Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

Human Molecular Genetics

Volumn 9, Issue 9, 2000, Pages 1259-1271

  Luthi Carter, Ruth ^a   Strand, Andrew ^b   Peters, Nikki L ^a   Solano, Steven M ^a   Hollingsworth, Zane R ^a   Menon, Anil S ^a   Frey, Ariel S ^a   Spektor, Boris S ^a   Penney, Ellen B ^a   Schilling, Gabriele ^c   Ross, Christopher A ^c   Borchelt, David R ^c   Tapscott, Stephen J ^b   Young, Anne B ^a   Cha, Jang Ho J ^a   Olson, James M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DNA; MESSENGER RNA; NEUROTRANSMITTER; OLIGONUCLEOTIDE; RETINOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; GENE EXPRESSION; HUNTINGTON CHOREA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0034702030     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.9.1259     Document Type: Article

References (60)

1. Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is unstable in Huntington's disease chromosomes. Cell, 72, 971-983.
2. 2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann. Neurol., 40, 49-54.
3. Cha, J.-H., Kosinski, C.M., Kemer, J.A., Alsdorf, S.A., Mangiarini, L., Davies, S.W., Penney, J.B., Bates, G.P. and Young, A.B. (1998) Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc. Natl Acad. Sci. USA, 95, 6480-6485.
4. Cha, J.-H., Frey, A.S., Alsdorf, S.A., Kerner, J.A., Kosinski, C.M., Mangiarini, L., Penney, J.B., Davies, S.W., Bates, G.P. and Young, A.B. (1999) Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease. Phil. Trans. R. Soc. Lond. B Biol. Sci., 354, 981-989.
5. Li, S.H., Cheng, A.L., Li, H. and Li, X.J. (1999) Cellular defects and altered gene expression in PC 12 cells stably expressing mutant huntingtin. J. Neurosci., 19, 5159-5172.
6. Huang, C.C., Faber, P.W., Persichetti, F., Mittal, V., Vonsatte, J.-P., MacDonald, M.E. and Gusella, J.F. (1998) Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polygluatmine proteins. Somat. Cell Mol. Genet., 24, 217-233.
7. Boutell, J.M., Thomas, P., Neal, J.W., Weston, V.J., Duce, J., Harper, P.S. and Jones, A.L. (1999) Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Hum. Mol. Genet., 8, 1647-1655.
8. Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. and Lockhart, D.J. (1999) High density synthetic oligonucleotide arrays. Nature Genet., 21 (suppl. 1), 20-24.
9. Clagett-Dame, M. and Plum, L.A. (1997) Retinoid-regulated gene expression in neural development. Crit. Rev. Eukaryot. Gene Expr., 7, 299-342.
10. Matkovits, T. and Christakos, S. (1995) Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation. Mol. Endocrinol., 9, 232-242.
11. Horlein, A.J., Nar, A.M., Heinzel, T., Torchia, J., Gloss, B., Kurokawa, R., Ryan, A., Kamel, Y., Soderstrom, M., Glass, C.K. and Rosenfeld, M.G. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature, 377, 397-404.
12. Toresson, H., Urquiza, A.M., Fagerstrom, C., Perlmann, T. and Campbell, K. (1999) Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development, 126, 1317-1326.
13. Samad, T.A., Krezel, W., Chambon, P. and Borrelli, E. (1997) Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoic X receptor family. Proc. Natl Acad. Sci. USA, 94, 14349-14354.
14. Jonk, L.J.C., deJonge, M.E.J., Vervaart, J.M.A., Wissink, S. and Kruijer, W. (1994) Isolation and developmental expression of retinoic-acid-induced genes. Dev. Biol., 161, 604-614.
15. Bain, G., Ray, W.J., Yao, M. and Gottlieb, D.I. (1994) From embryonal carcinoma cells to neurons: the P19 pathway. Bioessays, 16, 343-348.
16. Kogner, P., Borgstrom, P., Bjellerup, P., Schilling, F.H., Refai, E., Jonsson, C., Dominici, C., Wassberg, E., Bihl, H. and Jacobsson, H., Theodorsson, E. and Hassan, M. (1997) Somatostatin in neuroblastoma and ganglioneuroma. Eur. J. Cancer, 33, 2084-2089.
17. Sato, T., Xiao, D.M., Li, H., Huang, F.L. and Huang, K.P. (1995) Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein). J. Biol. Chem., 270, 10314-10322.
