-
1
-
-
70350380989
-
Phosphorylation of threonine 3: Implications for Huntingtin aggregation and neurotoxicity
-
CrossRef Medline
-
Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL (2009) Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem 284:29427-29436. CrossRef Medline
-
(2009)
J Biol Chem
, vol.284
, pp. 29427-29436
-
-
Aiken, C.T.1
Steffan, J.S.2
Guerrero, C.M.3
Khashwji, H.4
Lukacsovich, T.5
Simmons, D.6
Purcell, J.M.7
Menhaji, K.8
Zhu, Y.Z.9
Green, K.10
Laferla, F.11
Huang, L.12
Thompson, L.M.13
Marsh, J.L.14
-
2
-
-
79551517312
-
Selective toxicity by HDAC3 in neurons: Regulation by Akt and GSK3
-
CrossRef Medline
-
Bardai FH, D'Mello SR (2011) Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3. J Neurosci 31:1746-1751. CrossRef Medline
-
(2011)
J Neurosci
, vol.31
, pp. 1746-1751
-
-
Bardai, F.H.1
D'Mello, S.R.2
-
3
-
-
84867431257
-
Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death
-
CrossRef Medline
-
Bardai FH, Price V, Zaayman M, Wang L, D'Mello SR (2012) Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. J Biol Chem 287:35444-35453. CrossRef Medline
-
(2012)
J Biol Chem
, vol.287
, pp. 35444-35453
-
-
Bardai, F.H.1
Price, V.2
Zaayman, M.3
Wang, L.4
D'Mello, S.R.5
-
4
-
-
33644830913
-
Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity
-
CrossRef Medline
-
Bates EA, Victor M, Jones AK, Shi Y, Hart AC (2006) Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci 26:2830-2838. CrossRef Medline
-
(2006)
J Neurosci
, vol.26
, pp. 2830-2838
-
-
Bates, E.A.1
Victor, M.2
Jones, A.K.3
Shi, Y.4
Hart, A.C.5
-
5
-
-
0037072807
-
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington'S disease mutation
-
CrossRef Medline
-
Carmichael J, Sugars KL, Bao YP, Rubinsztein DC (2002) Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington'S disease mutation. J Biol Chem 277:33791-33798. CrossRef Medline
-
(2002)
J Biol Chem
, vol.277
, pp. 33791-33798
-
-
Carmichael, J.1
Sugars, K.L.2
Bao, Y.P.3
Rubinsztein, D.C.4
-
6
-
-
0034283877
-
Transcriptional dysregulation in huntington'S disease
-
CrossRef Medline
-
Cha JH (2000) Transcriptional dysregulation in huntington'S disease. Trends Neurosci 23:387-392. CrossRef Medline
-
(2000)
Trends Neurosci
, vol.23
, pp. 387-392
-
-
Cha, J.H.1
-
7
-
-
79551655290
-
Huntington'S disease: Can mice lead the way to treatment?
