROIC ACID; CELF1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HDAC1 PROTEIN, HUMAN; HISTONE DEACETYLASE INHIBITOR; HTT PROTEIN, HUMAN; LITHIUM; NERVE PROTEIN; NEUROPROTECTIVE AGENT; RNA BINDING PROTEIN;

ARTICLE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; ENZYME REPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; HDAC1 GENE; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; RNA TRANSLATION; ANTAGONISTS AND INHIBITORS; DOWN REGULATION; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM;

AUTOPHAGY; DOWN-REGULATION; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HELA CELLS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; LITHIUM; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; PROTEOLYSIS; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 84894355071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.479865     Document Type: Article

References (39)

1. Hynes, R. O. (2002) Integrins. Bidirectional, allosteric signaling machines. Cell 110, 673-687
2. Harburger, D. S., and Calderwood, D. A. (2009) Integrin signalling at a glance. J. Cell Sci. 122, 159-163
3. Calderwood, D. A. (2004) Integrin activation. J. Cell Sci. 117, 657-666
4. Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., and Calderwood, D. A. (2003) Talin binding to integrin - tails. A final common step in integrin activation. Science 302, 103-106
5. Montanez, E., Ussar, S., Schifferer, M., Bösl, M., Zent, R., Moser, M., and Fässler, R. (2008) Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 22, 1325-1330
6. Zaidel-Bar, R., Itzkovitz, S., Ma'ayan, A., Iyengar, R., and Geiger, B. (2007) Functional atlas of the integrin adhesome. Nat. Cell Biol. 9, 858-867
7. Wehrle-Haller, B. (2012) Structure and function of focal adhesions. Curr. Opin. Cell Biol. 24, 116-124
8. Ma, Y. Q., Qin, J., Wu, C., and Plow, E. F. (2008) Kindlin-2 (Mig-2). A co-activator of -3 integrins. J. Cell Biol. 181, 439-446
9. Moser, M., Nieswandt, B., Ussar, S., Pozgajova, M., and Fässler, R. (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat. Med. 14, 325-330
10. Harburger, D. S., Bouaouina, M., and Calderwood, D. A. (2009) Kindlin-1 and -2 directly bind the C-terminal region of - integrin cytoplasmic tails and exert integrin-specific activation effects. J. Biol. Chem. 284, 11485-11497
11. Ussar, S., Wang, H. V., Linder, S., Fässler, R., and Moser, M. (2006) The Kindlins. Subcellular localization and expression during murine development. Exp. Cell Res. 312, 3142-3151
12. Siegel, D. H., Ashton, G. H., Penagos, H. G., Lee, J. V., Feiler, H. S., Wilhelmsen, K. C., South, A. P., Smith, F. J., Prescott, A. R., Wessagowit, V., Oyama, N., Akiyama, M., Al Aboud, D., Al Aboud, K., Al Githami, A., Al Hawsawi, K., Al Ismaily, A., Al-Suwaid, R., Atherton, D. J., Caputo, R., Fine, J. D., Frieden, I. J., Fuchs, E., Haber, R. M., Harada, T., Kitajima, Y., Mallory, S. B., Ogawa, H., Sahin, S., Shimizu, H., Suga, Y., Tadini, G., Tsuchiya, K., Wiebe, C. B., Wojnarowska, F., Zaghloul, A. B., Hamada, T., Mallipeddi, R., Eady, R. A., McLean, W. H., McGrath, J. A., and Epstein, E. H. (2003) Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular- matrix linker protein UNC-112, causes Kindler syndrome. Am. J. Hum. Genet. 73, 174-187
13. Shi, X., Ma, Y. Q., Tu, Y., Chen, K., Wu, S., Fukuda, K., Qin, J., Plow, E. F., and Wu, C. (2007) The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility. J. Biol. Chem. 282, 20455-20466
14. Pluskota, E., Dowling, J. J., Gordon, N., Golden, J. A., Szpak, D., West, X. Z., Nestor, C., Ma, Y. Q., Bialkowska, K., Byzova, T., and Plow, E. F. (2011) The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood 117, 4978-4987
15. Bialkowska, K., Ma, Y. Q., Bledzka, K., Sossey-Alaoui, K., Izem, L., Zhang, X., Malinin, N., Qin, J., Byzova, T., and Plow, E. F. (2010) The integrin co-activator kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. J. Biol. Chem. 285, 18640-18649
16. Kuijpers, T. W., van de Vijver, E., Weterman, M. A., de Boer, M., Tool, A. T., van den Berg, T. K., Moser, M., Jakobs, M. E., Seeger, K., Sanal, O., Unal, S., Cetin, M., Roos, D., Verhoeven, A. J., and Baas, F. (2009) LAD-1/ variant syndrome is caused by mutations in FERMT3. Blood 113, 4740-4746
17. Moser, M., Bauer, M., Schmid, S., Ruppert, R., Schmidt, S., Sixt, M., Wang, H. V., Sperandio, M., and Fässler, R. (2009) Kindlin-3 is required for -2 integrin-mediated leukocyte adhesion to endothelial cells. Nat. Med. 15, 300-305