18. Pennypacker, K.R., Kincaid, R.L., Polli, J.W. and Billingsley, M.L. (1989) Expression of calmodulin-dependent phosphodiesterase, calmodulin-dependent protein phosphatase and other calmodulin-binding proteins in human SMS-KCNR neuroblastoma cells. J. Neurochem., 52, 1438-1448.
19. Lipskaia, L., Djiane, A., Defer, N. and Hanoune, J. (1997) Different expression of adenylyl cyclase isoforms after retinoic acid induction of P19 teratocarcinoma cells. FEBS Lett., 415, 275-280.
20. Kihira, H., Hiasa, A., Yamamoto, M., Katayama, N., Kuno, T, Ohtsuka, K., Shiku, H. and Nishikawa, M. (1998) Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation. Int. J. Oncol., 12, 629-634.
21. Comb, M., Mermod, N., Hyman, S.E., Pearlberg, J., Ross, M.E. and Goodman, H.M. (1988) Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J., 7, 3798-3805.
22. Montminy, M.R., Low, M.J., Tapia-Arancibia, L., Reichlin, S., Mandel, G. and Goodman, R.H. (1986) Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblasts. J. Neurosci., 6, 1171-1176.
23. Laprade, N. and Soghomonian, J.J. (1997) Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons. Brain Res. Mol. Brain Res., 48, 333-345.
24. Reutter, M.A., Richards, E.M. and Sumners, C. (1997) Regulation of alpha 2A-adrenergic receptor mRNA in rat astroglial cultures: role of cyclic AMP and protein kinase C. J. Neurochem., 68, 47-57.
25. 2+ pump isoform 1 promoter: cloning and characterization. Arch. Biochem. Biophys., 316, 302-310.
26. Matranga, V., Oliva, D., Sciarrino, S., D'Amelio, L. and Giallongo, A. (1993) Differential expression of neuron-specific enolase mRNA in mouse neuroblastoma cells in response to differentiation inducing agents. Cell. Mol. Neurobiol., 13, 137-145.
27. Vaccarino, F.M., Hayward, M.D., Le, H.N., Hartigan, D.J., Duman, R.S. and Nestler, E.J. (1993) Induction of immediate early genes by cyclic AMP in primary cultures of neurons from rat cerebral cortex. Brain Res. Mol. Brain Res., 19, 76-82.
28. Kuzhikandathil, E.V. and Molloy, G.R. (1994) Transcription of the brain creatine kinase gene in glial cells is modulated by cyclic AMP-dependent protein. J. Neurosci. Res., 39, 70-82
29. Rubinsztein, D.C., Leggo, J., Chiano, M., Dodge, A., Norbury, G., Rosser, E. and Craudfurd, D. (1997) Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington's disease. Proc. Natl Acad. Sci. USA, 94, 3872-3876.
30. 2+ and other second messengers in excitatory amino acid receptor mediated neurodegeneration: clinical perspectives. Clin. Neurosci., 4, 194-198.
31. Hodgson, J.G., Agopyan, N., Gutekunst, C.A., Leavitt, B.R., LePiane, F., Singaraja, R., Smith, D.J., Bissada, N., McCutcheon, K., Nasir, J. et al. (1999) A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity and selective striatal neurodegeneration. Neuron, 23, 181-192.
32. Bao, J., Sharp, A.H., Wagster, M.V., Becher, M., Schilling, G., Ross, C.A., Dawson, V.L. and Dawson, T.M. (1996) Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proc. Natl Acad. Sci. USA, 93, 5037-5042.
33. Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S.W. and Bates, G.P. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87, 493-506.
34. Hurlbert, M.S., Zhou, W., Wasmeier, C., Kaddis, F.G., Hutton, J.C. and Freed, C.R. (1999) Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes, 48, 649-651.
35. Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.P., Lasmezas, C., Dormont, D., Tovey, M.G. and Dron, M. (1998) Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. J. Biol. Sci., 273, 7691-7697.
36. Greengard, P., Allen, P.B. and Nairn, A.C. (1999) Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron, 23, 435-447.
37. Schilling, G., Becher, M.W., Sharp, A.H., Jinnah, H.A., Duan, K., Kotzuk, J.A., Slunt, H.H., Ratovitski, T., Cooper, J.K., Jenkins, N.A., Copeland, N.G., Price, D.L., Ross, C.A. and Borchelt, D.R. (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet., 8, 397-407.