-
Erratum (2011) 69:1038, CrossRef Medline
-
Crook ZR, Housman D (2011) Huntington'S disease: can mice lead the way to treatment? Neuron [Erratum (2011) 69:1038] 69:423-435. CrossRef Medline
-
(2011)
Neuron
, vol.69
, pp. 423-435
-
-
Crook, Z.R.1
Housman, D.2
-
8
-
-
78651469151
-
FoxG1 promotes the survival of postmitotic neurons
-
CrossRef Medline
-
Dastidar SG, Landrieu PM, D'Mello SR (2011) FoxG1 promotes the survival of postmitotic neurons. J Neurosci 31:402-413. CrossRef Medline
-
(2011)
J Neurosci
, vol.31
, pp. 402-413
-
-
Dastidar, S.G.1
Landrieu, P.M.2
D'mello, S.R.3
-
9
-
-
0027483920
-
Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
-
CrossRef Medline
-
D'Mello SR, Galli C, Ciotti T, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci U S A 90: 10989-10993. CrossRef Medline
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 10989-10993
-
-
D'Mello, S.R.1
Galli, C.2
Ciotti, T.3
Calissano, P.4
-
10
-
-
0033757718
-
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
-
CrossRef Medline
-
Dragatsis I, Levine MS, Zeitlin S (2000) Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet 26:300-306. CrossRef Medline
-
(2000)
Nat Genet
, vol.26
, pp. 300-306
-
-
Dragatsis, I.1
Levine, M.S.2
Zeitlin, S.3
-
11
-
-
0034933959
-
Wild type huntingtin reduces the cellular toxicity of mutant huntingtin in mammalian cell models of huntington'S disease
-
CrossRef Medline
-
Ho LW, Brown R, Maxwell M, Wyttenbach A, Rubinsztein DC (2001) Wild type huntingtin reduces the cellular toxicity of mutant huntingtin in mammalian cell models of huntington'S disease. J Med Genet 38:450-452. CrossRef Medline
-
(2001)
J Med Genet
, vol.38
, pp. 450-452
-
-
Ho, L.W.1
Brown, R.2
Maxwell, M.3
Wyttenbach, A.4
Rubinsztein, D.C.5
-
12
-
-
0036083379
-
The IGF-1/akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by akt
-
CrossRef Medline
-
Humbert S, Bryson EA, Cordelieres FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F (2002) The IGF-1/akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by akt. Dev Cell 2:831-837. CrossRef Medline
-
(2002)
Dev Cell
, vol.2
, pp. 831-837
-
-
Humbert, S.1
Bryson, E.A.2
Cordelieres, F.P.3
Connors, N.C.4
Datta, S.R.5
Finkbeiner, S.6
Greenberg, M.E.7
Saudou, F.8
-
13
-
-
63049132756
-
Acetylation targets mutant huntingtin to autophagosomes for degradation
-
CrossRef Medline
-
Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D (2009) Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137: 60-72. CrossRef Medline
-
(2009)
Cell
, vol.137
, pp. 60-72
-
-
Jeong, H.1
Then, F.2
Melia Jr., T.J.3
Mazzulli, J.R.4
Cui, L.5
Savas, J.N.6
Voisine, C.7
Paganetti, P.8
Tanese, N.9
Hart, A.C.10
Yamamoto, A.11
Krainc, D.12
-
14
-
-
84862819579
-
Histone deacetylase (HDAC) inhibitors targetingHDAC3andHDAC1ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease
-
CrossRef Medline
-
Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR, Darnell SB, Plasterer H, Sadri-Vakili G, Gottesfeld JM, Thompson LM, Rusche JR, Marsh JL, Thomas EA (2012) Histone deacetylase (HDAC) inhibitors targetingHDAC3andHDAC1ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease. Neurobiol Dis 46:351-361. CrossRef Medline
-
(2012)
Neurobiol Dis
, vol.46
, pp. 351-361
-
-
Jia, H.1
Pallos, J.2
Jacques, V.3
Lau, A.4
Tang, B.5
Cooper, A.6
Syed, A.7
Purcell, J.8
Chen, Y.9
Sharma, S.10
Sangrey, G.R.11
Darnell, S.B.12
Plasterer, H.13
Sadri-Vakili, G.14
Gottesfeld, J.M.15
Thompson, L.M.16
Rusche, J.R.17
