HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 1, 2015, Pages E56-E64

  Jia, Haiqun ^a   Morris, Charles D ^a   Williams, Roy M ^a,b   Loring, Jeanne F ^a   Thomas, Elizabeth A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Epigenetic; Histone; Neurodegenerative; Therapeutic; Transgenerational

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; DIAMIDE; DNA; HISTONE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; N1 (2 AMINOPHENYL) N7 PHENYLHEPTANEDIAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA MICROARRAY; DRUG MECHANISM; ENZYME INHIBITION; EPIGENETICS; FEMALE; FIBROBLAST; GENE; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; K SPECIFIC DEMETHYLASE 5D GENE; MALE; METABOLIC DISORDER; MICROARRAY ANALYSIS; MOUSE; MUTANT; NEUROPHARMACOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERLAPPING GENE; PHENOTYPE; PROGENY; SIGNAL TRANSDUCTION; SPERM; TRANSGENIC MOUSE; Y CHROMOSOME LINKAGE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUNTINGTON DISEASE; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; SPERMATOZOON;

MUS; MUS MUSCULUS;

ANIMALS; DISEASE MODELS, ANIMAL; DNA METHYLATION; FIBROBLASTS; GENETIC LOCI; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; HUNTINGTON DISEASE; MALE; MICE, TRANSGENIC; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; SPERMATOZOA;

EID: 84920374074     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415195112     Document Type: Article

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