38. Menalled, L., Zanjani, H., MacKenzie, L., Koppel, A., Carpenter, E., Zeitlin, S. and Chesselet, M.-F. (2000) Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease. Exp. Neurol., 162, 328-342.
39. Albin, R.L., Qin, Y., Young, A.B., Penney, J.B. and Chesselet, M.F. (1991) Preproenkephalin messenger RNA-containing neurons in striatum of patients with symptomatic and presymptomatic Huntington's disease: an in situ hybridization study. Ann. Neurol., 30, 542-549.
40. Augood, S.J., Faull, R.L.M., Love, D.R. and Emson, P.C. (1996) Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study. Neuroscience, 72, 1023-1036.
41. Marangos, P.J. and Paul, S.M. (1981) Brain levels of neuron-specific and nonneuronal enolase in Huntington's disease. J. Neurochem., 37, 1338-1340.
42. Tanaka, C., Nishino, N., Hashimoto, T., Kitamura, N., Yoshihara, C. and Saito, N. (1993) Second messenger systems in brains of patients with Parkinson's or Huntington's disease. Adv. Neurol., 60, 175-180.
43. Enna, S.J., Bird, E.D., Bennett, J.P., Bylund, D.B., Yammura, H.I., Iversen, L.L. and Snyder, S.H. (1976) Huntington's chorea: changes in neurotransmitter receptors in the brain. N. Engl. J. Med., 294, 1305-1309.
44. 3H]inositol 1, 4, 5-trisphosphate binding in Huntington's disease. J. Neurochem., 56, 1417-1422.
45. Sen, A.P., Boksa, P. and Quirion, R. (1993) Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases. Brain Res., 611, 216-221.
46. Glass, M., Faull, R.L.M. and Dragunow, M. (1993) Loss of cannabinoid receptors in the substantia nigra in Huntington's disease. Neuroscience, 56, 523-527.
47. Robertson, H.A., MacDonald, C.J. and Denovan-Wright, E.M. (1999) Cannabinoid receptor (CB1) mRNA loss in the lateral striatum of Huntington's disease transgenic mice. Soc. Neurosci. Abstr., 25 (Part 1), 829.
48. Tallman, M.S. (1998) Therapy of acute promyelocytic leukemia: all-trans retinoic acid and beyond. Leukemia, 12 (suppl. 1), S37-S40.
49. Carter, R.J., Lione, L.A., Humby, T., Mangiarini, L., Mahal, A., Bates, G.P., Dunnett, S.B. and Morton, A.J. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci., 19, 3248-3257.
50. Ross, C.A., Wood, J.D., Schilling, G., Peters, M.F., Nucifora Jr, F.C., Cooper, J.K., Sharp, A.H., Margolis, R.L. and Borchelt, D.R. (1999) Polyglutamine pathogenesis. Phils. Trans. R. Soc. Lond. B Biol. Sci., 354, 1005-1011.
51. Cooper, J.K., Schilling, G., Peters, M.F., Herring, W.J., Sharp, A.H., Kaminsky, Z., Masone, J., Khan, F.A., Delanoy, M., Borchelt, D.R. et al. (1998) Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum. Mol. Genet., 7, 783-790.
52. DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.-P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
53. Sittler, A., Walter, S., Wedemeyer, N., Hasenbank, R., Scherzinger, E., Eickhoff, H., Bates, G.P., Lehrach, H. and Wanker, E.E. (1998) SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. Mol. Cell, 2, 427-436.
54. Faber, P.W., Barnes, G.T., Srinidhi, J., Chen, J., Gusella, J.F. and MacDonald, M.E. (1998) Huntingtin interacts with a family of WW domain proteins. Hum. Mol. Genet., 7, 1463-1474.
55. Landwehrmeyer, G.B., McNeil, S.M., Dure, L.S., Ge, P., Aizawa, H., Huang, Q., Ambrose, C.M., Duyao, M.P., Bird, E.D., Bonilla, E. et al. (1995) Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals. Ann. Neurol., 37, 218-230.
56. Augood, S.J., Faull, R.L.M. and Emson, P.C. (1997) Dopamine D1 and D2 receptor gene expression in the striatum in Huntington's disease. Ann. Neurol., 42, 215-221.
57. Richfield, E.K., Young, A.B. and Penney, J.B. (1986) Properties of D2 dopamine receptor autoradiography: high percentage of high-affinity agonist sites and increased nucleotide sensitivity in tissue sections. Brain Res., 383, 121-128.
58. 3H]YM-09151-2. Eur. J. Pharmacol., 199, 103-106.
59. 3H]CGS 21680. Eur. J. Pharmacol., 168, 243-246.
60. Worley, P.F., Baraban, J.M., De Souza, E.B. and Snyder, S.H. (1986) Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C. Proc. Natl Acad. Sci. USA, 83, 4053-4057.