Marsh, J.L.18
Thomas, E.A.19
-
15
-
-
0035127907
-
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo
-
CrossRef Medline
-
Leavitt BR, Guttman JA, Hodgson JG, Kimel GH, Singaraja R, Vogl AW, Hayden MR (2001) Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. Am J Hum Genet 68:313-324. CrossRef Medline
-
(2001)
Am J Hum Genet
, vol.68
, pp. 313-324
-
-
Leavitt, B.R.1
Guttman, J.A.2
Hodgson, J.G.3
Kimel, G.H.4
Singaraja, R.5
Vogl, A.W.6
Hayden, M.R.7
-
16
-
-
33645100553
-
Wild-type huntingtin protects neurons from excitotoxicity
-
CrossRef Medline
-
Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR (2006) Wild-type huntingtin protects neurons from excitotoxicity. J Neurochem 96:1121-1129. CrossRef Medline
-
(2006)
J Neurochem
, vol.96
, pp. 1121-1129
-
-
Leavitt, B.R.1
van Raamsdonk, J.M.2
Shehadeh, J.3
Fernandes, H.4
Murphy, Z.5
Graham, R.K.6
Wellington, C.L.7
Raymond, L.A.8
Hayden, M.R.9
-
17
-
-
46149115160
-
HDAC4 inhibits cell-cycle progression and protects neurons from cell death
-
CrossRef Medline
-
Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR (2008) HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol 68:1076-1092. CrossRef Medline
-
(2008)
Dev Neurobiol
, vol.68
, pp. 1076-1092
-
-
Majdzadeh, N.1
Wang, L.2
Morrison, B.E.3
Bassel-Duby, R.4
Olson, E.N.5
D'mello, S.R.6
-
18
-
-
84856710176
-
Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of huntington'S disease
-
CrossRef Medline
-
Moumné L, Campbell K, Howland D, Ouyang Y, Bates GP (2012) Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of huntington's disease. PLoS One 7:e31080. CrossRef Medline
-
(2012)
PLoS One
, vol.7
-
-
Moumné, L.1
Campbell, K.2
Howland, D.3
Ouyang, Y.4
Bates, G.P.5
-
19
-
-
0029055717
-
Targeted disruption of the huntington'S disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
-
CrossRef Medline
-
Nasir J, Floresco SB, O'Kusky JR, Diewert VM, Richman JM, Zeisler J, Borowski A, Marth JD, Phillips AG, Hayden MR (1995) Targeted disruption of the huntington'S disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81:811-823. CrossRef Medline
-
(1995)
Cell
, vol.81
, pp. 811-823
-
-
Nasir, J.1
Floresco, S.B.2
O'Kusky, J.R.3
Diewert, V.M.4
Richman, J.M.5
Zeisler, J.6
Borowski, A.7
Marth, J.D.8
Phillips, A.G.9
Hayden, M.R.10
-
20
-
-
20444455430
-
Phosphorylation of arfaptin 2 at Ser260 by akt inhibits PolyQ-huntingtininduced toxicity by rescuing proteasome impairment
-
CrossRef Medline
-
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (2005) Phosphorylation of arfaptin 2 at Ser260 by akt inhibits PolyQ-huntingtininduced toxicity by rescuing proteasome impairment. J Biol Chem 280: 22021-22028. CrossRef Medline
-
(2005)
J Biol Chem
, vol.280
, pp. 22021-22028
-
-
Rangone, H.1
Pardo, R.2
Colin, E.3
Girault, J.A.4
Saudou, F.5
Humbert, S.6
-
21
-
-
0034657112
-
Wild-type huntingtin protects from apoptosis upstream of caspase-3
-
Medline
-
Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E (2000) Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci 20:3705-3713. Medline
-
(2000)
J Neurosci
, vol.20
, pp. 3705-3713
-
-
Rigamonti, D.1
Bauer, J.H.2
De-Fraja, C.3
Conti, L.4
Sipione, S.5
Sciorati, C.6
Clementi, E.7
Hackam, A.8
Hayden, M.R.9
Li, Y.10
Cooper, J.K.11
Ross, C.A.12
Govoni, S.13
Vincenz, C.14
Cattaneo, E.15
-
22
-
-
78650031174
-
Huntington'S disease: From molecular pathogenesis to clinical treatment
-
CrossRef Medline
-