18. Malinin, N. L., Zhang, L., Choi, J., Ciocea, A., Razorenova, O., Ma, Y. Q., Podrez, E. A., Tosi, M., Lennon, D. P., Caplan, A. I., Shurin, S. B., Plow, E. F., and Byzova, T. V. (2009) A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat. Med. 15, 313-318
19. Bandyopadhyay, A., Rothschild, G., Kim, S., Calderwood, D. A., and Raghavan, S. (2012) Functional differences between kindlin-1 and kindlin- 2 in keratinocytes. J. Cell Sci. 125, 2172-2184
20. Bouaouina, M., Goult, B. T., Huet-Calderwood, C., Bate, N., Brahme, N. N., Barsukov, I. L., Critchley, D. R., and Calderwood, D. A. (2012) A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated -IIb-3 integrin coactivation. J. Biol. Chem. 287, 6979-6990
21. Has, C., Herz, C., Zimina, E., Qu, H. Y., He, Y., Zhang, Z. G., Wen, T. T., Gache, Y., Aumailley, M., and Bruckner-Tuderman, L. (2009) Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Am J. Pathol. 175, 1442-1452
22. Lai-Cheong, J. E., Ussar, S., Arita, K., Hart, I. R., and McGrath, J. A. (2008) Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J. Invest. Dermatol. 128, 2156-2165
23. Tu, Y., Wu, S., Shi, X., Chen, K., and Wu, C. (2003) Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113, 37-47
24. Xiao, G., Cheng, H., Cao, H., Chen, K., Tu, Y., Yu, S., Jiao, H., Yang, S., Im, H. J., Chen, D., Chen, J., and Wu, C. (2012) Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J. Biol. Chem. 287, 21450-21460
25. Ou, Y., Ma, L., Dong, L., Ma, L., Zhao, Z., Ma, L., Zhou, W., Fan, J., Wu, C., Yu, C., Zhan, Q., and Song, Y. (2012) Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptormediated phospholipase C- and STAT3 protein signaling pathways. J. Biol. Chem. 287, 32394-32405
26. Papachristou, D. J., Gkretsi, V., Tu, Y., Shi, X., Chen, K., Larjava, H., Rao, U. N., and Wu, C. (2007) Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. Histopathology 51, 499-508
27. Zhang, Y., Tu, Y., Gkretsi, V., and Wu, C. (2006) Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. J. Biol. Chem. 281, 12397-12407
28. Ithychanda, S. S., Das, M., Ma, Y. Q., Ding, K., Wang, X., Gupta, S., Wu, C., Plow, E. F., and Qin, J. (2009) Migfilin, a molecular switch in regulation of integrin activation. J. Biol. Chem. 284, 4713-4722
29. Lad, Y., Jiang, P., Ruskamo, S., Harburger, D. S., Ylänne, J., Campbell, I. D., and Calderwood, D. A. (2008) Structural basis of the migfilin/filamin interaction and competition with integrin - tails. J. Biol. Chem. 283, 35154-35163
30. Das, M., Ithychanda, S. S., Qin, J., and Plow, E. F. (2011) Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils. PloS One 6, e26355
31. Kiema, T., Lad, Y., Jiang, P., Oxley, C. L., Baldassarre, M., Wegener, K. L., Campbell, I. D., Ylänne, J., and Calderwood, D. A. (2006) The molecular basis of filamin binding to integrins and competition with talin. Mol. Cell 21, 337-347
32. Gkretsi, V., Zhang, Y., Tu, Y., Chen, K., Stolz, D. B., Yang, Y., Watkins, S. C., and Wu, C. (2005) Physical and functional association of migfilin with cell-cell adhesions. J. Cell Sci. 118, 697-710
33. Heuzé, M. L., Lamsoul, I., Baldassarre, M., Lad, Y., Lévêque, S., Razinia, Z., Moog-Lutz, C., Calderwood, D. A., and Lutz, P. G. (2008) ASB2 targets filamins A and B to proteasomal degradation. Blood 112, 5130-5140
34. Kloeker, S., Major, M. B., Calderwood, D. A., Ginsberg, M. H., Jones, D. A., and Beckerle, M. C. (2004) The Kindler syndrome protein is regulated by transforming growth factor- and involved in integrin-mediated adhesion. J. Biol. Chem. 279, 6824-6833
35. Parsons, M., Messent, A. J., Humphries, J. D., Deakin, N. O., and Humphries, M. J. (2008) Quantification of integrin receptor agonism by fluorescence lifetime imaging. J. Cell Sci. 121, 265-271
36. Worth, D. C., Hodivala-Dilke, K., Robinson, S. D., King, S. J., Morton, P. E., Gertler, F. B., Humphries, M. J., and Parsons, M. (2010) -v-3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J. Cell Biol. 189, 369-383
37. Morton, P. E., and Parsons, M. (2011) Measuring FRET using time-resolved FLIM. Methods Mol. Biol. 769, 403-413
38. Petricca, G., Leppilampi, M., Jiang, G., Owen, G. R., Wiebe, C., Tu, Y., Koivisto, L., Häkkinen, L., Wu, C., and Larjava, H. (2009) Localization and potential function of kindlin-1 in periodontal tissues. Eur. J. Oral Sci. 117, 518-527
39. Moik, D. V., Janbandhu, V. C., and Fässler, R. (2011) Loss of migfilin expression has no overt consequences on murine development and homeostasis. J. Cell Sci. 124, 414-421