Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

Science Translational Medicine

Volumn 6, Issue 268, 2014, Pages 268ra178-

  Lu, Xiao Hong ^a,b,c   Mattis, Virginia B ^d   Wang, Nan ^a,b,c   Al Ramahi, Ismael ^e,f   Van Den Berg, Nick ^g   Fratantoni, Silvina A ^g   Waldvogel, Henry ^h   Greiner, Erin ^a,b,c   Osmand, Alex ⁱ   Elzein, Karla ^e,f   Xiao, Jingbo ^j   Dijkstra, Sipke ^g   De Pril, Remko ^k   Vinters, Harry V ^b   Faull, Richard ^h   Signer, Ethan ^l   Kwak, Seung ^l   Marugan, Juan J ^j   Botas, Juan ^e,f   Fischer, David F ^g   Svendsen, Clive N ^d   Munoz Sanjuan, Ignacio ^l   Yang, X William ^a,b,c   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f TEXAS CHILDREN S HOSPITAL   (United States)

^g BioFocus DPI   (United Kingdom)

^h UNIVERSITY OF AUCKLAND   (New Zealand)

ⁱ Department of Biochemistry and Cellular and Molecular Biology ^*  (United States)

^j NATIONAL INSTITUTES OF HEALTH   (United States)

^k Galapagos   (Netherlands)

^l CHDI MANAGEMENT CHDI FOUNDATION   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; HISTONE H2AX; HUNTINGTIN; KU 60019; UNCLASSIFIED DRUG; 2-(2,6-DIMETHYLMORPHOLIN-4-YL)-N-(5-(6-MORPHOLIN-4-YL-4-OXO-4H-PYRAN-2-YL)-9H-THIOXANTHEN-2-YL)ACETAMIDE; HISTONE; HTT PROTEIN, HUMAN; MORPHOLINE DERIVATIVE; MUTANT PROTEIN; NERVE PROTEIN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, MOUSE; THIOXANTHENE DERIVATIVE;

ADULT; AGED; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATM GENE; BEHAVIOR DISORDER; BRAIN TISSUE; CONTROLLED STUDY; CYTOTOXICITY; DROSOPHILA; DRUG EFFECT; EMBRYO; FEMALE; FIBROBLAST; GENE DOSAGE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOCYTOCHEMISTRY; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; BRAIN; CELL LINE; CELL PROTECTION; CYTOLOGY; DISEASE MODEL; DROSOPHILA MELANOGASTER; DRUG EFFECTS; GENE SILENCING; METABOLISM; MIDDLE AGED; MOUSE MUTANT; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PLURIPOTENT STEM CELL; POSTMORTEM CHANGE;

ADULT; AGED; ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BEHAVIOR, ANIMAL; BRAIN; CELL LINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; GENE DOSAGE; GENE KNOCKDOWN TECHNIQUES; HISTONES; HUMANS; HUNTINGTON DISEASE; INDUCED PLURIPOTENT STEM CELLS; MICE, NEUROLOGIC MUTANTS; MIDDLE AGED; MORPHOLINES; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; POSTMORTEM CHANGES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIGNAL TRANSDUCTION; THIOXANTHENES;

EID: 84919756166     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3010523     Document Type: Article

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