Ross CA, Tabrizi SJ (2011) Huntington'S disease: From molecular pathogenesis to clinical treatment. Lancet Neurol 10:83-98. CrossRef Medline
-
(2011)
Lancet Neurol
, vol.10
, pp. 83-98
-
-
Ross, C.A.1
Tabrizi, S.J.2
-
23
-
-
0035909330
-
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
-
CrossRef Medline
-
Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739-743. CrossRef Medline
-
(2001)
Nature
, vol.413
, pp. 739-743
-
-
Steffan, J.S.1
Bodai, L.2
Pallos, J.3
Poelman, M.4
McCampbell, A.5
Apostol, B.L.6
Kazantsev, A.7
Schmidt, E.8
Zhu, Y.Z.9
Greenwald, M.10
Kurokawa, R.11
Housman, D.E.12
Jackson, G.R.13
Marsh, J.L.14
Thompson, L.M.15
-
24
-
-
55749103407
-
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in huntington'S disease transgenic mice
-
CrossRef Medline
-
Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM (2008) The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in huntington'S disease transgenic mice. Proc Natl Acad Sci U S A 105:15564-15569. CrossRef Medline
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 15564-15569
-
-
Thomas, E.A.1
Coppola, G.2
Desplats, P.A.3
Tang, B.4
Soragni, E.5
Burnett, R.6
Gao, F.7
Fitzgerald, K.M.8
Borok, J.F.9
Herman, D.10
Geschwind, D.H.11
Gottesfeld, J.M.12
-
25
-
-
82555176567
-
Reagents that block neuronal death from huntington'S disease also curb oxidative stress
-
CrossRef Medline
-
Valencia A, Sapp E, Reeves PB, Alexander J, Masso N, Li X, Kegel KB, DiFiglia M (2012) Reagents that block neuronal death from huntington'S disease also curb oxidative stress. Neuroreport 23:10-15. CrossRef Medline
-
(2012)
Neuroreport
, vol.23
, pp. 10-15
-
-
Valencia, A.1
Sapp, E.2
Reeves, P.B.3
Alexander, J.4
Masso, N.5
Li, X.6
Kegel, K.B.7
Difiglia, M.8
-
26
-
-
19744380273
-
Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of huntington disease
-
CrossRef Medline
-
Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR (2005) Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of huntington disease. Hum Mol Genet 14:1379-1392. CrossRef Medline
-
(2005)
Hum Mol Genet
, vol.14
, pp. 1379-1392
-
-
van Raamsdonk, J.M.1
Pearson, J.2
Rogers, D.A.3
Bissada, N.4
Vogl, A.W.5
Hayden, M.R.6
Leavitt, B.R.7
-
27
-
-
0141531987
-
Depletion of wild-type huntingtin in mouse models of neurologic diseases
-
CrossRef Medline
-
Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM (2003) Depletion of wild-type huntingtin in mouse models of neurologic diseases. J Neurochem 87:101-106. CrossRef Medline
-
(2003)
J Neurochem
, vol.87
, pp. 101-106
-
-
Zhang, Y.1
Li, M.2
Drozda, M.3
Chen, M.4
Ren, S.5
Mejia, S.R.O.6
Leavitt, B.R.7
Cattaneo, E.8
Ferrante, R.J.9
Hayden, M.R.10
Friedlander, R.M.11
-
28
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in huntington'S disease
-
CrossRef Medline
-
Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington'S disease. Science 293:493-498. CrossRef Medline
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
Ciammola, A.2
Rigamonti, D.3
Leavitt, B.R.4
Goffredo, D.5
Conti, L.6
Macdonald, M.E.7
Friedlander, R.M.8
Silani, V.9
Hayden, M.R.10
Timmusk, T.11
Sipione, S.12
Cattaneo, E.13
-
29
-
-
77955643169
-
Molecular mechanisms and potential therapeutical targets in huntington'S disease
-
CrossRef Medline
-
Zuccato C, Valenza M, Cattaneo E (2010) Molecular mechanisms and potential therapeutical targets in huntington'S disease. Physiol Rev 90:905-981. CrossRef Medline
-
(2010)
Physiol Rev
, vol.90
, pp. 905-981
-
-
Zuccato, C.1
Valenza, M.2
Cattaneo, E.3
|